Dataset | MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations |
Category | transcriptomics |
Type | gene perturbation |
Description | gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database) |
External Link | http://www.broadinstitute.org/gsea/msigdb/cards/RAF_UP.V1_UP |
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388 genes differentially expressed following the RAF_UP.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.
Symbol | Name |
---|---|
AAK1 | AP2 associated kinase 1 |
ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 |
ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 |
ABHD6 | abhydrolase domain containing 6 |
ACOX1 | acyl-CoA oxidase 1, palmitoyl |
ACSL1 | acyl-CoA synthetase long-chain family member 1 |
ACSL4 | acyl-CoA synthetase long-chain family member 4 |
ACYP1 | acylphosphatase 1, erythrocyte (common) type |
ALAS1 | 5'-aminolevulinate synthase 1 |
ALPP | alkaline phosphatase, placental |
ANGPTL4 | angiopoietin-like 4 |
ANKMY2 | ankyrin repeat and MYND domain containing 2 |
ANKRD6 | ankyrin repeat domain 6 |
ARHGAP26 | Rho GTPase activating protein 26 |
ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 |
ASPH | aspartate beta-hydroxylase |
B3GNT3 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 |
BACE2 | beta-site APP-cleaving enzyme 2 |
BLNK | B-cell linker |
BPGM | 2,3-bisphosphoglycerate mutase |
C1GALT1 | core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 |
C4ORF19 | chromosome 4 open reading frame 19 |
C8ORF4 | chromosome 8 open reading frame 4 |
CABYR | calcium binding tyrosine-(Y)-phosphorylation regulated |
CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 |
CAPN2 | calpain 2, (m/II) large subunit |
CAPN6 | calpain 6 |
CAPRIN2 | caprin family member 2 |
CAST | calpastatin |
CCR1 | chemokine (C-C motif) receptor 1 |
CD44 | CD44 molecule (Indian blood group) |
CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 |
CDK18 | cyclin-dependent kinase 18 |
CEBPD | CCAAT/enhancer binding protein (C/EBP), delta |
CEP70 | centrosomal protein 70kDa |
CERK | ceramide kinase |
CGA | glycoprotein hormones, alpha polypeptide |
CLDN1 | claudin 1 |
CLMN | calmin (calponin-like, transmembrane) |
CORO1A | coronin, actin binding protein, 1A |
COTL1 | coactosin-like F-actin binding protein 1 |
CREB3L2 | cAMP responsive element binding protein 3-like 2 |
CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) |
CRISPLD2 | cysteine-rich secretory protein LCCL domain containing 2 |
CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 |
CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 |
DBNDD2 | dysbindin (dystrobrevin binding protein 1) domain containing 2 |
DHRS7 | dehydrogenase/reductase (SDR family) member 7 |
DHTKD1 | dehydrogenase E1 and transketolase domain containing 1 |
DSC2 | desmocollin 2 |
DUSP4 | dual specificity phosphatase 4 |
EGFR | epidermal growth factor receptor |
ENPEP | glutamyl aminopeptidase (aminopeptidase A) |
EPAS1 | endothelial PAS domain protein 1 |
ERAP1 | endoplasmic reticulum aminopeptidase 1 |
ERVMER34-1 | endogenous retrovirus group MER34, member 1 |
ETV5 | ets variant 5 |
FAM13A | family with sequence similarity 13, member A |
FAM49A | family with sequence similarity 49, member A |
FBXO3 | F-box protein 3 |
FCHSD2 | FCH and double SH3 domains 2 |
FERMT2 | fermitin family member 2 |
FGF1 | fibroblast growth factor 1 (acidic) |
FYN | FYN proto-oncogene, Src family tyrosine kinase |
FZD5 | frizzled class receptor 5 |
GABBR2 | gamma-aminobutyric acid (GABA) B receptor, 2 |
GALNT12 | polypeptide N-acetylgalactosaminyltransferase 12 |
