RAG1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description recombination activating gene 1|The protein encoded by this gene is involved in activation of immunoglobulin V-D-J recombination. The encoded protein is involved in recognition of the DNA substrate, but stable binding and cleavage activity also requires RAG2. Defects in this gene can be the cause of several diseases. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5896)
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Genes

368 genes differentially expressed following the RAG1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CD300E CD300e molecule 3.43237
IGFL2 IGF-like family member 2 3.43237
TMEM176A transmembrane protein 176A 3.43237
SCGB3A1 secretoglobin, family 3A, member 1 3.43237
PRELP proline/arginine-rich end leucine-rich repeat protein 3.43237
AKR1C2 aldo-keto reductase family 1, member C2 3.43237
MGAM2 maltase-glucoamylase 2 (putative) 3.43237
PCDHB4 protocadherin beta 4 3.43237
MILR1 mast cell immunoglobulin-like receptor 1 3.43237
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 3.43237
ALOX15 arachidonate 15-lipoxygenase 3.43237
WDR87 WD repeat domain 87 3.43237
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 3.43237
TAS2R31 taste receptor, type 2, member 31 3.43237
RAET1E retinoic acid early transcript 1E 3.43237
HBA2 hemoglobin, alpha 2 3.43237
HNF4A hepatocyte nuclear factor 4, alpha 3.43237
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 3.43237
TSSK4 testis-specific serine kinase 4 3.43237
NDRG1 N-myc downstream regulated 1 3.43237
IL11RA interleukin 11 receptor, alpha 3.43237
LRRD1 leucine-rich repeats and death domain containing 1 3.43237
CRISP1 cysteine-rich secretory protein 1 3.43237
TKTL1 transketolase-like 1 3.43237
PAX6 paired box 6 3.43237
PRSS36 protease, serine, 36 3.43237
SPDYE11 speedy/RINGO cell cycle regulator family member E11 3.43237
TBATA thymus, brain and testes associated 3.43237
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 3.43237
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 3.43237
TRPC5OS TRPC5 opposite strand 3.43237
MPL MPL proto-oncogene, thrombopoietin receptor 3.43237
BMP3 bone morphogenetic protein 3 3.43237
MRC1 mannose receptor, C type 1 3.43237
KIAA2012 KIAA2012 3.43237
LCN15 lipocalin 15 3.43237
THRSP thyroid hormone responsive 3.43237
TUBB1 tubulin, beta 1 class VI 3.43237
CIITA class II, major histocompatibility complex, transactivator 3.43237
MFAP5 microfibrillar associated protein 5 3.43237
ARSF arylsulfatase F 3.43237
SLC39A5 solute carrier family 39 (zinc transporter), member 5 3.43237
SLC9C2 solute carrier family 9, member C2 (putative) 3.43237
RFPL2 ret finger protein-like 2 3.43237
FAM221B family with sequence similarity 221, member B 3.43237
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) 3.43237
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 3.43237
LOC124900192 uncharacterized LOC124900192 3.43237
AVPR1A arginine vasopressin receptor 1A 3.43237
AVPR1B arginine vasopressin receptor 1B 3.43237
RHCG Rh family, C glycoprotein 3.43237
SPRR2F small proline-rich protein 2F 3.43237
PDC phosducin 3.43237
TFF2 trefoil factor 2 3.43237
ADRB3 adrenoceptor beta 3 3.43237
SLC25A2 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2 3.43237
PROZ protein Z, vitamin K-dependent plasma glycoprotein 3.43237
GBP2 guanylate binding protein 2, interferon-inducible 3.43237
ARX aristaless related homeobox 3.43237
SLC7A13 solute carrier family 7 (anionic amino acid transporter), member 13 3.43237
COXFA4L2 cytochrome c oxidase hypoxia associated subunit FA4L2 3.43237
ZC3H11C zinc finger CCCH-type containing 11C 3.43237
LITAFD LITAF domain containing 3.43237
