RAF_UP.V1 Gene Set

Dataset MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations
Category transcriptomics
Type gene perturbation
Description gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/RAF_UP.V1_UP
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Genes

388 genes differentially expressed following the RAF_UP.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.

increased expression

Symbol Name
AAK1 AP2 associated kinase 1
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABHD6 abhydrolase domain containing 6
ACOX1 acyl-CoA oxidase 1, palmitoyl
ACSL1 acyl-CoA synthetase long-chain family member 1
ACSL4 acyl-CoA synthetase long-chain family member 4
ACYP1 acylphosphatase 1, erythrocyte (common) type
ALAS1 5'-aminolevulinate synthase 1
ALPP alkaline phosphatase, placental
ANGPTL4 angiopoietin-like 4
ANKMY2 ankyrin repeat and MYND domain containing 2
ANKRD6 ankyrin repeat domain 6
ARHGAP26 Rho GTPase activating protein 26
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ASPH aspartate beta-hydroxylase
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BACE2 beta-site APP-cleaving enzyme 2
BLNK B-cell linker
BPGM 2,3-bisphosphoglycerate mutase
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
C4ORF19 chromosome 4 open reading frame 19
C8ORF4 chromosome 8 open reading frame 4
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPN2 calpain 2, (m/II) large subunit
CAPN6 calpain 6
CAPRIN2 caprin family member 2
CAST calpastatin
CCR1 chemokine (C-C motif) receptor 1
CD44 CD44 molecule (Indian blood group)
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDK18 cyclin-dependent kinase 18
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CEP70 centrosomal protein 70kDa
CERK ceramide kinase
CGA glycoprotein hormones, alpha polypeptide
CLDN1 claudin 1
CLMN calmin (calponin-like, transmembrane)
CORO1A coronin, actin binding protein, 1A
COTL1 coactosin-like F-actin binding protein 1
CREB3L2 cAMP responsive element binding protein 3-like 2
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBNDD2 dysbindin (dystrobrevin binding protein 1) domain containing 2
DHRS7 dehydrogenase/reductase (SDR family) member 7
DHTKD1 dehydrogenase E1 and transketolase domain containing 1
DSC2 desmocollin 2
DUSP4 dual specificity phosphatase 4
EGFR epidermal growth factor receptor
ENPEP glutamyl aminopeptidase (aminopeptidase A)
EPAS1 endothelial PAS domain protein 1
ERAP1 endoplasmic reticulum aminopeptidase 1
ERVMER34-1 endogenous retrovirus group MER34, member 1
ETV5 ets variant 5
FAM13A family with sequence similarity 13, member A
FAM49A family with sequence similarity 49, member A
FBXO3 F-box protein 3
FCHSD2 FCH and double SH3 domains 2
FERMT2 fermitin family member 2
FGF1 fibroblast growth factor 1 (acidic)
FYN FYN proto-oncogene, Src family tyrosine kinase
FZD5 frizzled class receptor 5
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GAREM GRB2 associated, regulator of MAPK1
GATA2 GATA binding protein 2
GCLM glutamate-cysteine ligase, modifier subunit
GJA5 gap junction protein, alpha 5, 40kDa
GLRX glutaredoxin (thioltransferase)
GM2A GM2 ganglioside activator
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GRAMD3 GRAM domain containing 3
GRB10 growth factor receptor-bound protein 10
HACD1 3-hydroxyacyl-CoA dehydratase 1
HBEGF heparin-binding EGF-like growth factor
HEG1 heart development protein with EGF-like domains 1
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
HSPA2 heat shock 70kDa protein 2
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITGA6 integrin, alpha 6
ITGB6 integrin, beta 6
JAM2 junctional adhesion molecule 2
KAT2B K(lysine) acetyltransferase 2B
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KCTD12 potassium channel tetramerization domain containing 12
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KLF6 Kruppel-like factor 6
KLHL7 kelch-like family member 7
L1CAM L1 cell adhesion molecule
LAIR2 leukocyte-associated immunoglobulin-like receptor 2
LAMC1 laminin, gamma 1 (formerly LAMB2)
LRP5 low density lipoprotein receptor-related protein 5
MALT1 MALT1 paracaspase
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPRE2 microtubule-associated protein, RP/EB family, member 2
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MORC4 MORC family CW-type zinc finger 4
MPZL2 myelin protein zero-like 2
MSX2 msh homeobox 2
MTMR11 myotubularin related protein 11
MTMR2 myotubularin related protein 2
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
NAV2 neuron navigator 2
NDC80 NDC80 kinetochore complex component
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NFE2L3 nuclear factor, erythroid 2-like 3
