RAC1 GTPase cycle Gene Set

Dataset Reactome Pathways 2024
Category structural or functional annotations
Type pathway
External Link https://reactome.org/PathwayBrowser/#/R-HSA-9013149
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184 proteins participating in the RAC1 GTPase cycle pathway from the Reactome Pathways 2024 dataset.

Symbol Name
ABI1 abl-interactor 1
ABI2 abl-interactor 2
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ABR active BCR-related
ALS2 amyotrophic lateral sclerosis 2 (juvenile)
AMIGO2 adhesion molecule with Ig-like domain 2
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
ARHGAP1 Rho GTPase activating protein 1
ARHGAP10 Rho GTPase activating protein 10
ARHGAP12 Rho GTPase activating protein 12
ARHGAP15 Rho GTPase activating protein 15
ARHGAP17 Rho GTPase activating protein 17
ARHGAP20 Rho GTPase activating protein 20
ARHGAP21 Rho GTPase activating protein 21
ARHGAP22 Rho GTPase activating protein 22
ARHGAP23 Rho GTPase activating protein 23
ARHGAP24 Rho GTPase activating protein 24
ARHGAP25 Rho GTPase activating protein 25
ARHGAP26 Rho GTPase activating protein 26
ARHGAP27 Rho GTPase activating protein 27
ARHGAP29 Rho GTPase activating protein 29
ARHGAP30 Rho GTPase activating protein 30
ARHGAP31 Rho GTPase activating protein 31
ARHGAP32 Rho GTPase activating protein 32
ARHGAP33 Rho GTPase activating protein 33
ARHGAP35 Rho GTPase activating protein 35
ARHGAP39 Rho GTPase activating protein 39
ARHGAP4 Rho GTPase activating protein 4
ARHGAP42 Rho GTPase activating protein 42
ARHGAP44 Rho GTPase activating protein 44
ARHGAP45 Rho GTPase activating protein 45
ARHGAP5 Rho GTPase activating protein 5
ARHGAP9 Rho GTPase activating protein 9
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
ARHGEF19 Rho guanine nucleotide exchange factor (GEF) 19
ARHGEF25 Rho guanine nucleotide exchange factor (GEF) 25
ARHGEF39 Rho guanine nucleotide exchange factor (GEF) 39
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
BAIAP2 BAI1-associated protein 2
BAIAP2L1 BAI1-associated protein 2-like 1
BCR breakpoint cluster region
BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit
CAV1 caveolin 1, caveolae protein, 22kDa
CDC42 cell division cycle 42
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CHN1 chimerin 1
CHN2 chimerin 2
CIT citron rho-interacting serine/threonine kinase
CYBA cytochrome b-245, alpha polypeptide
CYBB cytochrome b-245, beta polypeptide
CYFIP1 cytoplasmic FMR1 interacting protein 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DEPDC1B DEP domain containing 1B
DIAPH3 diaphanous-related formin 3
DLC1 DLC1 Rho GTPase activating protein
DOCK1 dedicator of cytokinesis 1
DOCK10 dedicator of cytokinesis 10
DOCK11 dedicator of cytokinesis 11
DOCK2 dedicator of cytokinesis 2
DOCK3 dedicator of cytokinesis 3
DOCK4 dedicator of cytokinesis 4
DOCK5 dedicator of cytokinesis 5
DOCK6 dedicator of cytokinesis 6
DOCK7 dedicator of cytokinesis 7
DOCK8 dedicator of cytokinesis 8
DOCK9 dedicator of cytokinesis 9
ECT2 epithelial cell transforming 2
EMD emerin
EPHA2 EPH receptor A2
ERBIN erbb2 interacting protein
ESYT1 extended synaptotagmin-like protein 1
FAM13A family with sequence similarity 13, member A
FAM13B family with sequence similarity 13, member B
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FERMT2 fermitin family member 2
FGD5 FYVE, RhoGEF and PH domain containing 5
FMNL1 formin-like 1
GARRE1 granule associated Rac and RHOG effector 1
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GMIP GEM interacting protein
GNA13 guanine nucleotide binding protein (G protein), alpha 13
IQGAP1 IQ motif containing GTPase activating protein 1
IQGAP2 IQ motif containing GTPase activating protein 2
IQGAP3 IQ motif containing GTPase activating protein 3
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
JAG1 jagged 1
KALRN kalirin, RhoGEF kinase
KTN1 kinectin 1 (kinesin receptor)
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
LBR lamin B receptor
LEMD3 LEM domain containing 3
MCAM melanoma cell adhesion molecule
MCF2 MCF.2 cell line derived transforming sequence
MCF2L MCF.2 cell line derived transforming sequence-like
MPP7 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
MYO9B myosin IXB
NCF1 neutrophil cytosolic factor 1
NCF2 neutrophil cytosolic factor 2
NCF4 neutrophil cytosolic factor 4, 40kDa
NCKAP1 NCK-associated protein 1
NCKAP1L NCK-associated protein 1-like
NGEF neuronal guanine nucleotide exchange factor
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies)
NISCH nischarin
NOX1 NADPH oxidase 1
NOX3 NADPH oxidase 3
NOXA1 NADPH oxidase activator 1
NOXO1 NADPH oxidase organizer 1
OPHN1 oligophrenin 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PAK5 p21 (RAC1) activated kinase 5
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PARD6A par-6 family cell polarity regulator alpha
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PKN1 protein kinase N1
PKN2 protein kinase N2
PLD1 phospholipase D1, phosphatidylcholine-specific
PLD2 phospholipase D2
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
PLEKHG4 pleckstrin homology domain containing, family G (with RhoGef domain) member 4
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
RAB7A RAB7A, member RAS oncogene family
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RACGAP1 Rac GTPase activating protein 1
RALBP1 ralA binding protein 1
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2
SH3BP1 SH3-domain binding protein 1
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SNAP23 synaptosomal-associated protein, 23kDa
SOS1 son of sevenless homolog 1 (Drosophila)
SOS2 son of sevenless homolog 2 (Drosophila)
SPATA13 spermatogenesis associated 13
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYDE2 synapse defective 1, Rho GTPase, homolog 2 (C. elegans)
TAGAP T-cell activation RhoGTPase activating protein
TAOK3 TAO kinase 3
TFRC transferrin receptor
TIAM1 T-cell lymphoma invasion and metastasis 1
TIAM2 T-cell lymphoma invasion and metastasis 2
TMPO thymopoietin
TRIO trio Rho guanine nucleotide exchange factor
VAMP3 vesicle-associated membrane protein 3
VANGL1 VANGL planar cell polarity protein 1
VAV1 vav 1 guanine nucleotide exchange factor
VAV2 vav 2 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor
VRK2 vaccinia related kinase 2
WAS Wiskott-Aldrich syndrome
WASF1 WAS protein family, member 1
WASF2 WAS protein family, member 2
WASF3 WAS protein family, member 3
WASL Wiskott-Aldrich syndrome-like
WIPF1 WAS/WASL interacting protein family, member 1
WIPF2 WAS/WASL interacting protein family, member 2
WIPF3 WAS/WASL interacting protein family, member 3
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)