RARA Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description retinoic acid receptor, alpha|This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010] (NCBI Entrez Gene Database, 5914)
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Genes

284 genes differentially expressed following the RARA gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
LACTBL1 lactamase, beta-like 1 2.96109
STMND1 stathmin domain containing 1 2.96109
HSPB6 heat shock protein, alpha-crystallin-related, B6 2.96109
TMED6 transmembrane emp24 protein transport domain containing 6 2.96109
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) 2.96109
FAM228A family with sequence similarity 228, member A 2.96109
RIMBP2 RIMS binding protein 2 2.96109
HTR3E 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic 2.96109
OR14A16 olfactory receptor, family 14, subfamily A, member 16 2.96109
F2RL2 coagulation factor II (thrombin) receptor-like 2 2.96109
ASCL5 achaete-scute family bHLH transcription factor 5 2.96109
ENTHD1 ENTH domain containing 1 2.96109
MAEL maelstrom spermatogenic transposon silencer 2.96109
SBSN suprabasin 2.96109
SCN10A sodium channel, voltage gated, type X alpha subunit 2.96109
PCDHGB4 protocadherin gamma subfamily B, 4 2.96109
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 2.96109
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 2.96109
FGF8 fibroblast growth factor 8 (androgen-induced) 2.96109
PDILT protein disulfide isomerase-like, testis expressed 2.96109
PCDHA7 protocadherin alpha 7 2.96109
SPTBN5 spectrin, beta, non-erythrocytic 5 2.96109
SPON2 spondin 2, extracellular matrix protein 2.96109
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 2.96109
PLEK pleckstrin 2.88083
NANOS3 nanos homolog 3 (Drosophila) 2.88083
MAP3K7CL MAP3K7 C-terminal like 2.88083
RXFP3 relaxin/insulin-like family peptide receptor 3 2.88083
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 2.88083
MILR1 mast cell immunoglobulin-like receptor 1 2.88083
DCAF4L1 DDB1 and CUL4 associated factor 4-like 1 2.88083
HEATR9 HEAT repeat containing 9 2.88083
SSTR3 somatostatin receptor 3 2.88083
APLN apelin 2.88083
CRH corticotropin releasing hormone 2.88083
PTH2 parathyroid hormone 2 2.88083
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) 2.88083
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 2.88083
GPR101 G protein-coupled receptor 101 2.88083
MUC22 mucin 22 2.88083
TREML1 triggering receptor expressed on myeloid cells-like 1 2.88083
TAS2R13 taste receptor, type 2, member 13 2.88083
LGALS2 lectin, galactoside-binding, soluble, 2 2.88083
GMFG glia maturation factor, gamma 2.88083
TNFRSF4 tumor necrosis factor receptor superfamily, member 4 2.88083
SH2D6 SH2 domain containing 6 2.88083
TIAM2 T-cell lymphoma invasion and metastasis 2 2.88083
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 2.88083
TYRP1 tyrosinase-related protein 1 2.88083
ASB17 ankyrin repeat and SOCS box containing 17 2.88083
SNAP29 synaptosomal-associated protein, 29kDa 2.88083
PLXNB3 plexin B3 2.88083
LYNX1 Ly6/neurotoxin 1 2.88083
ASMT acetylserotonin O-methyltransferase 2.88083
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 2.88083
KRABD1 KRAB domain containing 1 2.88083
VSIR V-set immunoregulatory receptor 2.88083
H1-6 H1.6 linker histone, cluster member 2.88083
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 2.88083
OR2T8 olfactory receptor, family 2, subfamily T, member 8 2.88083
SRGN serglycin 2.88083
TBC1D3B TBC1 domain family, member 3B 2.88083
XKR3 XK, Kell blood group complex subunit-related family, member 3 2.88083
XKRX XK, Kell blood group complex subunit-related, X-linked 2.88083