LINC02268 long intergenic non-protein coding RNA 2268 3.43237
LINC02798 long intergenic non-protein coding RNA 2798 3.43237
INSYN1 inhibitory synaptic factor 1 3.43237
SPAAR small regulatory polypeptide of amino acid response 3.43237
H2AC1 H2A clustered histone 1 3.43237
DEPP1 DEPP autophagy regulator 1 3.43237
SPATA25 spermatogenesis associated 25 3.43237
GATA2 GATA binding protein 2 3.43237
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 3.43237
ZIC4 Zic family member 4 3.43237
GOLGA7B golgin A7 family, member B 3.43237
ANXA13 annexin A13 3.43237
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 3.43237
DAO D-amino-acid oxidase 3.43237
PYDC1 PYD (pyrin domain) containing 1 3.43237
PTGDR2 prostaglandin D2 receptor 2 3.43237
TMIE transmembrane inner ear 3.43237
RAB44 RAB44, member RAS oncogene family 3.43237
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 3.43237
TFEC transcription factor EC 3.43237
GDF10 growth differentiation factor 10 3.43237
SOAT2 sterol O-acyltransferase 2 3.43237
LGSN lengsin, lens protein with glutamine synthetase domain 3.43237
LRRC72 leucine rich repeat containing 72 3.43237
PLEK2 pleckstrin 2 3.43237
VCX3B variable charge, X-linked 3B 3.43237
S100G S100 calcium binding protein G 3.43237
RASAL3 RAS protein activator like 3 3.43237
C1QL2 complement component 1, q subcomponent-like 2 3.43237
MYH13 myosin, heavy chain 13, skeletal muscle 3.43237
RLBP1 retinaldehyde binding protein 1 3.43237
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 3.43237
OR9A2 olfactory receptor, family 9, subfamily A, member 2 3.43237
POU3F2 POU class 3 homeobox 2 3.43237
SMIM23 small integral membrane protein 23 3.43237
WFDC8 WAP four-disulfide core domain 8 3.43237
TRIM50 tripartite motif containing 50 3.43237
APOL1 apolipoprotein L, 1 3.43237
TRPM5 transient receptor potential cation channel, subfamily M, member 5 3.43237
PCDHGA4 protocadherin gamma subfamily A, 4 3.43237
MUC13 mucin 13, cell surface associated 3.43237
TUBAL3 tubulin, alpha-like 3 3.43237
DHRS7C dehydrogenase/reductase (SDR family) member 7C 3.43237
ISLR immunoglobulin superfamily containing leucine-rich repeat 3.43237
RTN4RL1 reticulon 4 receptor-like 1 3.43237
ERP27 endoplasmic reticulum protein 27 3.43237
AQP8 aquaporin 8 3.43237
PMP2 peripheral myelin protein 2 3.43237
HS3ST6 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 3.43237
HSF4 heat shock transcription factor 4 3.43237
HGFAC HGF activator 3.43237
A3GALT2 alpha 1,3-galactosyltransferase 2 3.43237
GAL3ST2 galactose-3-O-sulfotransferase 2 3.43237
FNDC9 fibronectin type III domain containing 9 3.43237
ACSM1 acyl-CoA synthetase medium-chain family member 1 3.43237
CST4 cystatin S 3.43237
CLDN34 claudin 34 3.43237
GPR12 G protein-coupled receptor 12 3.43237
C6ORF163 chromosome 6 open reading frame 163 3.43237
C5AR2 complement component 5a receptor 2 3.43237
FOXP3 forkhead box P3 3.43237
TMEM45B transmembrane protein 45B 3.43237
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 3.43237
RIN1 Ras and Rab interactor 1 3.43237
CPN2 carboxypeptidase N, polypeptide 2 3.43237
ABRA actin binding Rho activating protein 3.43237
FXYD3 FXYD domain containing ion transport regulator 3 3.43237
ADAM18 ADAM metallopeptidase domain 18 3.43237
GBX2 gastrulation brain homeobox 2 3.43237
CD180 CD180 molecule 3.43237
FKBP1C FK506 binding protein 1C 3.43237
TTC22 tetratricopeptide repeat domain 22 3.43237
NR4A3 nuclear receptor subfamily 4, group A, member 3 3.43237
GOLGA8Q golgin A8 family, member Q 3.43237
EPHB3 EPH receptor B3 3.43237
NLRP14 NLR family, pyrin domain containing 14 3.43237
EFCC1 EF-hand and coiled-coil domain containing 1 3.43237
GCGR glucagon receptor 3.43237
NR5A1 nuclear receptor subfamily 5, group A, member 1 3.43237
