RFX6 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description regulatory factor X, 6|The nuclear protein encoded by this gene is a member of the regulatory factor X (RFX) family of transcription factors. Studies in mice suggest that this gene is specifically required for the differentiation of islet cells for the production of insulin, but not for the differentiation of pancreatic polypeptide-producing cells. It regulates the transcription factors involved in beta-cell maturation and function, thus, restricting the expression of the beta-cell differentiation and specification genes. Mutations in this gene are associated with Mitchell-Riley syndrome, which is characterized by neonatal diabetes with pancreatic hypoplasia, duodenal and jejunal atresia, and gall bladder agenesis.[provided by RefSeq, Sep 2010] (NCBI Entrez Gene Database, 222546)
External Link http://www.ncbi.nlm.nih.gov/gene/222546
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15 interacting proteins for RFX6 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
CCNK cyclin K
CYFIP1 cytoplasmic FMR1 interacting protein 1
DGCR6 DiGeorge syndrome critical region gene 6
DTX2 deltex 2, E3 ubiquitin ligase
ESR2 estrogen receptor 2 (ER beta)
FHL3 four and a half LIM domains 3
KIF1A kinesin family member 1A
LMO3 LIM domain only 3 (rhombotin-like 2)
PITX1 paired-like homeodomain 1
RFX2 regulatory factor X, 2 (influences HLA class II expression)
RFX3 regulatory factor X, 3 (influences HLA class II expression)
RIPK3 receptor-interacting serine-threonine kinase 3
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1