ALPG alkaline phosphatase, germ cell 2.88083
LORICRIN loricrin cornified envelope precursor protein 2.88083
MSANTD5 Myb/SANT DNA binding domain containing 5 2.88083
COXFA4L3 cytochrome c oxidase associated subunit FA4L3 2.88083
TEKTL1 tektin like 1 2.88083
DUSP13B dual specificity phosphatase 13B 2.88083
EZHIP EZH inhibitory protein 2.88083
CLEC20A C-type lectin domain containing 20A 2.88083
DEFB131B defensin beta 131B 2.88083
CCDC190 coiled-coil domain containing 190 2.88083
CALHM5 calcium homeostasis modulator family member 5 2.88083
SPATA22 spermatogenesis associated 22 2.88083
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 2.88083
TMCO2 transmembrane and coiled-coil domains 2 2.88083
C3ORF80 chromosome 3 open reading frame 80 2.88083
VSX2 visual system homeobox 2 2.88083
RAB44 RAB44, member RAS oncogene family 2.88083
OR5H6 olfactory receptor, family 5, subfamily H, member 6 (gene/pseudogene) 2.88083
ERAS ES cell expressed Ras 2.88083
KBTBD13 kelch repeat and BTB (POZ) domain containing 13 2.88083
GPR6 G protein-coupled receptor 6 2.88083
TFEC transcription factor EC 2.88083
AMZ1 archaelysin family metallopeptidase 1 2.88083
ESR1 estrogen receptor 1 2.88083
NDP Norrie disease (pseudoglioma) 2.88083
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 2.88083
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) 2.88083
MS4A5 membrane-spanning 4-domains, subfamily A, member 5 2.88083
FGFBP1 fibroblast growth factor binding protein 1 2.88083
SAMD15 sterile alpha motif domain containing 15 2.88083
PLB1 phospholipase B1 2.88083
CDKN2A cyclin-dependent kinase inhibitor 2A 2.88083
LAPTM5 lysosomal protein transmembrane 5 2.88083
IL12A interleukin 12A 2.88083
DUOX2 dual oxidase 2 2.88083
MKRN3 makorin ring finger protein 3 2.88083
PTF1A pancreas specific transcription factor, 1a 2.88083
WFDC1 WAP four-disulfide core domain 1 2.88083
OLFML1 olfactomedin-like 1 2.88083
NPFFR1 neuropeptide FF receptor 1 2.88083
AKNAD1 AKNA domain containing 1 2.88083
CPA2 carboxypeptidase A2 (pancreatic) 2.88083
OTC ornithine carbamoyltransferase 2.88083
UBQLNL ubiquilin-like 2.88083
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 2.88083
MBOAT4 membrane bound O-acyltransferase domain containing 4 2.88083
KCNK9 potassium channel, two pore domain subfamily K, member 9 2.88083
HAMP hepcidin antimicrobial peptide 2.88083
DYDC1 DPY30 domain containing 1 2.88083
CTAGE15 CTAGE family, member 15 2.88083
RAD51AP2 RAD51 associated protein 2 2.88083
GPR12 G protein-coupled receptor 12 2.88083
ZFPM2 zinc finger protein, FOG family member 2 2.88083
APOC2 apolipoprotein C-II 2.88083
APOC4 apolipoprotein C-IV 2.88083
PDCD1LG2 programmed cell death 1 ligand 2 2.88083
VAV1 vav 1 guanine nucleotide exchange factor 2.88083
INSM1 insulinoma-associated 1 2.88083
LGALS12 lectin, galactoside-binding, soluble, 12 2.88083
C1ORF105 chromosome 1 open reading frame 105 2.88083
TM4SF19 transmembrane 4 L six family member 19 2.88083
CCNA1 cyclin A1 2.88083
GJC2 gap junction protein, gamma 2, 47kDa 2.88083
CPA1 carboxypeptidase A1 (pancreatic) 2.88083
TBX1 T-box 1 2.88083
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.88083
MAB21L3 mab-21-like 3 (C. elegans) 2.88083
ODF4 outer dense fiber of sperm tails 4 2.88083
PCDHGA3 protocadherin gamma subfamily A, 3 2.88083
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 2.88083
DNTT DNA nucleotidylexotransferase 2.88083
ISL1 ISL LIM homeobox 1 2.88083
PLA1A phospholipase A1 member A 2.88083
ITGA8 integrin, alpha 8 2.88083
NMUR1 neuromedin U receptor 1 2.88083
SIGLEC15 sialic acid binding Ig-like lectin 15 2.88083
ADAM20 ADAM metallopeptidase domain 20 2.88083
FITM1 fat storage-inducing transmembrane protein 1 2.88083
