RFX6 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description regulatory factor X, 6|The nuclear protein encoded by this gene is a member of the regulatory factor X (RFX) family of transcription factors. Studies in mice suggest that this gene is specifically required for the differentiation of islet cells for the production of insulin, but not for the differentiation of pancreatic polypeptide-producing cells. It regulates the transcription factors involved in beta-cell maturation and function, thus, restricting the expression of the beta-cell differentiation and specification genes. Mutations in this gene are associated with Mitchell-Riley syndrome, which is characterized by neonatal diabetes with pancreatic hypoplasia, duodenal and jejunal atresia, and gall bladder agenesis.[provided by RefSeq, Sep 2010] (NCBI Entrez Gene Database, 222546)
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Genes

335 genes differentially expressed following the RFX6 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CLDN9 claudin 9 2.76958
CLEC12A C-type lectin domain family 12, member A 2.76958
DNAJC5B DnaJ (Hsp40) homolog, subfamily C, member 5 beta 2.76958
CARD16 caspase recruitment domain family, member 16 2.76958
ZSCAN5B zinc finger and SCAN domain containing 5B 2.76958
COLEC10 collectin sub-family member 10 (C-type lectin) 2.76958
SLC26A4 solute carrier family 26 (anion exchanger), member 4 2.76958
NPPB natriuretic peptide B 2.76958
ZNF208 zinc finger protein 208 2.76958
THAP10 THAP domain containing 10 2.76958
MUC6 mucin 6, oligomeric mucus/gel-forming 2.76958
PCDHB1 protocadherin beta 1 2.76958
NAPSA napsin A aspartic peptidase 2.76958
RHOXF2B Rhox homeobox family, member 2B 2.76958
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 2.76958
OR1F1 olfactory receptor, family 1, subfamily F, member 1 2.76958
RAB44 RAB44, member RAS oncogene family 2.76958
TAS2R39 taste receptor, type 2, member 39 2.76958
FPR3 formyl peptide receptor 3 2.76958
FPR2 formyl peptide receptor 2 2.76958
FAM3D family with sequence similarity 3, member D 2.76958
COL19A1 collagen, type XIX, alpha 1 2.76958
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 2.76958
LAPTM5 lysosomal protein transmembrane 5 2.76958
FOLR1 folate receptor 1 (adult) 2.76958
UPB1 ureidopropionase, beta 2.76958
CASP5 caspase 5, apoptosis-related cysteine peptidase 2.76958
TCHH trichohyalin 2.76958
PCDH8 protocadherin 8 2.76958
KCNIP3 Kv channel interacting protein 3, calsenilin 2.76958
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 2.76958
TRIM41 tripartite motif containing 41 2.76958
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) 2.76958
MUC21 mucin 21, cell surface associated 2.76958
FAM216B family with sequence similarity 216, member B 2.76958
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.76958
ASGR2 asialoglycoprotein receptor 2 2.76958
SP6 Sp6 transcription factor 2.76958
MYL2 myosin, light chain 2, regulatory, cardiac, slow 2.76958
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 2.76958
C3ORF22 chromosome 3 open reading frame 22 2.76958
NRAP nebulin-related anchoring protein 2.76958
TKTL1 transketolase-like 1 2.76958
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 2.76958
PAX3 paired box 3 2.76958
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 2.76958
DIRAS2 DIRAS family, GTP-binding RAS-like 2 2.76958
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 2.76958
