RAN Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description RAN, member RAS oncogene family|RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5901)
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Genes

286 genes differentially expressed following the RAN gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
EIF4E1B eukaryotic translation initiation factor 4E family member 1B 2.5445
KLK5 kallikrein-related peptidase 5 2.5445
KLRF1 killer cell lectin-like receptor subfamily F, member 1 2.5445
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1 2.5445
NWD2 NACHT and WD repeat domain containing 2 2.5445
NWD1 NACHT and WD repeat domain containing 1 2.5445
DRD2 dopamine receptor D2 2.5445
CAPN9 calpain 9 2.5445
NXNL1 nucleoredoxin-like 1 2.5445
AKNAD1 AKNA domain containing 1 2.5445
KLB klotho beta 2.5445
SPATA22 spermatogenesis associated 22 2.5445
MEIKIN meiotic kinetochore factor 2.5445
IKZF3 IKAROS family zinc finger 3 (Aiolos) 2.5445
NGB neuroglobin 2.5445
CFAP74 cilia and flagella associated protein 74 2.5445
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 2.5445
LGALS4 lectin, galactoside-binding, soluble, 4 2.5445
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 2.5445
SPMIP8 sperm microtubule inner protein 8 2.5445
TSGA10IP testis specific, 10 interacting protein 2.5445
SMIM31 small integral membrane protein 31 2.5445
PRH2 proline-rich protein HaeIII subfamily 2 2.5445
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 2.50784
CD48 CD48 molecule 2.50784
ACTA1 actin, alpha 1, skeletal muscle 2.50784
SLC6A19 solute carrier family 6 (neutral amino acid transporter), member 19 2.50784
RNF17 ring finger protein 17 2.50784
MEP1A meprin A, alpha (PABA peptide hydrolase) 2.50784
SLC22A10 solute carrier family 22, member 10 2.50784
TBX20 T-box 20 2.50784
TRIM63 tripartite motif containing 63, E3 ubiquitin protein ligase 2.50784
LIPC lipase, hepatic 2.50784
IRF8 interferon regulatory factor 8 2.50784
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 2.50784
TMEM95 transmembrane protein 95 2.50784
WDR87 WD repeat domain 87 2.50784
OR2J3 olfactory receptor, family 2, subfamily J, member 3 2.50784
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 2.50784
GDNF glial cell derived neurotrophic factor 2.50784
SLC30A2 solute carrier family 30 (zinc transporter), member 2 2.50784
ALPK2 alpha-kinase 2 2.50784
LYNX1 Ly6/neurotoxin 1 2.50784
C11ORF87 chromosome 11 open reading frame 87 2.50784
DLX4 distal-less homeobox 4 2.50784
WT1 Wilms tumor 1 2.50784
NCF1 neutrophil cytosolic factor 1 2.50784
VWA5B2 von Willebrand factor A domain containing 5B2 2.50784
SCGN secretagogin, EF-hand calcium binding protein 2.50784
GPR52 G protein-coupled receptor 52 2.50784
SCN2B sodium channel, voltage gated, type II beta subunit 2.50784
SLC46A2 solute carrier family 46, member 2 2.50784
BSND barttin CLCNK-type chloride channel accessory beta subunit 2.50784
PLIN1 perilipin 1 2.50784
TM4SF1 transmembrane 4 L six family member 1 2.50784
GALNT9 polypeptide N-acetylgalactosaminyltransferase 9 2.50784
FAM90A20 family with sequence similarity 90 member A20 2.50784
PHF24 PHD finger protein 24 2.50784
SEPTIN14 septin 14 2.50784
PROP1 PROP paired-like homeobox 1 2.50784
ETAA1 Ewing tumor-associated antigen 1 2.50784
FMOD fibromodulin 2.50784
SMLR1 small leucine-rich protein 1 2.50784
ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12 2.50784
TMPRSS6 transmembrane protease, serine 6 2.50784
CCDC9B coiled-coil domain containing 9B 2.50784
