REC8 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description REC8 meiotic recombination protein|This gene encodes a member of the kleisin family of SMC (structural maintenance of chromosome) protein partners. The protein localizes to the axial elements of chromosomes during meiosis in both oocytes and spermatocytes. In the mouse, the homologous protein is a key component of the meiotic cohesion complex, which regulates sister chromatid cohesion and recombination between homologous chromosomes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 9985)
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Genes

366 genes differentially expressed following the REC8 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
TLR9 toll-like receptor 9 3.44758
BMP3 bone morphogenetic protein 3 3.44758
SP5 Sp5 transcription factor 3.44758
SP9 Sp9 transcription factor 3.44758
HMX2 H6 family homeobox 2 3.44758
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) 3.44758
NMUR2 neuromedin U receptor 2 3.44758
HIC1 hypermethylated in cancer 1 3.44758
HES2 hes family bHLH transcription factor 2 3.44758
TBX3 T-box 3 3.44758
PTK6 protein tyrosine kinase 6 3.44758
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28 3.44758
HCST hematopoietic cell signal transducer 3.44758
TDRD9 tudor domain containing 9 3.44758
OR2AJ1 olfactory receptor, family 2, subfamily AJ, member 1 3.44758
MIA melanoma inhibitory activity 3.44758
KHDC3L KH domain containing 3-like, subcortical maternal complex member 3.44758
CD68 CD68 molecule 3.44758
NPIPA3 nuclear pore complex interacting protein family, member A3 3.44758
SETSIP SET-like protein 3.44758
S100B S100 calcium binding protein B 3.44758
SPAG8 sperm associated antigen 8 3.44758
OXER1 oxoeicosanoid (OXE) receptor 1 3.44758
LTB lymphotoxin beta (TNF superfamily, member 3) 3.44758
DNAH8 dynein, axonemal, heavy chain 8 3.44758
ANGPTL5 angiopoietin-like 5 3.44758
HEPACAM hepatic and glial cell adhesion molecule 3.44758
ANXA8 annexin A8 3.44758
MTTP microsomal triglyceride transfer protein 3.44758
PARVG parvin, gamma 3.44758
ACE2 angiotensin I converting enzyme 2 3.44758
FRK fyn-related Src family tyrosine kinase 3.44758
NLRP5 NLR family, pyrin domain containing 5 3.44758
GSC goosecoid homeobox 3.44758
PCDHGA12 protocadherin gamma subfamily A, 12 3.44758
PRSS21 protease, serine, 21 (testisin) 3.44758
CELA2A chymotrypsin-like elastase family, member 2A 3.44758
MEIG1 meiosis/spermiogenesis associated 1 3.44758
CD34 CD34 molecule 3.44758
ISLR2 immunoglobulin superfamily containing leucine-rich repeat 2 3.44758
CLEC17A C-type lectin domain family 17, member A 3.44758
LYZL1 lysozyme-like 1 3.44758
PTGER4 prostaglandin E receptor 4 (subtype EP4) 3.44758
HNF4A hepatocyte nuclear factor 4, alpha 3.44758
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1 3.44758
FGD2 FYVE, RhoGEF and PH domain containing 2 3.44758
TUBA3E tubulin, alpha 3e 3.44758
TRH thyrotropin-releasing hormone 3.44758
HEATR9 HEAT repeat containing 9 3.44758
ANKRD22 ankyrin repeat domain 22 3.44758
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 3.44758
CCDC17 coiled-coil domain containing 17 3.44758
MAP3K7CL MAP3K7 C-terminal like 3.44758
PCDHA5 protocadherin alpha 5 3.44758
CEMP1 cementum protein 1 3.44758
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 3.44758
SRL sarcalumenin 3.44758
FABP9 fatty acid binding protein 9, testis 3.44758
SIX3 SIX homeobox 3 3.44758
SIX6 SIX homeobox 6 3.44758
TMPRSS11A transmembrane protease, serine 11A 3.44758
FAM90A26 family with sequence similarity 90, member A26, pseudogene 3.44758
CATSPERH catsper channel auxiliary subunit eta 3.44758
PKP1 plakophilin 1 3.44758
