RHEB Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description Ras homolog enriched in brain|This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6009)
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Genes

350 genes differentially expressed following the RHEB gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 4.06381
OSGIN1 oxidative stress induced growth inhibitor 1 4.06381
RRAD Ras-related associated with diabetes 4.06381
BLK BLK proto-oncogene, Src family tyrosine kinase 4.06381
OSR2 odd-skipped related transciption factor 2 4.06381
GSTM5 glutathione S-transferase mu 5 4.06381
LRRC53 leucine rich repeat containing 53 4.06381
MTTP microsomal triglyceride transfer protein 4.06381
GFAP glial fibrillary acidic protein 4.06381
MFAP5 microfibrillar associated protein 5 4.06381
C19ORF67 chromosome 19 open reading frame 67 4.06381
CNTNAP4 contactin associated protein-like 4 4.06381
HGD homogentisate 1,2-dioxygenase 4.06381
PKP1 plakophilin 1 4.06381
CD5 CD5 molecule 4.06381
EGFLAM EGF-like, fibronectin type III and laminin G domains 4.06381
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 4.06381
TXLNB taxilin beta 4.06381
RP1L1 retinitis pigmentosa 1-like 1 4.06381
AKR7L aldo-keto reductase family 7-like (gene/pseudogene) 4.06381
GPR52 G protein-coupled receptor 52 4.06381
OR1A1 olfactory receptor, family 1, subfamily A, member 1 4.06381
PCDHB1 protocadherin beta 1 4.06381
SLC35G5 solute carrier family 35, member G5 4.06381
SHCBP1L SHC SH2-domain binding protein 1-like 4.06381
REN renin 4.06381
CLEC14A C-type lectin domain family 14, member A 4.06381
THSD1 thrombospondin, type I, domain containing 1 4.06381
OIT3 oncoprotein induced transcript 3 4.06381
ITIH6 inter-alpha-trypsin inhibitor heavy chain family, member 6 4.06381
EVPL envoplakin 4.06381
STAP1 signal transducing adaptor family member 1 4.06381
NPY neuropeptide Y 4.06381
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 4.06381
BTBD19 BTB (POZ) domain containing 19 4.06381
HRG histidine-rich glycoprotein 4.06381
BMP1 bone morphogenetic protein 1 4.06381
PRDM16 PR domain containing 16 4.06381
BRICD5 BRICHOS domain containing 5 4.06381
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 4.06381
SFTPB surfactant protein B 4.06381
ZSCAN22 zinc finger and SCAN domain containing 22 4.06381
C2ORF80 chromosome 2 open reading frame 80 4.06381
EDDM3A epididymal protein 3A 4.06381
OXCT2 3-oxoacid CoA transferase 2 4.06381
CPB2 carboxypeptidase B2 (plasma) 4.06381
SOWAHB sosondowah ankyrin repeat domain family member B 4.06381
FOXJ1 forkhead box J1 4.06381
LRRC61 leucine rich repeat containing 61 4.06381
HIGD1C HIG1 hypoxia inducible domain family, member 1C 4.06381
FAM90A11 family with sequence similarity 90 member A11 4.06381
CFAP157 cilia and flagella associated protein 157 4.06381
PLPP4 phospholipid phosphatase 4 4.06381
CCDC9B coiled-coil domain containing 9B 4.06381
GPAT3 glycerol-3-phosphate acyltransferase 3 4.06381
GOLGA6L7 golgin A6 family like 7 4.06381
PLG plasminogen 4.06381
MCHR1 melanin-concentrating hormone receptor 1 4.06381
ROPN1L rhophilin associated tail protein 1-like 4.06381
FOXN4 forkhead box N4 4.06381
WDR64 WD repeat domain 64 4.06381
GARIN1A golgi associated RAB2 interactor 1A 4.06381
MEIOSIN meiosis initiator 4.06381
MUCL3 mucin like 3 4.06381
FAM90A12 family with sequence similarity 90 member A12 4.06381
SPMAP2L sperm microtubule associated protein 2 like 4.06381
TMSB15C thymosin beta 15C 4.06381
