RELA Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description v-rel avian reticuloendotheliosis viral oncogene homolog A|NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] (NCBI Entrez Gene Database, 5970)
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Genes

319 genes differentially expressed following the RELA gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SCARA3 scavenger receptor class A, member 3 2.51309
DUXB double homeobox B 2.51309
IZUMO3 IZUMO family member 3 2.51309
XAF1 XIAP associated factor 1 2.51309
KNG1 kininogen 1 2.51309
PTX3 pentraxin 3, long 2.51309
TMEM176B transmembrane protein 176B 2.51309
FGL2 fibrinogen-like 2 2.51309
CD163 CD163 molecule 2.51309
DCAF4L1 DDB1 and CUL4 associated factor 4-like 1 2.51309
CELA3A chymotrypsin-like elastase family, member 3A 2.51309
CHRNG cholinergic receptor, nicotinic, gamma (muscle) 2.51309
VTN vitronectin 2.51309
ALB albumin 2.51309
MEP1A meprin A, alpha (PABA peptide hydrolase) 2.51309
TAS2R5 taste receptor, type 2, member 5 2.51309
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 2.51309
PIGL phosphatidylinositol glycan anchor biosynthesis, class L 2.51309
TSSK4 testis-specific serine kinase 4 2.51309
CFHR3 complement factor H-related 3 2.51309
TPBGL trophoblast glycoprotein-like 2.51309
CST11 cystatin 11 2.51309
SLC6A18 solute carrier family 6 (neutral amino acid transporter), member 18 2.51309
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites 2.51309
PCDHB6 protocadherin beta 6 2.51309
GLYAT glycine-N-acyltransferase 2.51309
TMEM217 transmembrane protein 217 2.51309
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 2.51309
LRRIQ4 leucine-rich repeats and IQ motif containing 4 2.51309
SETSIP SET-like protein 2.51309
ACOT12 acyl-CoA thioesterase 12 2.51309
MYO1A myosin IA 2.51309
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene) 2.51309
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) 2.51309
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 2.51309
KCNU1 potassium channel, subfamily U, member 1 2.51309
MS4A18 membrane-spanning 4-domains, subfamily A, member 18 2.51309
C11ORF87 chromosome 11 open reading frame 87 2.51309
ANKRD34A ankyrin repeat domain 34A 2.51309
HORMAD1 HORMA domain containing 1 2.51309
RIMBP2 RIMS binding protein 2 2.51309
PCDHGB3 protocadherin gamma subfamily B, 3 2.51309
SLC25A41 solute carrier family 25, member 41 2.51309
PTH2 parathyroid hormone 2 2.51309
SIGLEC9 sialic acid binding Ig-like lectin 9 2.51309
BCL7B B-cell CLL/lymphoma 7B 2.51309
RSPO1 R-spondin 1 2.51309
SLC23A3 solute carrier family 23, member 3 2.51309
ARSF arylsulfatase F 2.51309
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 2.51309
FOXD1 forkhead box D1 2.51309
LOC107986837 uncharacterized LOC107986837 2.51309
RAG1 recombination activating gene 1 2.51309
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.51309
GPR33 G protein-coupled receptor 33 (gene/pseudogene) 2.51309
CXCL13 chemokine (C-X-C motif) ligand 13 2.51309
ACER1 alkaline ceramidase 1 2.51309
FMO2 flavin containing monooxygenase 2 (non-functional) 2.51309
FOXN4 forkhead box N4 2.51309
TMPRSS7 transmembrane protease, serine 7 2.51309
TMPRSS5 transmembrane protease, serine 5 2.51309
ADRB1 adrenoceptor beta 1 2.51309
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 2.51309
CCN3 cellular communication network factor 3 2.51309
SMIM38 small integral membrane protein 38 2.51309
SPMIP11 sperm microtubule inner protein 11 2.51309
SPMIP10 sperm microtubule inner protein 10 2.51309
CIMAP1A ciliary microtubule associated protein 1A 2.51309
CIMIP2C ciliary microtubule inner protein 2C 2.51309
ADAMTSL4-AS2 ADAMTSL4 antisense RNA 2 2.51309
MDFIC2 MyoD family inhibitor domain containing 2 2.51309
SPAAR small regulatory polypeptide of amino acid response 2.51309
CFAP97D1 CFAP97 domain containing 1 2.51309
CCDC163 CCDC163 homolog 2.51309
DEPP1 DEPP autophagy regulator 1 2.51309
WNT16 wingless-type MMTV integration site family, member 16 2.51309
