Quinestrol_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Quinestrol perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Quinestrol_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.248915
PABPC1 poly(A) binding protein, cytoplasmic 1 0.195732
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.139842
SAMD4A sterile alpha motif domain containing 4A 0.114616
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.100485
EXT1 exostosin glycosyltransferase 1 0.0826717
CANX calnexin 0.0792976
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0780857
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.077546
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0659792
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0646318
TPT1 tumor protein, translationally-controlled 1 0.062121
ZSWIM6 zinc finger, SWIM-type containing 6 0.0599337
PTK2 protein tyrosine kinase 2 0.0591004
LAMC2 laminin, gamma 2 0.0575597
LAMB3 laminin, beta 3 0.0568513
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0561779
SQSTM1 sequestosome 1 0.055736
MYO6 myosin VI 0.0552267
GRB10 growth factor receptor-bound protein 10 0.0550172
LIMCH1 LIM and calponin homology domains 1 0.0545954
ARRDC3 arrestin domain containing 3 0.053697
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0517079
FBXO32 F-box protein 32 0.0503997
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0496767
RCOR1 REST corepressor 1 0.0493326
CALR calreticulin 0.0487517
MACC1 metastasis associated in colon cancer 1 0.0485938
RBM39 RNA binding motif protein 39 0.0483779
FNDC3B fibronectin type III domain containing 3B 0.045835
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0452496
GOLGA4 golgin A4 0.043831
BLZF1 basic leucine zipper nuclear factor 1 0.0431454
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0431186
APLP2 amyloid beta (A4) precursor-like protein 2 0.0428636
MYO1E myosin IE 0.0424532
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0422139
TPM3 tropomyosin 3 0.0418288
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0413112
NAV2 neuron navigator 2 0.0413112
LPP LIM domain containing preferred translocation partner in lipoma 0.0412138
MACF1 microtubule-actin crosslinking factor 1 0.0411816
SMAD3 SMAD family member 3 0.0410106
TMF1 TATA element modulatory factor 1 0.0407146
GOLGB1 golgin B1 0.0402233
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0401633
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0399388
EFNA5 ephrin-A5 0.0392723
PPARD peroxisome proliferator-activated receptor delta 0.039226
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0389507
ELL2 elongation factor, RNA polymerase II, 2 0.0389315
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.038922
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0387826
SEC31A SEC31 homolog A (S. cerevisiae) 0.0383261
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.0382892
SPAG9 sperm associated antigen 9 0.0379285
FNIP1 folliculin interacting protein 1 0.0373546
SFPQ splicing factor proline/glutamine-rich 0.037258
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0369477
FAM13A family with sequence similarity 13, member A 0.0368238
MYH9 myosin, heavy chain 9, non-muscle 0.0361016
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0360335
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.0359665
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.035839
RBM25 RNA binding motif protein 25 0.0352455
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.035212
ADM adrenomedullin 0.0349752
VCL vinculin 0.0348803
YTHDC1 YTH domain containing 1 0.034765
UBE2H ubiquitin-conjugating enzyme E2H 0.0345465
MCL1 myeloid cell leukemia 1 0.0344344
BRD2 bromodomain containing 2 0.0342277
PRRC2C proline-rich coiled-coil 2C 0.0340512
VGLL3 vestigial-like family member 3 0.0339849
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0339377
TRIO trio Rho guanine nucleotide exchange factor 0.0338039
EIF1 eukaryotic translation initiation factor 1 0.0337098
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0336755
PCBP2 poly(rC) binding protein 2 0.0333519
DUSP10 dual specificity phosphatase 10 0.0332842
VMP1 vacuole membrane protein 1 0.0329964
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0328895
AFF1 AF4/FMR2 family, member 1 0.0324787
HSPA8 heat shock 70kDa protein 8 0.0324031
BBX bobby sox homolog (Drosophila) 0.0323109
PGBD5 piggyBac transposable element derived 5 0.0322017
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.0320243
RND3 Rho family GTPase 3 0.0318075
ANKHD1 ankyrin repeat and KH domain containing 1 0.0316782
DSCAM Down syndrome cell adhesion molecule 0.0316465
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0316337
AKAP13 A kinase (PRKA) anchor protein 13 0.0311406
CTNND1 catenin (cadherin-associated protein), delta 1 0.0310018
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.030958
TTC3 tetratricopeptide repeat domain 3 0.0309331