KLK11 kallikrein-related peptidase 11 3.43237
ALLC allantoicase 3.43237
CCNO cyclin O 3.43237
LHB luteinizing hormone beta polypeptide 3.43237
TGM6 transglutaminase 6 3.43237
KLK7 kallikrein-related peptidase 7 3.43237
SLCO2B1 solute carrier organic anion transporter family, member 2B1 3.43237
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 3.43237
CRYBA1 crystallin, beta A1 3.43237
TPPP3 tubulin polymerization-promoting protein family member 3 3.43237
ART1 ADP-ribosyltransferase 1 3.43237
FAM9B family with sequence similarity 9, member B 3.43237
ANGPTL7 angiopoietin-like 7 3.33225
S1PR5 sphingosine-1-phosphate receptor 5 3.33225
CNTN5 contactin 5 3.33225
SPNS2 spinster homolog 2 (Drosophila) 3.33225
CHDH choline dehydrogenase 3.18068
BGN biglycan 3.00858
RPL10A ribosomal protein L10a 2.75138
WDR43 WD repeat domain 43 2.73548
RBP1 retinol binding protein 1, cellular 2.72542
DLL3 delta-like 3 (Drosophila) 2.68328
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 2.65288
TPT1 tumor protein, translationally-controlled 1 2.62361
NPHP1 nephronophthisis 1 (juvenile) 2.61442
KANK1 KN motif and ankyrin repeat domains 1 2.48621
RAD18 RAD18 E3 ubiquitin protein ligase 2.46579
COPG2 coatomer protein complex, subunit gamma 2 2.42996
SMIM10L1 small integral membrane protein 10 like 1 2.4245
TEX46 testis expressed 46 2.4245
ARHGAP19 Rho GTPase activating protein 19 2.4245
CHRM1 cholinergic receptor, muscarinic 1 2.4245
ZBTB4 zinc finger and BTB domain containing 4 2.41435
ATP2A3 ATPase, Ca++ transporting, ubiquitous 2.40388
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C 2.37476
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 2.31481
MTTP microsomal triglyceride transfer protein 2.31481
GHRL ghrelin/obestatin prepropeptide 2.31481
C10ORF67 chromosome 10 open reading frame 67 2.31481
EXD1 exonuclease 3'-5' domain containing 1 2.31481
CLCNKB chloride channel, voltage-sensitive Kb 2.31481
CSPP1 centrosome and spindle pole associated protein 1 2.31481
C17ORF99 chromosome 17 open reading frame 99 2.31272
NACA2 nascent polypeptide-associated complex alpha subunit 2 2.31272
RSPH10B2 radial spoke head 10 homolog B2 (Chlamydomonas) 2.31272
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 2.31272
MPPE1 metallophosphoesterase 1 2.30767
ABHD4 abhydrolase domain containing 4 2.28633
DXO decapping exoribonuclease 2.28462
SF3B5 splicing factor 3b, subunit 5, 10kDa 2.26924
INAVA innate immunity activator 2.25855
TRAPPC11 trafficking protein particle complex 11 2.25855
SYT15 synaptotagmin XV 2.25039
LRRIQ1 leucine-rich repeats and IQ motif containing 1 2.25039
KNSTRN kinetochore-localized astrin/SPAG5 binding protein 2.25039
NOP10 NOP10 ribonucleoprotein 2.25039
TASOR2 transcription activation suppressor family member 2 2.25039
DPP8 dipeptidyl-peptidase 8 2.23565
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.22395
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 2.20943
ATF6B activating transcription factor 6 beta 2.19856
DDB1 damage-specific DNA binding protein 1, 127kDa 2.18558
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1 2.18083
TRABD2B TraB domain containing 2B 2.17493
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51 2.17417
LLPH LLP homolog, long-term synaptic facilitation (Aplysia) 2.17315
SLC33A2 solute carrier family 33 member 2 2.17299
SMN1 survival of motor neuron 1, telomeric 2.17054
RPS13 ribosomal protein S13 2.16602
SOCS1 suppressor of cytokine signaling 1 2.15505
MTERF3 mitochondrial transcription termination factor 3 2.1275
SETD7 SET domain containing (lysine methyltransferase) 7 2.12585
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2 2.11706
COPS3 COP9 signalosome subunit 3 2.10251
