Dataset MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations
Category transcriptomics
Type gene perturbation
Description gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/RAPA_EARLY_UP.V1_UP
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370 genes differentially expressed following the RAPA_EARLY_UP.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.

increased expression

Symbol Name
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ACOX3 acyl-CoA oxidase 3, pristanoyl
ADCY10 adenylate cyclase 10 (soluble)
ADGRB2 adhesion G protein-coupled receptor B2
ADGRE5 adhesion G protein-coupled receptor E5
ADRA1B adrenoceptor alpha 1B
AEBP1 AE binding protein 1
ALOX15 arachidonate 15-lipoxygenase
AMOT angiomotin
ANK1 ankyrin 1, erythrocytic
ANPEP alanyl (membrane) aminopeptidase
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15
ASMT acetylserotonin O-methyltransferase
ASPH aspartate beta-hydroxylase
ASTN2 astrotactin 2
ATF6 activating transcription factor 6
ATG13 autophagy related 13
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2
AVPR2 arginine vasopressin receptor 2
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BASP1 brain abundant, membrane attached signal protein 1
C1ORF95 chromosome 1 open reading frame 95
C2ORF72 chromosome 2 open reading frame 72
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CBX5 chromobox homolog 5
CCDC88C coiled-coil domain containing 88C
CCDC9 coiled-coil domain containing 9
CCNG2 cyclin G2
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2
CDH4 cadherin 4, type 1, R-cadherin (retinal)
CDK10 cyclin-dependent kinase 10
CDON cell adhesion associated, oncogene regulated
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CES1 carboxylesterase 1
CHD5 chromodomain helicase DNA binding protein 5
CHRD chordin
CLCC1 chloride channel CLIC-like 1
CLDN14 claudin 14
CLK1 CDC-like kinase 1
COL5A2 collagen, type V, alpha 2
COL6A1 collagen, type VI, alpha 1
COPG2 coatomer protein complex, subunit gamma 2
CTBP2 C-terminal binding protein 2
CTSD cathepsin D
CTSF cathepsin F
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1
CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11
DAGLA diacylglycerol lipase, alpha
DKFZP586I1420 uncharacterized protein DKFZp586I1420
DLX5 distal-less homeobox 5
DNAH3 dynein, axonemal, heavy chain 3
DRD3 dopamine receptor D3
EFNA5 ephrin-A5
ESRRB estrogen-related receptor beta
ETV2 ets variant 2
FABP7 fatty acid binding protein 7, brain
FAM50A family with sequence similarity 50, member A
FGFR2 fibroblast growth factor receptor 2
FKBP1A FK506 binding protein 1A, 12kDa
FOXJ1 forkhead box J1
FPGS folylpolyglutamate synthase
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
FSCN1 fascin actin-bundling protein 1
FZD9 frizzled class receptor 9
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
GAS8 growth arrest-specific 8
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B
GMDS GDP-mannose 4,6-dehydratase
GML glycosylphosphatidylinositol anchored molecule like
GNAT1 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1
GNG12 guanine nucleotide binding protein (G protein), gamma 12
GPR182 G protein-coupled receptor 182
GPR31 G protein-coupled receptor 31
GREB1 growth regulation by estrogen in breast cancer 1
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C
GRK1 G protein-coupled receptor kinase 1
GRPR gastrin-releasing peptide receptor
HAB1 B1 for mucin
HBP1 HMG-box transcription factor 1
HCRTR2 hypocretin (orexin) receptor 2
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
HLA-DRB6 major histocompatibility complex, class II, DR beta 6 (pseudogene)
HMBS hydroxymethylbilane synthase
HOXD10 homeobox D10
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPB6 heat shock protein, alpha-crystallin-related, B6
ICOS inducible T-cell co-stimulator
INS insulin
IRF7 interferon regulatory factor 7
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
ITPKA inositol-trisphosphate 3-kinase A
KCNC4 potassium channel, voltage gated Shaw related subfamily C, member 4
KIAA0040 KIAA0040
KLHL35 kelch-like family member 35
KLK6 kallikrein-related peptidase 6
KMT2A lysine (K)-specific methyltransferase 2A
KRT13 keratin 13, type I
KRT14 keratin 14, type I
KRT19 keratin 19, type I
KSR1 kinase suppressor of ras 1
L1CAM L1 cell adhesion molecule
LDOC1 leucine zipper, down-regulated in cancer 1
LHX2 LIM homeobox 2
LST1 leukocyte specific transcript 1
MAN1A2 mannosidase, alpha, class 1A, member 2
MATN1 matrilin 1, cartilage matrix protein
MPO myeloperoxidase
MPPED1 metallophosphoesterase domain containing 1
MXRA7 matrix-remodelling associated 7
MYRF myelin regulatory factor
NAT9 N-acetyltransferase 9 (GCN5-related, putative)
NCOA1 nuclear receptor coactivator 1
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NINJ1 ninjurin 1
NKX2-8 NK2 homeobox 8
