RB_P130_DN.V1 Gene Set

Dataset MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations
Category transcriptomics
Type gene perturbation
Description gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/RB_P130_DN.V1_UP
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Genes

272 genes differentially expressed following the RB_P130_DN.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.

increased expression

Symbol Name
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4
ADCK3 aarF domain containing kinase 3
ALK anaplastic lymphoma receptor tyrosine kinase
ANAPC5 anaphase promoting complex subunit 5
AQP5 aquaporin 5
ART1 ADP-ribosyltransferase 1
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
ATP2A3 ATPase, Ca++ transporting, ubiquitous
AURKA aurora kinase A
AURKB aurora kinase B
AVP arginine vasopressin
B4GALT4 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4
BIRC5 baculoviral IAP repeat containing 5
C11ORF31 chromosome 11 open reading frame 31
C11ORF71 chromosome 11 open reading frame 71
C12ORF10 chromosome 12 open reading frame 10
C9ORF89 chromosome 9 open reading frame 89
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCNB2 cyclin B2
CDC7 cell division cycle 7
CDK1 cyclin-dependent kinase 1
CHCHD6 coiled-coil-helix-coiled-coil-helix domain containing 6
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
CMTM7 CKLF-like MARVEL transmembrane domain containing 7
COL11A2 collagen, type XI, alpha 2
CRB3 crumbs family member 3
CRLF1 cytokine receptor-like factor 1
CRTAC1 cartilage acidic protein 1
CUEDC2 CUE domain containing 2
CYBA cytochrome b-245, alpha polypeptide
DCTPP1 dCTP pyrophosphatase 1
DUSP13 dual specificity phosphatase 13
EFTUD2 elongation factor Tu GTP binding domain containing 2
EIF1B eukaryotic translation initiation factor 1B
ELOF1 elongation factor 1 homolog (S. cerevisiae)
ENKD1 enkurin domain containing 1
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
EXOSC2 exosome component 2
FADS2 fatty acid desaturase 2
FAM187A family with sequence similarity 187, member A
FAM220A family with sequence similarity 220, member A
FAM64A family with sequence similarity 64, member A
FAM73B family with sequence similarity 73, member B
FGF10 fibroblast growth factor 10
FOXI1 forkhead box I1
FST follistatin
GC group-specific component (vitamin D binding protein)
GFER growth factor, augmenter of liver regeneration
GLIS2 GLIS family zinc finger 2
GPN3 GPN-loop GTPase 3
GREM2 gremlin 2, DAN family BMP antagonist
GRTP1 growth hormone regulated TBC protein 1
H2AFB1 H2A histone family, member B1
HINT1 histidine triad nucleotide binding protein 1
HMGA2 high mobility group AT-hook 2
HYAL3 hyaluronoglucosaminidase 3
ICA1 islet cell autoantigen 1, 69kDa
IER3 immediate early response 3
KAZN kazrin, periplakin interacting protein
KIF20A kinesin family member 20A
KIF22 kinesin family member 22
LITAF lipopolysaccharide-induced TNF factor
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MBD3 methyl-CpG binding domain protein 3
MRAS muscle RAS oncogene homolog
MYLK myosin light chain kinase
MYOZ2 myozenin 2
NKD2 naked cuticle homolog 2 (Drosophila)
NKX2-8 NK2 homeobox 8
NPPB natriuretic peptide B
NSMCE1 non-SMC element 1 homolog (S. cerevisiae)
NXNL1 nucleoredoxin-like 1
OAF OAF homolog (Drosophila)
ORC1 origin recognition complex, subunit 1
OXLD1 oxidoreductase-like domain containing 1
PARS2 prolyl-tRNA synthetase 2, mitochondrial (putative)
PCSK5 proprotein convertase subtilisin/kexin type 5
PDZK1 PDZ domain containing 1
PF4 platelet factor 4
PIWIL1 piwi-like RNA-mediated gene silencing 1
POLD2 polymerase (DNA directed), delta 2, accessory subunit
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PPP1R15B protein phosphatase 1, regulatory subunit 15B
QTRT1 queuine tRNA-ribosyltransferase 1
RABEPK Rab9 effector protein with kelch motifs
RACGAP1 Rac GTPase activating protein 1
RAD51D RAD51 paralog D
RASA4 RAS p21 protein activator 4
RASD1 RAS, dexamethasone-induced 1
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
RENBP renin binding protein
RGL3 ral guanine nucleotide dissociation stimulator-like 3
RGS16 regulator of G-protein signaling 16
RHOJ ras homolog family member J
RIPK3 receptor-interacting serine-threonine kinase 3
RSPH9 radial spoke head 9 homolog (Chlamydomonas)
RUVBL2 RuvB-like AAA ATPase 2
SDF2L1 stromal cell-derived factor 2-like 1
SEMA5B sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
SGSM3 small G protein signaling modulator 3
SIM1 single-minded family bHLH transcription factor 1
SIM2 single-minded family bHLH transcription factor 2
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC13A2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
SLC22A3 solute carrier family 22 (organic cation transporter), member 3
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC43A3 solute carrier family 43, member 3
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
SNN stannin
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SNRPC small nuclear ribonucleoprotein polypeptide C
SNTA1 syntrophin, alpha 1
SPATA13 spermatogenesis associated 13
STAT5B signal transducer and activator of transcription 5B
STMN3 stathmin-like 3
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TAL2 T-cell acute lymphocytic leukemia 2
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor)
TINAG tubulointerstitial nephritis antigen
TK1 thymidine kinase 1, soluble
TMEM151B transmembrane protein 151B
TRAF2 TNF receptor-associated factor 2
TRAF4 TNF receptor-associated factor 4
TWIST2 twist family bHLH transcription factor 2
UBE2C ubiquitin-conjugating enzyme E2C
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
VSIG2 V-set and immunoglobulin domain containing 2
WNT2B wingless-type MMTV integration site family, member 2B
ZBTB12 zinc finger and BTB domain containing 12
ZBTB17 zinc finger and BTB domain containing 17
ZNF428 zinc finger protein 428

