| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | Raf-1 proto-oncogene, serine/threonine kinase|This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5894) |
| External Link | https://ncbi.nlm.nih.gov/gene/5894 |
| Similar Terms | |
| Downloads & Tools |
500 genes differentially expressed following the RAF1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IFI27 | interferon, alpha-inducible protein 27 | 0.023374 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.0178139 |
| MT1X | metallothionein 1X | 0.0147263 |
| MT1F | metallothionein 1F | 0.0143427 |
| ADH1B | alcohol dehydrogenase 1B (class I), beta polypeptide | 0.0137974 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | 0.0133199 |
| ANXA1 | annexin A1 | 0.0132716 |
| MT1E | metallothionein 1E | 0.0129359 |
| MT1H | metallothionein 1H | 0.0126057 |
| MT1G | metallothionein 1G | 0.0124562 |
| IFI44L | interferon-induced protein 44-like | 0.0124331 |
| MT1HL1 | metallothionein 1H-like 1 | 0.0124307 |
| MX1 | MX dynamin-like GTPase 1 | 0.0121214 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 0.012076 |
| FXYD3 | FXYD domain containing ion transport regulator 3 | 0.0120375 |
| GNAS | GNAS complex locus | 0.0120003 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.0118603 |
| MT2A | metallothionein 2A | 0.0118577 |
| COQ8A | coenzyme Q8A | 0.011727 |
| AQP3 | aquaporin 3 (Gill blood group) | 0.0115784 |
| LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | 0.0114878 |
| SPRR3 | small proline-rich protein 3 | 0.011199 |
| MX2 | MX dynamin-like GTPase 2 | 0.0111811 |
| SLC2A10 | solute carrier family 2 (facilitated glucose transporter), member 10 | 0.0111392 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | 0.0111218 |
| AOX1 | aldehyde oxidase 1 | 0.0109013 |
| C1S | complement component 1, s subcomponent | 0.0107876 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0107459 |
| KRT7 | keratin 7, type II | 0.0107164 |
| ABLIM1 | actin binding LIM protein 1 | 0.0103736 |
| CSTA | cystatin A (stefin A) | 0.0103331 |
| LHFP | lipoma HMGIC fusion partner | 0.0102389 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | 0.0101869 |
| CSRP3 | cysteine and glycine-rich protein 3 (cardiac LIM protein) | 0.0101826 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.010135 |
| CXCL12 | chemokine (C-X-C motif) ligand 12 | 0.0100669 |
| ALDH3A1 | aldehyde dehydrogenase 3 family, member A1 | 0.0100567 |
| JPT1 | Jupiter microtubule associated homolog 1 | 0.0100107 |
| KRT13 | keratin 13, type I | 0.00999425 |
| XIC | X chromosome inactivation center | 0.00989682 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | 0.00978257 |
| PSAP | prosaposin | 0.00977582 |
| S100A9 | S100 calcium binding protein A9 | 0.00972982 |
| CD9 | CD9 molecule | 0.00966856 |
| PSCA | prostate stem cell antigen | 0.00966277 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | 0.00963773 |
| SLPI | secretory leukocyte peptidase inhibitor | 0.00962185 |
| C1R | complement component 1, r subcomponent | 0.00952732 |
| DEFB1 | defensin, beta 1 | 0.00951826 |
| C3 | complement component 3 | 0.00949353 |
| CLU | clusterin | 0.00947427 |
| CRISP3 | cysteine-rich secretory protein 3 | 0.00944916 |
| TRIM22 | tripartite motif containing 22 | 0.00944691 |
| DNAJC6 | DnaJ (Hsp40) homolog, subfamily C, member 6 | 0.0094388 |
| SERPINA5 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 | 0.00941115 |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) | 0.00936677 |
| CNTN1 | contactin 1 | 0.00930498 |
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide | 0.00926951 |
| FKBP11 | FK506 binding protein 11, 19 kDa | 0.00922306 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.00921463 |