GFI1 growth factor independent 1 transcription repressor 2.76958
THRSP thyroid hormone responsive 2.76958
SFTPD surfactant protein D 2.76958
NOTUM notum pectinacetylesterase homolog (Drosophila) 2.76958
NMUR2 neuromedin U receptor 2 2.76958
FAM90A12 family with sequence similarity 90 member A12 2.76958
RTL5 retrotransposon Gag like 5 2.76958
CRACDL CRACD like 2.76958
TTLL13 tubulin tyrosine ligase like 13 2.76958
GRAMD2B GRAM domain containing 2B 2.76958
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 2.76958
PCDHGA9 protocadherin gamma subfamily A, 9 2.76958
MCHR2 melanin-concentrating hormone receptor 2 2.76958
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.76958
TRAPPC3L trafficking protein particle complex 3-like 2.76958
PLN phospholamban 2.76958
FRG2C FSHD region gene 2 family, member C 2.76958
NFILZ NFIL3 like basic leucine zipper 2.76958
PPDPFL pancreatic progenitor cell differentiation and proliferation factor like 2.76958
SPMIP1 sperm microtubule inner protein 1 2.76958
SAXO5 stabilizer of axonemal microtubules 5 2.76958
SPEGNB SPEG neighbor 2.76958
PRR20G proline rich 20G 2.76958
LITAFD LITAF domain containing 2.76958
EXOC1L exocyst complex component 1 like 2.76958
C1ORF232 chromosome 1 open reading frame 230 2.76958
GNG5B G protein subunit gamma 5B 2.76958
SERTM2 serine rich and transmembrane domain containing 2 2.76958
EZHIP EZH inhibitory protein 2.76958
ARMH2 armadillo like helical domain containing 2 2.76958
STX11 syntaxin 11 2.76958
FMOD fibromodulin 2.76958
PKD2L1 polycystic kidney disease 2-like 1 2.76958
S100B S100 calcium binding protein B 2.76958
CDSN corneodesmosin 2.76958
FOXI2 forkhead box I2 2.76958
EXOC3L1 exocyst complex component 3-like 1 2.76958
GDF10 growth differentiation factor 10 2.76958
TFEC transcription factor EC 2.76958
ADGRG1 adhesion G protein-coupled receptor G1 2.76958
DMBX1 diencephalon/mesencephalon homeobox 1 2.76958
SIM2 single-minded family bHLH transcription factor 2 2.76958
MSX2 msh homeobox 2 2.76958
DSG1 desmoglein 1 2.76958
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 2.76958
C6 complement component 6 2.76958
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) 2.76958
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A 2.76958
TRIM31 tripartite motif containing 31 2.76958
ASB9 ankyrin repeat and SOCS box containing 9 2.76958
XKRX XK, Kell blood group complex subunit-related, X-linked 2.76958
LY6H lymphocyte antigen 6 complex, locus H 2.76958
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 2.76958
SRP72 signal recognition particle 72kDa 2.76958
CSAG3 CSAG family, member 3 2.76958
SOAT2 sterol O-acyltransferase 2 2.76958
BEST3 bestrophin 3 2.76958
CLDN2 claudin 2 2.76958
LIMS3 LIM and senescent cell antigen-like domains 3 2.76958
RETNLB resistin like beta 2.76958
DPRX divergent-paired related homeobox 2.76958
PKHD1L1 polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 2.76958
GOLGA6D golgin A6 family, member D 2.76958
FAM209A family with sequence similarity 209, member A 2.76958
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 2.76958
C17ORF99 chromosome 17 open reading frame 99 2.76958
IL11 interleukin 11 2.76958
TEKT5 tektin 5 2.76958
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 2.76958
CSTA cystatin A (stefin A) 2.76958
MYF6 myogenic factor 6 (herculin) 2.76958
CSF3R colony stimulating factor 3 receptor (granulocyte) 2.76958
IHH indian hedgehog 2.76958
RUFY4 RUN and FYVE domain containing 4 2.76958
ANKRD62 ankyrin repeat domain 62 2.76958
FCN3 ficolin (collagen/fibrinogen domain containing) 3 2.76958
DYTN dystrotelin 2.76958
MORC1 MORC family CW-type zinc finger 1 2.76958
NPIPB15 nuclear pore complex interacting protein family, member B15 2.76958
NPPA natriuretic peptide A 2.76958
THBD thrombomodulin 2.76958
C8ORF89 chromosome 8 open reading frame 89 2.76958
EGR2 early growth response 2 2.76958
RBBP8NL RBBP8 N-terminal like 2.76958
POU4F1 POU class 4 homeobox 1 2.76958
IL20 interleukin 20 2.76958
ARHGAP40 Rho GTPase activating protein 40 2.76958
DKK1 dickkopf WNT signaling pathway inhibitor 1 2.76958
CNGB1 cyclic nucleotide gated channel beta 1 2.76958
ZNF835 zinc finger protein 835 2.76958
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 2.76958
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 2.76958
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 2.76958
NYX nyctalopin 2.76958
CYTH4 cytohesin 4 2.76958
MDGA1 MAM domain containing glycosylphosphatidylinositol anchor 1 2.76958
SPATA9 spermatogenesis associated 9 2.76958
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) 2.76958
SAMD5 sterile alpha motif domain containing 5 2.76958
CHIT1 chitinase 1 (chitotriosidase) 2.76958
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1 2.76958
TH tyrosine hydroxylase 2.76958
AGAP3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 2.76958
SYNGR4 synaptogyrin 4 2.76958
DMRTB1 DMRT-like family B with proline-rich C-terminal, 1 2.76958
NUTM2D NUT family member 2D 2.76958
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 2.76958
MEIG1 meiosis/spermiogenesis associated 1 2.76958
MMP12 matrix metallopeptidase 12 2.76958
RNASE6 ribonuclease, RNase A family, k6 2.76958
CTRB2 chymotrypsinogen B2 2.76958
LOXL4 lysyl oxidase-like 4 2.76958
MRGPRX3 MAS-related GPR, member X3 2.76958
RAB7B RAB7B, member RAS oncogene family 2.76958
C2CD2L C2CD2-like 2.76958
OR5A1 olfactory receptor, family 5, subfamily A, member 1 2.76958
OR14A2 olfactory receptor, family 14, subfamily A, member 2 2.76958
CD33 CD33 molecule 2.76958
R3HDML R3H domain containing-like 2.76958
RBP4 retinol binding protein 4, plasma 2.76958
ZNF648 zinc finger protein 648 2.76958
OR51A4 olfactory receptor, family 51, subfamily A, member 4 2.76958
MMP10 matrix metallopeptidase 10 2.76958
ANXA8 annexin A8 2.76958
RXRG retinoid X receptor, gamma 2.76958
ISLR2 immunoglobulin superfamily containing leucine-rich repeat 2 2.76958
CLCNKB chloride channel, voltage-sensitive Kb 2.76958
ALLC allantoicase 2.76958
C5ORF46 chromosome 5 open reading frame 46 2.76958
IFNE interferon, epsilon 2.76958
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 2.76958
ANKRD30B ankyrin repeat domain 30B 2.76958
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 2.76958
ERAP2 endoplasmic reticulum aminopeptidase 2 2.76958
PADI4 peptidyl arginine deiminase, type IV 2.76958
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 2.76958
ADAM21 ADAM metallopeptidase domain 21 2.76958
MID2 midline 2 2.76371
SMYD5 SMYD family member 5 2.74446
RHOB ras homolog family member B 2.68723
FGF4 fibroblast growth factor 4 2.67848
AKAP14 A kinase (PRKA) anchor protein 14 2.67848
PCDHA6 protocadherin alpha 6 2.67848
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 2.67614
ZNF496 zinc finger protein 496 2.64255
NAIF1 nuclear apoptosis inducing factor 1 2.62331
