RAC3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)|The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5881)
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Genes

310 genes differentially expressed following the RAC3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ZBTB16 zinc finger and BTB domain containing 16 3.43993
CELA3B chymotrypsin-like elastase family, member 3B 3.24311
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15 3.24311
SLC9C2 solute carrier family 9, member C2 (putative) 3.24311
UNC45B unc-45 homolog B (C. elegans) 3.24311
ADGB androglobin 3.24311
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 3.24311
TDRD1 tudor domain containing 1 3.24311
LRRC10B leucine rich repeat containing 10B 3.24311
CRIP1 cysteine-rich protein 1 (intestinal) 3.24311
LYNX1 Ly6/neurotoxin 1 3.24311
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 3.24311
WNT3A wingless-type MMTV integration site family, member 3A 3.24311
SSTR1 somatostatin receptor 1 3.24311
KRT20 keratin 20, type I 3.24311
DDO D-aspartate oxidase 3.24311
PCDHGB3 protocadherin gamma subfamily B, 3 3.24311
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 3.24311
CXORF65 chromosome X open reading frame 65 3.24311
PAX6 paired box 6 3.24311
MUC22 mucin 22 3.24311
HBM hemoglobin, mu 3.24311
CRYGN crystallin, gamma N 3.24311
PASD1 PAS domain containing 1 3.24311
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 3.24311
NLRP6 NLR family, pyrin domain containing 6 3.24311
RAB7B RAB7B, member RAS oncogene family 3.24311
PLA2G1B phospholipase A2, group IB (pancreas) 3.24311
ANGPTL5 angiopoietin-like 5 3.24311
SDSL serine dehydratase-like 3.24311
HEPN1 hepatocellular carcinoma, down-regulated 1 3.24311
APOA5 apolipoprotein A-V 3.24311
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 3.24311
SOST sclerostin 3.24311
MYO1A myosin IA 3.24311
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 3.24311
PODNL1 podocan-like 1 3.24311
CRYAA crystallin, alpha A 3.24311
SPMIP11 sperm microtubule inner protein 11 3.24311
EVPL envoplakin 3.24311
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 3.24311
SMCO3 single-pass membrane protein with coiled-coil domains 3 3.24311
LHB luteinizing hormone beta polypeptide 3.24311
CD160 CD160 molecule 3.24311
TEKTL1 tektin like 1 3.24311
SPATS1 spermatogenesis associated, serine-rich 1 3.24311
PTH1R parathyroid hormone 1 receptor 3.24311
PCDHGA9 protocadherin gamma subfamily A, 9 3.24311
HBG2 hemoglobin, gamma G 3.24311
CD300LF CD300 molecule-like family member f 3.24311
POM121L2 POM121 transmembrane nucleoporin-like 2 3.24311
RPS5 ribosomal protein S5 3.24311
RAB36 RAB36, member RAS oncogene family 3.24311
DERPC DERPC proline and glycine rich nuclear protein 3.24311
GMCL2 germ cell-less 2, spermatogenesis associated 3.24311
GK3 glycerol kinase 3 3.24311
SPATA31H1 SPATA31 subfamily H member 1 3.24311
CIMIP2C ciliary microtubule inner protein 2C 3.24311
NOTCH2NLB notch 2 N-terminal like B 3.24311
CTXND1 cortexin domain containing 1 3.24311
MYMK myomaker, myoblast fusion factor 3.24311
CIBAR2 CBY1 interacting BAR domain containing 2 3.24311
PCARE photoreceptor cilium actin regulator 3.24311
MSANTD5 Myb/SANT DNA binding domain containing 5 3.24311
XKR3 XK, Kell blood group complex subunit-related family, member 3 3.24311
OR52E5 olfactory receptor, family 52, subfamily E, member 5 3.24311
CATSPER3 cation channel, sperm associated 3 3.24311
NXPE1 neurexophilin and PC-esterase domain family, member 1 3.24311
IL15RA interleukin 15 receptor, alpha 3.24311
CES1 carboxylesterase 1 3.24311
LOX lysyl oxidase 3.24311
LRRD1 leucine-rich repeats and death domain containing 1 3.24311
CHRNG cholinergic receptor, nicotinic, gamma (muscle) 3.24311
SCG2 secretogranin II 3.24311
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 3.24311
NHLRC4 NHL repeat containing 4 3.24311
TLR9 toll-like receptor 9 3.24311
