RELA_DN.V1 Gene Set

Dataset MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations
Category transcriptomics
Type gene perturbation
Description gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database)
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288 genes differentially expressed following the RELA_DN.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.

increased expression

Symbol Name
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
APOB apolipoprotein B
ATF3 activating transcription factor 3
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2
BCO1 beta-carotene oxygenase 1
BIN1 bridging integrator 1
BPNT1 3'(2'), 5'-bisphosphate nucleotidase 1
C10ORF10 chromosome 10 open reading frame 10
CCL2 chemokine (C-C motif) ligand 2
CD38 CD38 molecule
CDHR5 cadherin-related family member 5
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39)
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CELP carboxyl ester lipase pseudogene
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CLDN15 claudin 15
CLK1 CDC-like kinase 1
CRB1 crumbs family member 1, photoreceptor morphogenesis associated
CRYGA crystallin, gamma A
CST5 cystatin D
CTF1 cardiotrophin 1
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DEFB1 defensin, beta 1
DGKI diacylglycerol kinase, iota
DLGAP1 discs, large (Drosophila) homolog-associated protein 1
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like
DUSP8 dual specificity phosphatase 8
DYSF dysferlin
EFNA1 ephrin-A1
EGR1 early growth response 1
EGR3 early growth response 3
ESM1 endothelial cell-specific molecule 1
ETFDH electron-transferring-flavoprotein dehydrogenase
F3 coagulation factor III (thromboplastin, tissue factor)
F9 coagulation factor IX
FGF17 fibroblast growth factor 17
FGF2 fibroblast growth factor 2 (basic)
FHL5 four and a half LIM domains 5
FLRT1 fibronectin leucine rich transmembrane protein 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FXYD7 FXYD domain containing ion transport regulator 7
FZD9 frizzled class receptor 9
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GADD45B growth arrest and DNA-damage-inducible, beta
GAS7 growth arrest-specific 7
GHRH growth hormone releasing hormone
GJB1 gap junction protein, beta 1, 32kDa
GLS2 glutaminase 2 (liver, mitochondrial)
GLYAT glycine-N-acyltransferase
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GPR183 G protein-coupled receptor 183
GPR85 G protein-coupled receptor 85
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
GRAP GRB2-related adaptor protein
HOOK1 hook microtubule-tethering protein 1
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
IL1B interleukin 1, beta
INE1 inactivation escape 1 (non-protein coding)
INTS6 integrator complex subunit 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1
KCNC4 potassium channel, voltage gated Shaw related subfamily C, member 4
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4
KDM5D lysine (K)-specific demethylase 5D
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
LAMC2 laminin, gamma 2
LGMN legumain
LHCGR luteinizing hormone/choriogonadotropin receptor
LILRP2 leukocyte immunoglobulin-like receptor pseudogene 2
LMO7 LIM domain 7
MAGEB4 melanoma antigen family B4
MAK male germ cell-associated kinase
MC3R melanocortin 3 receptor
MEP1B meprin A, beta
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MTMR11 myotubularin related protein 11
MYBPC3 myosin binding protein C, cardiac
NFIC nuclear factor I/C (CCAAT-binding transcription factor)
NLK nemo-like kinase
NOL4 nucleolar protein 4
NOVA1 neuro-oncological ventral antigen 1
NTM neurotrimin
NTS neurotensin
P2RY10 purinergic receptor P2Y, G-protein coupled, 10
P2RY11 purinergic receptor P2Y, G-protein coupled, 11
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PDE5A phosphodiesterase 5A, cGMP-specific
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PEX6 peroxisomal biogenesis factor 6
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PIP prolactin-induced protein
PNLIPRP1 pancreatic lipase-related protein 1
PODXL2 podocalyxin-like 2
PPAN peter pan homolog (Drosophila)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRDM11 PR domain containing 11
PRKG1 protein kinase, cGMP-dependent, type I
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNF25 ring finger protein 25
RNF39 ring finger protein 39
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCG5 secretogranin V
SIRPB1 signal-regulatory protein beta 1
SIRT4 sirtuin 4
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SNAI1 snail family zinc finger 1
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SRCAP Snf2-related CREBBP activator protein
TANK TRAF family member-associated NFKB activator
TEX14 testis expressed 14
THBD thrombomodulin
TLX1 T-cell leukemia homeobox 1
TNC tenascin C
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TPMT thiopurine S-methyltransferase
TREX1 three prime repair exonuclease 1
TRIM38 tripartite motif containing 38
ULBP2 UL16 binding protein 2
USP9Y ubiquitin specific peptidase 9, Y-linked
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VEGFB vascular endothelial growth factor B
WASL Wiskott-Aldrich syndrome-like
WRNIP1 Werner helicase interacting protein 1
XCL1 chemokine (C motif) ligand 1
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP37 ZFP37 zinc finger protein
ZNF165 zinc finger protein 165
ZNF222 zinc finger protein 222
ZNF286A zinc finger protein 286A
ZNF324 zinc finger protein 324
ZNHIT2 zinc finger, HIT-type containing 2