GAREM | GRB2 associated, regulator of MAPK1 |
GATA2 | GATA binding protein 2 |
GCLM | glutamate-cysteine ligase, modifier subunit |
GJA5 | gap junction protein, alpha 5, 40kDa |
GLRX | glutaredoxin (thioltransferase) |
GM2A | GM2 ganglioside activator |
GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 |
GNE | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase |
GPR37 | G protein-coupled receptor 37 (endothelin receptor type B-like) |
GRAMD3 | GRAM domain containing 3 |
GRB10 | growth factor receptor-bound protein 10 |
HACD1 | 3-hydroxyacyl-CoA dehydratase 1 |
HBEGF | heparin-binding EGF-like growth factor |
HEG1 | heart development protein with EGF-like domains 1 |
HERC5 | HECT and RLD domain containing E3 ubiquitin protein ligase 5 |
HPGD | hydroxyprostaglandin dehydrogenase 15-(NAD) |
HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 |
HSD3B1 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 |
HSPA2 | heat shock 70kDa protein 2 |
IMPA2 | inositol(myo)-1(or 4)-monophosphatase 2 |
ITGA6 | integrin, alpha 6 |
ITGB6 | integrin, beta 6 |
JAM2 | junctional adhesion molecule 2 |
KAT2B | K(lysine) acetyltransferase 2B |
KCNN4 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 |
KCTD12 | potassium channel tetramerization domain containing 12 |
KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 |
KLF6 | Kruppel-like factor 6 |
KLHL7 | kelch-like family member 7 |
L1CAM | L1 cell adhesion molecule |
LAIR2 | leukocyte-associated immunoglobulin-like receptor 2 |
LAMC1 | laminin, gamma 1 (formerly LAMB2) |
LRP5 | low density lipoprotein receptor-related protein 5 |
MALT1 | MALT1 paracaspase |
MAN1A1 | mannosidase, alpha, class 1A, member 1 |
MAP3K5 | mitogen-activated protein kinase kinase kinase 5 |
MAPRE2 | microtubule-associated protein, RP/EB family, member 2 |
ME2 | malic enzyme 2, NAD(+)-dependent, mitochondrial |
MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 |
MORC4 | MORC family CW-type zinc finger 4 |
MPZL2 | myelin protein zero-like 2 |
MSX2 | msh homeobox 2 |
MTMR11 | myotubularin related protein 11 |
MTMR2 | myotubularin related protein 2 |
MYCL | v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog |
NAV2 | neuron navigator 2 |
NDC80 | NDC80 kinetochore complex component |
NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase |
NFE2L3 | nuclear factor, erythroid 2-like 3 |
NMI | N-myc (and STAT) interactor |
NMT2 | N-myristoyltransferase 2 |
NMU | neuromedin U |
NPC2 | Niemann-Pick disease, type C2 |
NPL | N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) |
NR4A3 | nuclear receptor subfamily 4, group A, member 3 |
NTAN1 | N-terminal asparagine amidase |
NUAK1 | NUAK family, SNF1-like kinase, 1 |
OPN3 | opsin 3 |
OPTN | optineurin |
OSBPL1A | oxysterol binding protein-like 1A |
P3H2 | prolyl 3-hydroxylase 2 |
PARVA | parvin, alpha |
PDE4D | phosphodiesterase 4D, cAMP-specific |
PEG10 | paternally expressed 10 |
PER3 | period circadian clock 3 |
PGM1 | phosphoglucomutase 1 |
PHYH | phytanoyl-CoA 2-hydroxylase |
PKD2 | polycystic kidney disease 2 (autosomal dominant) |
PLS3 | plastin 3 |
PPARG | peroxisome proliferator-activated receptor gamma |
PRKCH | protein kinase C, eta |
PRPS1 | phosphoribosyl pyrophosphate synthetase 1 |
PSMB10 | proteasome (prosome, macropain) subunit, beta type, 10 |
PSMB9 | proteasome (prosome, macropain) subunit, beta type, 9 |
PTER | phosphotriesterase related |
PTGER4 | prostaglandin E receptor 4 (subtype EP4) |
PTMS | parathymosin |
PXDC1 | PX domain containing 1 |
PYGL | phosphorylase, glycogen, liver |
QPCT | glutaminyl-peptide cyclotransferase |
RASL11B | RAS-like, family 11, member B |