SYT15 synaptotagmin XV 3.24311
RBPMS RNA binding protein with multiple splicing 3.24311
CLEC17A C-type lectin domain family 17, member A 3.24311
S100G S100 calcium binding protein G 3.24311
CDKN2A cyclin-dependent kinase inhibitor 2A 3.24311
FOXI2 forkhead box I2 3.24311
PIWIL1 piwi-like RNA-mediated gene silencing 1 3.24311
SH3TC2 SH3 domain and tetratricopeptide repeats 2 3.24311
ZFP57 ZFP57 zinc finger protein 3.24311
B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2 3.24311
PKDREJ polycystin (PKD) family receptor for egg jelly 3.24311
TRADD TNFRSF1A-associated via death domain 3.24311
WFDC9 WAP four-disulfide core domain 9 3.24311
UTS2R urotensin 2 receptor 3.24311
HMGB4 high mobility group box 4 3.24311
LEUTX leucine twenty homeobox 3.24311
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 3.24311
TAS2R50 taste receptor, type 2, member 50 3.24311
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 3.24311
PCP2 Purkinje cell protein 2 3.24311
CCDC70 coiled-coil domain containing 70 3.24311
CRYBB2 crystallin, beta B2 3.24311
RESP18 regulated endocrine-specific protein 18 3.24311
UBQLN3 ubiquilin 3 3.24311
CNGB1 cyclic nucleotide gated channel beta 1 3.24311
QRFP pyroglutamylated RFamide peptide 3.24311
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 3.24311
SPEF2 sperm flagellar 2 3.24311
GPR61 G protein-coupled receptor 61 3.24311
CTSS cathepsin S 3.24311
PATE4 prostate and testis expressed 4 3.24311
VWA7 von Willebrand factor A domain containing 7 3.24311
DMRT2 doublesex and mab-3 related transcription factor 2 3.24311
FAM135B family with sequence similarity 135, member B 3.24311
AGXT2 alanine--glyoxylate aminotransferase 2 3.24311
CD27 CD27 molecule 3.24311
MOG myelin oligodendrocyte glycoprotein 3.24311
TTC9B tetratricopeptide repeat domain 9B 3.24311
SIRPG signal-regulatory protein gamma 3.24311
CCDC27 coiled-coil domain containing 27 3.24311
POU2AF1 POU class 2 associating factor 1 3.24311
IL36R interleukin 36 receptor 3.24311
PAGE4 P antigen family, member 4 (prostate associated) 3.24311
EOMES eomesodermin 3.24311
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 3.24311
TMIGD3 transmembrane and immunoglobulin domain containing 3 3.24311
TBC1D28 TBC1 domain family, member 28 3.24311
CD8A CD8a molecule 3.24311
SCNN1D sodium channel, non voltage gated 1 delta subunit 3.24311
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 3.24311
ELP6 elongator acetyltransferase complex subunit 6 3.24311
ACKR2 atypical chemokine receptor 2 3.24311
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 3.24311
ERP27 endoplasmic reticulum protein 27 3.24311
PSORS1C1 psoriasis susceptibility 1 candidate 1 3.24311
NT5DC4 5'-nucleotidase domain containing 4 3.24311
POTEI POTE ankyrin domain family, member I 3.24311
POTEA POTE ankyrin domain family, member A 3.24311
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 3.24311
TG thyroglobulin 3.24311
DRC1 dynein regulatory complex subunit 1 3.24311
CCL27 chemokine (C-C motif) ligand 27 3.24311
SLC17A3 solute carrier family 17 (organic anion transporter), member 3 3.24311
STMND1 stathmin domain containing 1 3.24311
GOLGA8K golgin A8 family, member K 3.24311
GP1BB glycoprotein Ib (platelet), beta polypeptide 3.24311
APOF apolipoprotein F 3.24311
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1 3.24311
GOLGA8N golgin A8 family, member N 3.24311
NBPF8 neuroblastoma breakpoint family, member 8 3.24311
RORC RAR-related orphan receptor C 3.24311
MAGEB17 melanoma antigen family B17 3.24311
PHOX2A paired-like homeobox 2a 3.24311
TLE6 transducin-like enhancer of split 6 3.13671
MDN1 MDN1, midasin homolog (yeast) 3.13671
TMIE transmembrane inner ear 3.13671
LEF1 lymphoid enhancer-binding factor 1 3.13671
HIPK4 homeodomain interacting protein kinase 4 3.13671
CNTF ciliary neurotrophic factor 2.92728
C2CD2 C2 calcium-dependent domain containing 2 2.88377
