RET Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description ret proto-oncogene|This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5979)
External Link http://www.ncbi.nlm.nih.gov/gene/5979
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Genes

63 interacting proteins for RET from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AFAP1L2 actin filament associated protein 1-like 2
AKAP5 A kinase (PRKA) anchor protein 5
AKT1 v-akt murine thymoma viral oncogene homolog 1
BCAR1 breast cancer anti-estrogen resistance 1
CASP3 caspase 3, apoptosis-related cysteine peptidase
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBLC Cbl proto-oncogene C, E3 ubiquitin protein ligase
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CREB1 cAMP responsive element binding protein 1
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNND1 catenin (cadherin-associated protein), delta 1
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DOK2 docking protein 2, 56kDa
DOK3 docking protein 3
DOK4 docking protein 4
DOK5 docking protein 5
DOK6 docking protein 6
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed
FRS2 fibroblast growth factor receptor substrate 2
GAB1 GRB2-associated binding protein 1
GDNF glial cell derived neurotrophic factor
GFRA1 GDNF family receptor alpha 1
GFRA4 GDNF family receptor alpha 4
GRB10 growth factor receptor-bound protein 10
GRB2 growth factor receptor-bound protein 2
GRB7 growth factor receptor-bound protein 7
HIST1H4F histone cluster 1, H4f
HRAS Harvey rat sarcoma viral oncogene homolog
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
LRRK1 leucine-rich repeat kinase 1
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MCRS1 microspherule protein 1
NRTN neurturin
PDLIM7 PDZ and LIM domain 7 (enigma)
PDPK1 3-phosphoinositide dependent protein kinase 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PKM pyruvate kinase, muscle
PLCG1 phospholipase C, gamma 1
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PRKCA protein kinase C, alpha
PSPN persephin
PTK2 protein tyrosine kinase 2
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPRF protein tyrosine phosphatase, receptor type, F
PXN paxillin
RAP1A RAP1A, member of RAS oncogene family
RAP1B RAP1B, member of RAS oncogene family
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHC3 SHC (Src homology 2 domain containing) transforming protein 3
SOS1 son of sevenless homolog 1 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
UBC ubiquitin C