RB1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description retinoblastoma 1|The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5925)
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Genes

343 genes differentially expressed following the RB1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 3.40629
DSG3 desmoglein 3 3.40629
PLCH2 phospholipase C, eta 2 3.40629
SULT1A4 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4 3.40629
SIGLEC9 sialic acid binding Ig-like lectin 9 3.40629
TUBB8 tubulin, beta 8 class VIII 3.40629
GPR22 G protein-coupled receptor 22 3.40629
GIMAP4 GTPase, IMAP family member 4 3.40629
POSTN periostin, osteoblast specific factor 3.40629
PTGER3 prostaglandin E receptor 3 (subtype EP3) 3.40629
WT1 Wilms tumor 1 3.40629
CCL5 chemokine (C-C motif) ligand 5 3.40629
SYNPO2L synaptopodin 2-like 3.40629
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 3.40629
NXPH4 neurexophilin 4 3.40629
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 3.40629
PDIA2 protein disulfide isomerase family A, member 2 3.40629
OR1A1 olfactory receptor, family 1, subfamily A, member 1 3.40629
PRODH2 proline dehydrogenase (oxidase) 2 3.40629
TNNI1 troponin I type 1 (skeletal, slow) 3.40629
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase 3.40629
TM4SF1 transmembrane 4 L six family member 1 3.40629
MISP mitotic spindle positioning 3.40629
HBM hemoglobin, mu 3.40629
RBP3 retinol binding protein 3, interstitial 3.40629
AMIGO3 adhesion molecule with Ig-like domain 3 3.40629
PITX3 paired-like homeodomain 3 3.40629
TMEM52B transmembrane protein 52B 3.40629
NEUROD4 neuronal differentiation 4 3.40629
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 3.40629
ASCL1 achaete-scute family bHLH transcription factor 1 3.40629
OR14A2 olfactory receptor, family 14, subfamily A, member 2 3.40629
IL17B interleukin 17B 3.40629
RBP4 retinol binding protein 4, plasma 3.40629
FGF7 fibroblast growth factor 7 3.40629
TLDC2 TBC/LysM-associated domain containing 2 3.40629
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 3.40629
CRYGA crystallin, gamma A 3.40629
LBX2 ladybird homeobox 2 3.40629
DIO3 deiodinase, iodothyronine, type III 3.40629
GRP gastrin-releasing peptide 3.40629
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 3.40629
GRIFIN galectin-related inter-fiber protein 3.40629
EPHB3 EPH receptor B3 3.40629
NR4A3 nuclear receptor subfamily 4, group A, member 3 3.40629
ADAM29 ADAM metallopeptidase domain 29 3.40629
SPMIP9 sperm microtubule inner protein 9 3.40629
RHCG Rh family, C glycoprotein 3.40629
DUSP8 dual specificity phosphatase 8 3.40629
OR2T8 olfactory receptor, family 2, subfamily T, member 8 3.40629
KRT86 keratin 86, type II 3.40629
KRT81 keratin 81, type II 3.40629
GSG1L GSG1-like 3.40629
C20ORF202 chromosome 20 open reading frame 202 3.40629
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 3.40629
SPMIP10 sperm microtubule inner protein 10 3.40629
MYH4 myosin, heavy chain 4, skeletal muscle 3.40629
RIPK4 receptor-interacting serine-threonine kinase 4 3.40629
CD300LF CD300 molecule-like family member f 3.40629
PRR20G proline rich 20G 3.40629
REELD1 reeler domain containing 1 3.40629
GNG5B G protein subunit gamma 5B 3.40629
CCDC197 coiled-coil domain containing 197 3.40629
ACOD1 aconitate decarboxylase 1 3.40629
PLAAT4 phospholipase A and acyltransferase 4 3.40629
TMEM275 transmembrane protein 275 3.40629
SLC7A13 solute carrier family 7 (anionic amino acid transporter), member 13 3.40629
C3AR1 complement component 3a receptor 1 3.40629
KL klotho 3.40629
HNF1B HNF1 homeobox B 3.40629
LTBP2 latent transforming growth factor beta binding protein 2 3.40629
NKX2-6 NK2 homeobox 6 3.40629
SLC35D3 solute carrier family 35, member D3 3.40629
RAET1G retinoic acid early transcript 1G 3.40629
ACR acrosin 3.40629
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 3.40629
TAS2R5 taste receptor, type 2, member 5 3.40629
WEE2 WEE1 homolog 2 (S. pombe) 3.40629
ELF5 E74-like factor 5 (ets domain transcription factor) 3.40629
DSG1 desmoglein 1 3.40629
THPO thrombopoietin 3.40629
GDF10 growth differentiation factor 10 3.40629
DLK2 delta-like 2 homolog (Drosophila) 3.40629
SOAT2 sterol O-acyltransferase 2 3.40629
ASZ1 ankyrin repeat, SAM and basic leucine zipper domain containing 1 3.40629
FGFBP2 fibroblast growth factor binding protein 2 3.40629
PGA4 pepsinogen 4, group I (pepsinogen A) 3.40629
ALG10B ALG10B, alpha-1,2-glucosyltransferase 3.40629
CCR7 chemokine (C-C motif) receptor 7 3.40629
SH3TC1 SH3 domain and tetratricopeptide repeats 1 3.40629
MYH13 myosin, heavy chain 13, skeletal muscle 3.40629
SOX3 SRY (sex determining region Y)-box 3 3.40629
AMDHD1 amidohydrolase domain containing 1 3.40629
GOLGA6B golgin A6 family, member B 3.40629
GAB4 GRB2-associated binding protein family, member 4 3.40629
POU2AF1 POU class 2 associating factor 1 3.40629
PCDHGA4 protocadherin gamma subfamily A, 4 3.40629
ZNF132 zinc finger protein 132 3.40629
KCNK9 potassium channel, two pore domain subfamily K, member 9 3.40629
MYF6 myogenic factor 6 (herculin) 3.40629
GFI1B growth factor independent 1B transcription repressor 3.40629
PCDHGA7 protocadherin gamma subfamily A, 7 3.40629
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 3.40629
KLK15 kallikrein-related peptidase 15 3.40629
PRDM9 PR domain containing 9 3.40629
CABP7 calcium binding protein 7 3.40629
CDRT15L2 CMT1A duplicated region transcript 15-like 2 3.40629
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 3.40629
EFCAB3 EF-hand calcium binding domain 3 3.40629
MAB21L2 mab-21-like 2 (C. elegans) 3.40629
WFDC8 WAP four-disulfide core domain 8 3.40629
GML glycosylphosphatidylinositol anchored molecule like 3.40629
ADAM7 ADAM metallopeptidase domain 7 3.40629
IGFALS insulin-like growth factor binding protein, acid labile subunit 3.40629
NPFFR1 neuropeptide FF receptor 1 3.40629
RNASE11 ribonuclease, RNase A family, 11 (non-active) 3.40629
KLF2 Kruppel-like factor 2 3.40629
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15 3.40629
CPA3 carboxypeptidase A3 (mast cell) 3.40629
CDH10 cadherin 10, type 2 (T2-cadherin) 3.40629
SMIM23 small integral membrane protein 23 3.40629
AQP8 aquaporin 8 3.40629
THTPA thiamine triphosphatase 3.40629
SERPINB10 serpin peptidase inhibitor, clade B (ovalbumin), member 10 3.40629
PRR35 proline rich 35 3.40629
SPEF1 sperm flagellar 1 3.40629
HS3ST6 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 3.40629
CHRM1 cholinergic receptor, muscarinic 1 3.40629
NYX nyctalopin 3.40629
CLCA1 chloride channel accessory 1 3.40629
CLCA4 chloride channel accessory 4 3.40629
TICAM1 toll-like receptor adaptor molecule 1 3.40629
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 3.40629
CPN2 carboxypeptidase N, polypeptide 2 3.40629
CIB4 calcium and integrin binding family member 4 3.40629
ADAM12 ADAM metallopeptidase domain 12 3.40629
GOLGA8J golgin A8 family, member J 3.40629
PDE10A phosphodiesterase 10A 3.40629
ITGAD integrin, alpha D 3.40629
ITGA8 integrin, alpha 8 3.40629
AQP10 aquaporin 10 3.40629
HEPN1 hepatocellular carcinoma, down-regulated 1 3.40629
RBM24 RNA binding motif protein 24 3.40629
CALML5 calmodulin-like 5 3.40629
ECM1 extracellular matrix protein 1 3.40629
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 3.40629
PLA2G4E phospholipase A2, group IVE 3.40629
TMIGD3 transmembrane and immunoglobulin domain containing 3 3.40629
CRHBP corticotropin releasing hormone binding protein 3.40629
CTSE cathepsin E 3.40629
CARNS1 carnosine synthase 1 3.40629
OR4D5 olfactory receptor, family 4, subfamily D, member 5 3.40629
CD28 CD28 molecule 3.40629
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 3.40629
CIDEA cell death-inducing DFFA-like effector a 3.40629
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 3.37992
CDKL4 cyclin-dependent kinase-like 4 3.33667
CD48 CD48 molecule 3.33667
DLG5 discs, large homolog 5 (Drosophila) 3.25546
COL23A1 collagen, type XXIII, alpha 1 3.07821
CC2D2B coiled-coil and C2 domain containing 2B 3.01246
SRL sarcalumenin 2.96561
CEP89 centrosomal protein 89kDa 2.88955
MYEOV myeloma overexpressed 2.88382
ACTR3C ARP3 actin-related protein 3 homolog C (yeast) 2.82493
RASSF2 Ras association (RalGDS/AF-6) domain family member 2 2.7327
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 2.71902
TPST1 tyrosylprotein sulfotransferase 1 2.65316
CCDC169 coiled-coil domain containing 169 2.57616
PHF20 PHD finger protein 20 2.54994
ATPAF1 ATP synthase mitochondrial F1 complex assembly factor 1 2.53011
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14 2.4764
KIF18B kinesin family member 18B 2.42699
SPIN2A spindlin family, member 2A 2.40334
C10ORF67 chromosome 10 open reading frame 67 2.35741
ALPK2 alpha-kinase 2 2.35741
UBALD1 UBA-like domain containing 1 2.35741
RBMS1 RNA binding motif, single stranded interacting protein 1 2.35311
CATIP ciliogenesis associated TTC17 interacting protein 2.35115
BORCS8 BLOC-1 related complex subunit 8 2.35115
APOB apolipoprotein B 2.35115
PRKCB protein kinase C, beta 2.32859
CCN3 cellular communication network factor 3 2.32534
GPR146 G protein-coupled receptor 146 2.32534
CCDC38 coiled-coil domain containing 38 2.32534
COTL1 coactosin-like F-actin binding protein 1 2.32534
TTBK1 tau tubulin kinase 1 2.32534
TEX11 testis expressed 11 2.32534
KPNA7 karyopherin alpha 7 (importin alpha 8) 2.32534
AKR1D1 aldo-keto reductase family 1, member D1 2.32534
ICAM1 intercellular adhesion molecule 1 2.32534
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.3214
SALL3 spalt-like transcription factor 3 2.3214
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 2.2949
SLK STE20-like kinase 2.29318
SHISAL2B shisa like 2B 2.29077
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 2.24254
UXT ubiquitously-expressed, prefoldin-like chaperone 2.22789
OTULIN OTU deubiquitinase with linear linkage specificity 2.22059
VPS36 vacuolar protein sorting 36 homolog (S. cerevisiae) 2.22059
GRB7 growth factor receptor-bound protein 7 2.21427
EXOSC8 exosome component 8 2.2095
TFG TRK-fused gene 2.17914
SLC2A12 solute carrier family 2 (facilitated glucose transporter), member 12 2.16898
GABARAP GABA(A) receptor-associated protein 2.16563
KLHDC4 kelch domain containing 4 2.16417
ZNF782 zinc finger protein 782 2.14517
ATP5MC3 ATP synthase membrane subunit c locus 3 2.12998
MED27 mediator complex subunit 27 2.12998
CSDE1 cold shock domain containing E1, RNA-binding 2.12998
SDCCAG8 serologically defined colon cancer antigen 8 2.12599
CLDN7 claudin 7 2.11611
KLC2 kinesin light chain 2 2.11611
RECQL5 RecQ protein-like 5 2.11611
SGSM3 small G protein signaling modulator 3 2.11611
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12 2.11414
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 2.11414
ZNF644 zinc finger protein 644 2.10295
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 2.0838
TPI1 triosephosphate isomerase 1 2.08281
ZIC1 Zic family member 1 2.05581
TMCO6 transmembrane and coiled-coil domains 6 2.05492
WDR82 WD repeat domain 82 2.05345
PNMA8A PNMA family member 8A 2.04695
UPRT uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae) 2.04608
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 2.02771
KIAA0930 KIAA0930 2.00998

decreased expression

Symbol Name Standardized Value
UNC13C unc-13 homolog C (C. elegans) -3.40629
SPINT4 serine peptidase inhibitor, Kunitz type 4 -3.40629
DNAH8 dynein, axonemal, heavy chain 8 -3.40629
SAMD15 sterile alpha motif domain containing 15 -3.40629
ZAR1L zygote arrest 1-like -3.40629
CD8A CD8a molecule -3.40629
PRDM7 PR domain containing 7 -3.40629
ANKRD62 ankyrin repeat domain 62 -3.40629
ZMYND15 zinc finger, MYND-type containing 15 -3.40629
PCDHGB5 protocadherin gamma subfamily B, 5 -3.40629
DOK7 docking protein 7 -3.40629
KRTAP13-4 keratin associated protein 13-4 -3.40629
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 -3.40629
ALOX15 arachidonate 15-lipoxygenase -3.40629
HBA2 hemoglobin, alpha 2 -3.40629
FPR3 formyl peptide receptor 3 -3.40629
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 -3.40629
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic -3.40629
B3GNT9 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 -3.40629
CATSPERD catsper channel auxiliary subunit delta -3.40629
LDHC lactate dehydrogenase C -3.40629
HAPLN1 hyaluronan and proteoglycan link protein 1 -3.40629
ACRBP acrosin binding protein -3.40629
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 -3.40629
LCT lactase -3.40629
CERKL ceramide kinase-like -3.40629
STYXL2 serine/threonine/tyrosine interacting like 2 -3.40629
MDGA1 MAM domain containing glycosylphosphatidylinositol anchor 1 -3.40629
CLEC1A C-type lectin domain family 1, member A -3.40629
STING1 stimulator of interferon response cGAMP interactor 1 -3.40629
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C -3.40629
DND1 DND microRNA-mediated repression inhibitor 1 -3.40629
LOXHD1 lipoxygenase homology domains 1 -3.40629
ANKRD63 ankyrin repeat domain 63 -3.40629
SPATA9 spermatogenesis associated 9 -3.40629
CFAP157 cilia and flagella associated protein 157 -3.40629
DCDC2B doublecortin domain containing 2B -3.40629
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2 -3.40629
IGFBP3 insulin-like growth factor binding protein 3 -3.34232
HSF5 heat shock transcription factor family member 5 -3.34232
KIAA1614 KIAA1614 -3.15425
DTX4 deltex 4, E3 ubiquitin ligase -2.90303
FHL1 four and a half LIM domains 1 -2.82075
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -2.77326
CENPX centromere protein X -2.76673
RIT1 Ras-like without CAAX 1 -2.69728