NPY neuropeptide Y
NR2F6 nuclear receptor subfamily 2, group F, member 6
NRL neural retina leucine zipper
NUCB1 nucleobindin 1
NUDCD3 NudC domain containing 3
OLFML2A olfactomedin-like 2A
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PAQR4 progestin and adipoQ receptor family member IV
PARM1 prostate androgen-regulated mucin-like protein 1
PART1 prostate androgen-regulated transcript 1 (non-protein coding)
PDE1B phosphodiesterase 1B, calmodulin-dependent
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDE4A phosphodiesterase 4A, cAMP-specific
PDE5A phosphodiesterase 5A, cGMP-specific
PHKA1 phosphorylase kinase, alpha 1 (muscle)
PIGO phosphatidylinositol glycan anchor biosynthesis, class O
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PLA2G5 phospholipase A2, group V
PLEKHA6 pleckstrin homology domain containing, family A member 6
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRKCG protein kinase C, gamma
PROP1 PROP paired-like homeobox 1
PTGDR prostaglandin D2 receptor (DP)
PTGIR prostaglandin I2 (prostacyclin) receptor (IP)
PTH2R parathyroid hormone 2 receptor
PTK6 protein tyrosine kinase 6
PTPRD protein tyrosine phosphatase, receptor type, D
RAD9A RAD9 homolog A (S. pombe)
SCN2B sodium channel, voltage gated, type II beta subunit
SEPT11 septin 11
SFPQ splicing factor proline/glutamine-rich
SHC3 SHC (Src homology 2 domain containing) transforming protein 3
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC25A42 solute carrier family 25, member 42
SLIT1 slit homolog 1 (Drosophila)
SNCG synuclein, gamma (breast cancer-specific protein 1)
SOCS1 suppressor of cytokine signaling 1
SSH1 slingshot protein phosphatase 1
SST somatostatin
SSUH2 ssu-2 homolog (C. elegans)
ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
SYNPO synaptopodin
TAGLN3 transgelin 3
TCP10 t-complex 10
TCTA T-cell leukemia translocation altered
TGM4 transglutaminase 4
TICAM1 toll-like receptor adaptor molecule 1
TIMP2 TIMP metallopeptidase inhibitor 2
TLE3 transducin-like enhancer of split 3
TMSB4Y thymosin beta 4, Y-linked
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TRIM38 tripartite motif containing 38
USP9Y ubiquitin specific peptidase 9, Y-linked
VGF VGF nerve growth factor inducible
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae)
VSIG4 V-set and immunoglobulin domain containing 4
VTN vitronectin

decreased expression

Symbol Name
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ACHE acetylcholinesterase (Yt blood group)
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
ACY1 aminoacylase 1
ADGRE1 adhesion G protein-coupled receptor E1
ADH6 alcohol dehydrogenase 6 (class V)
ALDH1B1 aldehyde dehydrogenase 1 family, member B1
AOC3 amine oxidase, copper containing 3
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3
ARHGAP4 Rho GTPase activating protein 4
ASMTL acetylserotonin O-methyltransferase-like
ATG2A autophagy related 2A
AXL AXL receptor tyrosine kinase
BBC3 BCL2 binding component 3
BCAT2 branched chain amino-acid transaminase 2, mitochondrial
BCKDK branched chain ketoacid dehydrogenase kinase
BRMS1 breast cancer metastasis suppressor 1
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CAV3 caveolin 3
CBX4 chromobox homolog 4
CCDC85B coiled-coil domain containing 85B
CDH12 cadherin 12, type 2 (N-cadherin 2)
CDH22 cadherin 22, type 2
CHKB choline kinase beta
CHMP3 charged multivesicular body protein 3
CIB2 calcium and integrin binding family member 2
CIT citron rho-interacting serine/threonine kinase
CNKSR2 connector enhancer of kinase suppressor of Ras 2
COBLL1 cordon-bleu WH2 repeat protein-like 1
COG5 component of oligomeric golgi complex 5
COL10A1 collagen, type X, alpha 1
COL9A1 collagen, type IX, alpha 1
COL9A2 collagen, type IX, alpha 2
CRIP2 cysteine-rich protein 2
CRMP1 collapsin response mediator protein 1
CRY2 cryptochrome circadian clock 2
CYP2A7 cytochrome P450, family 2, subfamily A, polypeptide 7
CYP2F1 cytochrome P450, family 2, subfamily F, polypeptide 1
DDN dendrin
DPH1 diphthamide biosynthesis 1
DSG1 desmoglein 1
DUSP14 dual specificity phosphatase 14
DUSP2 dual specificity phosphatase 2
EDDM3A epididymal protein 3A
EDRF1 erythroid differentiation regulatory factor 1
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ENG endoglin
EPHB4 EPH receptor B4
ESRRA estrogen-related receptor alpha
F10 coagulation factor X
FAM168A family with sequence similarity 168, member A
FAM182B family with sequence similarity 182, member B
FAM49A family with sequence similarity 49, member A
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FLOT1 flotillin 1
FLT3LG fms-related tyrosine kinase 3 ligand
FOXI1 forkhead box I1
FTO fat mass and obesity associated
FXYD1 FXYD domain containing ion transport regulator 1
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1
GALNS galactosamine (N-acetyl)-6-sulfatase
