Quizartinib Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/24889392
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Genes

199 proteins with high or low expression in Quizartinib relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
C4BPA complement component 4 binding protein, alpha 2.32
DNAH2 dynein, axonemal, heavy chain 2 1.49
HBA1 hemoglobin, alpha 1 1.27
APOE apolipoprotein E 1.17
ZBED6 zinc finger, BED-type containing 6 0.94
RAB40C RAB40C, member RAS oncogene family 0.86
PLGRKT plasminogen receptor, C-terminal lysine transmembrane protein 0.76
F10 coagulation factor X 0.74
HMOX1 heme oxygenase 1 0.71
NCOA4 nuclear receptor coactivator 4 0.7
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 0.68
OSMR oncostatin M receptor 0.68
SLMAP sarcolemma associated protein 0.67
PRDM4 PR domain containing 4 0.67
APOB apolipoprotein B 0.64
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11 0.64
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.59
ODF2L outer dense fiber of sperm tails 2-like 0.58
CASP4 caspase 4, apoptosis-related cysteine peptidase 0.58
TSPAN3 tetraspanin 3 0.58
S100A14 S100 calcium binding protein A14 0.57
CKM creatine kinase, muscle 0.57
BRD7 bromodomain containing 7 0.55
MCFD2 multiple coagulation factor deficiency 2 0.54
ADM adrenomedullin 0.53
ALDH1L2 aldehyde dehydrogenase 1 family, member L2 0.52
MICA MHC class I polypeptide-related sequence A 0.51
TAGLN transgelin 0.51
TACSTD2 tumor-associated calcium signal transducer 2 0.5
KDM3A lysine (K)-specific demethylase 3A 0.5
MSLN mesothelin 0.49
WDSUB1 WD repeat, sterile alpha motif and U-box domain containing 1 0.48
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.47
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.47
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.46
MIEN1 migration and invasion enhancer 1 0.45
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1 0.44
ARG2 arginase 2 0.44
HAS3 hyaluronan synthase 3 0.44
ADAM19 ADAM metallopeptidase domain 19 0.44
VGF VGF nerve growth factor inducible 0.42
KDM4C lysine (K)-specific demethylase 4C 0.42
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 0.42
FAM219B family with sequence similarity 219, member B 0.42
CPA4 carboxypeptidase A4 0.42
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.41
PLAUR plasminogen activator, urokinase receptor 0.41
MAX MYC associated factor X 0.41
RNF145 ring finger protein 145 0.4
PPME1 protein phosphatase methylesterase 1 0.4
SQSTM1 sequestosome 1 0.4
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.4
CD63 CD63 molecule 0.4
PAH phenylalanine hydroxylase 0.4
GALT galactose-1-phosphate uridylyltransferase 0.4
INPP5J inositol polyphosphate-5-phosphatase J 0.4
ANGPTL4 angiopoietin-like 4 0.4
SDF2 stromal cell-derived factor 2 0.39
GJB3 gap junction protein, beta 3, 31kDa 0.39
COQ4 coenzyme Q4 0.39
SELENOK selenoprotein K 0.39
N4BP3 NEDD4 binding protein 3 0.39
TPM4 tropomyosin 4 0.39
OGFRL1 opioid growth factor receptor-like 1 0.38
KIAA1217 KIAA1217 0.38
DPY30 dpy-30 homolog (C. elegans) 0.38
IFI35 interferon-induced protein 35 0.38
EPHA5 EPH receptor A5 0.38
ZKSCAN2 zinc finger with KRAB and SCAN domains 2 0.37
PLSCR3 phospholipid scramblase 3 0.37
S100A16 S100 calcium binding protein A16 0.37
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 0.36
BCAR3 breast cancer anti-estrogen resistance 3 0.36
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 0.36
IFITM3 interferon induced transmembrane protein 3 0.36
GLRX glutaredoxin (thioltransferase) 0.36
IL18 interleukin 18 0.36
UPP1 uridine phosphorylase 1 0.36
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.35
SRXN1 sulfiredoxin 1 0.35
LSM11 LSM11, U7 small nuclear RNA associated 0.35
FRMD6 FERM domain containing 6 0.35
ZNF724 zinc finger protein 724 0.35
TPGS1 tubulin polyglutamylase complex subunit 1 0.35
CENPT centromere protein T 0.35
LYPLA2 lysophospholipase II 0.35
OSBPL2 oxysterol binding protein-like 2 0.35
TMSB10 thymosin beta 10 0.35
GCH1 GTP cyclohydrolase 1 0.34
TMOD2 tropomodulin 2 (neuronal) 0.34
ZNF430 zinc finger protein 430 0.34
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.34
TULP3 tubby like protein 3 0.34
IREB2 iron-responsive element binding protein 2 0.34
BRD9 bromodomain containing 9 0.34
IGFBP3 insulin-like growth factor binding protein 3 0.34
ISG15 ISG15 ubiquitin-like modifier 0.33
KCTD6 potassium channel tetramerization domain containing 6 0.33
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.33
KLHL21 kelch-like family member 21 0.33

low expression

Symbol Name Standardized Value
RMDN2 regulator of microtubule dynamics 2 -1.35
EGR1 early growth response 1 -1.26
ADCY10 adenylate cyclase 10 (soluble) -1.2
MDM1 Mdm1 nuclear protein homolog (mouse) -1.01
C1ORF43 chromosome 1 open reading frame 43 -0.87
DES desmin -0.78
NCKAP5L NCK-associated protein 5-like -0.74
PHETA1 PH domain containing endocytic trafficking adaptor 1 -0.71
ZNF778 zinc finger protein 778 -0.64
RHBDF1 rhomboid 5 homolog 1 (Drosophila) -0.64
ADGRL1 adhesion G protein-coupled receptor L1 -0.61
TTC17 tetratricopeptide repeat domain 17 -0.58
AZGP1 alpha-2-glycoprotein 1, zinc-binding -0.57
TMPPE transmembrane protein with metallophosphoesterase domain -0.55
TIPE1 TNF alpha induced protein 8 like 1 -0.54
SBSN suprabasin -0.53
TSC22D2 TSC22 domain family, member 2 -0.53
EFCAB14 EF-hand calcium binding domain 14 -0.51
TRHDE thyrotropin-releasing hormone degrading enzyme -0.51
ACTBL2 actin, beta-like 2 -0.5
UNKL unkempt family zinc finger-like -0.49
KLHL12 kelch-like family member 12 -0.49
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.48
NRP1 neuropilin 1 -0.48
WDR5B WD repeat domain 5B -0.47
TMEM64 transmembrane protein 64 -0.47
NEIL3 nei endonuclease VIII-like 3 (E. coli) -0.46
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.45
DENND3 DENN/MADD domain containing 3 -0.45
ZNF142 zinc finger protein 142 -0.45
VIM vimentin -0.44
ZNF525 zinc finger protein 525 -0.43
LYST lysosomal trafficking regulator -0.43
CPD carboxypeptidase D -0.41
IFI30 interferon, gamma-inducible protein 30 -0.4
KIF21B kinesin family member 21B -0.4
PDIA4 protein disulfide isomerase family A, member 4 -0.39
ZNF692 zinc finger protein 692 -0.39
PIP prolactin-induced protein -0.39
HEXIM2 hexamethylene bis-acetamide inducible 2 -0.39
GAS8 growth arrest-specific 8 -0.38
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 -0.38
LMBRD1 LMBR1 domain containing 1 -0.38
LMBR1 limb development membrane protein 1 -0.38
FAM193B family with sequence similarity 193, member B -0.38
FRMPD1 FERM and PDZ domain containing 1 -0.37
GLT8D2 glycosyltransferase 8 domain containing 2 -0.37
ZBTB41 zinc finger and BTB domain containing 41 -0.37
ABRACL ABRA C-terminal like -0.37
FUBP1 far upstream element (FUSE) binding protein 1 -0.36
SPC24 SPC24, NDC80 kinetochore complex component -0.36
TSPAN31 tetraspanin 31 -0.36
RGN regucalcin -0.35
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated) -0.35
JRK Jrk homolog (mouse) -0.35
UNC93B1 unc-93 homolog B1 (C. elegans) -0.34
GLT8D1 glycosyltransferase 8 domain containing 1 -0.34
GKAP1 G kinase anchoring protein 1 -0.34
AASDH aminoadipate-semialdehyde dehydrogenase -0.34
SLC38A9 solute carrier family 38, member 9 -0.33
WHAMM WAS protein homolog associated with actin, golgi membranes and microtubules -0.33
DIPK1A divergent protein kinase domain 1A -0.33
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase -0.33
BSN bassoon presynaptic cytomatrix protein -0.32
MZT2B mitotic spindle organizing protein 2B -0.32
ULBP1 UL16 binding protein 1 -0.31
GLI4 GLI family zinc finger 4 -0.31
ZNF608 zinc finger protein 608 -0.31
OTX1 orthodenticle homeobox 1 -0.31
MANEA mannosidase, endo-alpha -0.31
ANO8 anoctamin 8 -0.31
NR1D1 nuclear receptor subfamily 1, group D, member 1 -0.31
TSR2 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) -0.3
LTBP1 latent transforming growth factor beta binding protein 1 -0.3
ADCY9 adenylate cyclase 9 -0.3
GGACT gamma-glutamylamine cyclotransferase -0.3
GPRASP2 G protein-coupled receptor associated sorting protein 2 -0.29
FIZ1 FLT3-interacting zinc finger 1 -0.29
C15ORF61 chromosome 15 open reading frame 61 -0.29
PSPH phosphoserine phosphatase -0.29
MCEE methylmalonyl CoA epimerase -0.29
TMTC4 transmembrane and tetratricopeptide repeat containing 4 -0.29
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.28
ZNF721 zinc finger protein 721 -0.28
ZNF564 zinc finger protein 564 -0.28
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.28
ERCC8 excision repair cross-complementation group 8 -0.28
HOXB9 homeobox B9 -0.28
SMC1B structural maintenance of chromosomes 1B -0.28
BRSK2 BR serine/threonine kinase 2 -0.27
UBIAD1 UbiA prenyltransferase domain containing 1 -0.27
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 -0.27
NADK NAD kinase -0.27
FAM185A family with sequence similarity 185, member A -0.27
CYBA cytochrome b-245, alpha polypeptide -0.27
GTF3A general transcription factor IIIA -0.27
KBTBD11 kelch repeat and BTB (POZ) domain containing 11 -0.27
SARAF store-operated calcium entry-associated regulatory factor -0.27
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F -0.27