C1ORF54 chromosome 1 open reading frame 54 -2.66485
FKTN fukutin -2.5817
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 -2.53992
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 -2.53011
CAVIN4 caveolae associated protein 4 -2.5236
RASL11A RAS-like, family 11, member A -2.5089
CNTRL centriolin -2.44905
MYO9B myosin IXB -2.44001
FAM228B family with sequence similarity 228, member B -2.43174
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1 -2.42928
DUSP7 dual specificity phosphatase 7 -2.39352
THAP12 THAP domain containing 12 -2.39047
SPRY2 sprouty homolog 2 (Drosophila) -2.35539
SMTNL1 smoothelin-like 1 -2.35325
ANKRD65 ankyrin repeat domain 65 -2.35325
TMEM170A transmembrane protein 170A -2.35325
TRIM72 tripartite motif containing 72, E3 ubiquitin protein ligase -2.35325
TEKTIP1 tektin bundle interacting protein 1 -2.35311
H3C1 H3 clustered histone 1 -2.35311
PCDHA5 protocadherin alpha 5 -2.35311
SMIM47 small integral membrane protein 47 -2.35311
QRFPR pyroglutamylated RFamide peptide receptor -2.35311
RUMY3 RUMY family member 3 -2.35311
PCSK2 proprotein convertase subtilisin/kexin type 2 -2.35311
GJC1 gap junction protein, gamma 1, 45kDa -2.35311
GUCY2D guanylate cyclase 2D, membrane (retina-specific) -2.35311
PARP11 poly (ADP-ribose) polymerase family, member 11 -2.32534
CNTN4 contactin 4 -2.32534
BICC1 BicC family RNA binding protein 1 -2.31893
PEX11A peroxisomal biogenesis factor 11 alpha -2.31893
PLA2G10 phospholipase A2, group X -2.30558
TERB1 telomere repeat binding bouquet formation protein 1 -2.30558
PNRC1 proline-rich nuclear receptor coactivator 1 -2.29443
CEP55 centrosomal protein 55kDa -2.28781
ZNF135 zinc finger protein 135 -2.27716
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0 -2.23345
TENT5A terminal nucleotidyltransferase 5A -2.23345
MMP24OS MMP24 opposite strand -2.22789
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase -2.22128
ZNF626 zinc finger protein 626 -2.22059
HECA headcase homolog (Drosophila) -2.22059
PORCN porcupine homolog (Drosophila) -2.19599
PMEL premelanosome protein -2.17196
FCSK fucose kinase -2.16956
TMPRSS11E transmembrane protease, serine 11E -2.16563
CER1 cerberus 1, DAN family BMP antagonist -2.16563
GJB1 gap junction protein, beta 1, 32kDa -2.16563
CD226 CD226 molecule -2.16563
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -2.16417
TM2D3 TM2 domain containing 3 -2.11711
CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 -2.11711
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 -2.11414
GAB1 GRB2-associated binding protein 1 -2.11414
TSR3 TSR3, 20S rRNA accumulation, homolog (S. cerevisiae) -2.11414
PNCK pregnancy up-regulated nonubiquitous CaM kinase -2.11414
ZNF180 zinc finger protein 180 -2.10733
ATG9B autophagy related 9B -2.10295
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1 -2.09141
ASPHD2 aspartate beta-hydroxylase domain containing 2 -2.0838
ANKRD46 ankyrin repeat domain 46 -2.07951
JADE1 jade family PHD finger 1 -2.07951
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 -2.05581
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 -2.04836
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 -2.04695
RIOK3 RIO kinase 3 -2.04608
OXR1 oxidation resistance 1 -2.03111
ADAM17 ADAM metallopeptidase domain 17 -2.01939
TTBK2 tau tubulin kinase 2 -2.01875
VPS9D1 VPS9 domain containing 1 -2.01093
IRF6 interferon regulatory factor 6 -2.00643