REELD1 reeler domain containing 1 4.06381
LOC124903233 uncharacterized LOC124903233 4.06381
RHEX regulator of hemoglobinization and erythroid cell expansion 4.06381
SMIM43 small integral membrane protein 43 4.06381
ACP7 acid phosphatase 7, tartrate resistant (putative) 4.06381
LHFPL7 LHFPL tetraspan subfamily member 7 4.06381
IQCN IQ motif containing N 4.06381
OR52E5 olfactory receptor, family 52, subfamily E, member 5 4.06381
SPATA22 spermatogenesis associated 22 4.06381
DAO D-amino-acid oxidase 4.06381
NXPE2 neurexophilin and PC-esterase domain family, member 2 4.06381
PRB3 proline-rich protein BstNI subfamily 3 4.06381
ACOT1 acyl-CoA thioesterase 1 4.06381
LIPF lipase, gastric 4.06381
IZUMO4 IZUMO family member 4 4.06381
CATSPERT catsper channel auxiliary subunit tau 4.06381
FAM153A family with sequence similarity 153, member A 4.06381
SIX1 SIX homeobox 1 4.06381
HRH1 histamine receptor H1 4.06381
ULBP3 UL16 binding protein 3 4.06381
MIA melanoma inhibitory activity 4.06381
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 4.06381
GATA6 GATA binding protein 6 4.06381
PRDM7 PR domain containing 7 4.06381
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 4.06381
LTF lactotransferrin 4.06381
LRRC73 leucine rich repeat containing 73 4.06381
OOSP1 oocyte secreted protein 1, pseudogene 4.06381
BLNK B-cell linker 4.06381
FAM186A family with sequence similarity 186, member A 4.06381
C1QTNF8 C1q and tumor necrosis factor related protein 8 4.06381
PRRT4 proline-rich transmembrane protein 4 4.06381
UPK3B uroplakin 3B 4.06381
GP1BB glycoprotein Ib (platelet), beta polypeptide 4.06381
MUC13 mucin 13, cell surface associated 4.06381
EGR2 early growth response 2 4.06381
KLK4 kallikrein-related peptidase 4 4.06381
TBX1 T-box 1 4.06381
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2 4.06381
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1 4.06381
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1 4.06381
AMN amnion associated transmembrane protein 4.06381
TPPP3 tubulin polymerization-promoting protein family member 3 4.06381
FIBIN fin bud initiation factor homolog (zebrafish) 4.06381
SPATA3 spermatogenesis associated 3 4.06381
CALHM3 calcium homeostasis modulator 3 4.06381
APLNR apelin receptor 4.06381
MR1 major histocompatibility complex, class I-related 4.06381
HAMP hepcidin antimicrobial peptide 4.06381
SLC13A5 solute carrier family 13 (sodium-dependent citrate transporter), member 5 4.06381
OR56A4 olfactory receptor, family 56, subfamily A, member 4 4.06381
EFCAB3 EF-hand calcium binding domain 3 4.06381
BTNL2 butyrophilin-like 2 4.06381
CLRN1 clarin 1 4.06381
LCN9 lipocalin 9 4.06381
NRP1 neuropilin 1 4.06381
B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2 4.06381
CASQ2 calsequestrin 2 (cardiac muscle) 4.06381
FAM151A family with sequence similarity 151, member A 4.06381
EOMES eomesodermin 4.06381
BTG4 B-cell translocation gene 4 4.06381
GOLGA8M golgin A8 family, member M 4.06381
PDK4 pyruvate dehydrogenase kinase, isozyme 4 4.06381
MZB1 marginal zone B and B1 cell-specific protein 4.06381
GSDMA gasdermin A 4.06381
PHOX2A paired-like homeobox 2a 4.06381
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 4.06381
C11ORF42 chromosome 11 open reading frame 42 4.06381
TYR tyrosinase 4.06381
LMNTD1 lamin tail domain containing 1 4.06381
IP6K3 inositol hexakisphosphate kinase 3 4.06381
ATP10B ATPase, class V, type 10B 4.06381
DAW1 dynein assembly factor with WDR repeat domains 1 4.06381
