R-atenolol-2496 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the R-atenolol-2496 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A2M alpha-2-macroglobulin
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ABHD6 abhydrolase domain containing 6
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ADCY9 adenylate cyclase 9
ADGRL2 adhesion G protein-coupled receptor L2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
AQP1 aquaporin 1 (Colton blood group)
ATF7 activating transcription factor 7
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CAPN9 calpain 9
CFAP69 cilia and flagella associated protein 69
CKM creatine kinase, muscle
CPN2 carboxypeptidase N, polypeptide 2
CREM cAMP responsive element modulator
CRHR1 corticotropin releasing hormone receptor 1
CYTH1 cytohesin 1
DFNB31 deafness, autosomal recessive 31
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DNASE2B deoxyribonuclease II beta
DRD5 dopamine receptor D5
EDNRA endothelin receptor type A
EFNA5 ephrin-A5
ELL elongation factor RNA polymerase II
FBXO2 F-box protein 2
FER fer (fps/fes related) tyrosine kinase
FLOT1 flotillin 1
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GATA3 GATA binding protein 3
GCH1 GTP cyclohydrolase 1
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GPC1 glypican 1
HIC2 hypermethylated in cancer 2
HOXA4 homeobox A4
HPCAL4 hippocalcin like 4
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
INE1 inactivation escape 1 (non-protein coding)
IQCK IQ motif containing K
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIAA0226L KIAA0226-like
KIF1A kinesin family member 1A
KIF3A kinesin family member 3A
KLF3 Kruppel-like factor 3 (basic)
KLK1 kallikrein 1
KSR1 kinase suppressor of ras 1
LINC00216 long intergenic non-protein coding RNA 216
LINC00652 long intergenic non-protein coding RNA 652
MAU2 MAU2 sister chromatid cohesion factor
METTL7A methyltransferase like 7A
MFSD7 major facilitator superfamily domain containing 7
MT3 metallothionein 3
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NRP2 neuropilin 2
PDE8B phosphodiesterase 8B
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
RAB11B RAB11B, member RAS oncogene family
RANBP1 RAN binding protein 1
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RPS4Y1 ribosomal protein S4, Y-linked 1
RQCD1 RCD1 required for cell differentiation1 homolog (S. pombe)
SCN10A sodium channel, voltage gated, type X alpha subunit
SH2D1A SH2 domain containing 1A
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLAMF7 SLAM family member 7
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SNAPC5 small nuclear RNA activating complex, polypeptide 5, 19kDa
SPDEF SAM pointed domain containing ETS transcription factor
SPG20 spastic paraplegia 20 (Troyer syndrome)
SRPX sushi-repeat containing protein, X-linked
SSH3 slingshot protein phosphatase 3
SSTR4 somatostatin receptor 4
STX2 syntaxin 2
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TCF3 transcription factor 3
THSD7A thrombospondin, type I, domain containing 7A
TMPRSS15 transmembrane protease, serine 15
TNFRSF4 tumor necrosis factor receptor superfamily, member 4
TP53TG1 TP53 target 1 (non-protein coding)
TPMT thiopurine S-methyltransferase
TTC38 tetratricopeptide repeat domain 38
TXNRD3 thioredoxin reductase 3
WSCD1 WSC domain containing 1
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
ZBTB17 zinc finger and BTB domain containing 17
ZBTB38 zinc finger and BTB domain containing 38
ZNF154 zinc finger protein 154
ZNF185 zinc finger protein 185 (LIM domain)
ZNF76 zinc finger protein 76
ZSCAN18 zinc finger and SCAN domain containing 18
ZXDB zinc finger, X-linked, duplicated B

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
AAAS achalasia, adrenocortical insufficiency, alacrimia
ACP6 acid phosphatase 6, lysophosphatidic
ADGRE1 adhesion G protein-coupled receptor E1
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
AMDHD2 amidohydrolase domain containing 2
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1
ASPN asporin
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BNC2 basonuclin 2
BTBD2 BTB (POZ) domain containing 2
C17ORF70 chromosome 17 open reading frame 70
C1ORF56 chromosome 1 open reading frame 56
CCDC69 coiled-coil domain containing 69
CCDC9 coiled-coil domain containing 9
CD3D CD3d molecule, delta (CD3-TCR complex)
CDR2L cerebellar degeneration-related protein 2-like
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CIDEC cell death-inducing DFFA-like effector c
CLIP2 CAP-GLY domain containing linker protein 2
COQ6 coenzyme Q6 monooxygenase
CRELD1 cysteine-rich with EGF-like domains 1
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1
DGKG diacylglycerol kinase, gamma 90kDa
DNM3 dynamin 3
DNMBP dynamin binding protein
DOK5 docking protein 5
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
EFNA3 ephrin-A3
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM131A family with sequence similarity 131, member A
FBP1 fructose-1,6-bisphosphatase 1
FBXO31 F-box protein 31
FKBPL FK506 binding protein like
FLT4 fms-related tyrosine kinase 4
FMOD fibromodulin
GALK1 galactokinase 1
GAREM GRB2 associated, regulator of MAPK1
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GPR85 G protein-coupled receptor 85
GRIP2 glutamate receptor interacting protein 2
HIST1H4E histone cluster 1, H4e
HRH2 histamine receptor H2
ICAM5 intercellular adhesion molecule 5, telencephalin
IFI6 interferon, alpha-inducible protein 6
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
INF2 inverted formin, FH2 and WH2 domain containing
JMJD4 jumonji domain containing 4
KIAA1024 KIAA1024
KPTN kaptin (actin binding protein)
MBOAT2 membrane bound O-acyltransferase domain containing 2
MDM4 MDM4, p53 regulator
MED22 mediator complex subunit 22
MLPH melanophilin
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NXPE3 neurexophilin and PC-esterase domain family, member 3
PECR peroxisomal trans-2-enoyl-CoA reductase
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PNOC prepronociceptin
POLL polymerase (DNA directed), lambda
PQLC2 PQ loop repeat containing 2
PRMT7 protein arginine methyltransferase 7
PROS1 protein S (alpha)
PYGB phosphorylase, glycogen; brain
RAB3A RAB3A, member RAS oncogene family
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
S100A12 S100 calcium binding protein A12
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLMO1 slowmo homolog 1 (Drosophila)
SPATS2 spermatogenesis associated, serine-rich 2
SPINT1 serine peptidase inhibitor, Kunitz type 1
STAG3L4 stromal antigen 3-like 4 (pseudogene)
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TIMP2 TIMP metallopeptidase inhibitor 2
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMEM115 transmembrane protein 115
TMEM209 transmembrane protein 209
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1
TRIM36 tripartite motif containing 36
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TUBA4B tubulin, alpha 4b
UCN urocortin
USP19 ubiquitin specific peptidase 19
VASH1 vasohibin 1
ZNF225 zinc finger protein 225
ZNF747 zinc finger protein 747
ZNF862 zinc finger protein 862