DEFB1 defensin, beta 1 3.44758
ARSF arylsulfatase F 3.44758
REN renin 3.44758
GFI1 growth factor independent 1 transcription repressor 3.44758
OTUD6A OTU deubiquitinase 6A 3.44758
PTGFR prostaglandin F receptor (FP) 3.44758
OR2A14 olfactory receptor, family 2, subfamily A, member 14 3.44758
HAPLN2 hyaluronan and proteoglycan link protein 2 3.44758
F8A2 coagulation factor VIII-associated 2 3.44758
GPR20 G protein-coupled receptor 20 3.44758
GPR21 G protein-coupled receptor 21 3.44758
C19ORF67 chromosome 19 open reading frame 67 3.44758
VIT vitrin 3.44758
CCL5 chemokine (C-C motif) ligand 5 3.44758
GJB1 gap junction protein, beta 1, 32kDa 3.44758
HBA1 hemoglobin, alpha 1 3.44758
LGALS7B lectin, galactoside-binding, soluble, 7B 3.44758
CSTL1 cystatin-like 1 3.44758
FNDC7 fibronectin type III domain containing 7 3.44758
SSTR5 somatostatin receptor 5 3.44758
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa 3.44758
CLRN2 clarin 2 3.44758
MUC13 mucin 13, cell surface associated 3.44758
CFAP276 cilia and flagella associated protein 276 3.44758
ATOH1 atonal homolog 1 (Drosophila) 3.44758
MYMK myomaker, myoblast fusion factor 3.44758
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 3.44758
MDFIC2 MyoD family inhibitor domain containing 2 3.44758
C20ORF144 chromosome 20 open reading frame 144 3.44758
ZC3H11D zinc finger CCCH-type containing 11D 3.44758
WNT7B wingless-type MMTV integration site family, member 7B 3.44758
SCGB1D2 secretoglobin, family 1D, member 2 3.44758
ODF4 outer dense fiber of sperm tails 4 3.44758
NOX1 NADPH oxidase 1 3.44758
PRAMEF12 PRAME family member 12 3.44758
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 3.44758
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 3.44758
HKDC1 hexokinase domain containing 1 3.44758
CDH19 cadherin 19, type 2 3.44758
PSKH2 protein serine kinase H2 3.44758
TLR10 toll-like receptor 10 3.44758
CFAP61 cilia and flagella associated protein 61 3.44758
TPPP3 tubulin polymerization-promoting protein family member 3 3.44758
IGIP IgA-inducing protein 3.44758
ERVV-1 endogenous retrovirus group V, member 1 3.44758
CCDC78 coiled-coil domain containing 78 3.44758
PLA2G5 phospholipase A2, group V 3.44758
ZNF831 zinc finger protein 831 3.44758
GOLGA8S golgin A8 family, member S 3.44758
DMRTB1 DMRT-like family B with proline-rich C-terminal, 1 3.44758
CFB complement factor B 3.44758
CIMIP2B ciliary microtubule inner protein 2B 3.44758
CIMAP1D CIMAP1 family member D 3.44758
GCGR glucagon receptor 3.44758
SCNN1B sodium channel, non voltage gated 1 beta subunit 3.44758
PDCD1LG2 programmed cell death 1 ligand 2 3.44758
SIGLEC15 sialic acid binding Ig-like lectin 15 3.44758
CIMAP1B ciliary microtubule associated protein 1B 3.44758
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 3.44758
CDH17 cadherin 17, LI cadherin (liver-intestine) 3.44758
GPR61 G protein-coupled receptor 61 3.44758
ADGRD1 adhesion G protein-coupled receptor D1 3.44758
APOH apolipoprotein H (beta-2-glycoprotein I) 3.44758
OR52E4 olfactory receptor, family 52, subfamily E, member 4 3.44758
CD80 CD80 molecule 3.44758
NEURL3 neuralized E3 ubiquitin protein ligase 3 3.44758
GEMIN7 gem (nuclear organelle) associated protein 7 3.44758
PATE1 prostate and testis expressed 1 3.44758
VTCN1 V-set domain containing T cell activation inhibitor 1 3.44758
TMPRSS4 transmembrane protease, serine 4 3.44758
ADGRF4 adhesion G protein-coupled receptor F4 3.44758
CAPN9 calpain 9 3.44758
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 3.44758
FOXC1 forkhead box C1 3.44758
RTN4RL1 reticulon 4 receptor-like 1 3.44758
C10ORF90 chromosome 10 open reading frame 90 3.44758
