RAF1 Gene Set

Dataset Kinase Library Serine Threonine Kinome Atlas
Category proteomics
Type kinase
Description Raf-1 proto-oncogene, serine/threonine kinase|This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5894)
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Genes

100 substrates of the kinase RAF1 from the Kinase Library Serine Threonine Kinome Atlas dataset.

Symbol Name Standardized Value
UBE2O ubiquitin-conjugating enzyme E2O
CASP3 caspase 3, apoptosis-related cysteine peptidase
AKT2 v-akt murine thymoma viral oncogene homolog 2
KIAA1671 KIAA1671
EPS8L1 EPS8-like 1
SACK1H scaffolding CK1 anchoring protein H
AKAP13 A kinase (PRKA) anchor protein 13
BAHD1 bromo adjacent homology domain containing 1
SMARCAD1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
CADPS Ca++-dependent secretion activator
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
PDZD2 PDZ domain containing 2
SCAPER S-phase cyclin A-associated protein in the ER
ARHGAP39 Rho GTPase activating protein 39
TBC1D8B TBC1 domain family, member 8B (with GRAM domain)
CEP97 centrosomal protein 97kDa
C9ORF152 chromosome 9 open reading frame 152
WDR59 WD repeat domain 59
SLCO4C1 solute carrier organic anion transporter family, member 4C1
HAUS6 HAUS augmin-like complex, subunit 6
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
CYLD cylindromatosis (turban tumor syndrome)
DOCK6 dedicator of cytokinesis 6
ARHGAP31 Rho GTPase activating protein 31
RC3H2 ring finger and CCCH-type domains 2
BRCC3 BRCA1/BRCA2-containing complex, subunit 3
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
KIFAP3 kinesin-associated protein 3
STRN4 striatin, calmodulin binding protein 4
SHROOM2 shroom family member 2
BLM Bloom syndrome, RecQ helicase-like
CCDC109B coiled-coil domain containing 109B
TRPC1 transient receptor potential cation channel, subfamily C, member 1
PRRC2A proline-rich coiled-coil 2A
GRAMD3 GRAM domain containing 3
HPS5 Hermansky-Pudlak syndrome 5
CDC42BPG CDC42 binding protein kinase gamma (DMPK-like)
KIAA1551 KIAA1551
C2CD3 C2 calcium-dependent domain containing 3
SNX29 sorting nexin 29
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2
FAM171A2 family with sequence similarity 171, member A2
PLEKHA6 pleckstrin homology domain containing, family A member 6
MYH15 myosin, heavy chain 15
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
RASAL3 RAS protein activator like 3
XRN2 5'-3' exoribonuclease 2
SPTAN1 spectrin, alpha, non-erythrocytic 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ALMS1 Alstrom syndrome protein 1
TBXA2R thromboxane A2 receptor
CXORF23 chromosome X open reading frame 23
PEBP1 phosphatidylethanolamine binding protein 1
SLAIN2 SLAIN motif family, member 2
RPL3 ribosomal protein L3
KIF7 kinesin family member 7
CNOT12 CCR4-NOT transcription complex subunit 12
CXCR5 chemokine (C-X-C motif) receptor 5
DSN1 DSN1, MIS12 kinetochore complex component
NUP153 nucleoporin 153kDa
AEBP2 AE binding protein 2
KIAA1217 KIAA1217
CADPS2 Ca++-dependent secretion activator 2
SRBD1 S1 RNA binding domain 1
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
SORBS2 sorbin and SH3 domain containing 2
ADGRL2 adhesion G protein-coupled receptor L2
WHSC1 Wolf-Hirschhorn syndrome candidate 1
KIAA1522 KIAA1522
CEP128 centrosomal protein 128kDa
FRYL FRY-like
DOCK7 dedicator of cytokinesis 7
SYNE2 spectrin repeat containing, nuclear envelope 2
UBL7 ubiquitin-like 7
BOD1L1 biorientation of chromosomes in cell division 1-like 1
RBM15B RNA binding motif protein 15B
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
MAP3K8 mitogen-activated protein kinase kinase kinase 8
ANK2 ankyrin 2, neuronal
CENPF centromere protein F, 350/400kDa
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ETV1 ets variant 1
ETV5 ets variant 5
ZFP36L2 ZFP36 ring finger protein-like 2
DMWD dystrophia myotonica, WD repeat containing
PXN paxillin
PPP1R12A protein phosphatase 1, regulatory subunit 12A
SV2B synaptic vesicle glycoprotein 2B
GAB2 GRB2-associated binding protein 2
GAB3 GRB2-associated binding protein 3
ARHGAP23 Rho GTPase activating protein 23
C14ORF93 chromosome 14 open reading frame 93
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
PUM1 pumilio RNA-binding family member 1
LIMK2 LIM domain kinase 2
REEP3 receptor accessory protein 3
FAM189A2 family with sequence similarity 189, member A2