Quinestrol_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Quinestrol perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Quinestrol_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.189561
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.165593
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0856581
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0839348
CDH13 cadherin 13 0.0739938
DSCAM Down syndrome cell adhesion molecule 0.063797
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0623263
NDRG1 N-myc downstream regulated 1 0.0526846
COL5A1 collagen, type V, alpha 1 0.0515638
DLG1 discs, large homolog 1 (Drosophila) 0.05146
SEC31A SEC31 homolog A (S. cerevisiae) 0.0513221
ENO1 enolase 1, (alpha) 0.0505726
CALU calumenin 0.0470786
LOX lysyl oxidase 0.0464483
MACF1 microtubule-actin crosslinking factor 1 0.0437857
EXT1 exostosin glycosyltransferase 1 0.0425903
ZNF292 zinc finger protein 292 0.0420087
FUS FUS RNA binding protein 0.0413596
CXCL8 chemokine (C-X-C motif) ligand 8 0.0413057
CANX calnexin 0.040359
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0402889
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0397268
IQGAP1 IQ motif containing GTPase activating protein 1 0.0392127
FAM13A family with sequence similarity 13, member A 0.0384602
NRXN3 neurexin 3 0.0382014
MORF4L2 mortality factor 4 like 2 0.0379351
TRA2A transformer 2 alpha homolog (Drosophila) 0.0378707
SPAG9 sperm associated antigen 9 0.0374508
AHR aryl hydrocarbon receptor 0.0371932
SQSTM1 sequestosome 1 0.0367674
TTC3 tetratricopeptide repeat domain 3 0.0363125
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0362763
FNIP1 folliculin interacting protein 1 0.0361916
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0351312
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0350006
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0347942
CALR calreticulin 0.0344392
DST dystonin 0.0337817
SKIC3 SKI3 subunit of superkiller complex 0.0335491
MYH9 myosin, heavy chain 9, non-muscle 0.032891
AKAP9 A kinase (PRKA) anchor protein 9 0.0327733
ZSWIM6 zinc finger, SWIM-type containing 6 0.0324207
SETBP1 SET binding protein 1 0.0320936
INTS6 integrator complex subunit 6 0.031681
CYLD cylindromatosis (turban tumor syndrome) 0.031605
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0314428
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0311726
PGM3 phosphoglucomutase 3 0.0311438
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0308474
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0307183
ZCCHC7 zinc finger, CCHC domain containing 7 0.0306509
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0301327
DPYD dihydropyrimidine dehydrogenase 0.029829
TENT2 terminal nucleotidyltransferase 2 0.029533
ZMIZ1 zinc finger, MIZ-type containing 1 0.0294992
GOLGA4 golgin A4 0.0293902
VEGFC vascular endothelial growth factor C 0.0288163
CEP192 centrosomal protein 192kDa 0.0284401
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.028359
TIMP3 TIMP metallopeptidase inhibitor 3 0.0282534
PDGFC platelet derived growth factor C 0.0281576
DNAH11 dynein, axonemal, heavy chain 11 0.0275232
ADM adrenomedullin 0.0274751
AUTS2 autism susceptibility candidate 2 0.027446
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0271922
IFRD1 interferon-related developmental regulator 1 0.0270536
RYBP RING1 and YY1 binding protein 0.0270136
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0270043
ZNF395 zinc finger protein 395 0.0269765
LMAN1 lectin, mannose-binding, 1 0.0266961
GOLGB1 golgin B1 0.0265946
HAPSTR1 HUWE1 associated protein modifying stress responses 0.0264141
TMED9 transmembrane emp24 protein transport domain containing 9 0.0262918
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0259357
ANKRD36 ankyrin repeat domain 36 0.0255223
CNOT8 CCR4-NOT transcription complex, subunit 8 0.0255173
TMEM39A transmembrane protein 39A 0.0255004
SND1 staphylococcal nuclease and tudor domain containing 1 0.0254787
ABLIM3 actin binding LIM protein family, member 3 0.0254556
CDK19 cyclin-dependent kinase 19 0.0253969
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0248031
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0247989
AOPEP aminopeptidase O (putative) 0.0247596
SCAPER S-phase cyclin A-associated protein in the ER 0.0245809
STK4 serine/threonine kinase 4 0.0240727
RAB1A RAB1A, member RAS oncogene family 0.0239658
MAP3K13 mitogen-activated protein kinase kinase kinase 13 0.0235738
YTHDC1 YTH domain containing 1 0.0235493
KYNU kynureninase 0.0235483
MORF4L1 mortality factor 4 like 1 0.0235281
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0234653
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0233653
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0231606
ACVR1 activin A receptor, type I 0.0230357
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0229554
ERLEC1 endoplasmic reticulum lectin 1 0.0229545
RPL5 ribosomal protein L5 0.0229351
SAMD4A sterile alpha motif domain containing 4A 0.0229231
PAPOLA poly(A) polymerase alpha 0.0228279
