RAF/MAP kinase cascade Gene Set

Dataset Reactome Pathways 2024
Category structural or functional annotations
Type pathway
External Link https://reactome.org/PathwayBrowser/#/R-HSA-5673001
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Genes

264 proteins participating in the RAF/MAP kinase cascade pathway from the Reactome Pathways 2024 dataset.

Symbol Name
ABHD17A abhydrolase domain containing 17A
ABHD17B abhydrolase domain containing 17B
ABHD17C abhydrolase domain containing 17C
ACTB actin, beta
ACTG1 actin gamma 1
ACTN2 actinin, alpha 2
ADRM1 adhesion regulating molecule 1
ANGPT1 angiopoietin 1
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
ARAF A-Raf proto-oncogene, serine/threonine kinase
AREG amphiregulin
ARL2 ADP-ribosylation factor-like 2
ARRB1 arrestin, beta 1
ARRB2 arrestin, beta 2
ARTN artemin
BCL2L1 BCL2-like 1
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRAP BRCA1 associated protein
BTC betacellulin
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CAMK2D calcium/calmodulin-dependent protein kinase II delta
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CNKSR1 connector enhancer of kinase suppressor of Ras 1
CNKSR2 connector enhancer of kinase suppressor of Ras 2
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CSK c-src tyrosine kinase
CUL3 cullin 3
DAB2IP DAB2 interacting protein
DLG1 discs, large homolog 1 (Drosophila)
DLG2 discs, large homolog 2 (Drosophila)
DLG3 discs, large homolog 3 (Drosophila)
DLG4 discs, large homolog 4 (Drosophila)
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP16 dual specificity phosphatase 16
DUSP2 dual specificity phosphatase 2
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
DUSP8 dual specificity phosphatase 8
DUSP9 dual specificity phosphatase 9
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EPGN epithelial mitogen
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
EREG epiregulin
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGF1 fibroblast growth factor 1 (acidic)
FGF10 fibroblast growth factor 10
FGF16 fibroblast growth factor 16
FGF17 fibroblast growth factor 17
FGF18 fibroblast growth factor 18
FGF19 fibroblast growth factor 19
FGF2 fibroblast growth factor 2 (basic)
FGF20 fibroblast growth factor 20
FGF22 fibroblast growth factor 22
FGF23 fibroblast growth factor 23
FGF3 fibroblast growth factor 3
FGF4 fibroblast growth factor 4
FGF5 fibroblast growth factor 5
FGF6 fibroblast growth factor 6
FGF7 fibroblast growth factor 7
FGF8 fibroblast growth factor 8 (androgen-induced)
FGF9 fibroblast growth factor 9
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FGFR4 fibroblast growth factor receptor 4
FGG fibrinogen gamma chain
FLT3 fms-related tyrosine kinase 3
FLT3LG fms-related tyrosine kinase 3 ligand
FN1 fibronectin 1
FNTA farnesyltransferase, CAAX box, alpha
FNTB farnesyltransferase, CAAX box, beta
FRS2 fibroblast growth factor receptor substrate 2
FRS3 fibroblast growth factor receptor substrate 3
FYN FYN proto-oncogene, Src family tyrosine kinase
GDNF glial cell derived neurotrophic factor
GFRA1 GDNF family receptor alpha 1
GFRA2 GDNF family receptor alpha 2
GFRA3 GDNF family receptor alpha 3
GFRA4 GDNF family receptor alpha 4
GOLGA7 golgin A7
GRB2 growth factor receptor-bound protein 2
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D
HBEGF heparin-binding EGF-like growth factor
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HRAS Harvey rat sarcoma viral oncogene homolog
ICMT isoprenylcysteine carboxyl methyltransferase
IL17RD interleukin 17 receptor D
IL2 interleukin 2
IL2RA interleukin 2 receptor, alpha
IL2RB interleukin 2 receptor, beta
IL2RG interleukin 2 receptor, gamma
IL3 interleukin 3
IL3RA interleukin 3 receptor, alpha (low affinity)
IL5 interleukin 5
IL5RA interleukin 5 receptor, alpha
IQGAP1 IQ motif containing GTPase activating protein 1
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JAK1 Janus kinase 1
JAK2 Janus kinase 2
JAK3 Janus kinase 3
KBTBD7 kelch repeat and BTB (POZ) domain containing 7
