RET Gene Set

Dataset Kinase Library Tyrosine Kinome Atlas
Category proteomics
Type kinase
Description ret proto-oncogene|This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5979)
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100 substrates of the kinase RET from the Kinase Library Tyrosine Kinome Atlas dataset.

Symbol Name Standardized Value
WWP2 WW domain containing E3 ubiquitin protein ligase 2 99.96
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B 99.94
PLPPR4 phospholipid phosphatase related 4 99.89
NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa 99.82
SLC39A3 solute carrier family 39 (zinc transporter), member 3 99.74
SH2D3C SH2 domain containing 3C 99.72
HCST hematopoietic cell signal transducer 99.69
ZNF639 zinc finger protein 639 99.63
EML4 echinoderm microtubule associated protein like 4 99.61
MUC16 mucin 16, cell surface associated 99.59
DDIAS DNA damage-induced apoptosis suppressor 99.54
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 99.52
FCHO1 FCH domain only 1 99.48
CNOT9 CCR4-NOT transcription complex subunit 9 99.41
SRCIN1 SRC kinase signaling inhibitor 1 99.385
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 99.36
RFTN1 raftlin, lipid raft linker 1 99.28
MND1 meiotic nuclear divisions 1 homolog (S. cerevisiae) 99.25
PM20D2 peptidase M20 domain containing 2 99.08
RASA3 RAS p21 protein activator 3 99.02
KMT5A lysine methyltransferase 5A 99.01
RPS29 ribosomal protein S29 98.99
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 98.95
ARHGAP30 Rho GTPase activating protein 30 98.9
CEP170B centrosomal protein 170B 98.84
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 98.78
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 98.75
OPHN1 oligophrenin 1 98.69
TPRN taperin 98.66
SPRED1 sprouty-related, EVH1 domain containing 1 98.53
THADA thyroid adenoma associated 98.51
PADI2 peptidyl arginine deiminase, type II 98.43
ALOX5 arachidonate 5-lipoxygenase 98.38
STXBP3 syntaxin binding protein 3 98.31
TRAF3IP2 TRAF3 interacting protein 2 98.29
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 98.25
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa 98.18
TCF25 transcription factor 25 (basic helix-loop-helix) 98.14
TBL3 transducin (beta)-like 3 98.05
SPECC1 sperm antigen with calponin homology and coiled-coil domains 1 98.01
JMY junction mediating and regulatory protein, p53 cofactor 97.88
PPA2 pyrophosphatase (inorganic) 2 97.72
THRB thyroid hormone receptor, beta 97.68
FKBP5 FK506 binding protein 5 97.66
RPL36AL ribosomal protein L36a-like 97.57
TLK1 tousled-like kinase 1 97.55
RASGRP4 RAS guanyl releasing protein 4 97.53
MREG melanoregulin 97.48
UMPS uridine monophosphate synthetase 97.46
RIPOR3 RIPOR family member 3 97.42
PI4K2A phosphatidylinositol 4-kinase type 2 alpha 97.33
NUMA1 nuclear mitotic apparatus protein 1 97.29
TASOR2 transcription activation suppressor family member 2 97.21
GTSE1 G-2 and S-phase expressed 1 97.15
KAZN kazrin, periplakin interacting protein 97.13
DCTN4 dynactin 4 (p62) 97.11
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 97.04
PREB prolactin regulatory element binding 96.94
NKD2 naked cuticle homolog 2 (Drosophila) 96.93
LHX3 LIM homeobox 3 96.89
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 96.815
RASAL2 RAS protein activator like 2 96.8
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 96.78
MKNK1 MAP kinase interacting serine/threonine kinase 1 96.69
TFIP11 tuftelin interacting protein 11 96.63
KCTD12 potassium channel tetramerization domain containing 12 96.61
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 96.54
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) 96.54
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) 96.48
NOLC1 nucleolar and coiled-body phosphoprotein 1 96.46
NIPSNAP1 nipsnap homolog 1 (C. elegans) 96.42
TRPC6 transient receptor potential cation channel, subfamily C, member 6 96.39
USP25 ubiquitin specific peptidase 25 96.3
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 96.3
TYK2 tyrosine kinase 2 96.23
TENM3 teneurin transmembrane protein 3 96.17
THOC2 THO complex 2 96.11
FCMR Fc fragment of IgM receptor 96.1
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 96.02
IRS4 insulin receptor substrate 4 95.985
TNK1 tyrosine kinase, non-receptor, 1 95.88
EIF1B eukaryotic translation initiation factor 1B 95.82
EIF1 eukaryotic translation initiation factor 1 95.82
RIPOR1 RHO family interacting cell polarization regulator 1 95.67
IL2RG interleukin 2 receptor, gamma 95.64
PTBP3 polypyrimidine tract binding protein 3 95.56
NFYA nuclear transcription factor Y, alpha 95.53
LURAP1L leucine rich adaptor protein 1-like 95.51
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 95.49
PTPN7 protein tyrosine phosphatase, non-receptor type 7 95.43
CUEDC2 CUE domain containing 2 95.4
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 95.3
PRMT1 protein arginine methyltransferase 1 95.23
GRAMD4 GRAM domain containing 4 95.21
MYL12B myosin, light chain 12B, regulatory 95.19
FAM167A family with sequence similarity 167, member A 95.14
CGN cingulin 95.12
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 95.07
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15 95.07
MCC mutated in colorectal cancers 95.01