RAF1 Gene Set

Dataset Hub Proteins Protein-Protein Interactions
Category physical interactions
Type hub protein
Description Raf-1 proto-oncogene, serine/threonine kinase|This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5894)
External Link http://www.ncbi.nlm.nih.gov/gene/5894
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Genes

150 interacting proteins for hub protein RAF1 from the curated Hub Proteins Protein-Protein Interactions dataset.

Symbol Name
ADCY6 adenylate cyclase 6
AGTR1 angiotensin II receptor, type 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
AR androgen receptor
ARRB1 arrestin, beta 1
ARRB2 arrestin, beta 2
BAD BCL2-associated agonist of cell death
BAG1 BCL2-associated athanogene
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BRAF B-Raf proto-oncogene, serine/threonine kinase
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CASP9 caspase 9, apoptosis-related cysteine peptidase
CCT3 chaperonin containing TCP1, subunit 3 (gamma)
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC37 cell division cycle 37
CERK ceramide kinase
CFLAR CASP8 and FADD-like apoptosis regulator
CNKSR1 connector enhancer of kinase suppressor of Ras 1
CNKSR2 connector enhancer of kinase suppressor of Ras 2
COPS3 COP9 signalosome subunit 3
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
DMPK dystrophia myotonica-protein kinase
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENG endoglin
ERAS ES cell expressed Ras
ERBB2IP erbb2 interacting protein
FKBP10 FK506 binding protein 10, 65 kDa
FYN FYN proto-oncogene, Src family tyrosine kinase
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GRB10 growth factor receptor-bound protein 10
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
HCK HCK proto-oncogene, Src family tyrosine kinase
HNRNPK heterogeneous nuclear ribonucleoprotein K
HRAS Harvey rat sarcoma viral oncogene homolog
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA4 heat shock 70kDa protein 4
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IL2RB interleukin 2 receptor, beta
INSR insulin receptor
INTS10 integrator complex subunit 10
JAK1 Janus kinase 1
JAK2 Janus kinase 2
KLC1 kinesin light chain 1
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT18 keratin 18, type I
KRT19 keratin 19, type I
KRT8 keratin 8, type II
KSR1 kinase suppressor of ras 1
KSR2 kinase suppressor of ras 2
LCK LCK proto-oncogene, Src family tyrosine kinase
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
LTK leukocyte receptor tyrosine kinase
LYN LYN proto-oncogene, Src family tyrosine kinase
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPK7 mitogen-activated protein kinase 7
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MRAS muscle RAS oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NUDT14 nudix (nucleoside diphosphate linked moiety X)-type motif 14
OIP5 Opa interacting protein 5
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7
PBK PDZ binding kinase
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PEBP1 phosphatidylethanolamine binding protein 1
PEBP4 phosphatidylethanolamine-binding protein 4
PEX5L peroxisomal biogenesis factor 5-like
PHB prohibitin
PHKA2 phosphorylase kinase, alpha 2 (liver)
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PKM pyruvate kinase, muscle
PLK2 polo-like kinase 2
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRKCE protein kinase C, epsilon
PRKCG protein kinase C, gamma
PRKCZ protein kinase C, zeta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRKG1 protein kinase, cGMP-dependent, type I
PRPF6 pre-mRNA processing factor 6
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RAP1A RAP1A, member of RAS oncogene family
RAP1B RAP1B, member of RAS oncogene family
RAP2A RAP2A, member of RAS oncogene family
RASD2 RASD family, member 2
RB1 retinoblastoma 1
RBL2 retinoblastoma-like 2
RCAN1 regulator of calcineurin 1
RFXANK regulatory factor X-associated ankyrin-containing protein
RHEB Ras homolog enriched in brain
RIPK2 receptor-interacting serine-threonine kinase 2
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RRAS related RAS viral (r-ras) oncogene homolog
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RSU1 Ras suppressor protein 1
SFN stratifin
SHOC2 soc-2 suppressor of clear homolog (C. elegans)
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STK26 serine/threonine protein kinase 26
STK3 serine/threonine kinase 3
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TBXA2R thromboxane A2 receptor
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TP53 tumor protein p53
TSC22D3 TSC22 domain family, member 3
UBC ubiquitin C
UBE2D2 ubiquitin-conjugating enzyme E2D 2
VAV1 vav 1 guanine nucleotide exchange factor
VDAC1 voltage-dependent anion channel 1
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta