Quinestrol_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Quinestrol perturbation in NCI-H23 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Quinestrol_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.111331
YBX3 Y box binding protein 3 0.0899416
INTS6 integrator complex subunit 6 0.0872246
MCL1 myeloid cell leukemia 1 0.0776414
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0770994
ELL2 elongation factor, RNA polymerase II, 2 0.076827
HOMER1 homer scaffolding protein 1 0.0737974
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0725564
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0708109
ZSWIM6 zinc finger, SWIM-type containing 6 0.0679945
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0669826
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0659351
SFPQ splicing factor proline/glutamine-rich 0.0613109
WSB1 WD repeat and SOCS box containing 1 0.0606761
TRA2A transformer 2 alpha homolog (Drosophila) 0.0596202
SPRED2 sprouty-related, EVH1 domain containing 2 0.0594017
RAB7A RAB7A, member RAS oncogene family 0.0558419
VCL vinculin 0.0557042
PDE4D phosphodiesterase 4D, cAMP-specific 0.0542993
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0534626
PDLIM5 PDZ and LIM domain 5 0.0531129
SND1 staphylococcal nuclease and tudor domain containing 1 0.0526561
VMP1 vacuole membrane protein 1 0.0517944
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0503145
ZFAND3 zinc finger, AN1-type domain 3 0.0501975
NABP1 nucleic acid binding protein 1 0.0496779
RBM39 RNA binding motif protein 39 0.0489392
STK4 serine/threonine kinase 4 0.0486333
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0485553
JMJD1C jumonji domain containing 1C 0.0484941
UBE2H ubiquitin-conjugating enzyme E2H 0.0482312
DSCAM Down syndrome cell adhesion molecule 0.0465574
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0442659
FBXO11 F-box protein 11 0.0423052
SPAG9 sperm associated antigen 9 0.042232
ZCCHC7 zinc finger, CCHC domain containing 7 0.0403067
ADIPOR2 adiponectin receptor 2 0.0391444
NIPBL Nipped-B homolog (Drosophila) 0.0390457
CCNL1 cyclin L1 0.038973
SNAP25 synaptosomal-associated protein, 25kDa 0.0374947
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0358901
COPA coatomer protein complex, subunit alpha 0.035824
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0355679
AEBP2 AE binding protein 2 0.0355031
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.03528
SLC38A2 solute carrier family 38, member 2 0.0348209
SETD5 SET domain containing 5 0.0340977
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0340158
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0339621
FMNL2 formin-like 2 0.0336012
USP34 ubiquitin specific peptidase 34 0.0335264
PUM2 pumilio RNA-binding family member 2 0.0333507
USP9X ubiquitin specific peptidase 9, X-linked 0.0324903
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0324004
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.0322863
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 0.0317502
ATF6 activating transcription factor 6 0.0316638
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0315399
DOCK5 dedicator of cytokinesis 5 0.0314467
CPNE1 copine I 0.0313384
N4BP2L2 NEDD4 binding protein 2-like 2 0.0313194
ESYT2 extended synaptotagmin-like protein 2 0.0311296
CTNND1 catenin (cadherin-associated protein), delta 1 0.0310803
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0308971
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0302849
MACF1 microtubule-actin crosslinking factor 1 0.0302163
STAU1 staufen double-stranded RNA binding protein 1 0.0301783
ZFC3H1 zinc finger, C3H1-type containing 0.0296561
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0295953
CUL3 cullin 3 0.0295585
CTTN cortactin 0.0294959
SETX senataxin 0.0294725
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0293868
EXOC6B exocyst complex component 6B 0.0290181
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0289813
WWOX WW domain containing oxidoreductase 0.0287062
WWTR1 WW domain containing transcription regulator 1 0.0286881
SEC31A SEC31 homolog A (S. cerevisiae) 0.0285299
CAMTA1 calmodulin binding transcription activator 1 0.0283803
MED13 mediator complex subunit 13 0.028204
AKAP9 A kinase (PRKA) anchor protein 9 0.0280229
NDEL1 nudE neurodevelopment protein 1-like 1 0.0277962
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 0.0271368
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0270245
PRELID2 PRELI domain containing 2 0.0268793
CAPRIN2 caprin family member 2 0.0267652
MCTP1 multiple C2 domains, transmembrane 1 0.026737
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0267153
SCFD1 sec1 family domain containing 1 0.0266958
DDIT3 DNA-damage-inducible transcript 3 0.0265479
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.026535
RAB1A RAB1A, member RAS oncogene family 0.0263347
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0262133
