RAF1 Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description Raf-1 proto-oncogene, serine/threonine kinase|This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5894)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/MORF_RAF1
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Genes

145 co-expressed genes for RAF1 from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ABR active BCR-related
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
ARFGAP2 ADP-ribosylation factor GTPase activating protein 2
ATG12 autophagy related 12
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F
ATXN2L ataxin 2-like
BRD3 bromodomain containing 3
CANX calnexin
CAPRIN1 cell cycle associated protein 1
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1
CAPZB capping protein (actin filament) muscle Z-line, beta
CFL1 cofilin 1 (non-muscle)
CLTC clathrin, heavy chain (Hc)
CNBP CCHC-type zinc finger, nucleic acid binding protein
CNOT2 CCR4-NOT transcription complex, subunit 2
COX7A2L cytochrome c oxidase subunit VIIa polypeptide 2 like
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous)
CS citrate synthase
CSNK1D casein kinase 1, delta
CSNK1G2 casein kinase 1, gamma 2
CSNK2B casein kinase 2, beta polypeptide
CTDNEP1 CTD nuclear envelope phosphatase 1
CUX1 cut-like homeobox 1
DDB1 damage-specific DNA binding protein 1, 127kDa
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DEK DEK proto-oncogene
DENND4A DENN/MADD domain containing 4A
DHPS deoxyhypusine synthase
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7
DNAJC8 DnaJ (Hsp40) homolog, subfamily C, member 8
DNPEP aspartyl aminopeptidase
DR1 down-regulator of transcription 1, TBP-binding (negative cofactor 2)
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
DRG1 developmentally regulated GTP binding protein 1
EIF4A1 eukaryotic translation initiation factor 4A1
EIF4H eukaryotic translation initiation factor 4H
ETF1 eukaryotic translation termination factor 1
FAM168B family with sequence similarity 168, member B
FBXW11 F-box and WD repeat domain containing 11
FOXJ3 forkhead box J3
FUS FUS RNA binding protein
GMFB glia maturation factor, beta
GPAA1 glycosylphosphatidylinositol anchor attachment 1
GPER1 G protein-coupled estrogen receptor 1
GPS2 G protein pathway suppressor 2
H3F3B H3 histone, family 3B (H3.3B)
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit
HMGN1 high mobility group nucleosome binding domain 1
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2)
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HNRNPH2 heterogeneous nuclear ribonucleoprotein H2 (H')
HNRNPK heterogeneous nuclear ribonucleoprotein K
HNRNPL heterogeneous nuclear ribonucleoprotein L
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HTATSF1 HIV-1 Tat specific factor 1
IDH3B isocitrate dehydrogenase 3 (NAD+) beta
IDUA iduronidase, alpha-L-
IK IK cytokine, down-regulator of HLA II
ILF2 interleukin enhancer binding factor 2
IST1 increased sodium tolerance 1 homolog (yeast)
JTB jumping translocation breakpoint
KBTBD2 kelch repeat and BTB (POZ) domain containing 2
KDM3B lysine (K)-specific demethylase 3B
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
LMNB2 lamin B2
MARS methionyl-tRNA synthetase
MAZ MYC-associated zinc finger protein (purine-binding transcription factor)
METAP1 methionyl aminopeptidase 1
MFN2 mitofusin 2
MKRN1 makorin ring finger protein 1
MORC3 MORC family CW-type zinc finger 3
MRPL28 mitochondrial ribosomal protein L28
MRPL9 mitochondrial ribosomal protein L9
NACA nascent polypeptide-associated complex alpha subunit
NAP1L4 nucleosome assembly protein 1-like 4
NELFB negative elongation factor complex member B
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
NONO non-POU domain containing, octamer-binding
NUP188 nucleoporin 188kDa
NUP62 nucleoporin 62kDa
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1
OXA1L oxidase (cytochrome c) assembly 1-like
PABPC1 poly(A) binding protein, cytoplasmic 1
PABPN1 poly(A) binding protein, nuclear 1
PCBP1 poly(rC) binding protein 1
PCBP2 poly(rC) binding protein 2
PCM1 pericentriolar material 1
PDAP1 PDGFA associated protein 1
PLIN3 perilipin 3
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
POLR2C polymerase (RNA) II (DNA directed) polypeptide C, 33kDa
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit
PRKCSH protein kinase C substrate 80K-H
PRMT1 protein arginine methyltransferase 1
PRPF8 pre-mRNA processing factor 8
PTGES3 prostaglandin E synthase 3 (cytosolic)
PWP1 PWP1 homolog (S. cerevisiae)
RAB1A RAB1A, member RAS oncogene family
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RNF4 ring finger protein 4
RPRD2 regulation of nuclear pre-mRNA domain containing 2
SEC61B Sec61 beta subunit
SEC63 SEC63 homolog (S. cerevisiae)
SET SET nuclear proto-oncogene
SF1 splicing factor 1
SFSWAP splicing factor, suppressor of white-apricot family
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SMNDC1 survival motor neuron domain containing 1
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5)
SRRM1 serine/arginine repetitive matrix 1
SRRT serrate, RNA effector molecule
SRSF4 serine/arginine-rich splicing factor 4
STK19 serine/threonine kinase 19
SUMO1 small ubiquitin-like modifier 1
SUMO2 small ubiquitin-like modifier 2
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
TERF2IP telomeric repeat binding factor 2, interacting protein
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1
TOR1AIP1 torsin A interacting protein 1
TPR translocated promoter region, nuclear basket protein
TRIM28 tripartite motif containing 28
TUG1 taurine up-regulated 1 (non-protein coding)
UBE2D3 ubiquitin-conjugating enzyme E2D 3
UBE2I ubiquitin-conjugating enzyme E2I
UBN1 ubinuclein 1
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VAMP7 vesicle-associated membrane protein 7
XPC xeroderma pigmentosum, complementation group C
XPO6 exportin 6
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZC3H15 zinc finger CCCH-type containing 15
ZNF410 zinc finger protein 410
ZZZ3 zinc finger, ZZ-type containing 3