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KITLG KIT ligand
KL klotho
KLB klotho beta
KRAS Kirsten rat sarcoma viral oncogene homolog
KSR1 kinase suppressor of ras 1
KSR2 kinase suppressor of ras 2
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
LAT linker for activation of T cells
LRRC7 leucine rich repeat containing 7
LYPLA1 lysophospholipase I
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAPK1 mitogen-activated protein kinase 1
MAPK12 mitogen-activated protein kinase 12
MAPK3 mitogen-activated protein kinase 3
MARK3 MAP/microtubule affinity-regulating kinase 3
MET MET proto-oncogene, receptor tyrosine kinase
MRAS muscle RAS oncogene homolog
NCAM1 neural cell adhesion molecule 1
NEFL neurofilament, light polypeptide
NF1 neurofibromin 1
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NRG1 neuregulin 1
NRG2 neuregulin 2
NRG3 neuregulin 3
NRG4 neuregulin 4
NRTN neurturin
PAQR3 progestin and adipoQ receptor family member III
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta
PDGFA platelet-derived growth factor alpha polypeptide
PDGFB platelet-derived growth factor beta polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PEA15 phosphoprotein enriched in astrocytes 15
PEBP1 phosphatidylethanolamine binding protein 1
PHB1 prohibitin 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PPP2R5D protein phosphatase 2, regulatory subunit B', delta
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PPP5C protein phosphatase 5, catalytic subunit
PRKCQ protein kinase C, theta
PRKG2 protein kinase, cGMP-dependent, type II
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
PSPN persephin
PTK2 protein tyrosine kinase 2
PTPN3 protein tyrosine phosphatase, non-receptor type 3
PTPN7 protein tyrosine phosphatase, non-receptor type 7
PTPRA protein tyrosine phosphatase, receptor type, A
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RALGDS ral guanine nucleotide dissociation stimulator
RANBP9 RAN binding protein 9
RAP1A RAP1A, member of RAS oncogene family
RAP1B RAP1B, member of RAS oncogene family
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RASA2 RAS p21 protein activator 2
RASA3 RAS p21 protein activator 3
RASA4 RAS p21 protein activator 4
RASAL1 RAS protein activator like 1 (GAP1 like)
RASAL2 RAS protein activator like 2
RASAL3 RAS protein activator like 3
RASGEF1A RasGEF domain family, member 1A
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
RASGRP4 RAS guanyl releasing protein 4
RBX1 ring-box 1, E3 ubiquitin protein ligase
RCE1 Ras converting CAAX endopeptidase 1
RET ret proto-oncogene
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGL2 ral guanine nucleotide dissociation stimulator-like 2
RGL3 ral guanine nucleotide dissociation stimulator-like 3
RPS27A ribosomal protein S27a
SEM1 SEM1 26S proteasome subunit
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHC2 SHC (Src homology 2 domain containing) transforming protein 2
SHC3 SHC (Src homology 2 domain containing) transforming protein 3
SHOC2 soc-2 suppressor of clear homolog (C. elegans)
SOS1 son of sevenless homolog 1 (Drosophila)
SPRED1 sprouty-related, EVH1 domain containing 1
SPRED2 sprouty-related, EVH1 domain containing 2
SPRED3 sprouty-related, EVH1 domain containing 3
SPTA1 spectrin, alpha, erythrocytic 1
SPTAN1 spectrin, alpha, non-erythrocytic 1
SPTB spectrin, beta, erythrocytic
SPTBN1 spectrin, beta, non-erythrocytic 1
SPTBN2 spectrin, beta, non-erythrocytic 2
SPTBN4 spectrin, beta, non-erythrocytic 4
SPTBN5 spectrin, beta, non-erythrocytic 5
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SYNGAP1 synaptic Ras GTPase activating protein 1
TEK TEK tyrosine kinase, endothelial
TGFA transforming growth factor, alpha
TLN1 talin 1
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBB ubiquitin B
UBC ubiquitin C
USP17L2 ubiquitin specific peptidase 17-like family member 2
VCL vinculin
VWF von Willebrand factor
WDR83 WD repeat domain 83
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
ZDHHC9 zinc finger, DHHC-type containing 9