RCAN1 | regulator of calcineurin 1 |
RNF144A | ring finger protein 144A |
RRAS2 | related RAS viral (r-ras) oncogene homolog 2 |
RSAD2 | radical S-adenosyl methionine domain containing 2 |
S100A8 | S100 calcium binding protein A8 |
S100A9 | S100 calcium binding protein A9 |
S100P | S100 calcium binding protein P |
SAT1 | spermidine/spermine N1-acetyltransferase 1 |
SCARA3 | scavenger receptor class A, member 3 |
SCCPDH | saccharopine dehydrogenase (putative) |
SCG2 | secretogranin II |
SDCBP | syndecan binding protein (syntenin) |
SEPT10 | septin 10 |
SEPT6 | septin 6 |
SERPINI1 | serpin peptidase inhibitor, clade I (neuroserpin), member 1 |
SGCE | sarcoglycan, epsilon |
SGPP1 | sphingosine-1-phosphate phosphatase 1 |
SKAP2 | src kinase associated phosphoprotein 2 |
SLC2A6 | solute carrier family 2 (facilitated glucose transporter), member 6 |
SLC31A2 | solute carrier family 31 (copper transporter), member 2 |
SMAGP | small cell adhesion glycoprotein |
SOCS2 | suppressor of cytokine signaling 2 |
SPRR3 | small proline-rich protein 3 |
STS | steroid sulfatase (microsomal), isozyme S |
SYNE2 | spectrin repeat containing, nuclear envelope 2 |
TBC1D2 | TBC1 domain family, member 2 |
TBC1D2B | TBC1 domain family, member 2B |
TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) |
TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) |
TES | testin LIM domain protein |
TFPI2 | tissue factor pathway inhibitor 2 |
TLE2 | transducin-like enhancer of split 2 |
TMSB15B | thymosin beta 15B |
TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 |
TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 |
TNNT1 | troponin T type 1 (skeletal, slow) |
TSPAN12 | tetraspanin 12 |
TUBB2A | tubulin, beta 2A class IIa |
UGT8 | UDP glycosyltransferase 8 |
UPK2 | uroplakin 2 |
UPP1 | uridine phosphorylase 1 |
VGLL1 | vestigial-like family member 1 |
VTCN1 | V-set domain containing T cell activation inhibitor 1 |
VTN | vitronectin |
XYLT1 | xylosyltransferase I |
ZNF331 | zinc finger protein 331 |
Symbol | Name |
---|---|
ABAT | 4-aminobutyrate aminotransferase |
ABCA12 | ATP-binding cassette, sub-family A (ABC1), member 12 |
ABLIM1 | actin binding LIM protein 1 |
ACKR3 | atypical chemokine receptor 3 |
ADGRG1 | adhesion G protein-coupled receptor G1 |
AGR2 | anterior gradient 2 |
AIM1 | absent in melanoma 1 |
AK4 | adenylate kinase 4 |
AK4P3 | adenylate kinase 4 pseudogene 3 |
ALCAM | activated leukocyte cell adhesion molecule |
APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 |
ARL3 | ADP-ribosylation factor-like 3 |
ARMC9 | armadillo repeat containing 9 |
ARNT2 | aryl-hydrocarbon receptor nuclear translocator 2 |
ASCL1 | achaete-scute family bHLH transcription factor 1 |
AUTS2 | autism susceptibility candidate 2 |
B3GALNT1 | beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) |
BAG3 | BCL2-associated athanogene 3 |
BAMBI | BMP and activin membrane-bound inhibitor |
BCL2 | B-cell CLL/lymphoma 2 |
BTBD3 | BTB (POZ) domain containing 3 |
BTG3 | BTG family, member 3 |
C16ORF45 | chromosome 16 open reading frame 45 |
C9ORF3 | chromosome 9 open reading frame 3 |
C9ORF91 | chromosome 9 open reading frame 91 |
CA12 | carbonic anhydrase XII |
CALB2 | calbindin 2 |
CALCR | calcitonin receptor |
CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) |
CAV1 | caveolin 1, caveolae protein, 22kDa |
CBFA2T3 | core-binding factor, runt domain, alpha subunit 2; translocated to, 3 |
CCDC170 | coiled-coil domain containing 170 |
CCDC22 | coiled-coil domain containing 22 |
CCDC6 | coiled-coil domain containing 6 |
CCND1 | cyclin D1 |
CELSR2 | cadherin, EGF LAG seven-pass G-type receptor 2 |
CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 |
CLIC3 | chloride intracellular channel 3 |
COL9A3 | collagen, type IX, alpha 3 |
CPE | carboxypeptidase E |
CRABP1 | cellular retinoic acid binding protein 1 |
CRNKL1 | crooked neck pre-mRNA splicing factor 1 |
CSTA | cystatin A (stefin A) |
CSTF2T | cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant |
CTNNAL1 | catenin (cadherin-associated protein), alpha-like 1 |
DDIT4 | DNA-damage-inducible transcript 4 |
DIDO1 | death inducer-obliterator 1 |
DKK1 | dickkopf WNT signaling pathway inhibitor 1 |
DLC1 | DLC1 Rho GTPase activating protein |
DLG5 | discs, large homolog 5 (Drosophila) |
DNAJC12 | DnaJ (Hsp40) homolog, subfamily C, member 12 |
EFNB2 | ephrin-B2 |
EGR3 | early growth response 3 |
EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa |
ELOVL2 | ELOVL fatty acid elongase 2 |
ENAH | enabled homolog (Drosophila) |
EPB41L2 | erythrocyte membrane protein band 4.1-like 2 |
EPB41L4B | erythrocyte membrane protein band 4.1 like 4B |
FAM216A | family with sequence similarity 216, member A |
FANCF | Fanconi anemia, complementation group F |
FOS | FBJ murine osteosarcoma viral oncogene homolog |
FRAT2 | frequently rearranged in advanced T-cell lymphomas 2 |
FTO | fat mass and obesity associated |
FTSJ1 | FtsJ RNA methyltransferase homolog 1 (E. coli) |
GALC | galactosylceramidase |
GAPVD1 | GTPase activating protein and VPS9 domains 1 |
GDAP1 | ganglioside induced differentiation associated protein 1 |
GFRA1 | GDNF family receptor alpha 1 |
GHR | growth hormone receptor |
GPATCH2 | G patch domain containing 2 |
GPC4 | glypican 4 |
GPD2 | glycerol-3-phosphate dehydrogenase 2 (mitochondrial) |
GPER1 | G protein-coupled estrogen receptor 1 |
GREB1 | growth regulation by estrogen in breast cancer 1 |
GTF2I | general transcription factor IIi |
GULP1 | GULP, engulfment adaptor PTB domain containing 1 |
HDGFRP3 | hepatoma-derived growth factor, related protein 3 |
HIST1H4H | histone cluster 1, H4h |
HSPB8 | heat shock 22kDa protein 8 |
ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein |
ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein |
IFT57 | intraflagellar transport 57 |
IGF1R | insulin-like growth factor 1 receptor |
IGFBP2 | insulin-like growth factor binding protein 2, 36kDa |
IGFBP4 | insulin-like growth factor binding protein 4 |
IGFBP5 | insulin-like growth factor binding protein 5 |
IL24 | interleukin 24 |
INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa |
INPP5F | inositol polyphosphate-5-phosphatase F |
IRS1 | insulin receptor substrate 1 |
IRX5 | iroquois homeobox 5 |
JAK2 | Janus kinase 2 |
JMJD1C | jumonji domain containing 1C |
KDM6A | lysine (K)-specific demethylase 6A |
KIAA1324 | KIAA1324 |
KIAA1467 | KIAA1467 |
KITLG | KIT ligand |
KYNU | kynureninase |
LIN7C | lin-7 homolog C (C. elegans) |
LPGAT1 | lysophosphatidylglycerol acyltransferase 1 |
LRIG1 | leucine-rich repeats and immunoglobulin-like domains 1 |
MAFB | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B |
MDK | midkine (neurite growth-promoting factor 2) |
MED13L | mediator complex subunit 13-like |
MEGF9 | multiple EGF-like-domains 9 |
MGP | matrix Gla protein |
MICB | MHC class I polypeptide-related sequence B |
MINPP1 | multiple inositol-polyphosphate phosphatase 1 |
MPDZ | multiple PDZ domain protein |
MSMB | microseminoprotein, beta- |
MXI1 | MAX interactor 1, dimerization protein |
MYB | v-myb avian myeloblastosis viral oncogene homolog |
MYBL1 | v-myb avian myeloblastosis viral oncogene homolog-like 1 |
MYLK | myosin light chain kinase |
MYO10 | myosin X |
MYO1B | myosin IB |
NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase |
NPY1R | neuropeptide Y receptor Y1 |
OSR2 | odd-skipped related transciption factor 2 |
OSTM1 | osteopetrosis associated transmembrane protein 1 |
PALLD | palladin, cytoskeletal associated protein |
PCGF3 | polycomb group ring finger 3 |
PCSK6 | proprotein convertase subtilisin/kexin type 6 |
PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) |
PDGFRL | platelet-derived growth factor receptor-like |
PDK3 | pyruvate dehydrogenase kinase, isozyme 3 |
PDZK1 | PDZ domain containing 1 |
PGR | progesterone receptor |
PKP4 | plakophilin 4 |
PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) |
PLCB4 | phospholipase C, beta 4 |
PLK2 | polo-like kinase 2 |
PLS1 | plastin 1 |
PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 |
PMP22 | peripheral myelin protein 22 |
PPM1E | protein phosphatase, Mg2+/Mn2+ dependent, 1E |
PPP1R3C | protein phosphatase 1, regulatory subunit 3C |
PTBP2 | polypyrimidine tract binding protein 2 |
PXDN | peroxidasin |
RASGRP1 | RAS guanyl releasing protein 1 (calcium and DAG-regulated) |
RHOBTB3 | Rho-related BTB domain containing 3 |
RND3 | Rho family GTPase 3 |
ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) |
RRN3 | RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae) |
S100A14 | S100 calcium binding protein A14 |
SATB2 | SATB homeobox 2 |
SCUBE2 | signal peptide, CUB domain, EGF-like 2 |
SDC2 | syndecan 2 |
SELENBP1 | selenium binding protein 1 |
SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 |
SGCG | sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) |
SH3BGRL | SH3 domain binding glutamate-rich protein like |
SHQ1 | SHQ1, H/ACA ribonucleoprotein assembly factor |
SHROOM2 | shroom family member 2 |
SIDT1 | SID1 transmembrane family, member 1 |
SLC16A1 | solute carrier family 16 (monocarboxylate transporter), member 1 |
SLC19A2 | solute carrier family 19 (thiamine transporter), member 2 |
SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 |
SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 |
SLC39A8 | solute carrier family 39 (zinc transporter), member 8 |
SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 |
SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 |
SMAD7 | SMAD family member 7 |
SNAP23 | synaptosomal-associated protein, 23kDa |
SOX3 | SRY (sex determining region Y)-box 3 |
SOX4 | SRY (sex determining region Y)-box 4 |
SOX9 | SRY (sex determining region Y)-box 9 |
SPIN1 | spindlin 1 |
STC2 | stanniocalcin 2 |
SYTL2 | synaptotagmin-like 2 |
TBC1D16 | TBC1 domain family, member 16 |
TBC1D30 | TBC1 domain family, member 30 |
TCF12 | transcription factor 12 |
TCN1 | transcobalamin I (vitamin B12 binding protein, R binder family) |
TFAP2A | transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) |
TFF1 | trefoil factor 1 |
TFF3 | trefoil factor 3 (intestinal) |
TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) |
TGFB2 | transforming growth factor, beta 2 |
TGIF2 | TGFB-induced factor homeobox 2 |
THADA | thyroid adenoma associated |
TM4SF1 | transmembrane 4 L six family member 1 |
TMPRSS3 | transmembrane protease, serine 3 |
TRPS1 | trichorhinophalangeal syndrome I |
TSC22D3 | TSC22 domain family, member 3 |
TSPAN3 | tetraspanin 3 |
TTC39A | tetratricopeptide repeat domain 39A |
UGDH | UDP-glucose 6-dehydrogenase |
VAV3 | vav 3 guanine nucleotide exchange factor |
WASF3 | WAS protein family, member 3 |
WISP2 | WNT1 inducible signaling pathway protein 2 |
ZBTB10 | zinc finger and BTB domain containing 10 |
ZHX2 | zinc fingers and homeoboxes 2 |
ZNF32 | zinc finger protein 32 |