| PPM1H | protein phosphatase, Mg2+/Mn2+ dependent, 1H | 0.00920035 |
| WASHC4 | WASH complex subunit 4 | 0.00914729 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.00910418 |
| CP | ceruloplasmin (ferroxidase) | 0.00908201 |
| MICB | MHC class I polypeptide-related sequence B | 0.00907384 |
| GABRP | gamma-aminobutyric acid (GABA) A receptor, pi | 0.00904681 |
| IFI44 | interferon-induced protein 44 | 0.00903167 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | 0.00895405 |
| LMCD1 | LIM and cysteine-rich domains 1 | 0.00891772 |
| GAS1 | growth arrest-specific 1 | 0.00890948 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 0.00885065 |
| CFI | complement factor I | 0.00875486 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | 0.00867947 |
| FABP4 | fatty acid binding protein 4, adipocyte | 0.00866941 |
| CANT1 | calcium activated nucleotidase 1 | 0.0086681 |
| CHGB | chromogranin B | 0.00865263 |
| CFB | complement factor B | 0.00865038 |
| MSMB | microseminoprotein, beta- | 0.00864242 |
| OAS1 | 2'-5'-oligoadenylate synthetase 1, 40/46kDa | 0.00851923 |
| CAST | calpastatin | 0.00851099 |
| MUC5B | mucin 5B, oligomeric mucus/gel-forming | 0.00845881 |
| ANXA2P2 | annexin A2 pseudogene 2 | 0.00842545 |
| CYP4B1 | cytochrome P450, family 4, subfamily B, polypeptide 1 | 0.0084207 |
| ADIRF | adipogenesis regulatory factor | 0.00836386 |
| PTCH1 | patched 1 | 0.00833207 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.00830495 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.00827065 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.00825448 |
| CAV2 | caveolin 2 | 0.00821933 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | 0.00820351 |
| TRIB2 | tribbles pseudokinase 2 | 0.00810552 |
| KRT23 | keratin 23, type I | 0.00809766 |
| EEF1A2 | eukaryotic translation elongation factor 1 alpha 2 | 0.008085 |
| BCL6 | B-cell CLL/lymphoma 6 | 0.0080673 |
| PI3 | peptidase inhibitor 3, skin-derived | 0.00806461 |
| CHD7 | chromodomain helicase DNA binding protein 7 | 0.00805467 |
| CLDN10 | claudin 10 | 0.00803561 |
| ELF1 | E74-like factor 1 (ets domain transcription factor) | 0.00799842 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.00797052 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 0.0079676 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | 0.00795935 |
| KRT19 | keratin 19, type I | 0.00794169 |
| EFEMP1 | EGF containing fibulin-like extracellular matrix protein 1 | 0.00782536 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.00780772 |
| RND3 | Rho family GTPase 3 | 0.00779488 |
| WIPI1 | WD repeat domain, phosphoinositide interacting 1 | 0.00777253 |
| MRPS16 | mitochondrial ribosomal protein S16 | 0.00776814 |
| CLIC5 | chloride intracellular channel 5 | 0.00775238 |
| TSPAN1 | tetraspanin 1 | 0.00772002 |
| S100A7 | S100 calcium binding protein A7 | 0.00770637 |
| PSMB8 | proteasome (prosome, macropain) subunit, beta type, 8 | 0.00770217 |
| KLF4 | Kruppel-like factor 4 (gut) | 0.00768498 |
| ATP5PD | ATP synthase peripheral stalk subunit d | 0.00767633 |
| C7 | complement component 7 | 0.00764306 |
| S100A8 | S100 calcium binding protein A8 | 0.00764183 |
| IQCG | IQ motif containing G | 0.00762739 |
| DNAJB9 | DnaJ (Hsp40) homolog, subfamily B, member 9 | 0.00758849 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | 0.00752575 |
| GNLY | granulysin | 0.00751474 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.00747329 |
| SPOCK2 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 | 0.00745041 |
| NPY1R | neuropeptide Y receptor Y1 | 0.00743238 |
| LY6D | lymphocyte antigen 6 complex, locus D | 0.00741966 |
| HSPA2 | heat shock 70kDa protein 2 | 0.00741954 |