NMI N-myc (and STAT) interactor
NMT2 N-myristoyltransferase 2
NMU neuromedin U
NPC2 Niemann-Pick disease, type C2
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
NR4A3 nuclear receptor subfamily 4, group A, member 3
NTAN1 N-terminal asparagine amidase
NUAK1 NUAK family, SNF1-like kinase, 1
OPN3 opsin 3
OPTN optineurin
OSBPL1A oxysterol binding protein-like 1A
P3H2 prolyl 3-hydroxylase 2
PARVA parvin, alpha
PDE4D phosphodiesterase 4D, cAMP-specific
PEG10 paternally expressed 10
PER3 period circadian clock 3
PGM1 phosphoglucomutase 1
PHYH phytanoyl-CoA 2-hydroxylase
PKD2 polycystic kidney disease 2 (autosomal dominant)
PLS3 plastin 3
PPARG peroxisome proliferator-activated receptor gamma
PRKCH protein kinase C, eta
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTER phosphotriesterase related
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTMS parathymosin
PXDC1 PX domain containing 1
PYGL phosphorylase, glycogen, liver
QPCT glutaminyl-peptide cyclotransferase
RASL11B RAS-like, family 11, member B
RCAN1 regulator of calcineurin 1
RNF144A ring finger protein 144A
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RSAD2 radical S-adenosyl methionine domain containing 2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCARA3 scavenger receptor class A, member 3
SCCPDH saccharopine dehydrogenase (putative)
SCG2 secretogranin II
SDCBP syndecan binding protein (syntenin)
SEPT10 septin 10
SEPT6 septin 6
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SGCE sarcoglycan, epsilon
SGPP1 sphingosine-1-phosphate phosphatase 1
SKAP2 src kinase associated phosphoprotein 2
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC31A2 solute carrier family 31 (copper transporter), member 2
SMAGP small cell adhesion glycoprotein
SOCS2 suppressor of cytokine signaling 2
SPRR3 small proline-rich protein 3
STS steroid sulfatase (microsomal), isozyme S
SYNE2 spectrin repeat containing, nuclear envelope 2
TBC1D2 TBC1 domain family, member 2
TBC1D2B TBC1 domain family, member 2B
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor)
TES testin LIM domain protein
TFPI2 tissue factor pathway inhibitor 2
TLE2 transducin-like enhancer of split 2
TMSB15B thymosin beta 15B
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNNT1 troponin T type 1 (skeletal, slow)
TSPAN12 tetraspanin 12
TUBB2A tubulin, beta 2A class IIa
UGT8 UDP glycosyltransferase 8
UPK2 uroplakin 2
UPP1 uridine phosphorylase 1
VGLL1 vestigial-like family member 1
VTCN1 V-set domain containing T cell activation inhibitor 1
VTN vitronectin
XYLT1 xylosyltransferase I
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12
ABLIM1 actin binding LIM protein 1
ACKR3 atypical chemokine receptor 3
ADGRG1 adhesion G protein-coupled receptor G1
AGR2 anterior gradient 2
AIM1 absent in melanoma 1
AK4 adenylate kinase 4
AK4P3 adenylate kinase 4 pseudogene 3
ALCAM activated leukocyte cell adhesion molecule
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARL3 ADP-ribosylation factor-like 3
ARMC9 armadillo repeat containing 9
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASCL1 achaete-scute family bHLH transcription factor 1
AUTS2 autism susceptibility candidate 2
B3GALNT1 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BCL2 B-cell CLL/lymphoma 2
BTBD3 BTB (POZ) domain containing 3
BTG3 BTG family, member 3
C16ORF45 chromosome 16 open reading frame 45
C9ORF3 chromosome 9 open reading frame 3
C9ORF91 chromosome 9 open reading frame 91
CA12 carbonic anhydrase XII
CALB2 calbindin 2
CALCR calcitonin receptor
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CAV1 caveolin 1, caveolae protein, 22kDa
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CCDC170 coiled-coil domain containing 170
CCDC22 coiled-coil domain containing 22
CCDC6 coiled-coil domain containing 6
CCND1 cyclin D1
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLIC3 chloride intracellular channel 3
COL9A3 collagen, type IX, alpha 3
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
CRNKL1 crooked neck pre-mRNA splicing factor 1
CSTA cystatin A (stefin A)
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
DDIT4 DNA-damage-inducible transcript 4
DIDO1 death inducer-obliterator 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DLG5 discs, large homolog 5 (Drosophila)
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EFNB2 ephrin-B2
EGR3 early growth response 3
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ELOVL2 ELOVL fatty acid elongase 2
ENAH enabled homolog (Drosophila)
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
FAM216A family with sequence similarity 216, member A