ZNF441 zinc finger protein 441 2.51309
TBX3 T-box 3 2.51309
RNF113B ring finger protein 113B 2.51309
CATSPER1 cation channel, sperm associated 1 2.51309
MAL mal, T-cell differentiation protein 2.51309
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 2.51309
DSG1 desmoglein 1 2.51309
MAGEB3 melanoma antigen family B3 2.51309
CLDN9 claudin 9 2.51309
ARL5C ADP-ribosylation factor-like 5C 2.51309
PRB4 proline-rich protein BstNI subfamily 4 2.51309
SPDYC speedy/RINGO cell cycle regulator family member C 2.51309
EXOC3L1 exocyst complex component 3-like 1 2.51309
TACR3 tachykinin receptor 3 2.51309
SPATA22 spermatogenesis associated 22 2.51309
PARVG parvin, gamma 2.51309
NDP Norrie disease (pseudoglioma) 2.51309
DLK2 delta-like 2 homolog (Drosophila) 2.51309
TMEM119 transmembrane protein 119 2.51309
LRRC73 leucine rich repeat containing 73 2.51309
PLEK2 pleckstrin 2 2.51309
FGFBP1 fibroblast growth factor binding protein 1 2.51309
ARHGAP15 Rho GTPase activating protein 15 2.51309
PTH parathyroid hormone 2.51309
CAPN14 calpain 14 2.51309
PRDM1 PR domain containing 1, with ZNF domain 2.51309
PRSS57 protease, serine, 57 2.51309
HAMP hepcidin antimicrobial peptide 2.51309
ERICH4 glutamate-rich 4 2.51309
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 2.51309
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon 2.51309
CDC20B cell division cycle 20B 2.51309
CDHR4 cadherin-related family member 4 2.51309
KLF2 Kruppel-like factor 2 2.51309
RNASE11 ribonuclease, RNase A family, 11 (non-active) 2.51309
CPA2 carboxypeptidase A2 (pancreatic) 2.51309
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 2.51309
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 2.51309
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.51309
PRSS55 protease, serine, 55 2.51309
OR1B1 olfactory receptor, family 1, subfamily B, member 1 (gene/pseudogene) 2.51309
PDCD1 programmed cell death 1 2.51309
KPNA7 karyopherin alpha 7 (importin alpha 8) 2.51309
CMTM5 CKLF-like MARVEL transmembrane domain containing 5 2.51309
CLP1 cleavage and polyadenylation factor I subunit 1 2.51309
PRF1 perforin 1 (pore forming protein) 2.51309
GPR12 G protein-coupled receptor 12 2.51309
ENDOU endonuclease, polyU-specific 2.51309
FNDC1 fibronectin type III domain containing 1 2.51309
MAB21L3 mab-21-like 3 (C. elegans) 2.51309
VWA3B von Willebrand factor A domain containing 3B 2.51309
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene) 2.51309
PDXK pyridoxal (pyridoxine, vitamin B6) kinase 2.51309
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 2.51309
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 2.51309
OTP orthopedia homeobox 2.51309
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 2.51309
ADAM18 ADAM metallopeptidase domain 18 2.51309
GBX2 gastrulation brain homeobox 2 2.51309
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 2.51309
TEX28 testis expressed 28 2.51309
TEX26 testis expressed 26 2.51309
RBBP8NL RBBP8 N-terminal like 2.51309
CFAP126 cilia and flagella associated protein 126 2.51309
CATIP ciliogenesis associated TTC17 interacting protein 2.51309
KLK3 kallikrein-related peptidase 3 2.51309
XBP1 X-box binding protein 1 2.51309
BARHL2 BarH-like homeobox 2 2.51309
CLEC9A C-type lectin domain family 9, member A 2.51309
PENK proenkephalin 2.51309
CTSE cathepsin E 2.51309
ADGRD2 adhesion G protein-coupled receptor D2 2.51309
RGS8 regulator of G-protein signaling 8 2.51309
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 2.51309
ZNF831 zinc finger protein 831 2.51309
CD177 CD177 molecule 2.51309
CLCNKA chloride channel, voltage-sensitive Ka 2.51309
FGF10 fibroblast growth factor 10 2.51309
ITPKA inositol-trisphosphate 3-kinase A 2.51309
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 2.51309
TSKS testis-specific serine kinase substrate 2.51309
ST18 suppression of tumorigenicity 18, zinc finger 2.51309
LY6G5C lymphocyte antigen 6 complex, locus G5C 2.51309
