| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | A cinchona alkaloid consisting of cinchonine with the hydrogen at the 6-position of the quinoline ring substituted by methoxy. (Chemical Entities of Biological Interest Ontology, CHEBI_28593) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/441074 |
| Similar Terms | |
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198 proteins with high or low expression in Quinidine relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CELSR3 | cadherin, EGF LAG seven-pass G-type receptor 3 | 2.79 |
| HMOX1 | heme oxygenase 1 | 1.4 |
| NRM | nurim (nuclear envelope membrane protein) | 1.15 |
| FTL | ferritin, light polypeptide | 1.13 |
| CTNND2 | catenin (cadherin-associated protein), delta 2 | 1.04 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.98 |
| MYZAP | myocardial zonula adherens protein | 0.69 |
| TOR2A | torsin family 2, member A | 0.68 |
| SLC35A4 | solute carrier family 35, member A4 | 0.63 |
| CD63 | CD63 molecule | 0.59 |
| SCAI | suppressor of cancer cell invasion | 0.57 |
| GCLM | glutamate-cysteine ligase, modifier subunit | 0.57 |
| TSPAN3 | tetraspanin 3 | 0.57 |
| NFKBIE | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | 0.57 |
| ENTPD7 | ectonucleoside triphosphate diphosphohydrolase 7 | 0.56 |
| ZC3H6 | zinc finger CCCH-type containing 6 | 0.54 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.53 |
| LRRC49 | leucine rich repeat containing 49 | 0.51 |
| NCOA4 | nuclear receptor coactivator 4 | 0.5 |
| H1-2 | H1.2 linker histone, cluster member | 0.5 |
| ASTE1 | asteroid homolog 1 (Drosophila) | 0.49 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | 0.49 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 0.48 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.46 |
| CERS6 | ceramide synthase 6 | 0.44 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.43 |
| DDX11 | DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 | 0.42 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | 0.42 |
| DEAF1 | DEAF1 transcription factor | 0.42 |
| CEP57 | centrosomal protein 57kDa | 0.42 |
| ZCCHC10 | zinc finger, CCHC domain containing 10 | 0.41 |
| MIEN1 | migration and invasion enhancer 1 | 0.41 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.41 |
| SNX18 | sorting nexin 18 | 0.4 |
| CELSR1 | cadherin, EGF LAG seven-pass G-type receptor 1 | 0.4 |
| TCEA2 | transcription elongation factor A (SII), 2 | 0.4 |
| SLC33A1 | solute carrier family 33 (acetyl-CoA transporter), member 1 | 0.39 |
| RAB30 | RAB30, member RAS oncogene family | 0.39 |
| F13A1 | coagulation factor XIII, A1 polypeptide | 0.39 |
| SIDT2 | SID1 transmembrane family, member 2 | 0.38 |
| MYH6 | myosin, heavy chain 6, cardiac muscle, alpha | 0.38 |
| PKM | pyruvate kinase, muscle | 0.38 |
| ENPP5 | ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) | 0.37 |
| MGA | MGA, MAX dimerization protein | 0.36 |
| PLAU | plasminogen activator, urokinase | 0.36 |
| ZNF544 | zinc finger protein 544 | 0.36 |
| AZIN1 | antizyme inhibitor 1 | 0.36 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 0.35 |
| SEZ6L2 | seizure related 6 homolog (mouse)-like 2 | 0.35 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.35 |
| ZNF669 | zinc finger protein 669 | 0.34 |
| NBEA | neurobeachin | 0.34 |
| CLDN7 | claudin 7 | 0.34 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.34 |
| TMEM259 | transmembrane protein 259 | 0.33 |
| ZNF337 | zinc finger protein 337 | 0.33 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | 0.33 |
| CMC1 | C-x(9)-C motif containing 1 | 0.32 |
| TMEM183B | transmembrane protein 183B | 0.32 |
| MOCS1 | molybdenum cofactor synthesis 1 | 0.32 |
| ADSS1 | adenylosuccinate synthase 1 | 0.32 |
| SCARB2 | scavenger receptor class B, member 2 | 0.32 |
