Quinestrol_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Quinestrol perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Quinestrol_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EXT1 exostosin glycosyltransferase 1 0.110338
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0714332
VCL vinculin 0.0697525
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0647281
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0612138
NTN4 netrin 4 0.052324
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0522406
NPAS2 neuronal PAS domain protein 2 0.0520856
PDLIM5 PDZ and LIM domain 5 0.0465381
OGA O-GlcNAcase 0.0455432
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0445018
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0417807
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.041598
ZSWIM6 zinc finger, SWIM-type containing 6 0.0396545
JARID2 jumonji, AT rich interactive domain 2 0.0341895
TUFT1 tuftelin 1 0.0337431
NRIP1 nuclear receptor interacting protein 1 0.0335342
SMAD3 SMAD family member 3 0.0332425
CD109 CD109 molecule 0.0316447
RUNX1 runt-related transcription factor 1 0.0311665
TRA2A transformer 2 alpha homolog (Drosophila) 0.0307483
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0304083
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0298921
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0298655
MB21D2 Mab-21 domain containing 2 0.029365
AHRR aryl-hydrocarbon receptor repressor 0.0289422
WSB1 WD repeat and SOCS box containing 1 0.0278137
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0277846
SPAG9 sperm associated antigen 9 0.0276167
RBPMS RNA binding protein with multiple splicing 0.0273187
SFPQ splicing factor proline/glutamine-rich 0.0271685
ANKRD28 ankyrin repeat domain 28 0.0271328
PALLD palladin, cytoskeletal associated protein 0.0267945
LTBP1 latent transforming growth factor beta binding protein 1 0.0266185
CEMIP2 cell migration inducing hyaluronidase 2 0.0264312
DSCAM Down syndrome cell adhesion molecule 0.0263788
SIK3 SIK family kinase 3 0.0262494
ATXN1 ataxin 1 0.0252968
FBXO11 F-box protein 11 0.0251163
WAC WW domain containing adaptor with coiled-coil 0.0246083
RAB10 RAB10, member RAS oncogene family 0.0245597
ATF6 activating transcription factor 6 0.0243184
MYH9 myosin, heavy chain 9, non-muscle 0.0240631
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0240435
FNDC3A fibronectin type III domain containing 3A 0.0227939
NPTN neuroplastin 0.0225457
NFE2L2 nuclear factor, erythroid 2-like 2 0.0225242
ANKRD17 ankyrin repeat domain 17 0.0224492
CTBP2 C-terminal binding protein 2 0.0223376
FMNL2 formin-like 2 0.0221955
INTS6 integrator complex subunit 6 0.0220976
RCOR1 REST corepressor 1 0.0220528
DUSP16 dual specificity phosphatase 16 0.0216424
TPR translocated promoter region, nuclear basket protein 0.0214696
FHL2 four and a half LIM domains 2 0.0212554
YBX3 Y box binding protein 3 0.0209597
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0209568
ABLIM1 actin binding LIM protein 1 0.0208261
FLNA filamin A, alpha 0.0207571
ZC3H12C zinc finger CCCH-type containing 12C 0.0204655
ELL2 elongation factor, RNA polymerase II, 2 0.0204606
TPT1 tumor protein, translationally-controlled 1 0.0202674
TMEM156 transmembrane protein 156 0.0202306
DLG1 discs, large homolog 1 (Drosophila) 0.02017
PICALM phosphatidylinositol binding clathrin assembly protein 0.0197017
CHD1 chromodomain helicase DNA binding protein 1 0.019693
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0196383
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0196292
SPRED2 sprouty-related, EVH1 domain containing 2 0.0191246
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0190444
RBM39 RNA binding motif protein 39 0.0189675
SEPTIN9 septin 9 0.0189637
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0187987
SDC2 syndecan 2 0.0185352
TTC3 tetratricopeptide repeat domain 3 0.0183923
TM9SF3 transmembrane 9 superfamily member 3 0.0182604
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0181609
STC2 stanniocalcin 2 0.0177696
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0176032
NCOA7 nuclear receptor coactivator 7 0.0174233
SGMS2 sphingomyelin synthase 2 0.017381
ENAH enabled homolog (Drosophila) 0.0171621
CUL3 cullin 3 0.0169617
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0169073
AKAP13 A kinase (PRKA) anchor protein 13 0.0167391
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0165157
SIRT1 sirtuin 1 0.0164849
LCORL ligand dependent nuclear receptor corepressor-like 0.0164285
RDH10 retinol dehydrogenase 10 (all-trans) 0.0164218
RIGI RNA sensor RIG-I 0.0162827
LRP6 low density lipoprotein receptor-related protein 6 0.0162268
DPY19L1 dpy-19-like 1 (C. elegans) 0.0159463
ADORA2B adenosine A2b receptor 0.0158394
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0158237
PTBP2 polypyrimidine tract binding protein 2 0.0156575
ANKRD36 ankyrin repeat domain 36 0.0155226
ZFAND3 zinc finger, AN1-type domain 3 0.015458
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) 0.0153353
