Quinestrol_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Quinestrol perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Quinestrol_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.181941
DSCAM Down syndrome cell adhesion molecule 0.0811024
EXT1 exostosin glycosyltransferase 1 0.0599937
PDGFC platelet derived growth factor C 0.0577197
ZNF608 zinc finger protein 608 0.0543455
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0500476
TPT1 tumor protein, translationally-controlled 1 0.0445029
BIRC6 baculoviral IAP repeat containing 6 0.0403677
INTS6 integrator complex subunit 6 0.0397407
CAMTA1 calmodulin binding transcription activator 1 0.0389357
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0386713
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0378552
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0373959
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.037349
ZFAND3 zinc finger, AN1-type domain 3 0.0372122
ECT2 epithelial cell transforming 2 0.0363079
DST dystonin 0.0362242
ANKRD36 ankyrin repeat domain 36 0.0362178
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0359276
AKAP9 A kinase (PRKA) anchor protein 9 0.0354651
SFPQ splicing factor proline/glutamine-rich 0.0347848
QKI QKI, KH domain containing, RNA binding 0.0332306
COG5 component of oligomeric golgi complex 5 0.0332197
RBM39 RNA binding motif protein 39 0.0308066
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0307705
GOLGB1 golgin B1 0.0304649
RPS12 ribosomal protein S12 0.0304101
BTBD9 BTB (POZ) domain containing 9 0.0303633
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0300353
TTC21B tetratricopeptide repeat domain 21B 0.0298141
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0296224
RBM5 RNA binding motif protein 5 0.0296178
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0295784
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0293762
MACF1 microtubule-actin crosslinking factor 1 0.0287443
TRIM33 tripartite motif containing 33 0.0287059
DENND4A DENN/MADD domain containing 4A 0.0286428
PRELID2 PRELI domain containing 2 0.0286042
NCEH1 neutral cholesterol ester hydrolase 1 0.0283114
TNPO1 transportin 1 0.0277762
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0277742
ZEB1 zinc finger E-box binding homeobox 1 0.0277621
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0277214
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0276516
KLF6 Kruppel-like factor 6 0.0272915
APLP2 amyloid beta (A4) precursor-like protein 2 0.0271326
SMYD3 SET and MYND domain containing 3 0.026863
IFI16 interferon, gamma-inducible protein 16 0.0266964
CANX calnexin 0.0261657
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0255202
CNOT1 CCR4-NOT transcription complex, subunit 1 0.02524
CSNK1A1 casein kinase 1, alpha 1 0.0252107
MED13 mediator complex subunit 13 0.0251992
YAP1 Yes-associated protein 1 0.0247999
SON SON DNA binding protein 0.0245701
RPL26 ribosomal protein L26 0.0245499
TJP1 tight junction protein 1 0.0243186
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0242502
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0242468
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0241761
WAC WW domain containing adaptor with coiled-coil 0.0241058
SNX9 sorting nexin 9 0.0237875
CELF1 CUGBP, Elav-like family member 1 0.0237251
CTNND1 catenin (cadherin-associated protein), delta 1 0.0236253
CD44 CD44 molecule (Indian blood group) 0.023293
ANXA2 annexin A2 0.0231368
KDM4C lysine (K)-specific demethylase 4C 0.0231038
SGMS1 sphingomyelin synthase 1 0.0229962
ZCCHC7 zinc finger, CCHC domain containing 7 0.022895
TRRAP transformation/transcription domain-associated protein 0.0228864
MED13L mediator complex subunit 13-like 0.0228645
SENP6 SUMO1/sentrin specific peptidase 6 0.0228197
SMAD3 SMAD family member 3 0.0227627
ANKRD12 ankyrin repeat domain 12 0.0227475
ANK2 ankyrin 2, neuronal 0.0227288
SPRED2 sprouty-related, EVH1 domain containing 2 0.0226271
ELF2 E74-like factor 2 (ets domain transcription factor) 0.02257
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0225534
NUP58 nucleoporin 58 0.022505
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0224631
PTK2 protein tyrosine kinase 2 0.0223826
KIAA1328 KIAA1328 0.022257
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0220606
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 0.0217483
FN1 fibronectin 1 0.0216238
WSB1 WD repeat and SOCS box containing 1 0.0214757
TRIO trio Rho guanine nucleotide exchange factor 0.0210975
NUP98 nucleoporin 98kDa 0.020938
KDM5A lysine (K)-specific demethylase 5A 0.0209097
OGA O-GlcNAcase 0.020804
PARPBP PARP1 binding protein 0.0207648
TRAPPC8 trafficking protein particle complex 8 0.0206762
RFLNA refilin A 0.0206757
NCKAP1 NCK-associated protein 1 0.0206007
SERINC1 serine incorporator 1 0.0205779
TPM3 tropomyosin 3 0.0205615
VIM vimentin 0.0205051
TRA2A transformer 2 alpha homolog (Drosophila) 0.02036
NPTN neuroplastin 0.0200316
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0200154

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.262783
PTMA prothymosin, alpha -0.257492
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.162038
PKM pyruvate kinase, muscle -0.15794
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.143659
PDE4B phosphodiesterase 4B, cAMP-specific -0.114471
CPED1 cadherin-like and PC-esterase domain containing 1 -0.100443
RPS6 ribosomal protein S6 -0.0816958
POTEF POTE ankyrin domain family, member F -0.0811628
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0797341
CCND1 cyclin D1 -0.0791485
EEF2 eukaryotic translation elongation factor 2 -0.066018
FOXP1 forkhead box P1 -0.0640381
VCL vinculin -0.0609212
DLG1 discs, large homolog 1 (Drosophila) -0.0566914
NBEA neurobeachin -0.054428
BMP10 bone morphogenetic protein 10 -0.0537732
EGFR epidermal growth factor receptor -0.0514913
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0514803
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0499831
RPLP1 ribosomal protein, large, P1 -0.0491142
DUSP4 dual specificity phosphatase 4 -0.0481276
ACTG1 actin gamma 1 -0.0480085
SLC38A2 solute carrier family 38, member 2 -0.0479202
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0475662
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0465323
HSPB1 heat shock 27kDa protein 1 -0.0440851
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0440836
ENO2 enolase 2 (gamma, neuronal) -0.0439471
RPL31 ribosomal protein L31 -0.0439149
RHOA ras homolog family member A -0.0438864
S100A6 S100 calcium binding protein A6 -0.0438633
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0433652
ENO1 enolase 1, (alpha) -0.0431338
NPAS2 neuronal PAS domain protein 2 -0.0424996
RPL19 ribosomal protein L19 -0.0412364
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0404626
RPL7A ribosomal protein L7a -0.0394224
S100A4 S100 calcium binding protein A4 -0.0386832
ZNF438 zinc finger protein 438 -0.0380216
RPL4 ribosomal protein L4 -0.0378145
CAMKMT calmodulin-lysine N-methyltransferase -0.036633
RPS8 ribosomal protein S8 -0.0363478
TTC28 tetratricopeptide repeat domain 28 -0.0361652
DPYD dihydropyrimidine dehydrogenase -0.0359639
ARL4C ADP-ribosylation factor-like 4C -0.0358522
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0354727
RPL3 ribosomal protein L3 -0.0352704
RPL32 ribosomal protein L32 -0.0350242
PYGB phosphorylase, glycogen; brain -0.0349817
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.034751
SCMH1 sex comb on midleg homolog 1 (Drosophila) -0.0339769
IGF2 insulin-like growth factor 2 -0.0338799
GSE1 Gse1 coiled-coil protein -0.0338601
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0337725
RPLP0 ribosomal protein, large, P0 -0.033597
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0334595
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0330171
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0325213
SRRM2 serine/arginine repetitive matrix 2 -0.032224
SOX6 SRY (sex determining region Y)-box 6 -0.0320017
TMSB4X thymosin beta 4, X-linked -0.0317834
PTMS parathymosin -0.0312535
RPL28 ribosomal protein L28 -0.0310832
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.030726
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.030678
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0305384
DIAPH3 diaphanous-related formin 3 -0.0304811
EHBP1 EH domain binding protein 1 -0.0302171
NFIA nuclear factor I/A -0.0299528
AHNAK AHNAK nucleoprotein -0.029936
TXNRD1 thioredoxin reductase 1 -0.0290405
TPI1 triosephosphate isomerase 1 -0.0290361
LOC112694756 uncharaterized LOC112694756 -0.0287668
FLNB filamin B, beta -0.0280366
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0279178
LOXL3 lysyl oxidase-like 3 -0.0278791
SCAPER S-phase cyclin A-associated protein in the ER -0.0275265
DSTN destrin (actin depolymerizing factor) -0.0272759
CD47 CD47 molecule -0.0272427
TBC1D22A TBC1 domain family, member 22A -0.0272365
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0271647
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0270376
RPS25 ribosomal protein S25 -0.0270135
RPL27A ribosomal protein L27a -0.0265438
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0264575
GLI3 GLI family zinc finger 3 -0.0264202
EVI5 ecotropic viral integration site 5 -0.0262923
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0262094
MATR3 matrin 3 -0.0261631
EBNA1BP2 EBNA1 binding protein 2 -0.0260849
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0259889
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 -0.0259297
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0257838
GNAS GNAS complex locus -0.0257568
PRUNE2 prune homolog 2 (Drosophila) -0.0257447
PGK1 phosphoglycerate kinase 1 -0.0255472
SEPTIN11 septin 11 -0.0254418
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 -0.0254054
NEBL nebulette -0.0250317