SLC38A8 solute carrier family 38, member 8 4.06381
SLC38A3 solute carrier family 38, member 3 4.06381
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 4.06381
CSF1R colony stimulating factor 1 receptor 4.06381
TRIM7 tripartite motif containing 7 4.06381
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 4.06381
APOB apolipoprotein B 4.06381
GLRA1 glycine receptor, alpha 1 4.06381
C5AR2 complement component 5a receptor 2 4.06381
LPA lipoprotein, Lp(a) 4.06381
LST1 leukocyte specific transcript 1 4.06381
PPEF2 protein phosphatase, EF-hand calcium binding domain 2 4.06381
C2CD2L C2CD2-like 4.06381
ITPKA inositol-trisphosphate 3-kinase A 4.06381
FGF17 fibroblast growth factor 17 4.06381
AQP1 aquaporin 1 (Colton blood group) 4.06381
LAMP3 lysosomal-associated membrane protein 3 4.06381
CDCP2 CUB domain containing protein 2 4.06381
POU5F2 POU domain class 5, transcription factor 2 4.06381
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 4.06381
ISX intestine-specific homeobox 4.06381
GREM1 gremlin 1, DAN family BMP antagonist 4.06381
ZNF534 zinc finger protein 534 4.06381
TBC1D28 TBC1 domain family, member 28 4.06381
CD226 CD226 molecule 4.06381
ECM1 extracellular matrix protein 1 4.06381
ZMYND10 zinc finger, MYND-type containing 10 4.06381
KRTAP13-4 keratin associated protein 13-4 4.06381
NEUROD2 neuronal differentiation 2 4.06381
BMX BMX non-receptor tyrosine kinase 4.06381
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 3.93175
DNAI1 dynein, axonemal, intermediate chain 1 3.88112
ADAM21 ADAM metallopeptidase domain 21 3.88112
SEC63 SEC63 homolog (S. cerevisiae) 3.82982
TXN thioredoxin 3.5556
SIT1 signaling threshold regulating transmembrane adaptor 1 3.26977
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I 3.26977
SMC6 structural maintenance of chromosomes 6 3.19206
AP1S1 adaptor-related protein complex 1, sigma 1 subunit 3.13074
ZDHHC11 zinc finger, DHHC-type containing 11 3.02671
HLA-DRA major histocompatibility complex, class II, DR alpha 2.96967
TRIP13 thyroid hormone receptor interactor 13 2.95387
ZFAND1 zinc finger, AN1-type domain 1 2.78564
MED31 mediator complex subunit 31 2.74763
IFI27 interferon, alpha-inducible protein 27 2.70885
CCDC62 coiled-coil domain containing 62 2.70885
VSTM4 V-set and transmembrane domain containing 4 2.70885
SEC14L4 SEC14-like 4 (S. cerevisiae) 2.70885
GGTA1 glycoprotein alpha-galactosyltransferase 1 (inactive) 2.70885
SGK2 serum/glucocorticoid regulated kinase 2 2.70885
LOXHD1 lipoxygenase homology domains 1 2.70885
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 2.63495
TMEM231 transmembrane protein 231 2.58108
FABP5 fatty acid binding protein 5 (psoriasis-associated) 2.56975
ATP11C ATPase, class VI, type 11C 2.5402
GPBP1L1 GC-rich promoter binding protein 1-like 1 2.52212
BICDL2 BICD family like cargo adaptor 2 2.4938
PCSK4 proprotein convertase subtilisin/kexin type 4 2.46177
TSC22D3 TSC22 domain family, member 3 2.45699
PRELP proline/arginine-rich end leucine-rich repeat protein 2.41784
MROH6 maestro heat-like repeat family member 6 2.41784
ACRBP acrosin binding protein 2.41784
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 2.41151
AFP alpha-fetoprotein 2.38853
SARS1 seryl-tRNA synthetase 1 2.35705
HSPD1 heat shock 60kDa protein 1 (chaperonin) 2.35705
PHF5A PHD finger protein 5A 2.35705
NAA10 N(alpha)-acetyltransferase 10, NatA catalytic subunit 2.34596
PRDM10 PR domain containing 10 2.34582
PI15 peptidase inhibitor 15 2.33442
ANKRD29 ankyrin repeat domain 29 2.31911
DLEU7 deleted in lymphocytic leukemia, 7 2.30823
ZBTB41 zinc finger and BTB domain containing 41 2.29405
TMCC2 transmembrane and coiled-coil domain family 2 2.28367
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 2.21896
COX5A cytochrome c oxidase subunit Va 2.17291
DVL2 dishevelled segment polarity protein 2 2.15628
ERICH2 glutamate-rich 2 2.12818
JDP2 Jun dimerization protein 2 2.12313
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9 2.11552
SLC25A53 solute carrier family 25, member 53 2.10926
MCM3 minichromosome maintenance complex component 3 2.10926
CALU calumenin 2.10176
UBASH3B ubiquitin associated and SH3 domain containing B 2.09755
NPTN neuroplastin 2.0891
HAGHL hydroxyacylglutathione hydrolase-like 2.07335
FAM111A family with sequence similarity 111, member A 2.05901
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast) 2.05203
GPC6 glypican 6 2.05203
SRSF11 serine/arginine-rich splicing factor 11 2.04004
TERT telomerase reverse transcriptase 2.03131
TRPM4 transient receptor potential cation channel, subfamily M, member 4 2.03117
ZDHHC24 zinc finger, DHHC-type containing 24 2.02559
ZNF468 zinc finger protein 468 2.02559
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 2.02559
KLC3 kinesin light chain 3 2.02559

decreased expression

Symbol Name Standardized Value
BLOC1S3 biogenesis of lysosomal organelles complex-1, subunit 3 -4.06381
HCST hematopoietic cell signal transducer -4.06381
AKAP14 A kinase (PRKA) anchor protein 14 -4.06381
LTC4S leukotriene C4 synthase -4.06381
ALDH1L1 aldehyde dehydrogenase 1 family, member L1 -4.06381
TMEM236 transmembrane protein 236 -4.06381
HHAT hedgehog acyltransferase -4.06381
MEP1B meprin A, beta -4.06381
THTPA thiamine triphosphatase -4.06381
PRAM1 PML-RARA regulated adaptor molecule 1 -4.06381
PAQR6 progestin and adipoQ receptor family member VI -4.06381
FADS6 fatty acid desaturase 6 -4.06381
LHX1 LIM homeobox 1 -4.06381
NPB neuropeptide B -4.06381
TSHR thyroid stimulating hormone receptor -4.06381
MST1R macrophage stimulating 1 receptor -4.06381
DNAJB7 DnaJ (Hsp40) homolog, subfamily B, member 7 -4.06381
LONRF2 LON peptidase N-terminal domain and ring finger 2 -4.06381
MOGAT3 monoacylglycerol O-acyltransferase 3 -4.06381
POTEF POTE ankyrin domain family, member F -4.06381
C11ORF96 chromosome 11 open reading frame 96 -4.06381
PSKH2 protein serine kinase H2 -4.06381
UNC5CL unc-5 homolog C (C. elegans)-like -4.06381
CFAP61 cilia and flagella associated protein 61 -4.06381
EMID1 EMI domain containing 1 -4.06381
TYMP thymidine phosphorylase -4.06381
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic -4.06381
RGS2 regulator of G-protein signaling 2 -4.06381
SLC25A34 solute carrier family 25, member 34 -4.06381
RTL5 retrotransposon Gag like 5 -4.06381
GBX1 gastrulation brain homeobox 1 -4.06381
UPK1A uroplakin 1A -4.06381
TEX261 testis expressed 261 -4.06381
TRHR thyrotropin-releasing hormone receptor -4.06381
ATP6V1E2 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2 -4.06381
GUCY1A2 guanylate cyclase 1, soluble, alpha 2 -4.06381
GJD3 gap junction protein, delta 3, 31.9kDa -4.06381
PGLYRP1 peptidoglycan recognition protein 1 -4.06381
ZFP69B ZFP69 zinc finger protein B -4.06381
TBC1D9 TBC1 domain family, member 9 (with GRAM domain) -4.06381
ZNF805 zinc finger protein 805 -3.5777
SNX24 sorting nexin 24 -3.5525
SSNA1 Sjogren syndrome nuclear autoantigen 1 -3.33387
SYNM synemin, intermediate filament protein -3.31378