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) 2.10198
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 2.09344
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) 2.08556
NMU neuromedin U 2.0772
EXOC3L2 exocyst complex component 3-like 2 2.07437
RPL38 ribosomal protein L38 2.0598
MPG N-methylpurine-DNA glycosylase 2.05463
CYTL1 cytokine-like 1 2.03157
TPBG trophoblast glycoprotein 2.03071
IRF3 interferon regulatory factor 3 2.0213
CCDC126 coiled-coil domain containing 126 2.0213
RGN regucalcin 2.01437
UBE2F ubiquitin-conjugating enzyme E2F (putative) 2.01317
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.01086
TMEM182 transmembrane protein 182 2.01086
NOL12 nucleolar protein 12 2.01016
TPD52L2 tumor protein D52-like 2 2.00746
RPS23 ribosomal protein S23 2.00746
ZCCHC14 zinc finger, CCHC domain containing 14 2.00697

decreased expression

Symbol Name Standardized Value
RBM44 RNA binding motif protein 44 -3.43237
SMIM41 small integral membrane protein 41 -3.43237
TMEM150B transmembrane protein 150B -3.43237
PLK5 polo-like kinase 5 -3.43237
SV2C synaptic vesicle glycoprotein 2C -3.43237
PTGER4 prostaglandin E receptor 4 (subtype EP4) -3.43237
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa -3.43237
TREH trehalase (brush-border membrane glycoprotein) -3.43237
TRPV6 transient receptor potential cation channel, subfamily V, member 6 -3.43237
FAM161B family with sequence similarity 161, member B -3.43237
PTGDS prostaglandin D2 synthase 21kDa (brain) -3.43237
CLDN14 claudin 14 -3.43237
CHTF8 CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) -3.43237
CYGB cytoglobin -3.43237
SOST sclerostin -3.43237
GPR78 G protein-coupled receptor 78 -3.43237
RDH16 retinol dehydrogenase 16 (all-trans) -3.43237
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 -3.43237
THEM6 thioesterase superfamily member 6 -3.43237
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 -3.43237
SLC30A4 solute carrier family 30 (zinc transporter), member 4 -3.43237
NME8 NME/NM23 family member 8 -3.43237
CTXN2 cortexin 2 -3.43237
FAM167B family with sequence similarity 167, member B -3.43237
TMEM233 transmembrane protein 233 -3.43237
ACSL1 acyl-CoA synthetase long-chain family member 1 -3.43237
ATP10B ATPase, class V, type 10B -3.43237
CISH cytokine inducible SH2-containing protein -3.43237
LGALS14 lectin, galactoside-binding, soluble, 14 -3.43237
SVOP SV2 related protein homolog (rat) -3.43237
ARHGAP40 Rho GTPase activating protein 40 -3.43237
WNT4 wingless-type MMTV integration site family, member 4 -3.43237
CXORF58 chromosome X open reading frame 58 -3.43237
MINDY4B MINDY family member 4B -3.43237
RASSF10 Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 -3.43237
CFAP97D2 CFAP97 domain containing 2 -3.43237
AMH anti-Mullerian hormone -3.43237
CDK19 cyclin-dependent kinase 19 -3.4204
MAN2A2 mannosidase, alpha, class 2A, member 2 -3.35288
AVIL advillin -3.23462
CXCL17 chemokine (C-X-C motif) ligand 17 -3.1961
SPAG5 sperm associated antigen 5 -3.06187
SCLY selenocysteine lyase -3.00461
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 -2.97503
TMEM106A transmembrane protein 106A -2.9278
CASP8 caspase 8, apoptosis-related cysteine peptidase -2.86088
H3C4 H3 clustered histone 4 -2.77621
TULP3 tubby like protein 3 -2.76444
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 -2.70249
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide -2.68489
MBNL1 muscleblind-like splicing regulator 1 -2.65456
C1ORF159 chromosome 1 open reading frame 159 -2.63368
SYN2 synapsin II -2.61044
KIAA1217 KIAA1217 -2.45473
GABRG1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 -2.4415
SYNPO synaptopodin -2.4415
ZNF774 zinc finger protein 774 -2.4415
XPO6 exportin 6 -2.43229