GALR3 galanin receptor 3
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GFRA2 GDNF family receptor alpha 2
GLUL glutamate-ammonia ligase
GNRH2 gonadotropin-releasing hormone 2
GPR12 G protein-coupled receptor 12
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GRM1 glutamate receptor, metabotropic 1
GRM2 glutamate receptor, metabotropic 2
GRN granulin
GUCA2B guanylate cyclase activator 2B (uroguanylin)
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HDAC6 histone deacetylase 6
HIST2H4A histone cluster 2, H4a
HLA-E major histocompatibility complex, class I, E
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HSPA1A heat shock 70kDa protein 1A
IFI27 interferon, alpha-inducible protein 27
IGFBP3 insulin-like growth factor binding protein 3
IL11RA interleukin 11 receptor, alpha
IL12RB1 interleukin 12 receptor, beta 1
INPP5J inositol polyphosphate-5-phosphatase J
ITPKC inositol-trisphosphate 3-kinase C
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KDM4A lysine (K)-specific demethylase 4A
KDM4B lysine (K)-specific demethylase 4B
KISS1 KiSS-1 metastasis-suppressor
KRT17 keratin 17, type I
KRT4 keratin 4, type II
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LHB luteinizing hormone beta polypeptide
LMNA lamin A/C
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LTB lymphotoxin beta (TNF superfamily, member 3)
MAP1A microtubule-associated protein 1A
MARK2 MAP/microtubule affinity-regulating kinase 2
MEP1A meprin A, alpha (PABA peptide hydrolase)
MET MET proto-oncogene, receptor tyrosine kinase
MFSD7 major facilitator superfamily domain containing 7
MGST2 microsomal glutathione S-transferase 2
MICU1 mitochondrial calcium uptake 1
MID1 midline 1
MINK1 misshapen-like kinase 1
MOG myelin oligodendrocyte glycoprotein
MSMO1 methylsterol monooxygenase 1
MTMR2 myotubularin related protein 2
MTMR3 myotubularin related protein 3
MUC3A mucin 3A, cell surface associated
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
NCAPH non-SMC condensin I complex, subunit H
NCF1 neutrophil cytosolic factor 1
NFE2L1 nuclear factor, erythroid 2-like 1
NHLH1 nescient helix loop helix 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
NUMA1 nuclear mitotic apparatus protein 1
NUP210 nucleoporin 210kDa
NUPL2 nucleoporin like 2
OR2J2 olfactory receptor, family 2, subfamily J, member 2
OSBPL2 oxysterol binding protein-like 2
OVOL1 ovo-like zinc finger 1
PAX2 paired box 2
PCBP4 poly(rC) binding protein 4
PCSK2 proprotein convertase subtilisin/kexin type 2
PDZK1IP1 PDZK1 interacting protein 1
PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein
PINK1 PTEN induced putative kinase 1
PISD phosphatidylserine decarboxylase
PLEKHO2 pleckstrin homology domain containing, family O member 2
PLIN3 perilipin 3
PLXND1 plexin D1
PNPLA4 patatin-like phospholipase domain containing 4
PPAP2B phosphatidic acid phosphatase type 2B
PPY pancreatic polypeptide
PRELP proline/arginine-rich end leucine-rich repeat protein
PRH2 proline-rich protein HaeIII subfamily 2
PRKCE protein kinase C, epsilon
PSD pleckstrin and Sec7 domain containing
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
PTCH1 patched 1
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RAB5B RAB5B, member RAS oncogene family
RBMS1 RNA binding motif, single stranded interacting protein 1
RNF167 ring finger protein 167
ROR2 receptor tyrosine kinase-like orphan receptor 2
SCO2 SCO2 cytochrome c oxidase assembly protein
SEC16A SEC16 homolog A (S. cerevisiae)
SELPLG selectin P ligand
SERBP1 SERPINE1 mRNA binding protein 1
SF3A2 splicing factor 3a, subunit 2, 66kDa
SF3B1 splicing factor 3b, subunit 1, 155kDa
SLC22A14 solute carrier family 22, member 14
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMAD9 SMAD family member 9
SMAP1 small ArfGAP 1
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa
SNTA1 syntrophin, alpha 1
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
SOS1 son of sevenless homolog 1 (Drosophila)
SOX10 SRY (sex determining region Y)-box 10
SPRR1B small proline-rich protein 1B
STK11 serine/threonine kinase 11
SYNGR4 synaptogyrin 4
TACR1 tachykinin receptor 1
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TH tyrosine hydroxylase
THOC1 THO complex 1
TNN tenascin N
TRIM22 tripartite motif containing 22
TROAP trophinin associated protein
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TSPAN4 tetraspanin 4
VENTXP7 VENT homeobox pseudogene 7
WDTC1 WD and tetratricopeptide repeats 1
WFS1 Wolfram syndrome 1 (wolframin)
WNK1 WNK lysine deficient protein kinase 1
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
YIPF2 Yip1 domain family, member 2
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3
ZBTB6 zinc finger and BTB domain containing 6
ZNF175 zinc finger protein 175
ZNF3 zinc finger protein 3
ZNF799 zinc finger protein 799
ZNRF4 zinc and ring finger 4