KRTAP4-1 keratin associated protein 4-1 2.51309
SGK2 serum/glucocorticoid regulated kinase 2 2.51309
TMPRSS15 transmembrane protease, serine 15 2.51309
PRSS21 protease, serine, 21 (testisin) 2.51309
ADRA1B adrenoceptor alpha 1B 2.51309
PADI1 peptidyl arginine deiminase, type I 2.51309
ANXA1 annexin A1 2.51309
TAS2R42 taste receptor, type 2, member 42 2.51309
CALD1 caldesmon 1 2.51309
AOC1 amine oxidase, copper containing 1 2.51309
GHRH growth hormone releasing hormone 2.51309
SERHL2 serine hydrolase-like 2 2.51309
NUTM2A NUT family member 2A 2.51309
HES2 hes family bHLH transcription factor 2 2.51309
SLITRK1 SLIT and NTRK-like family, member 1 2.51309
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 2.51309
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma 2.51309
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial 2.51309
LST1 leukocyte specific transcript 1 2.51309
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 2.51309
ALOX15B arachidonate 15-lipoxygenase, type B 2.51309
FZD1 frizzled class receptor 1 2.51309
DBP D site of albumin promoter (albumin D-box) binding protein 2.51309
CSDC2 cold shock domain containing C2, RNA binding 2.46576
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 2.46576
ATAD3A ATPase family, AAA domain containing 3A 2.46576
SAMD4A sterile alpha motif domain containing 4A 2.46576
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) 2.45596
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3 2.45259
CRIP1 cysteine-rich protein 1 (intestinal) 2.42115
MSH5 mutS homolog 5 2.41391
TPPP tubulin polymerization promoting protein 2.38228
TSPAN16 tetraspanin 16 2.38228
PCDHGA12 protocadherin gamma subfamily A, 12 2.38228
TES testin LIM domain protein 2.38228
ZPLD1 zona pellucida-like domain containing 1 2.2723
PCP4L1 Purkinje cell protein 4 like 1 2.2723
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) 2.23057
FMC1 formation of mitochondrial complex V assembly factor 1 homolog 2.22353
TULP1 tubby like protein 1 2.21383
ITCH itchy E3 ubiquitin protein ligase 2.20722
ANGPTL2 angiopoietin-like 2 2.2015
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 2.1916
FBXO10 F-box protein 10 2.18655
DOC2B double C2-like domains, beta 2.17705
OBI1 ORC ubiquitin ligase 1 2.14445
OLFM2 olfactomedin 2 2.12795
TCTA T-cell leukemia translocation altered 2.12129
TALDO1 transaldolase 1 2.10421
CALCB calcitonin-related polypeptide beta 2.10421
BMERB1 bMERB domain containing 1 2.08442
DNAAF4 dynein axonemal assembly factor 4 2.07648
CPNE4 copine IV 2.06451
IPO5 importin 5 2.06451
MYH11 myosin, heavy chain 11, smooth muscle 2.06186
RBM15 RNA binding motif protein 15 2.06158
TACC3 transforming, acidic coiled-coil containing protein 3 2.06158
PTPRM protein tyrosine phosphatase, receptor type, M 2.06017
RIT2 Ras-like without CAAX 2 2.05964
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2 2.05964
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 2.05964
CLEC2L C-type lectin domain family 2, member L 2.05964
SH3BGR SH3 domain binding glutamate-rich protein 2.05964
SHPK sedoheptulokinase 2.05964
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 2.05964
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 2.05098
E2F7 E2F transcription factor 7 2.04751
ENO1 enolase 1, (alpha) 2.04751
PUSL1 pseudouridylate synthase-like 1 2.02592
TMEM167A transmembrane protein 167A 2.01992

decreased expression

Symbol Name Standardized Value
GPRASP2 G protein-coupled receptor associated sorting protein 2 -2.51309
AGFG2 ArfGAP with FG repeats 2 -2.51309
RPS20 ribosomal protein S20 -2.51309
SOCS1 suppressor of cytokine signaling 1 -2.51309
MAP6D1 MAP6 domain containing 1 -2.51309
STAT5B signal transducer and activator of transcription 5B -2.51309
BRWD1 bromodomain and WD repeat domain containing 1 -2.51309
TIPE1 TNF alpha induced protein 8 like 1 -2.51309
UPP2 uridine phosphorylase 2 -2.51309
TSACC TSSK6 activating co-chaperone -2.51309
CFAP221 cilia and flagella associated protein 221 -2.51309