| TMEM168 | transmembrane protein 168 | 0.32 |
| COMMD6 | COMM domain containing 6 | 0.32 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.32 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.31 |
| MRPL35 | mitochondrial ribosomal protein L35 | 0.31 |
| CEP44 | centrosomal protein 44kDa | 0.31 |
| CLPTM1L | CLPTM1-like | 0.31 |
| SGMS1 | sphingomyelin synthase 1 | 0.31 |
| PUM2 | pumilio RNA-binding family member 2 | 0.31 |
| TRMO | tRNA methyltransferase O | 0.31 |
| TRIM23 | tripartite motif containing 23 | 0.31 |
| POLR2H | polymerase (RNA) II (DNA directed) polypeptide H | 0.31 |
| CYP4V2 | cytochrome P450, family 4, subfamily V, polypeptide 2 | 0.3 |
| H1-5 | H1.5 linker histone, cluster member | 0.3 |
| NUDT6 | nudix (nucleoside diphosphate linked moiety X)-type motif 6 | 0.3 |
| MED10 | mediator complex subunit 10 | 0.3 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.3 |
| RELT | RELT tumor necrosis factor receptor | 0.3 |
| C4ORF33 | chromosome 4 open reading frame 33 | 0.3 |
| ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | 0.3 |
| KLK7 | kallikrein-related peptidase 7 | 0.3 |
| CMC4 | C-x(9)-C motif containing 4 | 0.3 |
| EPHX1 | epoxide hydrolase 1, microsomal (xenobiotic) | 0.29 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | 0.29 |
| NFIX | nuclear factor I/X (CCAAT-binding transcription factor) | 0.29 |
| MTRES1 | mitochondrial transcription rescue factor 1 | 0.29 |
| CBY1 | chibby homolog 1 (Drosophila) | 0.29 |
| CCNDBP1 | cyclin D-type binding-protein 1 | 0.29 |
| OTUD6B | OTU domain containing 6B | 0.29 |
| C3ORF38 | chromosome 3 open reading frame 38 | 0.29 |
| NLGN2 | neuroligin 2 | 0.29 |
| SLC25A44 | solute carrier family 25, member 44 | 0.29 |
| PCBP4 | poly(rC) binding protein 4 | 0.29 |
| CYB5B | cytochrome b5 type B (outer mitochondrial membrane) | 0.29 |
| BAK1 | BCL2-antagonist/killer 1 | 0.29 |
| ARF3 | ADP-ribosylation factor 3 | 0.29 |
| SAYSD1 | SAYSVFN motif domain containing 1 | 0.29 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MICOS10 | mitochondrial contact site and cristae organizing system subunit 10 | -1.79 |
| MYO15B | myosin XVB | -1.73 |
| ALAS1 | 5'-aminolevulinate synthase 1 | -1.41 |
| EIF3C | eukaryotic translation initiation factor 3, subunit C | -1.32 |
| SETD9 | SET domain containing 9 | -1.31 |
| CHST3 | carbohydrate (chondroitin 6) sulfotransferase 3 | -1.18 |
| YPEL5 | yippee-like 5 (Drosophila) | -1.12 |
| MRPL52 | mitochondrial ribosomal protein L52 | -1.09 |
| DPP4 | dipeptidyl-peptidase 4 | -1.01 |
| SUPT7L | suppressor of Ty 7 (S. cerevisiae)-like | -0.99 |
| HIST2H2AA3 | histone cluster 2, H2aa3 | -0.93 |
| RABGGTB | Rab geranylgeranyltransferase, beta subunit | -0.78 |
| COL14A1 | collagen, type XIV, alpha 1 | -0.76 |
| THAP9 | THAP domain containing 9 | -0.73 |
| COA5 | cytochrome c oxidase assembly factor 5 | -0.69 |
| ITGB5 | integrin, beta 5 | -0.69 |
| HIST3H2BB | histone cluster 3, H2bb | -0.68 |
| CDC42SE2 | CDC42 small effector 2 | -0.68 |
| VAMP8 | vesicle-associated membrane protein 8 | -0.64 |
| NME6 | NME/NM23 nucleoside diphosphate kinase 6 | -0.63 |
| NDFIP2 | Nedd4 family interacting protein 2 | -0.63 |
| STARD7 | StAR-related lipid transfer (START) domain containing 7 | -0.63 |
| TIMM10B | translocase of inner mitochondrial membrane 10 homolog B (yeast) | -0.62 |
| FAM20C | family with sequence similarity 20, member C | -0.62 |
| TIMM10 | translocase of inner mitochondrial membrane 10 homolog (yeast) | -0.62 |
| TMSB10 | thymosin beta 10 | -0.59 |
| CPEB3 | cytoplasmic polyadenylation element binding protein 3 | -0.59 |
| THEMIS2 | thymocyte selection associated family member 2 | -0.57 |
| ZNF561 | zinc finger protein 561 | -0.55 |
| PI4KA | phosphatidylinositol 4-kinase, catalytic, alpha | -0.55 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | -0.55 |
| PET100 | PET100 homolog (S. cerevisiae) | -0.54 |
| GPRC5B | G protein-coupled receptor, class C, group 5, member B | -0.53 |
| SGTB | small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta | -0.53 |
| DDX46 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 | -0.53 |
| PIEZO2 | piezo-type mechanosensitive ion channel component 2 | -0.52 |
| COX16 | COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) | -0.52 |
| ZNF511 | zinc finger protein 511 | -0.52 |
| ZNF653 | zinc finger protein 653 | -0.51 |
| LAMA2 | laminin, alpha 2 | -0.51 |
| COX7A2 | cytochrome c oxidase subunit VIIa polypeptide 2 (liver) | -0.51 |
| ZNF174 | zinc finger protein 174 | -0.5 |
| COX5B | cytochrome c oxidase subunit Vb | -0.5 |
| MBP | myelin basic protein | -0.5 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.49 |
| TFR2 | transferrin receptor 2 | -0.49 |
| ZMAT3 | zinc finger, matrin-type 3 | -0.49 |
| NIPA2 | non imprinted in Prader-Willi/Angelman syndrome 2 | -0.48 |
| ABCA3 | ATP-binding cassette, sub-family A (ABC1), member 3 | -0.48 |
| RPGR | retinitis pigmentosa GTPase regulator | -0.48 |
| GON7 | GON7 subunit of KEOPS complex | -0.47 |
| SYNE4 | spectrin repeat containing, nuclear envelope family member 4 | -0.47 |
| KDF1 | keratinocyte differentiation factor 1 | -0.46 |
| DST | dystonin | -0.46 |
| MICA | MHC class I polypeptide-related sequence A | -0.45 |
| ALKBH7 | alkB, alkylation repair homolog 7 (E. coli) | -0.45 |
| TP53I3 | tumor protein p53 inducible protein 3 | -0.44 |
| OMA1 | OMA1 zinc metallopeptidase | -0.44 |
| CAND2 | cullin-associated and neddylation-dissociated 2 (putative) | -0.44 |
| RAMAC | RNA guanine-7 methyltransferase activating subunit | -0.44 |
| ACTB | actin, beta | -0.43 |
| ZYX | zyxin | -0.43 |
| TMEM184A | transmembrane protein 184A | -0.43 |
| TYRO3 | TYRO3 protein tyrosine kinase | -0.43 |
| UBE2L6 | ubiquitin-conjugating enzyme E2L 6 | -0.42 |
| PNKD | paroxysmal nonkinesigenic dyskinesia | -0.42 |
| RNF126 | ring finger protein 126 | -0.42 |
| DBNL | drebrin-like | -0.42 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | -0.41 |
| VWA1 | von Willebrand factor A domain containing 1 | -0.41 |
| TP53 | tumor protein p53 | -0.41 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.41 |
| FRS2 | fibroblast growth factor receptor substrate 2 | -0.41 |
| ZNF146 | zinc finger protein 146 | -0.4 |
| MISP3 | MISP family member 3 | -0.4 |
| COX7A2L | cytochrome c oxidase subunit VIIa polypeptide 2 like | -0.39 |
| BRD8 | bromodomain containing 8 | -0.39 |
| LZTS1 | leucine zipper, putative tumor suppressor 1 | -0.39 |
| CNTNAP1 | contactin associated protein 1 | -0.39 |
| MBIP | MAP3K12 binding inhibitory protein 1 | -0.39 |
| KBTBD4 | kelch repeat and BTB (POZ) domain containing 4 | -0.38 |
| IREB2 | iron-responsive element binding protein 2 | -0.38 |
| TGOLN2 | trans-golgi network protein 2 | -0.38 |
| THAP11 | THAP domain containing 11 | -0.38 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.38 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | -0.38 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.38 |
| HSBP1 | heat shock factor binding protein 1 | -0.37 |
| BAIAP3 | BAI1-associated protein 3 | -0.37 |
| DMWD | dystrophia myotonica, WD repeat containing | -0.37 |
| HLA-B | major histocompatibility complex, class I, B | -0.37 |
| ZNF414 | zinc finger protein 414 | -0.37 |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F | -0.37 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.37 |
| ASDURF | ASNSD1 upstream open reading frame | -0.37 |
| C19ORF53 | chromosome 19 open reading frame 53 | -0.36 |
| NEMP1 | nuclear envelope integral membrane protein 1 | -0.36 |
| ENSA | endosulfine alpha | -0.36 |
| EED | embryonic ectoderm development | -0.36 |