| SERPING1 | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 | 0.00741504 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 0.00740343 |
| GNE | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | 0.00738755 |
| FDXR | ferredoxin reductase | 0.00737411 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.00734156 |
| IL32 | interleukin 32 | 0.00733972 |
| CLCA4 | chloride channel accessory 4 | 0.00733802 |
| GM2A | GM2 ganglioside activator | 0.00732022 |
| GOLM1 | golgi membrane protein 1 | 0.0072539 |
| ME2 | malic enzyme 2, NAD(+)-dependent, mitochondrial | 0.00722267 |
| TUBB2A | tubulin, beta 2A class IIa | 0.0072057 |
| LAMA3 | laminin, alpha 3 | 0.00718737 |
| RPS27L | ribosomal protein S27-like | 0.00717882 |
| ZMAT3 | zinc finger, matrin-type 3 | 0.00716188 |
| COL5A2 | collagen, type V, alpha 2 | 0.0071578 |
| SFRP1 | secreted frizzled-related protein 1 | 0.00713557 |
| S100P | S100 calcium binding protein P | 0.0071267 |
| CRYAB | crystallin, alpha B | 0.00712387 |
| MYO1C | myosin IC | 0.0071232 |
| IRS2 | insulin receptor substrate 2 | 0.00711401 |
| HPGD | hydroxyprostaglandin dehydrogenase 15-(NAD) | 0.00710491 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.00709898 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | 0.00708139 |
| SP110 | SP110 nuclear body protein | 0.00707538 |
| ANXA11 | annexin A11 | 0.00706238 |
| ANK2 | ankyrin 2, neuronal | 0.00705592 |
| LMO2 | LIM domain only 2 (rhombotin-like 1) | 0.00703241 |
| OASL | 2'-5'-oligoadenylate synthetase-like | 0.00702768 |
| PBX1 | pre-B-cell leukemia homeobox 1 | 0.00701986 |
| SCEL | sciellin | 0.00699147 |
| SCGB2A2 | secretoglobin, family 2A, member 2 | 0.00698487 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.00698375 |
| ABCA8 | ATP-binding cassette, sub-family A (ABC1), member 8 | 0.00698001 |
| DKK3 | dickkopf WNT signaling pathway inhibitor 3 | 0.00697914 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.00696579 |
| TSC22D1 | TSC22 domain family, member 1 | 0.00695464 |
| FEZ1 | fasciculation and elongation protein zeta 1 (zygin I) | 0.00692783 |
| TCN1 | transcobalamin I (vitamin B12 binding protein, R binder family) | 0.00690927 |
| MPDZ | multiple PDZ domain protein | 0.0068967 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.00687081 |
| EGFL6 | EGF-like-domain, multiple 6 | 0.00685406 |
| FMO1 | flavin containing monooxygenase 1 | 0.00684582 |
| PSAT1 | phosphoserine aminotransferase 1 | 0.00684412 |
| RIOK3 | RIO kinase 3 | 0.00681449 |
| GPX1 | glutathione peroxidase 1 | 0.00681416 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.00681185 |
| PHF11 | PHD finger protein 11 | 0.0067767 |
| S100A14 | S100 calcium binding protein A14 | 0.00677421 |
| CDO1 | cysteine dioxygenase type 1 | 0.00676396 |
| S100A10 | S100 calcium binding protein A10 | 0.00674767 |
| E2F2 | E2F transcription factor 2 | 0.00672718 |
| CTSW | cathepsin W | 0.00670445 |
| GSTK1 | glutathione S-transferase kappa 1 | 0.00670331 |
| TGFBR3 | transforming growth factor, beta receptor III | 0.00670215 |
| FRZB | frizzled-related protein | 0.00669482 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.00666793 |
| SUPV3L1 | suppressor of var1, 3-like 1 (S. cerevisiae) | 0.00665309 |
| SRPX | sushi-repeat containing protein, X-linked | 0.00664368 |
| ZIC1 | Zic family member 1 | 0.00662786 |
| PTGER4 | prostaglandin E receptor 4 (subtype EP4) | 0.00662682 |
| NCALD | neurocalcin delta | 0.0066228 |
| IL1R1 | interleukin 1 receptor, type I | 0.00661984 |
| AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) | 0.00661078 |
| KLRB1 | killer cell lectin-like receptor subfamily B, member 1 | 0.00659384 |
| MGST3 | microsomal glutathione S-transferase 3 | 0.00657826 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.00657656 |
| DCLRE1C | DNA cross-link repair 1C | 0.006558 |
| ALDOB | aldolase B, fructose-bisphosphate | 0.00655771 |
| MDFIC | MyoD family inhibitor domain containing | 0.00654647 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.0065335 |
| TMEM255A | transmembrane protein 255A | 0.00653108 |
| ECHDC2 | enoyl CoA hydratase domain containing 2 | 0.00652721 |
| IRF9 | interferon regulatory factor 9 | 0.00651978 |
| NT5C2 | 5'-nucleotidase, cytosolic II | 0.00650973 |
| SPRR2B | small proline-rich protein 2B | 0.00650059 |
| NFASC | neurofascin | 0.00649654 |
| CA2 | carbonic anhydrase II | 0.00646786 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | 0.00646003 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | 0.00645364 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | 0.00643914 |
| OPTN | optineurin | 0.00643735 |
| IFITM1 | interferon induced transmembrane protein 1 | 0.00643548 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.00642391 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.00642131 |
| ACTA1 | actin, alpha 1, skeletal muscle | 0.00641593 |
| RARRES2 | retinoic acid receptor responder (tazarotene induced) 2 | 0.00639543 |
| RUNX3 | runt-related transcription factor 3 | 0.00636832 |
| F2R | coagulation factor II (thrombin) receptor | 0.00636645 |
| HIST1H2BD | histone cluster 1, H2bd | 0.00636361 |
| DLD | dihydrolipoamide dehydrogenase | 0.0063489 |
| WNT5A | wingless-type MMTV integration site family, member 5A | 0.00634113 |
| ARHGEF6 | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 | 0.00631576 |
| VCAN | versican | 0.00630376 |
| CAPN3 | calpain 3, (p94) | 0.00630179 |
| MIR22HG | MIR22 host gene | 0.00629424 |
| INAVA | innate immunity activator | 0.00629254 |
| JAG1 | jagged 1 | 0.0062759 |
| FCN1 | ficolin (collagen/fibrinogen domain containing) 1 | 0.00626896 |
| ARPC3 | actin related protein 2/3 complex, subunit 3, 21kDa | 0.00626675 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | 0.00626053 |
| KLHL41 | kelch-like family member 41 | 0.00624782 |
| MUC16 | mucin 16, cell surface associated | 0.0062426 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 | 0.0062308 |
| PNMA2 | paraneoplastic Ma antigen 2 | 0.0062138 |
| PLTP | phospholipid transfer protein | 0.00619213 |
| SVEP1 | sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 | 0.00618972 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.00618696 |
| IL33R | interleukin 33 receptor | 0.00617464 |
| GBAP1 | glucosidase, beta, acid pseudogene 1 | 0.00617335 |
| ADA | adenosine deaminase | 0.00616793 |
| TOX | thymocyte selection-associated high mobility group box | 0.00616206 |
| CRABP2 | cellular retinoic acid binding protein 2 | 0.00615829 |
| PLSCR4 | phospholipid scramblase 4 | 0.0061581 |
| HBD | hemoglobin, delta | 0.00615453 |
| PKD1P1 | polycystic kidney disease 1 (autosomal dominant) pseudogene 1 | 0.0061483 |
| PNMA8A | PNMA family member 8A | 0.00614375 |
| S100A12 | S100 calcium binding protein A12 | 0.00612737 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | 0.00612727 |
| HNMT | histamine N-methyltransferase | 0.00610497 |
| PITX3 | paired-like homeodomain 3 | 0.00609595 |
| CXADR | coxsackie virus and adenovirus receptor | 0.00609453 |
| PDZK1IP1 | PDZK1 interacting protein 1 | 0.00608857 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.00607682 |
| MAL | mal, T-cell differentiation protein | 0.00607507 |
| PRNP | prion protein | 0.00605874 |
| NKG7 | natural killer cell granule protein 7 | 0.00604467 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MAP7 | microtubule-associated protein 7 | -0.0156222 |
| SIRT3 | sirtuin 3 | -0.0147223 |