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0260805
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0258492
BRD2 bromodomain containing 2 0.0256356
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0255102
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0254775
TPT1 tumor protein, translationally-controlled 1 0.0254459
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 0.0253756

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.254598
PTMA prothymosin, alpha -0.0782689
TMSB10 thymosin beta 10 -0.0736553
TPI1 triosephosphate isomerase 1 -0.0713339
AKAP12 A kinase (PRKA) anchor protein 12 -0.0705561
TFPI2 tissue factor pathway inhibitor 2 -0.0641834
EGR1 early growth response 1 -0.0612105
TXNRD1 thioredoxin reductase 1 -0.0596221
POTEF POTE ankyrin domain family, member F -0.0546266
VIM vimentin -0.0545918
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0486006
ACTG1 actin gamma 1 -0.0458268
PKM pyruvate kinase, muscle -0.0435441
SBF2 SET binding factor 2 -0.038639
RAD51B RAD51 paralog B -0.0372524
MKI67 marker of proliferation Ki-67 -0.036782
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0363457
CCND2 cyclin D2 -0.0354896
BSG basigin (Ok blood group) -0.0354483
ATP5F1B ATP synthase F1 subunit beta -0.0351984
CENPF centromere protein F, 350/400kDa -0.0349708
BASP1 brain abundant, membrane attached signal protein 1 -0.034715
CCND1 cyclin D1 -0.034585
SINHCAF SIN3-HDAC complex associated factor -0.0343866
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0338691
KTN1 kinectin 1 (kinesin receptor) -0.0337115
RPL35A ribosomal protein L35a -0.0337031
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0334145
RPS27 ribosomal protein S27 -0.0332178
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0328548
BBX bobby sox homolog (Drosophila) -0.0321852
CCDC91 coiled-coil domain containing 91 -0.0314328
MT2A metallothionein 2A -0.0308479
ZFR zinc finger RNA binding protein -0.0307842
RPS21 ribosomal protein S21 -0.0306978
ZNF292 zinc finger protein 292 -0.0305021
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0302257
RYR3 ryanodine receptor 3 -0.0298445
TLK1 tousled-like kinase 1 -0.029514
PFKP phosphofructokinase, platelet -0.0294163
RPL37A ribosomal protein L37a -0.0292664
LOC112694756 uncharaterized LOC112694756 -0.028723
RPL26 ribosomal protein L26 -0.0285749
EFNA5 ephrin-A5 -0.0284297
RPL34 ribosomal protein L34 -0.0282675
THSD4 thrombospondin, type I, domain containing 4 -0.0281563
YBX1 Y box binding protein 1 -0.0273085
RPS24 ribosomal protein S24 -0.0271695
RPLP1 ribosomal protein, large, P1 -0.0270788
LDHB lactate dehydrogenase B -0.0270083
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.0269783
RPS15 ribosomal protein S15 -0.0268343
RPL37 ribosomal protein L37 -0.0268281
ENO1 enolase 1, (alpha) -0.0268167
PFN1 profilin 1 -0.0265541
MAP4 microtubule-associated protein 4 -0.0263397
PGK1 phosphoglycerate kinase 1 -0.0263175
EEF2 eukaryotic translation elongation factor 2 -0.0262716
RPS6 ribosomal protein S6 -0.0262193
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0255548
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.025386
DEK DEK proto-oncogene -0.0250919
HMGA2 high mobility group AT-hook 2 -0.0248094
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E -0.0246627
CBX3 chromobox homolog 3 -0.0246224
TUBB tubulin, beta class I -0.0245008
ENOSF1 enolase superfamily member 1 -0.0243466
EEF1G eukaryotic translation elongation factor 1 gamma -0.0242015
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0241172
HLA-B major histocompatibility complex, class I, B -0.0240976
SMC4 structural maintenance of chromosomes 4 -0.0240853
CCT8 chaperonin containing TCP1, subunit 8 (theta) -0.0238504
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.02378
SRRM2 serine/arginine repetitive matrix 2 -0.0235191
BRWD1 bromodomain and WD repeat domain containing 1 -0.0231013
ZMYND8 zinc finger, MYND-type containing 8 -0.0229498
DENND5B DENN/MADD domain containing 5B -0.0228513
RPS3 ribosomal protein S3 -0.0226651
PTMS parathymosin -0.0224955
PTK2 protein tyrosine kinase 2 -0.0224215
RPL4 ribosomal protein L4 -0.022339
NUP155 nucleoporin 155kDa -0.0223231
S100A10 S100 calcium binding protein A10 -0.0221693
RPS8 ribosomal protein S8 -0.0221522
RPL12 ribosomal protein L12 -0.0221509
GATAD2B GATA zinc finger domain containing 2B -0.0221491
H1-0 H1.0 linker histone -0.0219439
RPL23 ribosomal protein L23 -0.0219085
RIMS2 regulating synaptic membrane exocytosis 2 -0.0218386
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -0.0216931
PCNX1 pecanex 1 -0.0216657
MATR3 matrin 3 -0.0216404
SET SET nuclear proto-oncogene -0.021531
KIF18B kinesin family member 18B -0.0215225
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1 -0.0211562
TPM4 tropomyosin 4 -0.0211424
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0208698
TAGLN2 transgelin 2 -0.0208656
RPL36 ribosomal protein L36 -0.020831
NCOR1 nuclear receptor corepressor 1 -0.0207031