Quinestrol_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Quinestrol perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Quinestrol_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.272494
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.146153
MYO1E myosin IE 0.100737
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.078716
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.07788
ERRFI1 ERBB receptor feedback inhibitor 1 0.0648189
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0647579
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0641767
LMO7 LIM domain 7 0.0593903
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.057924
EFNA5 ephrin-A5 0.0568039
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0556498
SAMD4A sterile alpha motif domain containing 4A 0.0525252
EGFR epidermal growth factor receptor 0.0521861
LIMCH1 LIM and calponin homology domains 1 0.0520703
IQGAP1 IQ motif containing GTPase activating protein 1 0.0486112
ZFAND3 zinc finger, AN1-type domain 3 0.0482966
PDE10A phosphodiesterase 10A 0.0481272
NAMPT nicotinamide phosphoribosyltransferase 0.0456807
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0451305
EPAS1 endothelial PAS domain protein 1 0.0425252
RBM39 RNA binding motif protein 39 0.0425105
ANXA1 annexin A1 0.042435
ATXN1 ataxin 1 0.0417816
AKAP13 A kinase (PRKA) anchor protein 13 0.0415876
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0411067
ZSWIM6 zinc finger, SWIM-type containing 6 0.0410192
FNDC3A fibronectin type III domain containing 3A 0.0389406
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0383627
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0378825
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0374987
PDIA4 protein disulfide isomerase family A, member 4 0.0374017
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0372385
ARHGAP26 Rho GTPase activating protein 26 0.0368328
CLTC clathrin, heavy chain (Hc) 0.0368074
TXNIP thioredoxin interacting protein 0.0367817
ARHGAP5 Rho GTPase activating protein 5 0.035733
BACE2 beta-site APP-cleaving enzyme 2 0.0348324
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0336584
ARB2A ARB2 cotranscriptional regulator A 0.0335274
CEP95 centrosomal protein 95kDa 0.0327756
CDCP1 CUB domain containing protein 1 0.0325714
VCL vinculin 0.0325343
ASPH aspartate beta-hydroxylase 0.03239
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0321506
NKTR natural killer cell triggering receptor 0.031886
IRS2 insulin receptor substrate 2 0.0317934
COLEC11 collectin sub-family member 11 0.0314037
DSCAM Down syndrome cell adhesion molecule 0.03086
SH3KBP1 SH3-domain kinase binding protein 1 0.0306785
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0305744
CATSPERB catsper channel auxiliary subunit beta 0.0302553
ATP11A ATPase, class VI, type 11A 0.0301142
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.0300226
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0299785
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.02978
CXCL8 chemokine (C-X-C motif) ligand 8 0.0297286
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0295793
MAN2A1 mannosidase, alpha, class 2A, member 1 0.0293134
PDLIM5 PDZ and LIM domain 5 0.0292257
HPCAL1 hippocalcin-like 1 0.0291612
FBXO11 F-box protein 11 0.0288801
MAP3K13 mitogen-activated protein kinase kinase kinase 13 0.0288689
CEP350 centrosomal protein 350kDa 0.0287044
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 0.0280586
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0279942
MCL1 myeloid cell leukemia 1 0.0279389
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.027913
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0276483
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0276396
MORF4L1 mortality factor 4 like 1 0.0274164
HIPK2 homeodomain interacting protein kinase 2 0.027384
ESYT2 extended synaptotagmin-like protein 2 0.0272253
SMAD3 SMAD family member 3 0.0272154
RUNX1 runt-related transcription factor 1 0.027189
IGF2R insulin-like growth factor 2 receptor 0.0271708
PTBP2 polypyrimidine tract binding protein 2 0.0271241
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0269306
DOCK5 dedicator of cytokinesis 5 0.0267279
LPP LIM domain containing preferred translocation partner in lipoma 0.026512
TFG TRK-fused gene 0.0264192
YME1L1 YME1-like 1 ATPase 0.026412
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0263317
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0262627
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0262359
PGK1 phosphoglycerate kinase 1 0.0261753
THSD4 thrombospondin, type I, domain containing 4 0.0261286
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0260201
HDAC4 histone deacetylase 4 0.0257008
HSPH1 heat shock 105kDa/110kDa protein 1 0.0256774
FRY furry homolog (Drosophila) 0.0252885
ZNF292 zinc finger protein 292 0.0251871
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0248913
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.024586
PLK2 polo-like kinase 2 0.0245837
EIF4A2 eukaryotic translation initiation factor 4A2 0.0245461