PADI6 peptidyl arginine deiminase, type VI 2.88083
TGM6 transglutaminase 6 2.88083
FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase) 2.88083
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 2.88083
TMEM156 transmembrane protein 156 2.88083
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6 2.88083
OR11G2 olfactory receptor, family 11, subfamily G, member 2 2.88083
LOXL4 lysyl oxidase-like 4 2.88083
EPX eosinophil peroxidase 2.88083
CLCA4 chloride channel accessory 4 2.88083
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 2.88083
SPDEF SAM pointed domain containing ETS transcription factor 2.88083
OR6B1 olfactory receptor, family 6, subfamily B, member 1 2.88083
HIC1 hypermethylated in cancer 1 2.88083
LOC102724877 uncharacterized LOC102724877 2.88083
LKAAEAR1 LKAAEAR motif containing 1 2.88083
FAM25G family with sequence similarity 25, member G 2.88083
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 2.88083
MT1M metallothionein 1M 2.88083
OGA O-GlcNAcase 2.85571
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 2.83112
PDE4B phosphodiesterase 4B, cAMP-specific 2.7778
COL5A2 collagen, type V, alpha 2 2.76614
MYBPC2 myosin binding protein C, fast type 2.69746
MEF2C myocyte enhancer factor 2C 2.67898
ZFAND4 zinc finger, AN1-type domain 4 2.57149
UBL4A ubiquitin-like 4A 2.5473
PUF60 poly-U binding splicing factor 60KDa 2.52765
LSM12 LSM12 homolog (S. cerevisiae) 2.50447
EIF4E2 eukaryotic translation initiation factor 4E family member 2 2.47454
CLEC4G C-type lectin domain family 4, member G 2.44238
C1ORF116 chromosome 1 open reading frame 116 2.44238
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 2.37751
KPNA7 karyopherin alpha 7 (importin alpha 8) 2.37352
TMSB4X thymosin beta 4, X-linked 2.36996
URI1 URI1, prefoldin-like chaperone 2.36283
ZNF772 zinc finger protein 772 2.29446
GAL3ST3 galactose-3-O-sulfotransferase 3 2.26962
MPP4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) 2.24842
NXPE3 neurexophilin and PC-esterase domain family, member 3 2.22992
RBBP4 retinoblastoma binding protein 4 2.218
RHOXF1 Rhox homeobox family, member 1 2.21499
ADPRHL1 ADP-ribosylhydrolase like 1 2.21425
AMBRA1 autophagy/beclin-1 regulator 1 2.20536
RBM3 RNA binding motif (RNP1, RRM) protein 3 2.20249
SLC39A7 solute carrier family 39 (zinc transporter), member 7 2.18801
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 2.1726
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) 2.16838
RPLP0 ribosomal protein, large, P0 2.14668
YIPF6 Yip1 domain family, member 6 2.14668
TNS1 tensin 1 2.11899
IL17RD interleukin 17 receptor D 2.10831
DMAC1 distal membrane arm assembly component 1 2.10092
OTOA otoancorin 2.10055
THOC7 THO complex 7 2.08926
ADCY10 adenylate cyclase 10 (soluble) 2.08208
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20 2.07806
AFAP1L2 actin filament associated protein 1-like 2 2.05383
DENND4A DENN/MADD domain containing 4A 2.05348
ERV3-1 endogenous retrovirus group 3, member 1 2.03871
EAF2 ELL associated factor 2 2.03094
ACAA1 acetyl-CoA acyltransferase 1 2.02279
TBCB tubulin folding cofactor B 2.02279
RPL5 ribosomal protein L5 2.02279
ALDH1L2 aldehyde dehydrogenase 1 family, member L2 2.02266
CCDC163 CCDC163 homolog 2.02266
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 2.02141
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 2.02141
SPATC1L spermatogenesis and centriole associated 1-like 2.01995
SLITRK5 SLIT and NTRK-like family, member 5 2.00652

decreased expression

Symbol Name Standardized Value
AZIN2 antizyme inhibitor 2 -2.96109
PIGH phosphatidylinositol glycan anchor biosynthesis, class H -2.88738