OSGIN1 oxidative stress induced growth inhibitor 1 2.8169
EIF3CL eukaryotic translation initiation factor 3, subunit C-like 2.81645
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) 2.67171
APAF1 apoptotic peptidase activating factor 1 2.5827
TMEM45B transmembrane protein 45B 2.5827
SYNGAP1 synaptic Ras GTPase activating protein 1 2.581
SLC25A29 solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29 2.57395
LIAS lipoic acid synthetase 2.54838
HS6ST3 heparan sulfate 6-O-sulfotransferase 3 2.53516
SLC22A25 solute carrier family 22, member 25 2.37153
SRL sarcalumenin 2.34265
IL1R1 interleukin 1 receptor, type I 2.34265
ZAN zonadhesin (gene/pseudogene) 2.34265
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 2.31476
CD80 CD80 molecule 2.28923
RAB38 RAB38, member RAS oncogene family 2.28631
C1ORF122 chromosome 1 open reading frame 122 2.28631
RNF208 ring finger protein 208 2.28293
AADACL3 arylacetamide deacetylase-like 3 2.2603
DCLK3 doublecortin-like kinase 3 2.2603
WFDC6 WAP four-disulfide core domain 6 2.2603
PCDHGA7 protocadherin gamma subfamily A, 7 2.25944
C20ORF203 chromosome 20 open reading frame 203 2.25051
IRAK1BP1 interleukin-1 receptor-associated kinase 1 binding protein 1 2.24349
BHLHE40 basic helix-loop-helix family, member e40 2.23086
PLAAT3 phospholipase A and acyltransferase 3 2.21796
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 2.21604
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 2.18877
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 2.18877
ORC2 origin recognition complex, subunit 2 2.17159
ANGPTL4 angiopoietin-like 4 2.16182
FOXI3 forkhead box I3 2.16182
ZNF443 zinc finger protein 443 2.13705
ZNF180 zinc finger protein 180 2.1288
SLC5A4 solute carrier family 5 (glucose activated ion channel), member 4 2.12325
ATG16L2 autophagy related 16-like 2 (S. cerevisiae) 2.11844
TMEM40 transmembrane protein 40 2.11516
CIMAP2 ciliary microtubule associated protein 2 2.11516
C1ORF146 chromosome 1 open reading frame 146 2.11516
KLHL10 kelch-like family member 10 2.11516
RPS11 ribosomal protein S11 2.11516
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 2.11514
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 2.09968
ZXDC ZXD family zinc finger C 2.09704
SPATA20 spermatogenesis associated 20 2.08144
RREB1 ras responsive element binding protein 1 2.06395
ZGRF1 zinc finger, GRF-type containing 1 2.04622
COPG2 coatomer protein complex, subunit gamma 2 2.04473
NABP2 nucleic acid binding protein 2 2.04469
ODAD3 outer dynein arm docking complex subunit 3 2.03489
NFE2L2 nuclear factor, erythroid 2-like 2 2.02842
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.02799
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta) 2.02677
ZNF394 zinc finger protein 394 2.02677
SFRP1 secreted frizzled-related protein 1 2.02414
CHCHD4 coiled-coil-helix-coiled-coil-helix domain containing 4 2.0168

decreased expression

Symbol Name Standardized Value
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic -3.24311
CA7 carbonic anhydrase VII -3.24311
GYS2 glycogen synthase 2 (liver) -3.24311
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) -3.24311
PANO1 proapoptotic nucleolar protein 1 -3.24311
FGF9 fibroblast growth factor 9 -3.24311
TMEM86B transmembrane protein 86B -3.24311
PRSS53 protease, serine, 53 -3.24311
CPO carboxypeptidase O -3.24311
AKR1B15 aldo-keto reductase family 1, member B15 -3.24311
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 -3.24311
ARR3 arrestin 3, retinal (X-arrestin) -3.24311
MUC5B mucin 5B, oligomeric mucus/gel-forming -3.24311
VSTM2A V-set and transmembrane domain containing 2A -3.24311
FRG2C FSHD region gene 2 family, member C -3.24311
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 -3.24311
MIOS missing oocyte, meiosis regulator, homolog (Drosophila) -3.24311
TUBA4B tubulin, alpha 4b -3.24311
HAL histidine ammonia-lyase -3.24311