| REEP1 | receptor accessory protein 1 | -0.0125677 |
| AKR7A2 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) | -0.0120435 |
| GPER1 | G protein-coupled estrogen receptor 1 | -0.0116488 |
| EFNB2 | ephrin-B2 | -0.0113398 |
| GNA11 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) | -0.011113 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | -0.01075 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | -0.0103999 |
| BSPRY | B-box and SPRY domain containing | -0.010189 |
| PRPF4 | pre-mRNA processing factor 4 | -0.00994133 |
| CXCL9 | chemokine (C-X-C motif) ligand 9 | -0.00943489 |
| PCP4 | Purkinje cell protein 4 | -0.00898654 |
| DEGS1 | delta(4)-desaturase, sphingolipid 1 | -0.00880384 |
| SLC37A4 | solute carrier family 37 (glucose-6-phosphate transporter), member 4 | -0.00871686 |
| COL1A2 | collagen, type I, alpha 2 | -0.00871597 |
| CGA | glycoprotein hormones, alpha polypeptide | -0.00871138 |
| CHKB | choline kinase beta | -0.00870124 |
| CNPY3 | canopy FGF signaling regulator 3 | -0.00860626 |
| ITGAE | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) | -0.00851388 |
| SH3TC1 | SH3 domain and tetratricopeptide repeats 1 | -0.00836146 |
| GNG10 | guanine nucleotide binding protein (G protein), gamma 10 | -0.00809537 |
| NVL | nuclear VCP-like | -0.00801954 |
| ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 | -0.00791159 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.00783021 |
| TIMM22 | translocase of inner mitochondrial membrane 22 homolog (yeast) | -0.00776718 |
| SC5D | sterol-C5-desaturase | -0.00773926 |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | -0.0077251 |
| PLK1 | polo-like kinase 1 | -0.0077243 |
| CIT | citron rho-interacting serine/threonine kinase | -0.00772101 |
| NRGN | neurogranin (protein kinase C substrate, RC3) | -0.00769146 |
| IMPA2 | inositol(myo)-1(or 4)-monophosphatase 2 | -0.0076704 |
| GAS6 | growth arrest-specific 6 | -0.00756777 |
| DNAJB14 | DnaJ (Hsp40) homolog, subfamily B, member 14 | -0.00749318 |
| H2AX | H2A.X variant histone | -0.00748751 |
| CRLF1 | cytokine receptor-like factor 1 | -0.00747796 |
| SPP1 | secreted phosphoprotein 1 | -0.0074631 |
| SKIV2L | superkiller viralicidic activity 2-like (S. cerevisiae) | -0.00743886 |
| TMEM106C | transmembrane protein 106C | -0.00741418 |
| FAM13A | family with sequence similarity 13, member A | -0.00729675 |
| ZBTB18 | zinc finger and BTB domain containing 18 | -0.00718655 |
| DHCR7 | 7-dehydrocholesterol reductase | -0.00717665 |
| NBL1 | neuroblastoma 1, DAN family BMP antagonist | -0.00714138 |
| GPR88 | G protein-coupled receptor 88 | -0.00713971 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.00712617 |
| TACC3 | transforming, acidic coiled-coil containing protein 3 | -0.00711687 |
| GRWD1 | glutamate-rich WD repeat containing 1 | -0.00711427 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | -0.00705537 |
| GSTM3 | glutathione S-transferase mu 3 (brain) | -0.00703047 |
| HMGB1 | high mobility group box 1 | -0.0070263 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -0.00702134 |
| GLB1L2 | galactosidase, beta 1-like 2 | -0.00701948 |
| DGKZ | diacylglycerol kinase, zeta | -0.00697516 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.00688599 |
| KDM5D | lysine (K)-specific demethylase 5D | -0.00688374 |
| NID2 | nidogen 2 (osteonidogen) | -0.00687217 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.0068025 |
| IFRD2 | interferon-related developmental regulator 2 | -0.0066582 |
| NFIC | nuclear factor I/C (CCAAT-binding transcription factor) | -0.00662521 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.00661269 |
| PGGHG | protein-glucosylgalactosylhydroxylysine glucosidase | -0.00660727 |