PHIP pleckstrin homology domain interacting protein 0.0152443
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0151946

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.317503
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.289024
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.212601
NRG1 neuregulin 1 -0.20617
HMGA2 high mobility group AT-hook 2 -0.123307
FTH1 ferritin, heavy polypeptide 1 -0.104959
NDRG1 N-myc downstream regulated 1 -0.104839
SQSTM1 sequestosome 1 -0.0877102
PTMA prothymosin, alpha -0.0865599
PLIN2 perilipin 2 -0.0733685
TMSB10 thymosin beta 10 -0.071805
ITGA1 integrin, alpha 1 -0.070987
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0701071
S100A6 S100 calcium binding protein A6 -0.0697651
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0692041
EFNA5 ephrin-A5 -0.0679706
PKM pyruvate kinase, muscle -0.0666701
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0664421
IFI27 interferon, alpha-inducible protein 27 -0.0650373
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0629772
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0629292
TMSB4X thymosin beta 4, X-linked -0.0613455
NAMPT nicotinamide phosphoribosyltransferase -0.0609265
MRPS6 mitochondrial ribosomal protein S6 -0.0605153
FTL ferritin, light polypeptide -0.0581862
ASPH aspartate beta-hydroxylase -0.0578195
HLA-B major histocompatibility complex, class I, B -0.0554298
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0536878
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0531409
TMEM165 transmembrane protein 165 -0.0492461
MT2A metallothionein 2A -0.0486119
RAI14 retinoic acid induced 14 -0.0472695
LIMCH1 LIM and calponin homology domains 1 -0.04712
ETV1 ets variant 1 -0.0469624
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0448498
ZMYND8 zinc finger, MYND-type containing 8 -0.0422153
GRB10 growth factor receptor-bound protein 10 -0.0418382
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0418208
POTEF POTE ankyrin domain family, member F -0.0416613
ENO1 enolase 1, (alpha) -0.0406477
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0401386
LOC112694756 uncharaterized LOC112694756 -0.0400061
TPI1 triosephosphate isomerase 1 -0.0395744
GLIS3 GLIS family zinc finger 3 -0.0383999
IGFBP3 insulin-like growth factor binding protein 3 -0.0382676
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0376871
VEGFA vascular endothelial growth factor A -0.0376461
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0376059
GLUL glutamate-ammonia ligase -0.0350098
OXR1 oxidation resistance 1 -0.0347732
B2M beta-2-microglobulin -0.034622
ENO2 enolase 2 (gamma, neuronal) -0.0344416
DUSP6 dual specificity phosphatase 6 -0.0341867
LOXL2 lysyl oxidase-like 2 -0.0329171
RPL31 ribosomal protein L31 -0.0324271
SFTPA2 surfactant protein A2 -0.0323761
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0322679
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0314216
LOX lysyl oxidase -0.0314115
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0305139
ZBTB20 zinc finger and BTB domain containing 20 -0.030453
TENM4 teneurin transmembrane protein 4 -0.0302674
AKAP12 A kinase (PRKA) anchor protein 12 -0.0301613
HLA-A major histocompatibility complex, class I, A -0.0296152
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0294357
FAM20C family with sequence similarity 20, member C -0.02926
CDCP1 CUB domain containing protein 1 -0.0291759
CTSD cathepsin D -0.0288429
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0286426
PGK1 phosphoglycerate kinase 1 -0.0280549
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -0.0278018
EGR1 early growth response 1 -0.0274973
RPS6 ribosomal protein S6 -0.0271889
RACK1 receptor for activated C kinase 1 -0.0268448
MAML2 mastermind-like 2 (Drosophila) -0.0267375
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0260731
SYT1 synaptotagmin I -0.0259464
HPS3 Hermansky-Pudlak syndrome 3 -0.0258353
SFRP1 secreted frizzled-related protein 1 -0.0253522
DPYD dihydropyrimidine dehydrogenase -0.0249473
SOX4 SRY (sex determining region Y)-box 4 -0.0249048
IGFBP5 insulin-like growth factor binding protein 5 -0.0247713
VIM vimentin -0.0246162
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0242604
HILPDA hypoxia inducible lipid droplet-associated -0.0241515
PDIA3 protein disulfide isomerase family A, member 3 -0.024139
RPS27 ribosomal protein S27 -0.0240989
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0234239
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0231714
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0229337
GPC6 glypican 6 -0.0228901
TNS3 tensin 3 -0.0228841
TSC22D1 TSC22 domain family, member 1 -0.0221008
CTSB cathepsin B -0.0220248
LOC102724023 ES1 protein homolog, mitochondrial -0.0218188
UBXN4 UBX domain protein 4 -0.0217276
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0216363
RPS5 ribosomal protein S5 -0.0214978
MBD5 methyl-CpG binding domain protein 5 -0.0214636
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0213787