RAD17 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description RAD17 homolog (S. pombe)|The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq, Jul 2013] (NCBI Entrez Gene Database, 5884)
External Link http://www.ncbi.nlm.nih.gov/gene/5884
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191 interacting proteins for RAD17 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain
AHDC1 AT hook, DNA binding motif, containing 1
ALK anaplastic lymphoma receptor tyrosine kinase
ALYREF Aly/REF export factor
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
ARHGAP9 Rho GTPase activating protein 9
ATAD3B ATPase family, AAA domain containing 3B
ATM ATM serine/threonine kinase
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
ATR ATR serine/threonine kinase
BMI1 BMI1 proto-oncogene, polycomb ring finger
BPTF bromodomain PHD finger transcription factor
BRWD1 bromodomain and WD repeat domain containing 1
C17ORF70 chromosome 17 open reading frame 70
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CASC5 cancer susceptibility candidate 5
CBX6 chromobox homolog 6
CBX7 chromobox homolog 7
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK13 cyclin-dependent kinase 13
CENPF centromere protein F, 350/400kDa
CEP135 centrosomal protein 135kDa
CEP350 centrosomal protein 350kDa
CHAF1A chromatin assembly factor 1, subunit A (p150)
CLSPN claspin
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2B casein kinase 2, beta polypeptide
DACT1 dishevelled-binding antagonist of beta-catenin 1
DCAF12L2 DDB1 and CUL4 associated factor 12-like 2
DCAF7 DDB1 and CUL4 associated factor 7
DGKZ diacylglycerol kinase, zeta
DNMT1 DNA (cytosine-5-)-methyltransferase 1
ECI2 enoyl-CoA delta isomerase 2
EIF3C eukaryotic translation initiation factor 3, subunit C
EIF3E eukaryotic translation initiation factor 3, subunit E
EIF4B eukaryotic translation initiation factor 4B
ELP4 elongator acetyltransferase complex subunit 4
EPHA1 EPH receptor A1
EPHB3 EPH receptor B3
ERCC6L2 excision repair cross-complementation group 6-like 2
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)
FANCA Fanconi anemia, complementation group A
FANCB Fanconi anemia, complementation group B
FANCC Fanconi anemia, complementation group C
FANCD2 Fanconi anemia, complementation group D2
FANCE Fanconi anemia, complementation group E
FANCF Fanconi anemia, complementation group F
FANCG Fanconi anemia, complementation group G
FANCI Fanconi anemia, complementation group I
FANCL Fanconi anemia, complementation group L
FECH ferrochelatase
FN3K fructosamine 3 kinase
FOXO3 forkhead box O3
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GAK cyclin G associated kinase
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2
H1FX H1 histone family, member X
H2AFX H2A histone family, member X
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H1E histone cluster 1, H1e
HIST1H2AB histone cluster 1, H2ab
HIST1H2BB histone cluster 1, H2bb
HIST1H4F histone cluster 1, H4f
HIST3H3 histone cluster 3, H3
HNF4A hepatocyte nuclear factor 4, alpha
HUS1 HUS1 checkpoint homolog (S. pombe)
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
ILF2 interleukin enhancer binding factor 2
ILF3 interleukin enhancer binding factor 3, 90kDa
INSL6 insulin-like 6
IRF7 interferon regulatory factor 7
IRS4 insulin receptor substrate 4
ITK IL2-inducible T-cell kinase
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JAK2 Janus kinase 2
JAK3 Janus kinase 3
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KIF20B kinesin family member 20B
KRI1 KRI1 homolog (S. cerevisiae)
KRT18 keratin 18, type I
KRT74 keratin 74, type II
LAS1L LAS1-like (S. cerevisiae)
LMNB1 lamin B1
LRRC59 leucine rich repeat containing 59
LTV1 LTV1 ribosome biogenesis factor
MAP2K4 mitogen-activated protein kinase kinase 4
MAP2K7 mitogen-activated protein kinase kinase 7
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP7D1 MAP7 domain containing 1
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MARK1 MAP/microtubule affinity-regulating kinase 1
MCM2 minichromosome maintenance complex component 2
MCM7 minichromosome maintenance complex component 7
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEP1B meprin A, beta
MOV10 Mov10 RISC complex RNA helicase
MTIF2 mitochondrial translational initiation factor 2
MYLK myosin light chain kinase
MYO1A myosin IA
MYO1C myosin IC
N4BP3 NEDD4 binding protein 3
NBN nibrin
NCOR2 nuclear receptor corepressor 2
NEURL4 neuralized E3 ubiquitin protein ligase 4
NHP2L1 NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)
NOA1 nitric oxide associated 1
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NUCLEOLIN nucleolin multifunctional protein
NUMA1 nuclear mitotic apparatus protein 1
NUP153 nucleoporin 153kDa
PABPC1 poly(A) binding protein, cytoplasmic 1
PCGF2 polycomb group ring finger 2
PCGF6 polycomb group ring finger 6
PCNA proliferating cell nuclear antigen
PDLIM5 PDZ and LIM domain 5
PDX1 pancreatic and duodenal homeobox 1
PHC2 polyhomeotic homolog 2 (Drosophila)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PLCB2 phospholipase C, beta 2
PLCG1 phospholipase C, gamma 1
PLEC plectin
PLEKHA7 pleckstrin homology domain containing, family A member 7
PLK1 polo-like kinase 1
POLDIP3 polymerase (DNA-directed), delta interacting protein 3
POLE polymerase (DNA directed), epsilon, catalytic subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
POLE4 polymerase (DNA-directed), epsilon 4, accessory subunit
PPP1R3A protein phosphatase 1, regulatory subunit 3A
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRMT6 protein arginine methyltransferase 6
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
PTPRK protein tyrosine phosphatase, receptor type, K
RAB35 RAB35, member RAS oncogene family
RAD1 RAD1 checkpoint DNA exonuclease
RAD9A RAD9 homolog A (S. pombe)
RAD9B RAD9 homolog B (S. pombe)
RFC1 replication factor C (activator 1) 1, 145kDa
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGAG1 retrotransposon gag domain containing 1
RGPD6 RANBP2-like and GRIP domain containing 6
RING1 ring finger protein 1
RNF2 ring finger protein 2
SCML2 sex comb on midleg-like 2 (Drosophila)
SFN stratifin
SH3GL3 SH3-domain GRB2-like 3
SMC6 structural maintenance of chromosomes 6
SOCS1 suppressor of cytokine signaling 1
SOCS5 suppressor of cytokine signaling 5
SPECC1 sperm antigen with calponin homology and coiled-coil domains 1
SRBD1 S1 RNA binding domain 1
SSB Sjogren syndrome antigen B (autoantigen La)
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SUN2 Sad1 and UNC84 domain containing 2
SYTL4 synaptotagmin-like 4
TOPAZ1 testis and ovary specific PAZ domain containing 1
TPR translocated promoter region, nuclear basket protein
UBASH3A ubiquitin associated and SH3 domain containing A
UBC ubiquitin C
UBE2O ubiquitin-conjugating enzyme E2O
UBE2T ubiquitin-conjugating enzyme E2T
UBE4A ubiquitination factor E4A
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
ULK2 unc-51 like autophagy activating kinase 2
USP20 ubiquitin specific peptidase 20
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C
YBX1 Y box binding protein 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZMYM4 zinc finger, MYM-type 4
ZNF33A zinc finger protein 33A
ZNF33B zinc finger protein 33B
ZNF770 zinc finger protein 770