| RAPSN | receptor-associated protein of the synapse | -0.00659972 |
| TRAPPC3 | trafficking protein particle complex 3 | -0.00658371 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0064973 |
| VWA1 | von Willebrand factor A domain containing 1 | -0.00648832 |
| AKR7A3 | aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) | -0.00647093 |
| ELN | elastin | -0.00642854 |
| MRPL12 | mitochondrial ribosomal protein L12 | -0.00641768 |
| NKX2-1 | NK2 homeobox 1 | -0.00640529 |
| AURKB | aurora kinase B | -0.00639552 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.00638998 |
| SMTN | smoothelin | -0.00631822 |
| LMNB2 | lamin B2 | -0.00625825 |
| PRDX4 | peroxiredoxin 4 | -0.00616165 |
| SLC29A1 | solute carrier family 29 (equilibrative nucleoside transporter), member 1 | -0.00614866 |
| TRAPPC4 | trafficking protein particle complex 4 | -0.00613813 |
| SFTPB | surfactant protein B | -0.0061297 |
| SFTPA2 | surfactant protein A2 | -0.00612607 |
| KLHDC3 | kelch domain containing 3 | -0.00612598 |
| IPO9 | importin 9 | -0.00609628 |
| DSP | desmoplakin | -0.00609605 |
| VEGFA | vascular endothelial growth factor A | -0.00608806 |
| TARDBP | TAR DNA binding protein | -0.00607275 |
| RACGAP1 | Rac GTPase activating protein 1 | -0.00606126 |
| UBE2S | ubiquitin-conjugating enzyme E2S | -0.00605653 |
| ATP7A | ATPase, Cu++ transporting, alpha polypeptide | -0.00603573 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.00602943 |
| RESF1 | retroelement silencing factor 1 | -0.00600488 |
| HMGB3 | high mobility group box 3 | -0.00598677 |
| KIF4A | kinesin family member 4A | -0.00598623 |
| ITPK1 | inositol-tetrakisphosphate 1-kinase | -0.00597892 |
| CNOT3 | CCR4-NOT transcription complex, subunit 3 | -0.00594937 |
| TBXAS1 | thromboxane A synthase 1 (platelet) | -0.00594288 |
| KDELR1 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 | -0.00594084 |
| GLG1 | golgi glycoprotein 1 | -0.0059176 |
| GUCY1A3 | guanylate cyclase 1, soluble, alpha 3 | -0.00591383 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | -0.00590944 |
| KIAA0930 | KIAA0930 | -0.00588354 |
| CBX6 | chromobox homolog 6 | -0.00587947 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -0.00587026 |
| MSRB1 | methionine sulfoxide reductase B1 | -0.00584819 |
| MYO5C | myosin VC | -0.00579521 |
| ZNF544 | zinc finger protein 544 | -0.00579491 |
| EPHA4 | EPH receptor A4 | -0.00579402 |
| EML3 | echinoderm microtubule associated protein like 3 | -0.00577682 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.00576915 |
| FOXM1 | forkhead box M1 | -0.00576436 |
| TNFAIP6 | tumor necrosis factor, alpha-induced protein 6 | -0.00573928 |
| GTSE1 | G-2 and S-phase expressed 1 | -0.00572052 |
| VIL1 | villin 1 | -0.00572019 |
| HNRNPL | heterogeneous nuclear ribonucleoprotein L | -0.00571134 |
| NUSAP1 | nucleolar and spindle associated protein 1 | -0.00570734 |
| MRPL20 | mitochondrial ribosomal protein L20 | -0.00570225 |
| ANGPT2 | angiopoietin 2 | -0.00567437 |
| ZMAT4 | zinc finger, matrin-type 4 | -0.00567388 |
| AZU1 | azurocidin 1 | -0.00566391 |
| PFKL | phosphofructokinase, liver | -0.00566334 |
| NOTCH3 | notch 3 | -0.00564256 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.00564025 |
| BIRC5 | baculoviral IAP repeat containing 5 | -0.00561911 |
| POLE | polymerase (DNA directed), epsilon, catalytic subunit | -0.00561341 |
| SLC25A6 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 | -0.00561114 |
| TMEM38B | transmembrane protein 38B | -0.00560389 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | -0.00560387 |
| CENPM | centromere protein M | -0.0056004 |
| TLR2 | toll-like receptor 2 | -0.00558231 |
| PRUNE1 | prune exopolyphosphatase 1 | -0.00557769 |