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0 2.54997
EXOSC8 exosome component 8 2.54612
HSPA1L heat shock 70kDa protein 1-like 2.50039
INHA inhibin, alpha 2.50039
RGS22 regulator of G-protein signaling 22 2.50039
NFE2 nuclear factor, erythroid 2 2.50039
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 2.50039
RTN4RL2 reticulon 4 receptor-like 2 2.45465
RGS5 regulator of G-protein signaling 5 2.44108
CYB5R1 cytochrome b5 reductase 1 2.42122
VARS2 valyl-tRNA synthetase 2, mitochondrial 2.40898
ABRAXAS1 abraxas 1, BRCA1 A complex subunit 2.37259
TEX9 testis expressed 9 2.36192
HMBOX1 homeobox containing 1 2.32732
ARHGEF39 Rho guanine nucleotide exchange factor (GEF) 39 2.29912
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) 2.28539
CPSF4L cleavage and polyadenylation specific factor 4-like 2.28539
RAB19 RAB19, member RAS oncogene family 2.28052
ZNF397 zinc finger protein 397 2.28052
STX2 syntaxin 2 2.25279
PDK3 pyruvate dehydrogenase kinase, isozyme 3 2.24786
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 2.22196
PUDP pseudouridine 5'-phosphatase 2.20092
NCAN neurocan 2.19353
MYO18A myosin XVIIIA 2.19296
CDADC1 cytidine and dCMP deaminase domain containing 1 2.16248
KLHDC8B kelch domain containing 8B 2.1579
RUMY2 RUMY family member 2 2.14146
LRATD2 LRAT domain containing 2 2.12785
SYT4 synaptotagmin IV 2.12785
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 2.12669
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit 2.09316
TMEM161A transmembrane protein 161A 2.08267
MAP2K6 mitogen-activated protein kinase kinase 6 2.0808
LYRM2 LYR motif containing 2 2.06928
DTWD2 DTW domain containing 2 2.06053
LRRC41 leucine rich repeat containing 41 2.04977
RBIS ribosomal biogenesis factor 2.04057
GPR137 G protein-coupled receptor 137 2.03319
MRPL23 mitochondrial ribosomal protein L23 2.02206
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1 2.01561

decreased expression

Symbol Name Standardized Value
SHPK sedoheptulokinase -2.76958
A1CF APOBEC1 complementation factor -2.76958
MTTP microsomal triglyceride transfer protein -2.76958
PRAP1 proline-rich acidic protein 1 -2.76958
MTDH metadherin -2.76958
SCN2A sodium channel, voltage gated, type II alpha subunit -2.76958
ZNF492 zinc finger protein 492 -2.76958
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 -2.76958
SPTBN5 spectrin, beta, non-erythrocytic 5 -2.76958
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -2.76958
SEMG1 semenogelin I -2.76958
SLCO1C1 solute carrier organic anion transporter family, member 1C1 -2.76958
PTGES prostaglandin E synthase -2.76958
C16ORF54 chromosome 16 open reading frame 54 -2.76958
TDRD1 tudor domain containing 1 -2.76958
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 -2.76958
SLC9C2 solute carrier family 9, member C2 (putative) -2.76958
GYPE glycophorin E (MNS blood group) -2.76958
CORO7 coronin 7 -2.76958
CAPS calcyphosine -2.76958
TMC2 transmembrane channel-like 2 -2.76958
SYCP3 synaptonemal complex protein 3 -2.76958
LMO1 LIM domain only 1 (rhombotin 1) -2.76958
OR10A2 olfactory receptor, family 10, subfamily A, member 2 -2.76958
PMP22 peripheral myelin protein 22 -2.76958
PLBD1 phospholipase B domain containing 1 -2.76958
C6ORF163 chromosome 6 open reading frame 163 -2.76958
SVOP SV2 related protein homolog (rat) -2.76958
LRRC14 leucine rich repeat containing 14 -2.76958
GPR83 G protein-coupled receptor 83 -2.76958
CD70 CD70 molecule -2.76958
B9D2 B9 protein domain 2 -2.76958
