| Dataset | CM4AI KOLF21J CRISPRi Gene Perturbation Atlas |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | RAN binding protein 2|RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5903) |
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87 genes differentially expressed following the RANBP2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.
| Symbol | Name | Standardized Value |
|---|---|---|
| H2BC5 | H2B clustered histone 5 | 2.06518 |
| HYKK | hydroxylysine kinase | 2.06518 |
| PNCK | pregnancy up-regulated nonubiquitous CaM kinase | 2.06518 |
| ESRRB | estrogen-related receptor beta | 2.06518 |
| LRCH4 | leucine-rich repeats and calponin homology (CH) domain containing 4 | 2.06518 |
| TMEM175 | transmembrane protein 175 | 2.06518 |
| CDKN2D | cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) | 2.06518 |
| FREM3 | FRAS1 related extracellular matrix 3 | 2.06518 |
| KLRD1 | killer cell lectin-like receptor subfamily D, member 1 | 2.06518 |
| EGFL8 | EGF-like-domain, multiple 8 | 2.06518 |
| ADCYAP1R1 | adenylate cyclase activating polypeptide 1 (pituitary) receptor type I | 2.06518 |
| ATP12A | ATPase, H+/K+ transporting, nongastric, alpha polypeptide | 2.06518 |
| DLC1 | DLC1 Rho GTPase activating protein | 2.06518 |
| GATA4 | GATA binding protein 4 | 2.06518 |
| SNRNP35 | small nuclear ribonucleoprotein 35kDa (U11/U12) | 2.06518 |
| DORIP1 | dopamine receptor interacting protein 1 | 2.06518 |
| DUSP7 | dual specificity phosphatase 7 | 2.06518 |
| C2ORF72 | chromosome 2 open reading frame 72 | 2.06518 |
| CCT6B | chaperonin containing TCP1, subunit 6B (zeta 2) | 2.06518 |
| PMM1 | phosphomannomutase 1 | 2.06518 |
| EVA1A | eva-1 homolog A (C. elegans) | 2.06518 |
| TMEM62 | transmembrane protein 62 | 2.06518 |
| LRRK2 | leucine-rich repeat kinase 2 | 2.06518 |
| MST1 | macrophage stimulating 1 | 2.06518 |
| HSPA4L | heat shock 70kDa protein 4-like | 2.06518 |
| DNAH5 | dynein, axonemal, heavy chain 5 | 2.06518 |
| MYLK4 | myosin light chain kinase family, member 4 | 2.06518 |
| WNT5B | wingless-type MMTV integration site family, member 5B | 2.06518 |
| ASCL3 | achaete-scute family bHLH transcription factor 3 | 2.06518 |
| ZNF763 | zinc finger protein 763 | 2.06518 |
| ITGA1 | integrin, alpha 1 | 2.06518 |
| SUSD5 | sushi domain containing 5 | 2.06518 |
| RBM46 | RNA binding motif protein 46 | 2.06438 |
| CNIH1 | cornichon family AMPA receptor auxiliary protein 1 | 2.06438 |
| SDHAF1 | succinate dehydrogenase complex assembly factor 1 | 2.06438 |
| HIST1H2BF | histone cluster 1, H2bf | 2.06438 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 2.06438 |
| STOX1 | storkhead box 1 | 2.06438 |
| ANKRD13B | ankyrin repeat domain 13B | 2.06438 |
| FGD3 | FYVE, RhoGEF and PH domain containing 3 | 2.06438 |
| SLC35F5 | solute carrier family 35, member F5 | 2.04254 |
| PKP3 | plakophilin 3 | 2.02851 |
| SS18L1 | synovial sarcoma translocation gene on chromosome 18-like 1 | 2.01648 |
| TENT5A | terminal nucleotidyltransferase 5A | 2.01648 |
| FBXW5 | F-box and WD repeat domain containing 5 | 2.01648 |
| FNTA | farnesyltransferase, CAAX box, alpha | 2.00658 |
| FBXO16 | F-box protein 16 | 2.00538 |
| Symbol | Name | Standardized Value |
|---|---|---|
| XPNPEP1 | X-prolyl aminopeptidase (aminopeptidase P) 1, soluble | -2.06518 |
| NDUFB9 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa | -2.06518 |
| ZNF32 | zinc finger protein 32 | -2.06518 |
| LARP6 | La ribonucleoprotein domain family, member 6 | -2.06518 |
| TTLL6 | tubulin tyrosine ligase-like family member 6 | -2.06518 |
| ELK3 | ELK3, ETS-domain protein (SRF accessory protein 2) | -2.06518 |
| INTS15 | integrator complex subunit 15 | -2.06518 |
| DENND10 | DENN domain containing 10 | -2.06518 |
| PEA15 | phosphoprotein enriched in astrocytes 15 | -2.06518 |
| M1AP | meiosis 1 associated protein | -2.06518 |
| C1ORF226 | chromosome 1 open reading frame 226 | -2.06518 |
| ADM | adrenomedullin | -2.06518 |
| KCNG1 | potassium channel, voltage gated modifier subfamily G, member 1 | -2.06518 |
| AMPD2 | adenosine monophosphate deaminase 2 | -2.06518 |
| PSEN2 | presenilin 2 | -2.06518 |
| RHBDD2 | rhomboid domain containing 2 | -2.06518 |
| RAB29 | RAB29, member RAS oncogene family | -2.06518 |
| PKD2 | polycystic kidney disease 2 (autosomal dominant) | -2.06518 |
| ZP3 | zona pellucida glycoprotein 3 (sperm receptor) | -2.06518 |
| APCDD1L | adenomatosis polyposis coli down-regulated 1-like | -2.06518 |
| PUS3 | pseudouridylate synthase 3 | -2.06518 |
| UCHL3 | ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) | -2.06518 |
| PPFIBP2 | PTPRF interacting protein, binding protein 2 (liprin beta 2) | -2.06518 |
| ATOSA | atos homolog A | -2.06518 |
| NMRK1 | nicotinamide riboside kinase 1 | -2.06518 |
| COQ10A | coenzyme Q10 homolog A (S. cerevisiae) | -2.06438 |
| IMPA1 | inositol(myo)-1(or 4)-monophosphatase 1 | -2.06438 |
| FAM174B | family with sequence similarity 174, member B | -2.06438 |
| DDX6 | DEAD (Asp-Glu-Ala-Asp) box helicase 6 | -2.06438 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -2.06438 |
| SIX5 | SIX homeobox 5 | -2.02851 |
| CYB561A3 | cytochrome b561 family, member A3 | -2.01648 |
| TUBE1 | tubulin, epsilon 1 | -2.01648 |
| RNF215 | ring finger protein 215 | -2.01648 |
| ADGRE2 | adhesion G protein-coupled receptor E2 | -2.01648 |
| NOL4 | nucleolar protein 4 | -2.01648 |
| HAUS7 | HAUS augmin-like complex, subunit 7 | -2.01648 |
| ZNF836 | zinc finger protein 836 | -2.01648 |
| FAM117A | family with sequence similarity 117, member A | -2.01648 |
| SLC38A12 | solute carrier family 38 member 12 | -2.01648 |