decreased expression

Symbol Name
ADGRE1 adhesion G protein-coupled receptor E1
ADRA1D adrenoceptor alpha 1D
APCS amyloid P component, serum
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4
AVP arginine vasopressin
BMPR1B bone morphogenetic protein receptor, type IB
C1ORF21 chromosome 1 open reading frame 21
C5AR2 complement component 5a receptor 2
C7 complement component 7
CA9 carbonic anhydrase IX
CALY calcyon neuron-specific vesicular protein
CAPN9 calpain 9
CASC5 cancer susceptibility candidate 5
CCNK cyclin K
CD247 CD247 molecule
CD53 CD53 molecule
CDON cell adhesion associated, oncogene regulated
CH25H cholesterol 25-hydroxylase
CHIT1 chitinase 1 (chitotriosidase)
CLCN1 chloride channel, voltage-sensitive 1
CLDN6 claudin 6
CRISP2 cysteine-rich secretory protein 2
CST1 cystatin SN
CUBN cubilin (intrinsic factor-cobalamin receptor)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCR3 chemokine (C-X-C motif) receptor 3
CYTIP cytohesin 1 interacting protein
DCSTAMP dendrocyte expressed seven transmembrane protein
DLK1 delta-like 1 homolog (Drosophila)
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DSG3 desmoglein 3
DUOX2 dual oxidase 2
ECEL1 endothelin converting enzyme-like 1
EGFL6 EGF-like-domain, multiple 6
ERC2-IT1 ERC2 intronic transcript 1
F13B coagulation factor XIII, B polypeptide
FMO5 flavin containing monooxygenase 5
FTCD formimidoyltransferase cyclodeaminase
GAGE3 G antigen 3
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GDF5 growth differentiation factor 5
GNMT glycine N-methyltransferase
GNRH2 gonadotropin-releasing hormone 2
GPER1 G protein-coupled estrogen receptor 1
GPR3 G protein-coupled receptor 3
GSTM1 glutathione S-transferase mu 1
HAS1 hyaluronan synthase 1
HDAC9 histone deacetylase 9
HIST1H2AE histone cluster 1, H2ae
HIST1H4B histone cluster 1, H4b
HIST1H4L histone cluster 1, H4l
HOXD3 homeobox D3
HRC histidine rich calcium binding protein
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
IDUA iduronidase, alpha-L-
IL17RB interleukin 17 receptor B
IL2RG interleukin 2 receptor, gamma
IL7R interleukin 7 receptor
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KCNK5 potassium channel, two pore domain subfamily K, member 5
KLF8 Kruppel-like factor 8
KLK11 kallikrein-related peptidase 11
KLK7 kallikrein-related peptidase 7
KRT1 keratin 1, type II
L1CAM L1 cell adhesion molecule
LCE2B late cornified envelope 2B
LGALS4 lectin, galactoside-binding, soluble, 4
LUZP4 leucine zipper protein 4
MBNL2 muscleblind-like splicing regulator 2
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MECOM MDS1 and EVI1 complex locus
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MST1R macrophage stimulating 1 receptor
MUC4 mucin 4, cell surface associated
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
MYOM1 myomesin 1
MYOM2 myomesin 2
NEURL1 neuralized E3 ubiquitin protein ligase 1
NFE2 nuclear factor, erythroid 2
NNAT neuronatin
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
NPY4R neuropeptide Y receptor Y4
NRXN3 neurexin 3
OR10H1 olfactory receptor, family 10, subfamily H, member 1
OXT oxytocin/neurophysin I prepropeptide
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PC pyruvate carboxylase
PKLR pyruvate kinase, liver and RBC
PLA2G10 phospholipase A2, group X
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
PRSS8 protease, serine, 8
PSCA prostate stem cell antigen
PSD pleckstrin and Sec7 domain containing
PTN pleiotrophin
PTPN7 protein tyrosine phosphatase, non-receptor type 7
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C)
RAB30 RAB30, member RAS oncogene family
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RASA3 RAS p21 protein activator 3
RBBP9 retinoblastoma binding protein 9
RBMXL2 RNA binding motif protein, X-linked-like 2
RBP1 retinol binding protein 1, cellular
RFX2 regulatory factor X, 2 (influences HLA class II expression)
RHOH ras homolog family member H
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1
SEZ6L seizure related 6 homolog (mouse)-like
SIGLEC5 sialic acid binding Ig-like lectin 5
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPRY4 sprouty homolog 4 (Drosophila)
SRPX2 sushi-repeat containing protein, X-linked 2
SSX1 synovial sarcoma, X breakpoint 1
STAG3 stromal antigen 3
TACR3 tachykinin receptor 3
TACSTD2 tumor-associated calcium signal transducer 2
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TBX5 T-box 5
TEF thyrotrophic embryonic factor
TFDP3 transcription factor Dp family, member 3
TFEC transcription factor EC
TFF1 trefoil factor 1
TMEM176A transmembrane protein 176A
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNNI3 troponin I type 3 (cardiac)
TPTE transmembrane phosphatase with tensin homology
TRAF1 TNF receptor-associated factor 1
TXNRD2 thioredoxin reductase 2
UTS2 urotensin 2
VEGFC vascular endothelial growth factor C
WNT2 wingless-type MMTV integration site family member 2
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound