Quinestrol_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Quinestrol perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Quinestrol_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.0792777
TSC22D2 TSC22 domain family, member 2 0.0637197
NTM neurotrimin 0.0628771
KDM3A lysine (K)-specific demethylase 3A 0.0492847
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.0491821
DSCAM Down syndrome cell adhesion molecule 0.044163
PICALM phosphatidylinositol binding clathrin assembly protein 0.0409439
HDAC9 histone deacetylase 9 0.0406336
SAMD4A sterile alpha motif domain containing 4A 0.0402354
UTRN utrophin 0.0342022
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0327617
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0311062
PDS5B PDS5 cohesin associated factor B 0.0307353
PTK2 protein tyrosine kinase 2 0.0303246
STRN3 striatin, calmodulin binding protein 3 0.0301317
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0301225
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0288893
APP amyloid beta (A4) precursor protein 0.0288108
TRIO trio Rho guanine nucleotide exchange factor 0.0287823
ATXN2 ataxin 2 0.0277662
STAG2 stromal antigen 2 0.027256
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0266218
KDM4C lysine (K)-specific demethylase 4C 0.0253214
FOXO1 forkhead box O1 0.0250845
PUM2 pumilio RNA-binding family member 2 0.0246776
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0244985
NEK7 NIMA-related kinase 7 0.0240577
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0239516
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0238948
KDM6A lysine (K)-specific demethylase 6A 0.0234016
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0233876
PPP4R1 protein phosphatase 4, regulatory subunit 1 0.0233396
MEF2A myocyte enhancer factor 2A 0.023328
ATXN1 ataxin 1 0.023285
CALU calumenin 0.0232734
PUM1 pumilio RNA-binding family member 1 0.0231616
AHNAK AHNAK nucleoprotein 0.0231252
UBE2H ubiquitin-conjugating enzyme E2H 0.0230888
PLCB4 phospholipase C, beta 4 0.02304
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0230149
GMDS GDP-mannose 4,6-dehydratase 0.0229318
RCOR1 REST corepressor 1 0.0226465
RICTOR RPTOR independent companion of MTOR, complex 2 0.022353
RYBP RING1 and YY1 binding protein 0.0222535
ZSWIM6 zinc finger, SWIM-type containing 6 0.0218186
AMBRA1 autophagy/beclin-1 regulator 1 0.0218103
WAC WW domain containing adaptor with coiled-coil 0.0217856
DLG1 discs, large homolog 1 (Drosophila) 0.0217835
RAB30 RAB30, member RAS oncogene family 0.0217314
PCBP2 poly(rC) binding protein 2 0.0216439
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0215758
PRR16 proline rich 16 0.0215491
GLS2 glutaminase 2 (liver, mitochondrial) 0.0214048
CDC73 cell division cycle 73 0.0213306
EP300 E1A binding protein p300 0.0211835
USP9X ubiquitin specific peptidase 9, X-linked 0.0210749
ZNF638 zinc finger protein 638 0.021072
ZFAND3 zinc finger, AN1-type domain 3 0.0209889
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0208938
SFPQ splicing factor proline/glutamine-rich 0.0208936
GPC4 glypican 4 0.0208785
YAP1 Yes-associated protein 1 0.0208625
XPO1 exportin 1 0.0205567
ZNF292 zinc finger protein 292 0.0204642
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0203996
DENND4C DENN/MADD domain containing 4C 0.0201888
NCKAP1 NCK-associated protein 1 0.0201565
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0201125
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0200832
MARCHF7 membrane associated ring-CH-type finger 7 0.0199128
UBQLN1 ubiquilin 1 0.0198956
USP3 ubiquitin specific peptidase 3 0.0198886
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0195877
RBM20 RNA binding motif protein 20 0.0194766
NEBL nebulette 0.0193424
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0193089
OGA O-GlcNAcase 0.0192424
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0190273
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0190248
MACF1 microtubule-actin crosslinking factor 1 0.0188919
PRTG protogenin 0.0188509
RAB1A RAB1A, member RAS oncogene family 0.0188351
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0186247
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0186074
CANX calnexin 0.0184871
FAM168A family with sequence similarity 168, member A 0.0183696
OSBPL8 oxysterol binding protein-like 8 0.018278
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0181957
CRY1 cryptochrome circadian clock 1 0.0181218
PARD3B par-3 family cell polarity regulator beta 0.0180716
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0180053
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0178137
TOX thymocyte selection-associated high mobility group box 0.0178119
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0177919
RIMKLB ribosomal modification protein rimK-like family member B 0.0177859