MICOS13 mitochondrial contact site and cristae organizing system subunit 13 2.50784
CARMIL3 capping protein regulator and myosin 1 linker 3 2.50784
PRR20G proline rich 20G 2.50784
SPEM3 SPEM family member 3 2.50784
CPNE8-AS1 CPNE8 antisense RNA 1 2.50784
REELD1 reeler domain containing 1 2.50784
ZNF593OS ZNF593 opposite strand 2.50784
C2ORF92 chromosome 2 open reading frame 92 2.50784
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 2.50784
PLPP4 phospholipid phosphatase 4 2.50784
TMPRSS4 transmembrane protease, serine 4 2.50784
ADRB1 adrenoceptor beta 1 2.50784
LSP1 lymphocyte-specific protein 1 2.50784
MIA melanoma inhibitory activity 2.50784
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 2.50784
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 2.50784
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 2.50784
TMEM234 transmembrane protein 234 2.50784
ANXA13 annexin A13 2.50784
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 2.50784
EXOC3L4 exocyst complex component 3-like 4 2.50784
CLEC17A C-type lectin domain family 17, member A 2.50784
C7 complement component 7 2.50784
BDKRB2 bradykinin receptor B2 2.50784
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough 2.50784
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 2.50784
OR7D2 olfactory receptor, family 7, subfamily D, member 2 2.50784
SYT15 synaptotagmin XV 2.50784
UGT2A1 UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus 2.50784
MOV10L1 Mov10 RISC complex RNA helicase like 1 2.50784
TAS1R1 taste receptor, type 1, member 1 2.50784
LYSMD2 LysM, putative peptidoglycan-binding, domain containing 2 2.50784
PRRX1 paired related homeobox 1 2.50784
NPPA natriuretic peptide A 2.50784
BRDT bromodomain, testis-specific 2.50784
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 2.50784
AMIGO1 adhesion molecule with Ig-like domain 1 2.50784
ADGRA1 adhesion G protein-coupled receptor A1 2.50784
DPRX divergent-paired related homeobox 2.50784
RNASE11 ribonuclease, RNase A family, 11 (non-active) 2.50784
WFDC1 WAP four-disulfide core domain 1 2.50784
PCDHGB5 protocadherin gamma subfamily B, 5 2.50784
TP53AIP1 tumor protein p53 regulated apoptosis inducing protein 1 2.50784
ZNF365 zinc finger protein 365 2.50784
LPAR5 lysophosphatidic acid receptor 5 2.50784
ACSM1 acyl-CoA synthetase medium-chain family member 1 2.50784
ANKRD62 ankyrin repeat domain 62 2.50784
FOSB FBJ murine osteosarcoma viral oncogene homolog B 2.50784
HSPB9 heat shock protein, alpha-crystallin-related, B9 2.50784
KRT17 keratin 17, type I 2.50784
PYHIN1 pyrin and HIN domain family, member 1 2.50784
VAX2 ventral anterior homeobox 2 2.50784
WFDC9 WAP four-disulfide core domain 9 2.50784
TDRD10 tudor domain containing 10 2.50784
TF transferrin 2.50784
NT5DC4 5'-nucleotidase domain containing 4 2.50784
INSM1 insulinoma-associated 1 2.50784
DND1 DND microRNA-mediated repression inhibitor 1 2.50784
LHX5 LIM homeobox 5 2.50784
LHX2 LIM homeobox 2 2.50784
MYADML2 myeloid-associated differentiation marker-like 2 2.50784
KLHDC1 kelch domain containing 1 2.50784
FGR FGR proto-oncogene, Src family tyrosine kinase 2.50784
KLK15 kallikrein-related peptidase 15 2.50784
ALOXE3 arachidonate lipoxygenase 3 2.50784
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 2.50784
CPA2 carboxypeptidase A2 (pancreatic) 2.50784
CD244 CD244 molecule, natural killer cell receptor 2B4 2.50784
IL36R interleukin 36 receptor 2.50784
MAB21L1 mab-21-like 1 (C. elegans) 2.50784
C22ORF42 chromosome 22 open reading frame 42 2.50784
TMEM139 transmembrane protein 139 2.50784