KDM2A lysine (K)-specific demethylase 2A 0.0309091
IFRD1 interferon-related developmental regulator 1 0.0306869
NDRG1 N-myc downstream regulated 1 0.0306806
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0296556
RAB7A RAB7A, member RAS oncogene family 0.0296052

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.192453
TMSB10 thymosin beta 10 -0.149797
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.145308
POTEF POTE ankyrin domain family, member F -0.114019
S100A6 S100 calcium binding protein A6 -0.0900582
HMGA1 high mobility group AT-hook 1 -0.0752715
KRT7 keratin 7, type II -0.0649569
S100A10 S100 calcium binding protein A10 -0.0548193
RPLP1 ribosomal protein, large, P1 -0.0515818
FTL ferritin, light polypeptide -0.0461576
ERRFI1 ERBB receptor feedback inhibitor 1 -0.044635
CCND1 cyclin D1 -0.0437179
TOP1 topoisomerase (DNA) I -0.0379341
LOC112694756 uncharaterized LOC112694756 -0.0376468
PKM pyruvate kinase, muscle -0.0357499
CTSD cathepsin D -0.0332213
RPL32 ribosomal protein L32 -0.0327852
RPL34 ribosomal protein L34 -0.0325009
RNF145 ring finger protein 145 -0.0321921
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) -0.0318589
FTH1 ferritin, heavy polypeptide 1 -0.0314817
RPL23 ribosomal protein L23 -0.0312894
LDHA lactate dehydrogenase A -0.0303847
RHOA ras homolog family member A -0.0301653
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0296545
UBC ubiquitin C -0.029419
RPL4 ribosomal protein L4 -0.0288761
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0282914
GNAS GNAS complex locus -0.0280356
SLC38A1 solute carrier family 38, member 1 -0.0279619
AREG amphiregulin -0.0276804
KRT8 keratin 8, type II -0.0276018
MSMO1 methylsterol monooxygenase 1 -0.0272013
FAM3C family with sequence similarity 3, member C -0.0265973
TKT transketolase -0.0264212
TMEM123 transmembrane protein 123 -0.0260613
MT2A metallothionein 2A -0.0258999
SACK1A scaffolding CK1 anchoring protein A -0.0256718
RACK1 receptor for activated C kinase 1 -0.0254751
RPS5 ribosomal protein S5 -0.0254501
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0244191
RPL19 ribosomal protein L19 -0.0242877
RPL28 ribosomal protein L28 -0.0237045
RPS23 ribosomal protein S23 -0.0235839
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0235243
RPS24 ribosomal protein S24 -0.0229961
LMAN1 lectin, mannose-binding, 1 -0.0228414
MBNL1 muscleblind-like splicing regulator 1 -0.0227958
FAM162A family with sequence similarity 162, member A -0.022517
IFI27 interferon, alpha-inducible protein 27 -0.0214021
NPC2 Niemann-Pick disease, type C2 -0.0209542
PLAU plasminogen activator, urokinase -0.020946
GPX4 glutathione peroxidase 4 -0.0208369
RPL30 ribosomal protein L30 -0.0206621
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0206367
EREG epiregulin -0.020579
RPS6 ribosomal protein S6 -0.020461
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0202832
LY6E lymphocyte antigen 6 complex, locus E -0.0194752
ARF1 ADP-ribosylation factor 1 -0.0193501
TUBA1B tubulin, alpha 1b -0.0189016
RPS19 ribosomal protein S19 -0.0181516
GARS1 glycyl-tRNA synthetase 1 -0.0180369
SFTPA1 surfactant protein A1 -0.0178037
MUC1 mucin 1, cell surface associated -0.0173388
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0172123
SSBP2 single-stranded DNA binding protein 2 -0.017136
CBX3 chromobox homolog 3 -0.0171328
GPX1 glutathione peroxidase 1 -0.0169104
HSPB1 heat shock 27kDa protein 1 -0.0167246
DSTN destrin (actin depolymerizing factor) -0.0163783
TUBB tubulin, beta class I -0.0162613
NDFIP1 Nedd4 family interacting protein 1 -0.0162454
F3 coagulation factor III (thromboplastin, tissue factor) -0.0161196
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0161072
S100A11 S100 calcium binding protein A11 -0.0159514
IFITM3 interferon induced transmembrane protein 3 -0.0157821
TAPBP TAP binding protein (tapasin) -0.0157774
RPL27A ribosomal protein L27a -0.0156886
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0156001
SCEL sciellin -0.0154933
MDK midkine (neurite growth-promoting factor 2) -0.0153103
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0153049
RPS4X ribosomal protein S4, X-linked -0.0151538
MATR3 matrin 3 -0.0150839
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0150715
CAPN2 calpain 2, (m/II) large subunit -0.0149855
BHLHE40 basic helix-loop-helix family, member e40 -0.0149304
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0148182
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0146885
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0146826
TPI1 triosephosphate isomerase 1 -0.0145711
RPLP2 ribosomal protein, large, P2 -0.0145582
ECT2 epithelial cell transforming 2 -0.0145114
RPS15 ribosomal protein S15 -0.014494
ARHGAP29 Rho GTPase activating protein 29 -0.0144763
KLHL5 kelch-like family member 5 -0.0144657
TRAM1 translocation associated membrane protein 1 -0.0144068
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0143327
RPL31 ribosomal protein L31 -0.0142664