decreased expression

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
AKAP9 A kinase (PRKA) anchor protein 9
ANKFY1 ankyrin repeat and FYVE domain containing 1
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
ARHGAP24 Rho GTPase activating protein 24
ARRDC4 arrestin domain containing 4
ASB13 ankyrin repeat and SOCS box containing 13
ATAD1 ATPase family, AAA domain containing 1
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
ATP9B ATPase, class II, type 9B
AVL9 AVL9 homolog (S. cerevisiase)
B2M beta-2-microglobulin
BNC1 basonuclin 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C10ORF99 chromosome 10 open reading frame 99
C17ORF62 chromosome 17 open reading frame 62
C3ORF70 chromosome 3 open reading frame 70
C9ORF72 chromosome 9 open reading frame 72
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CASP6 caspase 6, apoptosis-related cysteine peptidase
CD1D CD1d molecule
CHMP1B charged multivesicular body protein 1B
CLIP1 CAP-GLY domain containing linker protein 1
CLU clusterin
COPB1 coatomer protein complex, subunit beta 1
CSDE1 cold shock domain containing E1, RNA-binding
CTSB cathepsin B
CTSC cathepsin C
CTSK cathepsin K
CXCL12 chemokine (C-X-C motif) ligand 12
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46
DEFB1 defensin, beta 1
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7
DSP desmoplakin
DSTYK dual serine/threonine and tyrosine protein kinase
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2
EBPL emopamil binding protein-like
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
EIF3J eukaryotic translation initiation factor 3, subunit J
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
ERAP1 endoplasmic reticulum aminopeptidase 1
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)
EVI5 ecotropic viral integration site 5
FAM214B family with sequence similarity 214, member B
FAM32A family with sequence similarity 32, member A
FBXO28 F-box protein 28
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45A growth arrest and DNA-damage-inducible, alpha
GAS5 growth arrest-specific 5 (non-protein coding)
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GJB2 gap junction protein, beta 2, 26kDa
GLO1 glyoxalase I
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
GNS glucosamine (N-acetyl)-6-sulfatase
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)
GUCA2A guanylate cyclase activator 2A (guanylin)
HACD2 3-hydroxyacyl-CoA dehydratase 2
HK2 hexokinase 2
HLA-G major histocompatibility complex, class I, G
HSPA1B heat shock 70kDa protein 1B
HTRA1 HtrA serine peptidase 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDI1 isopentenyl-diphosphate delta isomerase 1
IFITM10 interferon induced transmembrane protein 10
KDM5B lysine (K)-specific demethylase 5B
KIAA1161 KIAA1161
KIF16B kinesin family member 16B
KLK6 kallikrein-related peptidase 6
KLK7 kallikrein-related peptidase 7
KRT1 keratin 1, type II
KRT10 keratin 10, type I
KRT6B keratin 6B, type II
KRT79 keratin 79, type II
LAMP1 lysosomal-associated membrane protein 1
LAMP2 lysosomal-associated membrane protein 2
LGALSL lectin, galactoside-binding-like
LIFR leukemia inhibitory factor receptor alpha
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
MFN1 mitofusin 1
MORC3 MORC family CW-type zinc finger 3
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
NCL nucleolin
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NRARP NOTCH-regulated ankyrin repeat protein
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
PARP9 poly (ADP-ribose) polymerase family, member 9
PCDHB17P protocadherin beta 17 pseudogene
PLBD1 phospholipase B domain containing 1
PNRC2 proline-rich nuclear receptor coactivator 2
PRPF38B pre-mRNA processing factor 38B
PVRL4 poliovirus receptor-related 4
PYROXD1 pyridine nucleotide-disulphide oxidoreductase domain 1
RAB24 RAB24, member RAS oncogene family
RAB8B RAB8B, member RAS oncogene family
RAP2C RAP2C, member of RAS oncogene family
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RB1 retinoblastoma 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RHOV ras homolog family member V
RNASET2 ribonuclease T2
RRAGA Ras-related GTP binding A
RRAS related RAS viral (r-ras) oncogene homolog
SCAMP1 secretory carrier membrane protein 1
SCEL sciellin
SEC23A Sec23 homolog A (S. cerevisiae)
SEC24C SEC24 family member C
SELK selenoprotein K
SH3BP5L SH3-binding domain protein 5-like
SLC10A6 solute carrier family 10 (sodium/bile acid cotransporter), member 6
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC35F6 solute carrier family 35, member F6
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SMIM14 small integral membrane protein 14
SNX2 sorting nexin 2
SOX21 SRY (sex determining region Y)-box 21
SPG11 spastic paraplegia 11 (autosomal recessive)
SPOP speckle-type POZ protein
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TFB2M transcription factor B2, mitochondrial
TMEM123 transmembrane protein 123
TMEM140 transmembrane protein 140
TMEM87A transmembrane protein 87A
TOMM34 translocase of outer mitochondrial membrane 34
TXLNG taxilin gamma
TXNDC9 thioredoxin domain containing 9
TYW5 tRNA-yW synthesizing protein 5
UBXN4 UBX domain protein 4
UHRF1BP1L UHRF1 binding protein 1-like
USP18 ubiquitin specific peptidase 18
USP47 ubiquitin specific peptidase 47
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
WDR26 WD repeat domain 26
ZDHHC20 zinc finger, DHHC-type containing 20
ZMPSTE24 zinc metallopeptidase STE24