HSPA13 heat shock protein 70kDa family, member 13 0.0228274

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.179781
IGFBP3 insulin-like growth factor binding protein 3 -0.171005
MT2A metallothionein 2A -0.133086
FN1 fibronectin 1 -0.128805
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.123045
VIM vimentin -0.0822709
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0757708
POTEF POTE ankyrin domain family, member F -0.0730455
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0690201
F3 coagulation factor III (thromboplastin, tissue factor) -0.0671052
PKM pyruvate kinase, muscle -0.0664139
FTL ferritin, light polypeptide -0.0644913
HLA-B major histocompatibility complex, class I, B -0.0638878
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0631225
LOC112694756 uncharaterized LOC112694756 -0.0623451
IGFBP7 insulin-like growth factor binding protein 7 -0.060203
MT1X metallothionein 1X -0.0539259
EGR1 early growth response 1 -0.0517938
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.051674
H3-3B H3.3 histone B -0.0507808
B2M beta-2-microglobulin -0.0476249
PTMA prothymosin, alpha -0.0453404
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0452708
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0449321
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.043409
COL1A2 collagen, type I, alpha 2 -0.0422542
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0418283
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0412623
RTN4 reticulon 4 -0.0408314
ZBTB20 zinc finger and BTB domain containing 20 -0.0399101
RPL11 ribosomal protein L11 -0.0393184
RPLP1 ribosomal protein, large, P1 -0.0392399
SEPTIN7 septin 7 -0.0388573
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0379188
TPM4 tropomyosin 4 -0.0379128
USP34 ubiquitin specific peptidase 34 -0.0364914
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0354139
TGFBI transforming growth factor, beta-induced, 68kDa -0.0336638
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0336517
TOP1 topoisomerase (DNA) I -0.0335074
RPS6 ribosomal protein S6 -0.033453
ZMYND8 zinc finger, MYND-type containing 8 -0.0334145
RAI1 retinoic acid induced 1 -0.0327952
RNF24 ring finger protein 24 -0.032682
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0321524
TAGLN2 transgelin 2 -0.0316791
CYB5R3 cytochrome b5 reductase 3 -0.0310151
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0309965
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0307433
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0302869
UBC ubiquitin C -0.0301604
STRN3 striatin, calmodulin binding protein 3 -0.0301411
NUP58 nucleoporin 58 -0.0299358
S100A6 S100 calcium binding protein A6 -0.0297135
CENPF centromere protein F, 350/400kDa -0.0289781
RASA3 RAS p21 protein activator 3 -0.028593
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0280138
SCFD2 sec1 family domain containing 2 -0.0278113
ZEB1 zinc finger E-box binding homeobox 1 -0.0277624
RPS5 ribosomal protein S5 -0.0276118
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0275426
CD63 CD63 molecule -0.0275324
BCAR1 breast cancer anti-estrogen resistance 1 -0.0273316
S100A10 S100 calcium binding protein A10 -0.0269815
RPL34 ribosomal protein L34 -0.0269615
RHOA ras homolog family member A -0.0268836
MSN moesin -0.0268654
FTH1 ferritin, heavy polypeptide 1 -0.0262185
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) -0.0261042
BSG basigin (Ok blood group) -0.0259277
SDC4 syndecan 4 -0.0259035
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0258041
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0257326
RGS17 regulator of G-protein signaling 17 -0.0255575
HIP1 huntingtin interacting protein 1 -0.0255264
HLA-C major histocompatibility complex, class I, C -0.0252407
C1R complement component 1, r subcomponent -0.0251992
SRRM2 serine/arginine repetitive matrix 2 -0.0251029
ZBTB7A zinc finger and BTB domain containing 7A -0.0249097
SEC24B SEC24 family member B -0.0248846
BRWD1 bromodomain and WD repeat domain containing 1 -0.0246417
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.024496
RPL31 ribosomal protein L31 -0.0243409
TMED4 transmembrane emp24 protein transport domain containing 4 -0.0243333
LOXL2 lysyl oxidase-like 2 -0.0242995
PIAS1 protein inhibitor of activated STAT, 1 -0.0242313
ARPP19 cAMP-regulated phosphoprotein, 19kDa -0.0240834
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0240436
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0239791
RNF216 ring finger protein 216 -0.0238841
STK17A serine/threonine kinase 17a -0.0236559
BAZ1B bromodomain adjacent to zinc finger domain, 1B -0.0236
RAP1A RAP1A, member of RAS oncogene family -0.0235052
INHBA inhibin, beta A -0.0233751
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0232974
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0232708
UBE2E1 ubiquitin-conjugating enzyme E2E 1 -0.0232094
MIER1 mesoderm induction early response 1, transcriptional regulator -0.0231646
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase -0.0230986
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0229478