CCM2L cerebral cavernous malformation 2-like -2.88083
CCDC22 coiled-coil domain containing 22 -2.88083
GLYATL1 glycine-N-acyltransferase-like 1 -2.88083
MDGA1 MAM domain containing glycosylphosphatidylinositol anchor 1 -2.88083
CCDC106 coiled-coil domain containing 106 -2.88083
LRP2BP LRP2 binding protein -2.88083
LCN10 lipocalin 10 -2.88083
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma -2.8563
MIXL1 Mix paired-like homeobox -2.83112
UPP2 uridine phosphorylase 2 -2.83112
SCN2A sodium channel, voltage gated, type II alpha subunit -2.83112
ITIH6 inter-alpha-trypsin inhibitor heavy chain family, member 6 -2.83112
TRIM73 tripartite motif containing 73 -2.83112
CA7 carbonic anhydrase VII -2.83112
GUCY2D guanylate cyclase 2D, membrane (retina-specific) -2.83112
RASL10A RAS-like, family 10, member A -2.83112
MEP1B meprin A, beta -2.83112
CHCT1 CHD1 helical C-terminal domain containing 1 -2.83112
H4C2 H4 clustered histone 2 -2.83112
SAPCD1 suppressor APC domain containing 1 -2.83112
SPDYE17 speedy/RINGO cell cycle regulator family member E17 -2.83112
ZNF575 zinc finger protein 575 -2.83112
NR1I3 nuclear receptor subfamily 1, group I, member 3 -2.83112
BBS5 Bardet-Biedl syndrome 5 -2.83112
LTBP2 latent transforming growth factor beta binding protein 2 -2.83112
IZUMO1 izumo sperm-egg fusion 1 -2.83112
RLBP1 retinaldehyde binding protein 1 -2.83112
KLF11 Kruppel-like factor 11 -2.83112
ASCL3 achaete-scute family bHLH transcription factor 3 -2.83112
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 -2.83112
PPP1R27 protein phosphatase 1, regulatory subunit 27 -2.83112
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 -2.83112
CDNF cerebral dopamine neurotrophic factor -2.83112
C20ORF144 chromosome 20 open reading frame 144 -2.83112
PEBP4 phosphatidylethanolamine-binding protein 4 -2.83112
IRGM immunity-related GTPase family, M -2.83112
FAM209B family with sequence similarity 209, member B -2.83112
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 -2.8309
MRPL30 mitochondrial ribosomal protein L30 -2.82547
STRA6 stimulated by retinoic acid 6 -2.8096
ZNF836 zinc finger protein 836 -2.78965
DOC2B double C2-like domains, beta -2.70062
CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa -2.6669
ZYG11B zyg-11 family member B, cell cycle regulator -2.59303
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) -2.53222
SPATA16 spermatogenesis associated 16 -2.53222
ARL16 ADP-ribosylation factor-like 16 -2.46421
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 -2.42374
ELAVL2 ELAV like neuron-specific RNA binding protein 2 -2.39652
TLCD3A TLC domain containing 3A -2.37939
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa -2.33863
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) -2.33626
WDR25 WD repeat domain 25 -2.30454
KCNE5 potassium channel, voltage gated subfamily E regulatory beta subunit 5 -2.29446
PDXK pyridoxal (pyridoxine, vitamin B6) kinase -2.26962
VPS26B vacuolar protein sorting 26 homolog B (S. pombe) -2.26962
TIPE3 TNF alpha induced protein 8 like 3 -2.2573
E4F1 E4F transcription factor 1 -2.21499
IFI27 interferon, alpha-inducible protein 27 -2.21499
KIAA1143 KIAA1143 -2.11322
LARP1B La ribonucleoprotein domain family, member 1B -2.08303
DENND1A DENN/MADD domain containing 1A -2.05972
AFAP1L1 actin filament associated protein 1-like 1 -2.04306
DGKQ diacylglycerol kinase, theta 110kDa -2.03798
RAB5IF RAB5 interacting factor -2.02266
POGLUT3 protein O-glucosyltransferase 3 -2.02141
ERICH1 glutamate-rich 1 -2.0081
AJAP1 adherens junctions associated protein 1 -2.00646
UXS1 UDP-glucuronate decarboxylase 1 -2.00001
SLC7A6OS solute carrier family 7, member 6 opposite strand -2.00001