RHOG ras homolog family member G -2.51309
LCORL ligand dependent nuclear receptor corepressor-like -2.51309
SYT4 synaptotagmin IV -2.51309
GRIK2 glutamate receptor, ionotropic, kainate 2 -2.51309
RAB19 RAB19, member RAS oncogene family -2.49396
SERF1B small EDRK-rich factor 1B (centromeric) -2.42115
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow -2.41409
AQP3 aquaporin 3 (Gill blood group) -2.41409
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1 -2.39895
ZNF160 zinc finger protein 160 -2.39308
CPSF3 cleavage and polyadenylation specific factor 3, 73kDa -2.38424
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 -2.38228
TERB1 telomere repeat binding bouquet formation protein 1 -2.38228
RHEX regulator of hemoglobinization and erythroid cell expansion -2.38228
H4C14 H4 clustered histone 14 -2.38228
DRC5 dynein regulatory complex subunit 5 -2.38228
CYGB cytoglobin -2.38228
ATP5MGL ATP synthase membrane subunit g like -2.38228
RNF227 ring finger protein 227 -2.38228
KISS1R KISS1 receptor -2.38228
BFSP2 beaded filament structural protein 2, phakinin -2.38228
CIMAP2 ciliary microtubule associated protein 2 -2.38228
CRYGN crystallin, gamma N -2.38228
RGPD4 RANBP2-like and GRIP domain containing 4 -2.38228
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 -2.38228
ANGPT4 angiopoietin 4 -2.38228
TNC tenascin C -2.38228
MMP19 matrix metallopeptidase 19 -2.38228
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease -2.38228
UPK1B uroplakin 1B -2.38228
BEAN1 brain expressed, associated with NEDD4, 1 -2.38228
RBM24 RNA binding motif protein 24 -2.38228
GAGE10 G antigen 10 -2.38228
MYLK4 myosin light chain kinase family, member 4 -2.38228
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis) -2.35148
KLF7 Kruppel-like factor 7 (ubiquitous) -2.30163
SSBP2 single-stranded DNA binding protein 2 -2.26629
NUDCD3 NudC domain containing 3 -2.26305
BCL2L11 BCL2-like 11 (apoptosis facilitator) -2.25119
MICALL2 MICAL-like 2 -2.23362
RB1 retinoblastoma 1 -2.23044
ZC3H6 zinc finger CCCH-type containing 6 -2.2264
BCLAF3 BCLAF1 and THRAP3 family member 3 -2.22353
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -2.21543
C20ORF203 chromosome 20 open reading frame 203 -2.21383
GREB1 growth regulation by estrogen in breast cancer 1 -2.20993
QDPR quinoid dihydropteridine reductase -2.20355
PRPF8 pre-mRNA processing factor 8 -2.19362
GPR160 G protein-coupled receptor 160 -2.17705
GFOD1 glucose-fructose oxidoreductase domain containing 1 -2.17686
SPDYE17 speedy/RINGO cell cycle regulator family member E17 -2.17686
TXNIP thioredoxin interacting protein -2.16882
SEC31B SEC31 homolog B (S. cerevisiae) -2.16688
RABL6 RAB, member RAS oncogene family-like 6 -2.1623
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 -2.14488
DOLPP1 dolichyldiphosphatase 1 -2.14445
LINC02762 long intergenic non-protein coding RNA 2762 -2.14445
PTCHD1 patched domain containing 1 -2.143
BUB3 BUB3 mitotic checkpoint protein -2.14033
STXBP6 syntaxin binding protein 6 (amisyn) -2.13139
SCX scleraxis basic helix-loop-helix transcription factor -2.13139
METTL27 methyltransferase like 27 -2.13139
SMG9 SMG9 nonsense mediated mRNA decay factor -2.11095
SF3A3 splicing factor 3a, subunit 3, 60kDa -2.11036
PHLDA2 pleckstrin homology-like domain, family A, member 2 -2.11003
BABAM2 BRISC and BRCA1 A complex member 2 -2.11003
SRA1 steroid receptor RNA activator 1 -2.07912
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 -2.0772
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 -2.07648
CLCN5 chloride channel, voltage-sensitive 5 -2.07457
ATXN2 ataxin 2 -2.06186
GPR137C G protein-coupled receptor 137C -2.05964
HELZ helicase with zinc finger -2.05964
CRB3 crumbs family member 3 -2.05964
WDR73 WD repeat domain 73 -2.05964
SNX5 sorting nexin 5 -2.04751
ZMIZ2 zinc finger, MIZ-type containing 2 -2.04751
SAR1A secretion associated, Ras related GTPase 1A -2.04751
BAG1 BCL2-associated athanogene -2.00892