| CDS1 | CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 | -0.00557153 |
| DPM3 | dolichyl-phosphate mannosyltransferase polypeptide 3 | -0.00556745 |
| MMP9 | matrix metallopeptidase 9 | -0.00556112 |
| NSMF | NMDA receptor synaptonuclear signaling and neuronal migration factor | -0.0055548 |
| HPCAL1 | hippocalcin-like 1 | -0.00554955 |
| CD44 | CD44 molecule (Indian blood group) | -0.00554246 |
| MAD2L1 | MAD2 mitotic arrest deficient-like 1 (yeast) | -0.00553747 |
| EPCAM | epithelial cell adhesion molecule | -0.00553571 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.00553047 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.00549463 |
| CHST1 | carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 | -0.00548639 |
| INTS1 | integrator complex subunit 1 | -0.00546835 |
| NFATC4 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 | -0.00546352 |
| LBR | lamin B receptor | -0.00546316 |
| PMM2 | phosphomannomutase 2 | -0.00544187 |
| CCNB2 | cyclin B2 | -0.00542894 |
| ACOT9 | acyl-CoA thioesterase 9 | -0.0054217 |
| BCR | breakpoint cluster region | -0.00541891 |
| H1-0 | H1.0 linker histone | -0.00541876 |
| PAEP | progestagen-associated endometrial protein | -0.00541097 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | -0.00534997 |
| TRMT2A | tRNA methyltransferase 2 homolog A (S. cerevisiae) | -0.00533924 |
| SPINT2 | serine peptidase inhibitor, Kunitz type, 2 | -0.00532652 |
| TLE2 | transducin-like enhancer of split 2 | -0.00531602 |
| LDOC1 | leucine zipper, down-regulated in cancer 1 | -0.00529926 |
| DGS2 | DiGeorge syndrome/velocardiofacial syndrome complex 2 | -0.00529785 |
| NEFM | neurofilament, medium polypeptide | -0.00529625 |
| GAL | galanin/GMAP prepropeptide | -0.00529335 |
| MAPT | microtubule-associated protein tau | -0.00528635 |
| SFTPC | surfactant protein C | -0.00527221 |
| IL6R | interleukin 6 receptor | -0.00525823 |
| GPC3 | glypican 3 | -0.00525347 |
| RAB40B | RAB40B, member RAS oncogene family | -0.00525088 |
| PIP | prolactin-induced protein | -0.00523173 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -0.00522304 |
| TIMM9 | translocase of inner mitochondrial membrane 9 homolog (yeast) | -0.00521013 |
| BRD4 | bromodomain containing 4 | -0.00519119 |
| EGFL7 | EGF-like-domain, multiple 7 | -0.00518723 |
| TBL1X | transducin (beta)-like 1X-linked | -0.00518431 |
| GTF3C1 | general transcription factor IIIC, polypeptide 1, alpha 220kDa | -0.0051808 |
| PSMD13 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 | -0.00516381 |
| NELL1 | NEL-like 1 (chicken) | -0.00516274 |
| MBOAT7 | membrane bound O-acyltransferase domain containing 7 | -0.00515944 |
| MEGF9 | multiple EGF-like-domains 9 | -0.00515069 |
| TENM4 | teneurin transmembrane protein 4 | -0.00514478 |
| ARMCX6 | armadillo repeat containing, X-linked 6 | -0.00513852 |
| GNMT | glycine N-methyltransferase | -0.00512001 |
| SLC12A7 | solute carrier family 12 (potassium/chloride transporter), member 7 | -0.00511688 |
| WIZ | widely interspaced zinc finger motifs | -0.00510645 |
| SPAG5 | sperm associated antigen 5 | -0.00508653 |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | -0.00508037 |
| ZW10 | zw10 kinetochore protein | -0.00507558 |
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | -0.00506901 |
| DVL1 | dishevelled segment polarity protein 1 | -0.00505748 |
| LAPTM4B | lysosomal protein transmembrane 4 beta | -0.00502924 |
| OVGP1 | oviductal glycoprotein 1, 120kDa | -0.00502808 |
| SMARCB1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 | -0.00502419 |
| ACSM3 | acyl-CoA synthetase medium-chain family member 3 | -0.00501435 |
| DDC | dopa decarboxylase (aromatic L-amino acid decarboxylase) | -0.00500753 |