DTYMK deoxythymidylate kinase (thymidylate kinase) -2.42996
MED29 mediator complex subunit 29 -2.42996
PPP6R2 protein phosphatase 6, regulatory subunit 2 -2.4245
ALKBH4 alkB, alkylation repair homolog 4 (E. coli) -2.4183
DPM2 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit -2.41649
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 -2.41649
MROH6 maestro heat-like repeat family member 6 -2.41275
ADH6 alcohol dehydrogenase 6 (class V) -2.41275
NOXRED1 NADP-dependent oxidoreductase domain containing 1 -2.41275
EMB embigin -2.40929
MOB3A MOB kinase activator 3A -2.40539
LHX1 LIM homeobox 1 -2.37596
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) -2.37596
HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 -2.37596
IRF6 interferon regulatory factor 6 -2.37585
SLC39A1 solute carrier family 39 (zinc transporter), member 1 -2.37476
ANKHD1 ankyrin repeat and KH domain containing 1 -2.36534
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -2.32643
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6 -2.31272
CTNND2 catenin (cadherin-associated protein), delta 2 -2.3097
IL6ST-DT IL6ST divergent transcript -2.28633
ZNF595 zinc finger protein 595 -2.28633
LCN10 lipocalin 10 -2.28633
STX19 syntaxin 19 -2.28633
MEF2C myocyte enhancer factor 2C -2.26924
ZBED8L ZBED8 like -2.26857
TMEM266 transmembrane protein 266 -2.25855
SCN7A sodium channel, voltage gated, type VII alpha subunit -2.25855
ANXA9 annexin A9 -2.25855
BAZ2A bromodomain adjacent to zinc finger domain, 2A -2.25855
GRM4 glutamate receptor, metabotropic 4 -2.25039
CPOX coproporphyrinogen oxidase -2.25039
SYNE1 spectrin repeat containing, nuclear envelope 1 -2.25039
NRF1 nuclear respiratory factor 1 -2.25039
NTSR1 neurotensin receptor 1 (high affinity) -2.23441
NFIX nuclear factor I/X (CCAAT-binding transcription factor) -2.23441
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -2.23441
CYP4X1 cytochrome P450, family 4, subfamily X, polypeptide 1 -2.23441
C2ORF69 chromosome 2 open reading frame 69 -2.22395
MCL1 myeloid cell leukemia 1 -2.22395
ERV3-1-ZNF117 ERV3-1-ZNF117 readthrough -2.22186
CNOT4 CCR4-NOT transcription complex, subunit 4 -2.212
FOXN2 forkhead box N2 -2.20943
MON1A MON1 secretory trafficking family member A -2.20722
SPTB spectrin, beta, erythrocytic -2.2037
ZNF771 zinc finger protein 771 -2.19875
SPATA16 spermatogenesis associated 16 -2.19856
TRIM52 tripartite motif containing 52 -2.1925
COX18 COX18 cytochrome c oxidase assembly factor -2.19178
ARHGAP32 Rho GTPase activating protein 32 -2.18558
NEMP1 nuclear envelope integral membrane protein 1 -2.17933
KPNB1 karyopherin (importin) beta 1 -2.17255
PWWP3A PWWP domain containing 3A, DNA repair factor -2.17054
RMP24 ribonuclease MRP subunit p24 -2.17054
SEPTIN3 septin 3 -2.16074
CCDC40 coiled-coil domain containing 40 -2.15802
MERTK MER proto-oncogene, tyrosine kinase -2.1411
RAD21 RAD21 homolog (S. pombe) -2.13659
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -2.12878
S100A6 S100 calcium binding protein A6 -2.12585
ZNF618 zinc finger protein 618 -2.11536
PCED1B PC-esterase domain containing 1B -2.10278
ANKRD13B ankyrin repeat domain 13B -2.09344
NLRC4 NLR family, CARD domain containing 4 -2.09344
TOX thymocyte selection-associated high mobility group box -2.08804
TDRD12 tudor domain containing 12 -2.08556
EYA1 EYA transcriptional coactivator and phosphatase 1 -2.08556
STIM2 stromal interaction molecule 2 -2.07204
PCLAF PCNA clamp associated factor -2.0598
OTUD6B OTU domain containing 6B -2.05689
DNM2 dynamin 2 -2.04556
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -2.03071
RBSN rabenosyn, RAB effector -2.02711
CTIF CBP80/20-dependent translation initiation factor -2.02711
PRKCA protein kinase C, alpha -2.00746