ARGFX arginine-fifty homeobox 3.44758
FOXP3 forkhead box P3 3.44758
SYTL4 synaptotagmin-like 4 3.44758
BIN2 bridging integrator 2 3.44758
GRAP GRB2-related adaptor protein 3.44758
DUOXA1 dual oxidase maturation factor 1 3.44758
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 3.44758
PRR15L proline rich 15-like 3.44758
TBC1D21 TBC1 domain family, member 21 3.44758
TMEM132D transmembrane protein 132D 3.44758
MRLN myoregulin 3.44758
CNTF ciliary neurotrophic factor 3.44758
ERICH3 glutamate-rich 3 3.44758
RAD21L1 RAD21-like 1 (S. pombe) 3.44758
GARIN3 golgi associated RAB2B interactor family member 3 3.44758
OXGR1 oxoglutarate (alpha-ketoglutarate) receptor 1 3.44758
MAJIN membrane anchored junction protein 3.44758
SYNE3 spectrin repeat containing, nuclear envelope family member 3 3.44758
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 3.44758
SOFU1 sperm-oocyte fusion factor 1 3.44758
AQP7 aquaporin 7 3.44758
CIDEA cell death-inducing DFFA-like effector a 3.44758
GIPC3 GIPC PDZ domain containing family, member 3 3.44758
COL11A2 collagen, type XI, alpha 2 3.44758
OR8H1 olfactory receptor, family 8, subfamily H, member 1 3.44758
OR9Q1 olfactory receptor, family 9, subfamily Q, member 1 3.44758
STING1 stimulator of interferon response cGAMP interactor 1 3.44758
RAB6D RAB6D, member RAS oncogene family 3.44758
PCDHGB1 protocadherin gamma subfamily B, 1 3.44758
FPR3 formyl peptide receptor 3 3.33366
CDC7 cell division cycle 7 3.2763
GTF2H5 general transcription factor IIH, polypeptide 5 3.09557
ALKBH8 alkB, alkylation repair homolog 8 (E. coli) 3.04863
SRPK2 SRSF protein kinase 2 2.98355
INHBE inhibin, beta E 2.89213
RIOX2 ribosomal oxygenase 2 2.84307
SPMIP6 sperm microtubule inner protein 6 2.82368
DTX1 deltex 1, E3 ubiquitin ligase 2.77297
TSC22D1 TSC22 domain family, member 1 2.63717
NDUFA12 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12 2.62037
ILRUN inflammation and lipid regulator with UBA-like and NBR1-like domains 2.57121
CCDC74A coiled-coil domain containing 74A 2.56934
POU2F1 POU class 2 homeobox 1 2.5639
ZNF322 zinc finger protein 322 2.54493
TEX19 testis expressed 19 2.53199
USP54 ubiquitin specific peptidase 54 2.50982
ZC3H13 zinc finger CCCH-type containing 13 2.46358
SMG9 SMG9 nonsense mediated mRNA decay factor 2.46358
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 2.44354
PHLDB3 pleckstrin homology-like domain, family B, member 3 2.40695
NRP1 neuropilin 1 2.36778
PTGER3 prostaglandin E receptor 3 (subtype EP3) 2.33799
SSC5D scavenger receptor cysteine rich family, 5 domains 2.33799
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 2.33799
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 2.33266
RIC3 RIC3 acetylcholine receptor chaperone 2.32776
WNT5A wingless-type MMTV integration site family, member 5A 2.32041
CHPF chondroitin polymerizing factor 2.31358
GPM6B glycoprotein M6B 2.30887
CCNC cyclin C 2.29882
FBRS fibrosin 2.29415
FOXL2 forkhead box L2 2.26958
ZNF491 zinc finger protein 491 2.24207
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 2.20125
KLHL29 kelch-like family member 29 2.18999
NUTM2G NUT family member 2G 2.18702
CLASP1 cytoplasmic linker associated protein 1 2.17696
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 2.15882
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 2.15766
TMEM167A transmembrane protein 167A 2.14802
CPNE8 copine VIII 2.1381
AXL AXL receptor tyrosine kinase 2.11852
TPM1 tropomyosin 1 (alpha) 2.11852
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 2.11852
NBN nibrin 2.11852
CRABP2 cellular retinoic acid binding protein 2 2.10841
FAN1 FANCD2/FANCI-associated nuclease 1 2.10841