UBN2 ubinuclein 2 0.0177843
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.0176638
AKAP13 A kinase (PRKA) anchor protein 13 0.0175753
QKI QKI, KH domain containing, RNA binding 0.017549
RBM33 RNA binding motif protein 33 0.0175093

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.224871
TMSB10 thymosin beta 10 -0.13223
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.130133
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.104411
RPS16 ribosomal protein S16 -0.0985493
RPS6 ribosomal protein S6 -0.0951007
COL11A1 collagen, type XI, alpha 1 -0.0797096
ACTG1 actin gamma 1 -0.0777564
RPL35A ribosomal protein L35a -0.0747167
PTMA prothymosin, alpha -0.0693083
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0683428
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0674899
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0671311
RPS8 ribosomal protein S8 -0.0655392
MDK midkine (neurite growth-promoting factor 2) -0.0634704
PCLO piccolo presynaptic cytomatrix protein -0.0626399
PCDH9 protocadherin 9 -0.0598878
RPL11 ribosomal protein L11 -0.0567989
CENPF centromere protein F, 350/400kDa -0.0567644
PEG10 paternally expressed 10 -0.0555239
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0554779
COL1A2 collagen, type I, alpha 2 -0.0542641
RPS19 ribosomal protein S19 -0.0539012
ISG15 ISG15 ubiquitin-like modifier -0.0529921
B2M beta-2-microglobulin -0.0519859
GNAS GNAS complex locus -0.0510468
TPT1 tumor protein, translationally-controlled 1 -0.050817
NACA nascent polypeptide-associated complex alpha subunit -0.0502232
MYL12B myosin, light chain 12B, regulatory -0.0450081
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0443002
HSPB1 heat shock 27kDa protein 1 -0.0442827
RPL23 ribosomal protein L23 -0.0435916
PFN1 profilin 1 -0.0433714
GPC3 glypican 3 -0.0429339
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0417002
RPLP1 ribosomal protein, large, P1 -0.0416976
MKI67 marker of proliferation Ki-67 -0.0415567
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0414965
TMSB4X thymosin beta 4, X-linked -0.0414595
NRG1 neuregulin 1 -0.0410179
RPS12 ribosomal protein S12 -0.0408208
RPL37 ribosomal protein L37 -0.0407109
EIF1 eukaryotic translation initiation factor 1 -0.0392627
CBX3 chromobox homolog 3 -0.0374081
SOX2 SRY (sex determining region Y)-box 2 -0.0373686
CSMD3 CUB and Sushi multiple domains 3 -0.0373148
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.0359032
TPR translocated promoter region, nuclear basket protein -0.0355694
RPS21 ribosomal protein S21 -0.0354076
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0352305
RPL37A ribosomal protein L37a -0.035211
RPLP0 ribosomal protein, large, P0 -0.0351622
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0342617
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0342229
CNRIP1 cannabinoid receptor interacting protein 1 -0.0341255
FBL fibrillarin -0.0340771
POTEF POTE ankyrin domain family, member F -0.0336108
ITGAV integrin, alpha V -0.0335597
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0335125
ATP5F1B ATP synthase F1 subunit beta -0.0326944
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0321671
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0321474
RPL34 ribosomal protein L34 -0.0321119
FTL ferritin, light polypeptide -0.0316321
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0313007
RPL19 ribosomal protein L19 -0.0303909
RPL12 ribosomal protein L12 -0.0303312
RPLP2 ribosomal protein, large, P2 -0.030156
TENM2 teneurin transmembrane protein 2 -0.0301402
RPL7 ribosomal protein L7 -0.0301017
RBM25 RNA binding motif protein 25 -0.0300847
ATP5F1E ATP synthase F1 subunit epsilon -0.02984
RPS3 ribosomal protein S3 -0.0297612
CADM2 cell adhesion molecule 2 -0.0295632
RFPL4B ret finger protein-like 4B -0.029453
MEIS2 Meis homeobox 2 -0.0292813
RPL31 ribosomal protein L31 -0.0292409
SNX6 sorting nexin 6 -0.0292326
RPS25 ribosomal protein S25 -0.0292018
CENPE centromere protein E, 312kDa -0.0290066
RPL5 ribosomal protein L5 -0.0288195
RPL30 ribosomal protein L30 -0.028785
MT2A metallothionein 2A -0.027959
RPL36 ribosomal protein L36 -0.0276577
RAI1 retinoic acid induced 1 -0.0275494
SERBP1 SERPINE1 mRNA binding protein 1 -0.0271929
RPL28 ribosomal protein L28 -0.0270389
APOE apolipoprotein E -0.0270125
RPS28 ribosomal protein S28 -0.0266516
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0264808
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0262928
RPS13 ribosomal protein S13 -0.0261915
GOLGB1 golgin B1 -0.0261422
FBXO17 F-box protein 17 -0.0259557
METAP2 methionyl aminopeptidase 2 -0.0258857
ARHGAP15 Rho GTPase activating protein 15 -0.025742
POU3F2 POU class 3 homeobox 2 -0.0256808
S100A9 S100 calcium binding protein A9 -0.0251562
ADGRV1 adhesion G protein-coupled receptor V1 -0.0251511
ATF4 activating transcription factor 4 -0.0247369