| AGPAT5 | 1-acylglycerol-3-phosphate O-acyltransferase 5 | -0.0050008 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.00498205 |
| RAD21 | RAD21 homolog (S. pombe) | -0.00496444 |
| ZBED5 | zinc finger, BED-type containing 5 | -0.00496382 |
| ACAN | aggrecan | -0.00496125 |
| MBD3 | methyl-CpG binding domain protein 3 | -0.0049612 |
| CLGN | calmegin | -0.0049573 |
| ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | -0.00492831 |
| POLR2E | polymerase (RNA) II (DNA directed) polypeptide E, 25kDa | -0.00492743 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.00492392 |
| APOBEC3B | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B | -0.00489979 |
| RGS5 | regulator of G-protein signaling 5 | -0.00489572 |
| NEO1 | neogenin 1 | -0.00489293 |
| ACTL6A | actin-like 6A | -0.00489175 |
| PTP4A3 | protein tyrosine phosphatase type IVA, member 3 | -0.00489149 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | -0.00487665 |
| MEA1 | male-enhanced antigen 1 | -0.00487466 |
| RUVBL1 | RuvB-like AAA ATPase 1 | -0.00487207 |
| HOXC10 | homeobox C10 | -0.00486891 |
| NXF3 | nuclear RNA export factor 3 | -0.00486317 |
| LPCAT1 | lysophosphatidylcholine acyltransferase 1 | -0.00485931 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | -0.00485682 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.00485646 |
| DGCR8 | DGCR8 microprocessor complex subunit | -0.00485599 |
| MATN2 | matrilin 2 | -0.0048522 |
| SLC7A8 | solute carrier family 7 (amino acid transporter light chain, L system), member 8 | -0.00484333 |
| UFL1 | UFM1-specific ligase 1 | -0.00484221 |
| ASRGL1 | asparaginase like 1 | -0.00483915 |
| DYNC1LI2 | dynein, cytoplasmic 1, light intermediate chain 2 | -0.0048275 |
| HSDL2 | hydroxysteroid dehydrogenase like 2 | -0.00482707 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | -0.00481354 |
| RRAGA | Ras-related GTP binding A | -0.00480837 |
| COL4A2 | collagen, type IV, alpha 2 | -0.00480597 |
| PKN1 | protein kinase N1 | -0.00479928 |
| NAA15 | N(alpha)-acetyltransferase 15, NatA auxiliary subunit | -0.00479793 |
| IFT122 | intraflagellar transport 122 | -0.00478436 |
| ADGRF5 | adhesion G protein-coupled receptor F5 | -0.00477221 |
| WDR7 | WD repeat domain 7 | -0.00476287 |
| EMP3 | epithelial membrane protein 3 | -0.00475661 |
| MCM5 | minichromosome maintenance complex component 5 | -0.00474122 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.00473219 |
| NEK2 | NIMA-related kinase 2 | -0.00472579 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | -0.00471583 |
| SSRP1 | structure specific recognition protein 1 | -0.00471232 |
| MTARC1 | mitochondrial amidoxime reducing component 1 | -0.00471041 |
| COL2A1 | collagen, type II, alpha 1 | -0.00470426 |
| TNK2 | tyrosine kinase, non-receptor, 2 | -0.00469789 |
| CA9 | carbonic anhydrase IX | -0.00469077 |
| PRC1 | protein regulator of cytokinesis 1 | -0.00468253 |
| NUP188 | nucleoporin 188kDa | -0.00465384 |
| TEX2 | testis expressed 2 | -0.00464037 |
| H2AZ1 | H2A.Z variant histone 1 | -0.00463451 |
| POMT1 | protein-O-mannosyltransferase 1 | -0.00463333 |
| IGHMBP2 | immunoglobulin mu binding protein 2 | -0.00462969 |
| THAP12 | THAP domain containing 12 | -0.00462894 |
| CASP6 | caspase 6, apoptosis-related cysteine peptidase | -0.00462589 |
| IPCEF1 | interaction protein for cytohesin exchange factors 1 | -0.00462282 |
| NADK | NAD kinase | -0.00461277 |
| TMEM80 | transmembrane protein 80 | -0.00461055 |
| NNAT | neuronatin | -0.00460166 |
| GRK2 | G protein-coupled receptor kinase 2 | -0.00459581 |
| ATP11B | ATPase, class VI, type 11B | -0.00459481 |
| INHBA | inhibin, beta A | -0.00458643 |
| PTDSS2 | phosphatidylserine synthase 2 | -0.00458512 |
