Quinestrol_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Quinestrol perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Quinestrol_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.0741208
SOD2 superoxide dismutase 2, mitochondrial 0.0733835
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0592496
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0588326
VEGFA vascular endothelial growth factor A 0.0570315
MYH9 myosin, heavy chain 9, non-muscle 0.0542298
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0416287
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0400886
APLP2 amyloid beta (A4) precursor-like protein 2 0.0388416
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0367887
MSN moesin 0.0364537
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0361156
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0358801
EEF2 eukaryotic translation elongation factor 2 0.0353082
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0344813
HDAC9 histone deacetylase 9 0.0307694
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0297363
TPM3 tropomyosin 3 0.0272099
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0270072
ZSWIM6 zinc finger, SWIM-type containing 6 0.0263414
SFPQ splicing factor proline/glutamine-rich 0.0262528
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.025309
ZMIZ1 zinc finger, MIZ-type containing 1 0.0248815
STC2 stanniocalcin 2 0.0243005
DST dystonin 0.0242497
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0239801
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0223244
HELZ helicase with zinc finger 0.0215912
CEP250 centrosomal protein 250kDa 0.0215352
NAV2 neuron navigator 2 0.021161
PDE10A phosphodiesterase 10A 0.0209494
RPS2 ribosomal protein S2 0.0198946
TRIP12 thyroid hormone receptor interactor 12 0.0192088
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0190813
ADM adrenomedullin 0.0189938
VMP1 vacuole membrane protein 1 0.0187577
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0175547
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0172679
GLS2 glutaminase 2 (liver, mitochondrial) 0.0160365
PCBP2 poly(rC) binding protein 2 0.0155844
PICALM phosphatidylinositol binding clathrin assembly protein 0.0155843
INTS6 integrator complex subunit 6 0.0155368
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0155307
UBA6 ubiquitin-like modifier activating enzyme 6 0.015495
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0154918
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0151745
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0148858
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0144156
PSD3 pleckstrin and Sec7 domain containing 3 0.0144155
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0143443
CORO1C coronin, actin binding protein, 1C 0.014162
EFNA5 ephrin-A5 0.014141
GTPBP2 GTP binding protein 2 0.0140236
NFE2L1 nuclear factor, erythroid 2-like 1 0.0140197
FAM120A family with sequence similarity 120A 0.0139785
PPARD peroxisome proliferator-activated receptor delta 0.0138296
KDM6A lysine (K)-specific demethylase 6A 0.0138154
CRYBG3 beta-gamma crystallin domain containing 3 0.0137999
TNIP1 TNFAIP3 interacting protein 1 0.0137599
YTHDC1 YTH domain containing 1 0.0136387
COL5A1 collagen, type V, alpha 1 0.013619
USP9X ubiquitin specific peptidase 9, X-linked 0.0136125
AHR aryl hydrocarbon receptor 0.0135743
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0134072
SPAG9 sperm associated antigen 9 0.0133623
CRY1 cryptochrome circadian clock 1 0.0133585
BRD4 bromodomain containing 4 0.0131806
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0131608
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0130637
ANKRD36 ankyrin repeat domain 36 0.0129347
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0128565
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0127391
ARRDC3 arrestin domain containing 3 0.01271
KYNU kynureninase 0.0123691
ANO6 anoctamin 6 0.0121863
CCNL1 cyclin L1 0.0120908
CANX calnexin 0.0118477
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0118427
EEF1G eukaryotic translation elongation factor 1 gamma 0.0117295
AHNAK AHNAK nucleoprotein 0.0116132
RBM33 RNA binding motif protein 33 0.0115514
WWTR1 WW domain containing transcription regulator 1 0.0112809
ANKRD36B ankyrin repeat domain 36B 0.0112308
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0112301
NOTCH2 notch 2 0.0112285
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0112282
XRN2 5'-3' exoribonuclease 2 0.0112258
GANAB glucosidase, alpha; neutral AB 0.0110484
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.0109977
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0109584
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0109471
TNS3 tensin 3 0.0108279
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0108166
RPS18 ribosomal protein S18 0.0107626
CUL3 cullin 3 0.0105813
TFG TRK-fused gene 0.0105327