PPP1R3E protein phosphatase 1, regulatory subunit 3E 2.09673
NIBAN2 niban apoptosis regulator 2 2.08364
ZCCHC8 zinc finger, CCHC domain containing 8 2.08342
GSTCD glutathione S-transferase, C-terminal domain containing 2.08273
MRPL55 mitochondrial ribosomal protein L55 2.06318
DUSP16 dual specificity phosphatase 16 2.06037
PNPLA3 patatin-like phospholipase domain containing 3 2.05141
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.05022
EPS15 epidermal growth factor receptor pathway substrate 15 2.04151
MLKL mixed lineage kinase domain-like 2.0222
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 2.01295
IL12RB2 interleukin 12 receptor, beta 2 2.01295
MAP3K12 mitogen-activated protein kinase kinase kinase 12 2.00324
TMEM131L transmembrane 131 like 2.00037

decreased expression

Symbol Name Standardized Value
OR2H2 olfactory receptor, family 2, subfamily H, member 2 -3.44758
RFPL2 ret finger protein-like 2 -3.44758
LYST lysosomal trafficking regulator -3.44758
PCDHB4 protocadherin beta 4 -3.44758
NXPH3 neurexophilin 3 -3.44758
NXPH4 neurexophilin 4 -3.44758
SPINK1 serine peptidase inhibitor, Kazal type 1 -3.44758
F11 coagulation factor XI -3.44758
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) -3.44758
DERL3 derlin 3 -3.44758
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 -3.44758
CFAP54 cilia and flagella associated 54 -3.44758
RERGL RERG/RAS-like -3.44758
RNF222 ring finger protein 222 -3.44758
DEFB134 defensin, beta 134 -3.44758
FZD9 frizzled class receptor 9 -3.44758
FZD1 frizzled class receptor 1 -3.44758
CCNO cyclin O -3.44758
GPR179 G protein-coupled receptor 179 -3.44758
POPDC2 popeye domain containing 2 -3.44758
MYBPHL myosin binding protein H-like -3.44758
PIGA phosphatidylinositol glycan anchor biosynthesis, class A -3.44758
LGALS12 lectin, galactoside-binding, soluble, 12 -3.44758
FMO3 flavin containing monooxygenase 3 -3.44758
RAG1 recombination activating gene 1 -3.44758
RIN1 Ras and Rab interactor 1 -3.44758
NSG2 neuronal vesicle trafficking associated 2 -3.44758
AOC2 amine oxidase, copper containing 2 (retina-specific) -3.44758
MARCHF10 membrane associated ring-CH-type finger 10 -3.44758
PEAK3 PEAK family member 3 -3.44758
SMIM43 small integral membrane protein 43 -3.44758
CCDC177 coiled-coil domain containing 177 -3.44758
TBC1D3L TBC1 domain family, member 3L -3.44758
LOC124901449 uncharacterized LOC124901449 -3.44758
IZUMO4 IZUMO family member 4 -3.44758
IRF5 interferon regulatory factor 5 -3.44758
DMBX1 diencephalon/mesencephalon homeobox 1 -3.44758
OTUD1 OTU deubiquitinase 1 -3.44758
CALR3 calreticulin 3 -3.44758
CTXN2 cortexin 2 -3.44758
SMIM17 small integral membrane protein 17 -3.44758
MYOT myotilin -3.44758
TMEM171 transmembrane protein 171 -3.34031
DCUN1D3 DCN1, defective in cullin neddylation 1, domain containing 3 -3.16888
RAP2B RAP2B, member of RAS oncogene family -3.16888
FBXL6 F-box and leucine-rich repeat protein 6 -3.07452
CC2D2B coiled-coil and C2 domain containing 2B -3.05315
ZNF562 zinc finger protein 562 -2.98583
VWA5B1 von Willebrand factor A domain containing 5B1 -2.95137
PRLR prolactin receptor -2.8012
HLA-B major histocompatibility complex, class I, B -2.732
ZNF784 zinc finger protein 784 -2.64354
LRRC8E leucine rich repeat containing 8 family, member E -2.64354
GALK1 galactokinase 1 -2.63717
PBX4 pre-B-cell leukemia homeobox 4 -2.59078
RFTN2 raftlin family member 2 -2.55466
ZNF75D zinc finger protein 75D -2.55456
FBXO16 F-box protein 16 -2.52748
TRMT9B tRNA methyltransferase 9B (putative) -2.4989
ARL11 ADP-ribosylation factor-like 11 -2.48443
LEKR1 leucine, glutamate and lysine rich 1 -2.48443
TP53BP2 tumor protein p53 binding protein 2 -2.47453