CYP2F1 cytochrome P450, family 2, subfamily F, polypeptide 1 -3.24311
DMP1 dentin matrix acidic phosphoprotein 1 -3.24311
IZUMO1 izumo sperm-egg fusion 1 -3.24311
ACP7 acid phosphatase 7, tartrate resistant (putative) -3.24311
MS4A6E membrane-spanning 4-domains, subfamily A, member 6E -3.24311
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime -3.24311
GOLGA6B golgin A6 family, member B -3.24311
XIRP2 xin actin binding repeat containing 2 -3.24311
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) -3.24311
RIBC1 RIB43A domain with coiled-coils 1 -3.24311
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 -3.24311
SIDT1 SID1 transmembrane family, member 1 -3.24311
KLHDC8A kelch domain containing 8A -3.24311
CYS1 cystin 1 -3.24311
H4C6 H4 clustered histone 6 -3.18412
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 -3.10693
RMI2 RecQ mediated genome instability 2 -2.95292
CUEDC1 CUE domain containing 1 -2.89811
SAMD4B sterile alpha motif domain containing 4B -2.89744
CLTC clathrin, heavy chain (Hc) -2.89573
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) -2.86844
BGN biglycan -2.78105
MOB3B MOB kinase activator 3B -2.75309
WFDC2 WAP four-disulfide core domain 2 -2.74426
ECE2 endothelin converting enzyme 2 -2.74426
MED18 mediator complex subunit 18 -2.72632
SNURF SNRPN upstream reading frame -2.72098
IL13RA1 interleukin 13 receptor, alpha 1 -2.68621
HES1 hes family bHLH transcription factor 1 -2.68477
SPRED2 sprouty-related, EVH1 domain containing 2 -2.68477
ZSCAN2 zinc finger and SCAN domain containing 2 -2.54385
U2AF1 U2 small nuclear RNA auxiliary factor 1 -2.52899
COL8A2 collagen, type VIII, alpha 2 -2.49511
ZNF25 zinc finger protein 25 -2.45074
ERBIN erbb2 interacting protein -2.4397
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 -2.41587
TADA2B transcriptional adaptor 2B -2.4072
ANO4 anoctamin 4 -2.3518
GLS2 glutaminase 2 (liver, mitochondrial) -2.35176
IFI35 interferon-induced protein 35 -2.32449
TRPC6 transient receptor potential cation channel, subfamily C, member 6 -2.32449
ZDHHC17 zinc finger, DHHC-type containing 17 -2.31476
RTN2 reticulon 2 -2.31036
ACOXL acyl-CoA oxidase-like -2.25421
KIAA1328 KIAA1328 -2.24741
AIM2 absent in melanoma 2 -2.24268
HIC2 hypermethylated in cancer 2 -2.23021
TP53I3 tumor protein p53 inducible protein 3 -2.21796
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) -2.21604
ZBED8 zinc finger, BED-type containing 8 -2.19221
FAM50B family with sequence similarity 50, member B -2.18877
ELAC2 elaC ribonuclease Z 2 -2.16497
PALLD palladin, cytoskeletal associated protein -2.16419
METAP2 methionyl aminopeptidase 2 -2.1288
TRIM56 tripartite motif containing 56 -2.1288
CPXM2 carboxypeptidase X (M14 family), member 2 -2.1288
SOD2 superoxide dismutase 2, mitochondrial -2.1288
DCK deoxycytidine kinase -2.1288
DPP10 dipeptidyl-peptidase 10 (non-functional) -2.12285
C12ORF56 chromosome 12 open reading frame 56 -2.12166
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae) -2.11964
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) -2.11913
FST follistatin -2.11706
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31 -2.11706
ANAPC7 anaphase promoting complex subunit 7 -2.08551
NODAL nodal growth differentiation factor -2.0669
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa -2.06423
HABP4 hyaluronan binding protein 4 -2.06395
ADA2 adenosine deaminase 2 -2.05831
RMDN3 regulator of microtubule dynamics 3 -2.04469
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2 -2.03155
MITF microphthalmia-associated transcription factor -2.03155
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) -2.02482
PTRH2 peptidyl-tRNA hydrolase 2 -2.02482
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28 -2.01945
DALRD3 DALR anticodon binding domain containing 3 -2.00594
CEP192 centrosomal protein 192kDa -2.0057
CDK7 cyclin-dependent kinase 7 -2.00057