FANCF Fanconi anemia, complementation group F
FOS FBJ murine osteosarcoma viral oncogene homolog
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
FTO fat mass and obesity associated
FTSJ1 FtsJ RNA methyltransferase homolog 1 (E. coli)
GALC galactosylceramidase
GAPVD1 GTPase activating protein and VPS9 domains 1
GDAP1 ganglioside induced differentiation associated protein 1
GFRA1 GDNF family receptor alpha 1
GHR growth hormone receptor
GPATCH2 G patch domain containing 2
GPC4 glypican 4
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
GPER1 G protein-coupled estrogen receptor 1
GREB1 growth regulation by estrogen in breast cancer 1
GTF2I general transcription factor IIi
GULP1 GULP, engulfment adaptor PTB domain containing 1
HDGFRP3 hepatoma-derived growth factor, related protein 3
HIST1H4H histone cluster 1, H4h
HSPB8 heat shock 22kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFT57 intraflagellar transport 57
IGF1R insulin-like growth factor 1 receptor
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP4 insulin-like growth factor binding protein 4
IGFBP5 insulin-like growth factor binding protein 5
IL24 interleukin 24
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
INPP5F inositol polyphosphate-5-phosphatase F
IRS1 insulin receptor substrate 1
IRX5 iroquois homeobox 5
JAK2 Janus kinase 2
JMJD1C jumonji domain containing 1C
KDM6A lysine (K)-specific demethylase 6A
KIAA1324 KIAA1324
KIAA1467 KIAA1467
KITLG KIT ligand
KYNU kynureninase
LIN7C lin-7 homolog C (C. elegans)
LPGAT1 lysophosphatidylglycerol acyltransferase 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MDK midkine (neurite growth-promoting factor 2)
MED13L mediator complex subunit 13-like
MEGF9 multiple EGF-like-domains 9
MGP matrix Gla protein
MICB MHC class I polypeptide-related sequence B
MINPP1 multiple inositol-polyphosphate phosphatase 1
MPDZ multiple PDZ domain protein
MSMB microseminoprotein, beta-
MXI1 MAX interactor 1, dimerization protein
MYB v-myb avian myeloblastosis viral oncogene homolog
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYLK myosin light chain kinase
MYO10 myosin X
MYO1B myosin IB
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NPY1R neuropeptide Y receptor Y1
OSR2 odd-skipped related transciption factor 2
OSTM1 osteopetrosis associated transmembrane protein 1
PALLD palladin, cytoskeletal associated protein
PCGF3 polycomb group ring finger 3
PCSK6 proprotein convertase subtilisin/kexin type 6
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFRL platelet-derived growth factor receptor-like
PDK3 pyruvate dehydrogenase kinase, isozyme 3
PDZK1 PDZ domain containing 1
PGR progesterone receptor
PKP4 plakophilin 4
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCB4 phospholipase C, beta 4
PLK2 polo-like kinase 2
PLS1 plastin 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PMP22 peripheral myelin protein 22
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTBP2 polypyrimidine tract binding protein 2
PXDN peroxidasin
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RHOBTB3 Rho-related BTB domain containing 3
RND3 Rho family GTPase 3
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
S100A14 S100 calcium binding protein A14
SATB2 SATB homeobox 2
SCUBE2 signal peptide, CUB domain, EGF-like 2
SDC2 syndecan 2
SELENBP1 selenium binding protein 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SH3BGRL SH3 domain binding glutamate-rich protein like
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor
SHROOM2 shroom family member 2
SIDT1 SID1 transmembrane family, member 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
SMAD7 SMAD family member 7
SNAP23 synaptosomal-associated protein, 23kDa
SOX3 SRY (sex determining region Y)-box 3
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPIN1 spindlin 1
STC2 stanniocalcin 2
SYTL2 synaptotagmin-like 2
TBC1D16 TBC1 domain family, member 16
TBC1D30 TBC1 domain family, member 30
TCF12 transcription factor 12
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFB2 transforming growth factor, beta 2
TGIF2 TGFB-induced factor homeobox 2
THADA thyroid adenoma associated
TM4SF1 transmembrane 4 L six family member 1
TMPRSS3 transmembrane protease, serine 3
TRPS1 trichorhinophalangeal syndrome I
TSC22D3 TSC22 domain family, member 3
TSPAN3 tetraspanin 3
TTC39A tetratricopeptide repeat domain 39A
UGDH UDP-glucose 6-dehydrogenase
VAV3 vav 3 guanine nucleotide exchange factor
WASF3 WAS protein family, member 3
WISP2 WNT1 inducible signaling pathway protein 2
ZBTB10 zinc finger and BTB domain containing 10
ZHX2 zinc fingers and homeoboxes 2
ZNF32 zinc finger protein 32