AGXT2 alanine--glyoxylate aminotransferase 2 2.50784
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 2.50784
CARD6 caspase recruitment domain family, member 6 2.50784
ANXA8 annexin A8 2.50784
VCX variable charge, X-linked 2.50784
IL33 interleukin 33 2.50784
METTL18 methyltransferase like 18 2.50784
ANG angiogenin, ribonuclease, RNase A family, 5 2.50784
DPYSL3 dihydropyrimidinase-like 3 2.50784
RNASE9 ribonuclease, RNase A family, 9 (non-active) 2.50784
CCDC83 coiled-coil domain containing 83 2.50784
LEP leptin 2.50784
DDX53 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 2.50784
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 2.50784
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 2.50784
HES2 hes family bHLH transcription factor 2 2.50784
C2ORF78 chromosome 2 open reading frame 78 2.50784
MMP10 matrix metallopeptidase 10 2.50784
MRC1 mannose receptor, C type 1 2.50784
TAS2R42 taste receptor, type 2, member 42 2.50784
LGI1 leucine-rich, glioma inactivated 1 2.50784
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 2.50784
EPN3 epsin 3 2.50784
CD80 CD80 molecule 2.50784
LY6G5C lymphocyte antigen 6 complex, locus G5C 2.50784
CRYAA crystallin, alpha A 2.50784
SLCO1C1 solute carrier organic anion transporter family, member 1C1 2.50784
PADI1 peptidyl arginine deiminase, type I 2.50784
PADI6 peptidyl arginine deiminase, type VI 2.50784
LGALS2 lectin, galactoside-binding, soluble, 2 2.50784
MYO1G myosin IG 2.50784
KIAA2012 KIAA2012 2.48787
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 2.47213
PIGH phosphatidylinositol glycan anchor biosynthesis, class H 2.3935
MYO19 myosin XIX 2.38901
ZSCAN25 zinc finger and SCAN domain containing 25 2.38277
CNR2 cannabinoid receptor 2 (macrophage) 2.37815
DES desmin 2.37815
KCNK17 potassium channel, two pore domain subfamily K, member 17 2.36058
LDB3 LIM domain binding 3 2.36058
SLC22A31 solute carrier family 22, member 31 2.36058
DAPK3 death-associated protein kinase 3 2.33477
SLC7A3 solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 2.28579
DNA2 DNA replication helicase/nuclease 2 2.24731
RBM46 RNA binding motif protein 46 2.24074
HDGFL2 HDGF like 2 2.21669
CXORF38 chromosome X open reading frame 38 2.20324
ZNF613 zinc finger protein 613 2.19379
RAF1 Raf-1 proto-oncogene, serine/threonine kinase 2.19323
PHF7 PHD finger protein 7 2.19317
KAZN kazrin, periplakin interacting protein 2.19088
SLC35G2 solute carrier family 35, member G2 2.09871
H1-3 H1.3 linker histone, cluster member 2.07122
EFR3A EFR3 homolog A (S. cerevisiae) 2.0332
FTO fat mass and obesity associated 2.0332
MT1G metallothionein 1G 2.02613
TSTD2 thiosulfate sulfurtransferase (rhodanese)-like domain containing 2 2.0168
TRIP10 thyroid hormone receptor interactor 10 2.01545

decreased expression

Symbol Name Standardized Value
VIL1 villin 1 -2.5445
VPS9D1 VPS9 domain containing 1 -2.5445
FSD2 fibronectin type III and SPRY domain containing 2 -2.5445
CEP15 centrosomal protein 15 -2.5445
LTBP2 latent transforming growth factor beta binding protein 2 -2.5445
ATG4A autophagy related 4A, cysteine peptidase -2.5445
FLT4 fms-related tyrosine kinase 4 -2.5445
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 -2.50784
TRIM17 tripartite motif containing 17 -2.50784
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 -2.50784
NAGK N-acetylglucosamine kinase -2.50784
FBLN7 fibulin 7 -2.50784
WDR54 WD repeat domain 54 -2.50784
TOR1A torsin family 1, member A (torsin A) -2.50784
MUC5B mucin 5B, oligomeric mucus/gel-forming -2.50784