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.010477
FXR1 fragile X mental retardation, autosomal homolog 1 0.0104519
EWSR1 EWS RNA-binding protein 1 0.0103436
HSPA8 heat shock 70kDa protein 8 0.010304

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.3881
TMSB10 thymosin beta 10 -0.204613
FTL ferritin, light polypeptide -0.167092
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.13531
IER3 immediate early response 3 -0.133752
HLA-B major histocompatibility complex, class I, B -0.114654
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0926474
ZMYND8 zinc finger, MYND-type containing 8 -0.0845682
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0820067
NDRG1 N-myc downstream regulated 1 -0.0818348
TPT1 tumor protein, translationally-controlled 1 -0.0763111
RPS24 ribosomal protein S24 -0.0759669
RPLP1 ribosomal protein, large, P1 -0.0735014
PTMA prothymosin, alpha -0.0725779
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0677731
MT2A metallothionein 2A -0.0661035
FRMD4A FERM domain containing 4A -0.0644352
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0618287
IGFBP3 insulin-like growth factor binding protein 3 -0.0615343
BASP1 brain abundant, membrane attached signal protein 1 -0.0610712
NAMPT nicotinamide phosphoribosyltransferase -0.0588593
BTG1 B-cell translocation gene 1, anti-proliferative -0.057227
TMSB4X thymosin beta 4, X-linked -0.0565232
SLC38A1 solute carrier family 38, member 1 -0.055716
PGK1 phosphoglycerate kinase 1 -0.0551215
EGR1 early growth response 1 -0.0519504
COL1A1 collagen, type I, alpha 1 -0.0509476
GNAS GNAS complex locus -0.0508543
HLA-E major histocompatibility complex, class I, E -0.0494302
PLIN2 perilipin 2 -0.0493104
RPS4X ribosomal protein S4, X-linked -0.047625
CD44 CD44 molecule (Indian blood group) -0.0467846
SFRP1 secreted frizzled-related protein 1 -0.0465846
CTSD cathepsin D -0.0462854
RPL36A ribosomal protein L36a -0.0444304
RPL32 ribosomal protein L32 -0.0439622
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0434797
LOC112694756 uncharaterized LOC112694756 -0.0425671
ACTG1 actin gamma 1 -0.0424894
CDH13 cadherin 13 -0.0415294
RPL31 ribosomal protein L31 -0.0412758
RPL19 ribosomal protein L19 -0.0403794
ENO1 enolase 1, (alpha) -0.0401238
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0401167
EIF1 eukaryotic translation initiation factor 1 -0.0396427
RPLP2 ribosomal protein, large, P2 -0.0383796
RPS6 ribosomal protein S6 -0.038228
RPL23 ribosomal protein L23 -0.0379752
RPL35A ribosomal protein L35a -0.0372082
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.036853
VDAC1 voltage-dependent anion channel 1 -0.0367977
FN1 fibronectin 1 -0.0364008
FTH1 ferritin, heavy polypeptide 1 -0.0363041
GLIS3 GLIS family zinc finger 3 -0.0361298
CAVIN1 caveolae associated protein 1 -0.0359859
CTSB cathepsin B -0.0349002
B2M beta-2-microglobulin -0.0347477
RPL11 ribosomal protein L11 -0.0345827
TUBB tubulin, beta class I -0.0340559
IFITM3 interferon induced transmembrane protein 3 -0.0339793
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0328184
RPL34 ribosomal protein L34 -0.0316038
MXI1 MAX interactor 1, dimerization protein -0.0309938
COL1A2 collagen, type I, alpha 2 -0.0309164
RPS19 ribosomal protein S19 -0.0304893
RPS23 ribosomal protein S23 -0.0302254
RPL7A ribosomal protein L7a -0.0299737
TPM4 tropomyosin 4 -0.0299519
IFI16 interferon, gamma-inducible protein 16 -0.0295294
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0294548
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0293796
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0292192
MORF4L2 mortality factor 4 like 2 -0.0287611
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0286539
ARL4C ADP-ribosylation factor-like 4C -0.0285277
RACK1 receptor for activated C kinase 1 -0.0284603
KDM3A lysine (K)-specific demethylase 3A -0.0282624
UBC ubiquitin C -0.0281182
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.027093
RPL38 ribosomal protein L38 -0.0270352
NPEPPS aminopeptidase puromycin sensitive -0.0268209
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.0266275
RPL37 ribosomal protein L37 -0.0265649
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0265145
NRN1 neuritin 1 -0.0265098
UBE2B ubiquitin-conjugating enzyme E2B -0.0264835
RPS25 ribosomal protein S25 -0.0263591
VCL vinculin -0.0263079
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0256159
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0255407
HMGA2 high mobility group AT-hook 2 -0.0255177
KPNB1 karyopherin (importin) beta 1 -0.0252388
RPLP0 ribosomal protein, large, P0 -0.025202
LOX lysyl oxidase -0.0251233
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0247588
CD63 CD63 molecule -0.0247312
IGF2R insulin-like growth factor 2 receptor -0.0246418
CD2AP CD2-associated protein -0.0244672
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A -0.0244463
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0240698