VSTM5 V-set and transmembrane domain containing 5 -3.31378
ALPK1 alpha-kinase 1 -3.31378
FMO5 flavin containing monooxygenase 5 -3.31378
RAB20 RAB20, member RAS oncogene family -3.07206
PARP9 poly (ADP-ribose) polymerase family, member 9 -3.05123
ZNF181 zinc finger protein 181 -3.04323
BMI1 BMI1 proto-oncogene, polycomb ring finger -3.02228
ETFBKMT electron transfer flavoprotein subunit beta lysine methyltransferase -3.02228
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) -2.93059
PDCD11 programmed cell death 11 -2.89887
FAAP24 FA core complex associated protein 24 -2.86248
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit -2.73867
DOCK4 dedicator of cytokinesis 4 -2.65001
LPIN2 lipin 2 -2.5402
TPX2 TPX2, microtubule-associated -2.49755
NRDE2 NRDE-2, necessary for RNA interference, domain containing -2.49615
KLK8 kallikrein-related peptidase 8 -2.49377
SYTL3 synaptotagmin-like 3 -2.49377
ZNF713 zinc finger protein 713 -2.46369
TBC1D5 TBC1 domain family, member 5 -2.45699
JADE2 jade family PHD finger 2 -2.43244
HRH3 histamine receptor H3 -2.43244
ZNF746 zinc finger protein 746 -2.42334
LINC02762 long intergenic non-protein coding RNA 2762 -2.41151
TLR3 toll-like receptor 3 -2.41151
SPDYE1 speedy/RINGO cell cycle regulator family member E1 -2.41004
MAN2A2 mannosidase, alpha, class 2A, member 2 -2.39165
C1ORF202 chromosome 1 open reading frame 202 -2.39165
NAP1L1 nucleosome assembly protein 1-like 1 -2.39165
FSCN3 fascin actin-bundling protein 3, testicular -2.39165
SUOX sulfite oxidase -2.38853
MNMIP1 manchette microtubule inner protein 1 -2.38853
STAMBP STAM binding protein -2.35835
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -2.3571
MYO1H myosin IH -2.35705
CDK2 cyclin-dependent kinase 2 -2.30554
ARMC1 armadillo repeat containing 1 -2.27035
INTS1 integrator complex subunit 1 -2.24286
RLIM ring finger protein, LIM domain interacting -2.21569
ARMCX1 armadillo repeat containing, X-linked 1 -2.20796
NOC4L nucleolar complex associated 4 homolog (S. cerevisiae) -2.20013
KCTD12 potassium channel tetramerization domain containing 12 -2.14869
CHGB chromogranin B -2.13276
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -2.10099
FMNL2 formin-like 2 -2.09094
PLIN3 perilipin 3 -2.08974
CKAP2L cytoskeleton associated protein 2-like -2.08114
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4 -2.08114
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase -2.07508
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -2.06694
NECAB1 N-terminal EF-hand calcium binding protein 1 -2.06681
GTF2B general transcription factor IIB -2.06681
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -2.05809
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -2.05203
LRRC37A leucine rich repeat containing 37A -2.04709
P2RY14 purinergic receptor P2Y, G-protein coupled, 14 -2.04004
TXNL1 thioredoxin-like 1 -2.03604
STX17 syntaxin 17 -2.03018
RBPJ recombination signal binding protein for immunoglobulin kappa J region -2.02559
RGS20 regulator of G-protein signaling 20 -2.02559
ATL1 atlastin GTPase 1 -2.02559
SEPTIN1 septin 1 -2.02559
MASP2 mannan-binding lectin serine peptidase 2 -2.02559
PJA1 praja ring finger 1, E3 ubiquitin protein ligase -2.01926
POFUT3 protein O-fucosyltransferase 3 -2.01926
HK2 hexokinase 2 -2.01349
ANKRD35 ankyrin repeat domain 35 -2.00879
LDLRAP1 low density lipoprotein receptor adaptor protein 1 -2.00481
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -2.00371
UVSSA UV-stimulated scaffold protein A -2.00109