CRIP2 cysteine-rich protein 2 -2.50784
SPX spexin hormone -2.50784
TECTA tectorin alpha -2.50784
AKR7L aldo-keto reductase family 7-like (gene/pseudogene) -2.50784
CFAP141 cilia and flagella associated protein 141 -2.50784
SKIC3 SKI3 subunit of superkiller complex -2.50784
SLF1 SMC5-SMC6 complex localization factor 1 -2.50784
ODAD1 outer dynein arm docking complex subunit 1 -2.50784
ALDOB aldolase B, fructose-bisphosphate -2.50784
GSG1L GSG1-like -2.50784
ASB4 ankyrin repeat and SOCS box containing 4 -2.50784
PCDHGC3 protocadherin gamma subfamily C, 3 -2.50784
CCDC92 coiled-coil domain containing 92 -2.50784
OR2A12 olfactory receptor, family 2, subfamily A, member 12 -2.50784
PCDHB14 protocadherin beta 14 -2.50784
FAM3D family with sequence similarity 3, member D -2.50784
S100PBP S100P binding protein -2.50784
HRH4 histamine receptor H4 -2.50784
C19ORF73 chromosome 19 open reading frame 73 -2.50784
BTN3A3 butyrophilin, subfamily 3, member A3 -2.50784
FGF9 fibroblast growth factor 9 -2.50784
BTBD17 BTB (POZ) domain containing 17 -2.50784
IRGM immunity-related GTPase family, M -2.50784
SH2D4B SH2 domain containing 4B -2.50784
PRIMA1 proline rich membrane anchor 1 -2.50784
MYT1L myelin transcription factor 1-like -2.50784
PIH1D2 PIH1 domain containing 2 -2.50784
RUFY4 RUN and FYVE domain containing 4 -2.50784
TNN tenascin N -2.50784
RAB40B RAB40B, member RAS oncogene family -2.50784
CEACAM19 carcinoembryonic antigen-related cell adhesion molecule 19 -2.50784
FAM114A1 family with sequence similarity 114, member A1 -2.50784
ITGA10 integrin, alpha 10 -2.50784
DHRS4 dehydrogenase/reductase (SDR family) member 4 -2.50784
F11 coagulation factor XI -2.50784
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -2.50784
NRSN1 neurensin 1 -2.50784
CAMSAP1 calmodulin regulated spectrin-associated protein 1 -2.50784
NTNG2 netrin G2 -2.50784
HSPB2 heat shock 27kDa protein 2 -2.50784
NRG4 neuregulin 4 -2.48238
MMP26 matrix metallopeptidase 26 -2.43436
KANK3 KN motif and ankyrin repeat domains 3 -2.40591
AGO3 argonaute RISC catalytic component 3 -2.3791
PF4 platelet factor 4 -2.36806
KLHL5 kelch-like family member 5 -2.31703
IGLON5 IgLON family member 5 -2.29191
CLIP3 CAP-GLY domain containing linker protein 3 -2.28997
UBE2I ubiquitin-conjugating enzyme E2I -2.28579
PPP1R1C protein phosphatase 1, regulatory (inhibitor) subunit 1C -2.27757
CLVS2 clavesin 2 -2.26195
DBF4 DBF4 zinc finger -2.24074
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 -2.21574
DPYS dihydropyrimidinase -2.19984
MITF microphthalmia-associated transcription factor -2.19984
SENP1 SUMO1/sentrin specific peptidase 1 -2.19608
FAF2 Fas associated factor family member 2 -2.19379
INSIG2 insulin induced gene 2 -2.19317
RPL23A ribosomal protein L23a -2.19088
ACTMAP actin maturation protease -2.18746
LRRC26 leucine rich repeat containing 26 -2.16536
PHLDA2 pleckstrin homology-like domain, family A, member 2 -2.1608
ZNF668 zinc finger protein 668 -2.15754
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 -2.15675
SIGLEC10 sialic acid binding Ig-like lectin 10 -2.15675
TMEM223 transmembrane protein 223 -2.14703
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -2.12737
EMC2 ER membrane protein complex subunit 2 -2.11707
RAN RAN, member RAS oncogene family -2.08477
TPCN1 two pore segment channel 1 -2.07897
PCDHB13 protocadherin beta 13 -2.04678
TRMT44 tRNA methyltransferase 44 homolog (S. cerevisiae) -2.04038
TDP2 tyrosyl-DNA phosphodiesterase 2 -2.01057
C9ORF40 chromosome 9 open reading frame 40 -2.0102
ATXN1 ataxin 1 -2.00671