RAB7A RAB7A, member RAS oncogene family 0.0242842
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.0242517
MYH9 myosin, heavy chain 9, non-muscle 0.0240897
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0238385

decreased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 -0.0958394
TMSB10 thymosin beta 10 -0.0725601
KRT17 keratin 17, type I -0.0679389
POTEF POTE ankyrin domain family, member F -0.0668821
IGFBP3 insulin-like growth factor binding protein 3 -0.0611308
RPS25 ribosomal protein S25 -0.0599565
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced -0.0578071
LSAMP limbic system-associated membrane protein -0.0577955
DLG1 discs, large homolog 1 (Drosophila) -0.0559981
RPL31 ribosomal protein L31 -0.0530865
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0513578
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0510862
LAMB3 laminin, beta 3 -0.0497711
RPL35A ribosomal protein L35a -0.0495467
ENO1 enolase 1, (alpha) -0.0490256
RPL12 ribosomal protein L12 -0.0475322
TPM4 tropomyosin 4 -0.0452583
EGR1 early growth response 1 -0.0449333
RPS16 ribosomal protein S16 -0.0443825
BRWD1 bromodomain and WD repeat domain containing 1 -0.0419868
ADNP activity-dependent neuroprotector homeobox -0.0415695
PLAU plasminogen activator, urokinase -0.0409682
RIGI RNA sensor RIG-I -0.0408815
RPL37A ribosomal protein L37a -0.0405803
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0398031
PTMA prothymosin, alpha -0.0397727
PARD3 par-3 family cell polarity regulator -0.0390852
RNF145 ring finger protein 145 -0.0382613
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0382341
AKAP12 A kinase (PRKA) anchor protein 12 -0.0381921
ZBTB20 zinc finger and BTB domain containing 20 -0.0381086
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0375253
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.037454
B2M beta-2-microglobulin -0.0370529
NDRG1 N-myc downstream regulated 1 -0.0369005
RPL15 ribosomal protein L15 -0.0368765
UBC ubiquitin C -0.0366797
JMJD1C jumonji domain containing 1C -0.0365432
RPS24 ribosomal protein S24 -0.035563
DOCK4 dedicator of cytokinesis 4 -0.0354986
MUC16 mucin 16, cell surface associated -0.0352876
RPS20 ribosomal protein S20 -0.0351141
SPAG9 sperm associated antigen 9 -0.0349223
RPL26 ribosomal protein L26 -0.0346068
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0345606
GPC6 glypican 6 -0.0345393
SH3D19 SH3 domain containing 19 -0.0344022
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0343002
MORF4L2 mortality factor 4 like 2 -0.0336543
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0335017
S100A6 S100 calcium binding protein A6 -0.0332687
NBAS neuroblastoma amplified sequence -0.0323587
GPHN gephyrin -0.0321971
RHOA ras homolog family member A -0.031974
RPLP1 ribosomal protein, large, P1 -0.0315109
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0314786
USP3 ubiquitin specific peptidase 3 -0.0313291
GSK3B glycogen synthase kinase 3 beta -0.0311359
RPS12 ribosomal protein S12 -0.0310813
RPLP2 ribosomal protein, large, P2 -0.0310073
CHD1 chromodomain helicase DNA binding protein 1 -0.030949
QKI QKI, KH domain containing, RNA binding -0.0309297
USP34 ubiquitin specific peptidase 34 -0.0307002
ZEB1 zinc finger E-box binding homeobox 1 -0.0304983
RRBP1 ribosome binding protein 1 -0.0304118
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 -0.0302723
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0302025
GARS1 glycyl-tRNA synthetase 1 -0.0299171
RPLP0 ribosomal protein, large, P0 -0.029296
GATAD2B GATA zinc finger domain containing 2B -0.0288333
SRP54 signal recognition particle 54kDa -0.0286816
INHBA inhibin, beta A -0.0285852
RAB10 RAB10, member RAS oncogene family -0.0285628
LDHA lactate dehydrogenase A -0.0284631
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0284581
LCORL ligand dependent nuclear receptor corepressor-like -0.028434
DST dystonin -0.0283818
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0283041
RPS6 ribosomal protein S6 -0.0279802
SLC38A1 solute carrier family 38, member 1 -0.0272505
TRIO trio Rho guanine nucleotide exchange factor -0.0270776
RPL37 ribosomal protein L37 -0.0268877
RPL28 ribosomal protein L28 -0.0266285
COG5 component of oligomeric golgi complex 5 -0.0266062
UBE2K ubiquitin-conjugating enzyme E2K -0.026602
ARHGAP21 Rho GTPase activating protein 21 -0.0263846
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.0262955
RPS27A ribosomal protein S27a -0.0262938
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0262806
RPS27 ribosomal protein S27 -0.0262632
TBC1D15 TBC1 domain family, member 15 -0.0261587
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0260368
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0258356
RPS17 ribosomal protein S17 -0.0258336
MED13 mediator complex subunit 13 -0.0255144
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0254428
COG6 component of oligomeric golgi complex 6 -0.0254063
RPS5 ribosomal protein S5 -0.0253777
RPL35 ribosomal protein L35 -0.0252939
NALF1 NALCN channel auxiliary factor 1 -0.025279