GPRIN2 G protein regulated inducer of neurite outgrowth 2 -2.46666
FKBP2 FK506 binding protein 2, 13kDa -2.44354
CLTC clathrin, heavy chain (Hc) -2.44354
TM4SF18 transmembrane 4 L six family member 18 -2.44354
DENND2B DENN domain containing 2B -2.4353
MAGEE1 melanoma antigen family E1 -2.43037
IGSF10 immunoglobulin superfamily, member 10 -2.43037
RGL4 ral guanine nucleotide dissociation stimulator-like 4 -2.428
ACADSB acyl-CoA dehydrogenase, short/branched chain -2.428
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 -2.428
H2AC16 H2A clustered histone 16 -2.428
NR1D1 nuclear receptor subfamily 1, group D, member 1 -2.428
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria -2.42655
ABHD14B abhydrolase domain containing 14B -2.40695
FXYD5 FXYD domain containing ion transport regulator 5 -2.39278
SARDH sarcosine dehydrogenase -2.39278
TARS3 threonyl-tRNA synthetase 3 -2.39278
DOLPP1 dolichyldiphosphatase 1 -2.37898
SHISAL2A shisa like 2A -2.37898
MIXL1 Mix paired-like homeobox -2.36559
PBX2 pre-B-cell leukemia homeobox 2 -2.34218
GAB3 GRB2-associated binding protein 3 -2.33541
RGPD6 RANBP2-like and GRIP domain containing 6 -2.33541
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9 -2.33235
SH3BP5L SH3-binding domain protein 5-like -2.33045
RYR2 ryanodine receptor 2 (cardiac) -2.32593
NOS3 nitric oxide synthase 3 (endothelial cell) -2.32044
FRAT1 frequently rearranged in advanced T-cell lymphomas 1 -2.31987
USP44 ubiquitin specific peptidase 44 -2.29894
PPM1N protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative) -2.29554
GANC glucosidase, alpha; neutral C -2.27937
ATP5MJ ATP synthase membrane subunit j -2.27937
C19ORF44 chromosome 19 open reading frame 44 -2.27582
GRAMD4 GRAM domain containing 4 -2.27582
ARID5A AT rich interactive domain 5A (MRF1-like) -2.27582
INSL6 insulin-like 6 -2.27582
SMIM8 small integral membrane protein 8 -2.27582
SYTL5 synaptotagmin-like 5 -2.26958
CENPH centromere protein H -2.24173
AP4S1 adaptor-related protein complex 4, sigma 1 subunit -2.24011
SDC3 syndecan 3 -2.21562
DDHD2 DDHD domain containing 2 -2.20016
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 -2.18999
LMNB1 lamin B1 -2.18999
TFRC transferrin receptor -2.15759
MEA1 male-enhanced antigen 1 -2.15483
UBN2 ubinuclein 2 -2.15483
PLEKHA3 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3 -2.14459
USP51 ubiquitin specific peptidase 51 -2.1381
FBXL2 F-box and leucine-rich repeat protein 2 -2.1381
MYCBP MYC binding protein -2.1381
NDC80 NDC80 kinetochore complex component -2.12117
BNIP1 BCL2/adenovirus E1B 19kDa interacting protein 1 -2.12117
SF3B1 splicing factor 3b, subunit 1, 155kDa -2.12052
STK32C serine/threonine kinase 32C -2.11852
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2 -2.1153
ACAA1 acetyl-CoA acyltransferase 1 -2.09673
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit -2.08364
ALKBH7 alkB, alkylation repair homolog 7 (E. coli) -2.08152
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 -2.06318
TBC1D31 TBC1 domain family, member 31 -2.06037
GPR75-ASB3 GPR75-ASB3 readthrough -2.04937
NUDT22 nudix (nucleoside diphosphate linked moiety X)-type motif 22 -2.0351
SMC2 structural maintenance of chromosomes 2 -2.01295
TNXB tenascin XB -2.01285
MAPK12 mitogen-activated protein kinase 12 -2.01285
CMC1 C-x(9)-C motif containing 1 -2.01186
HILPDA hypoxia inducible lipid droplet-associated -2.01137
SAP30 Sin3A-associated protein, 30kDa -2.00324
GPC6 glypican 6 -2.00324
RBMS3 RNA binding motif, single stranded interacting protein 3 -2.00037
FBXO30 F-box protein 30 -2.00037
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.00037