ZMYM5 zinc finger, MYM-type 5 -2.76958
RYK receptor-like tyrosine kinase -2.76958
CLEC4A C-type lectin domain family 4, member A -2.76958
PLCD4 phospholipase C, delta 4 -2.76958
LOXHD1 lipoxygenase homology domains 1 -2.76958
VN1R1 vomeronasal 1 receptor 1 -2.76958
FLACC1 flagellum associated containing coiled-coil domains 1 -2.76958
DDTL D-dopachrome tautomerase-like -2.76958
FBXO40 F-box protein 40 -2.76958
CRYBB3 crystallin, beta B3 -2.76958
SCARA5 scavenger receptor class A, member 5 -2.76958
NRM nurim (nuclear envelope membrane protein) -2.76958
ERAS ES cell expressed Ras -2.76958
GOLGA6B golgin A6 family, member B -2.76958
TLE2 transducin-like enhancer of split 2 -2.76958
C10ORF67 chromosome 10 open reading frame 67 -2.76958
GGACT gamma-glutamylamine cyclotransferase -2.76958
KLRF1 killer cell lectin-like receptor subfamily F, member 1 -2.76958
BHLHA15 basic helix-loop-helix family, member a15 -2.76958
FGF20 fibroblast growth factor 20 -2.75507
COL8A1 collagen, type VIII, alpha 1 -2.75507
BTN1A1 butyrophilin, subfamily 1, member A1 -2.72491
PROM2 prominin 2 -2.65763
FITM2 fat storage-inducing transmembrane protein 2 -2.65763
TSHR thyroid stimulating hormone receptor -2.62398
IL6R interleukin 6 receptor -2.62398
TRAK1 trafficking protein, kinesin binding 1 -2.6215
MRPS23 mitochondrial ribosomal protein S23 -2.56481
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) -2.55336
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit -2.55336
IKBIP IKBKB interacting protein -2.54997
HPSE heparanase -2.46285
NDUFA12 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12 -2.44402
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -2.41636
LIME1 Lck interacting transmembrane adaptor 1 -2.4136
EHMT1 euchromatic histone-lysine N-methyltransferase 1 -2.4032
BAG6 BCL2-associated athanogene 6 -2.39355
GTF3C6 general transcription factor IIIC, polypeptide 6, alpha 35kDa -2.39013
NSFL1C NSFL1 (p97) cofactor (p47) -2.38429
CA3 carbonic anhydrase III -2.35311
CCK cholecystokinin -2.35311
CEP63 centrosomal protein 63kDa -2.33371
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3 -2.33001
ZNF444 zinc finger protein 444 -2.3186
OGT O-linked N-acetylglucosamine (GlcNAc) transferase -2.28539
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed -2.28052
MEN1 multiple endocrine neoplasia I -2.27827
SLCO6A1 solute carrier organic anion transporter family, member 6A1 -2.22541
CNTN4 contactin 4 -2.22315
ZDHHC24 zinc finger, DHHC-type containing 24 -2.20969
ASIC1 acid sensing (proton gated) ion channel 1 -2.20114
CDC42 cell division cycle 42 -2.1929
APAF1 apoptotic peptidase activating factor 1 -2.1927
TMA7 translation machinery associated 7 homolog (S. cerevisiae) -2.17879
BASP1 brain abundant, membrane attached signal protein 1 -2.15965
TSPAN31 tetraspanin 31 -2.14793
CLDN10 claudin 10 -2.14215
GPRASP3 G protein-coupled receptor associated sorting protein family member 3 -2.12785
KLHDC4 kelch domain containing 4 -2.12785
SPDYE21 speedy/RINGO cell cycle regulator family member E21 -2.12785
OSBPL7 oxysterol binding protein-like 7 -2.12785
SH2D3C SH2 domain containing 3C -2.12534
CCNH cyclin H -2.11968
TSPAN9 tetraspanin 9 -2.11266
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -2.10356
CRIPT cysteine-rich PDZ-binding protein -2.08729
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -2.02512
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma -2.0212