RHO GTPase Effectors Gene Set

Dataset Reactome Pathways 2024
Category structural or functional annotations
Type pathway
External Link https://reactome.org/PathwayBrowser/#/R-HSA-195258
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Genes

291 proteins participating in the RHO GTPase Effectors pathway from the Reactome Pathways 2024 dataset.

Symbol Name
ABI1 abl-interactor 1
ABI2 abl-interactor 2
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACTB actin, beta
ACTG1 actin gamma 1
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ACTR3 ARP3 actin-related protein 3 homolog (yeast)
AHCTF1 AT hook containing transcription factor 1
AR androgen receptor
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa
AURKB aurora kinase B
B9D2 B9 protein domain 2
BAIAP2 BAI1-associated protein 2
BIRC5 baculoviral IAP repeat containing 5
BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit
BTK Bruton agammaglobulinemia tyrosine kinase
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
BUB3 BUB3 mitotic checkpoint protein
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CDC20 cell division cycle 20
CDC25C cell division cycle 25C
CDC42 cell division cycle 42
CDCA8 cell division cycle associated 8
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CENPA centromere protein A
CENPC centromere protein C
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPH centromere protein H
CENPI centromere protein I
CENPK centromere protein K
CENPL centromere protein L
CENPM centromere protein M
CENPN centromere protein N
CENPO centromere protein O
CENPP centromere protein P
CENPQ centromere protein Q
CENPS-CORT CENPS-CORT readthrough
CENPT centromere protein T
CENPU centromere protein U
CFL1 cofilin 1 (non-muscle)
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CIT citron rho-interacting serine/threonine kinase
CKAP5 cytoskeleton associated protein 5
CLASP1 cytoplasmic linker associated protein 1
CLASP2 cytoplasmic linker associated protein 2
CLIP1 CAP-GLY domain containing linker protein 1
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTTN cortactin
CYBA cytochrome b-245, alpha polypeptide
CYBB cytochrome b-245, beta polypeptide
CYFIP1 cytoplasmic FMR1 interacting protein 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
DAAM1 dishevelled associated activator of morphogenesis 1
DIAPH1 diaphanous-related formin 1
DIAPH2 diaphanous-related formin 2
DIAPH3 diaphanous-related formin 3
DLG4 discs, large homolog 4 (Drosophila)
DSN1 DSN1, MIS12 kinetochore complex component
DVL1 dishevelled segment polarity protein 1
DVL2 dishevelled segment polarity protein 2
DVL3 dishevelled segment polarity protein 3
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
DYNLL1 dynein, light chain, LC8-type 1
DYNLL2 dynein, light chain, LC8-type 2
ERCC6L excision repair cross-complementation group 6-like
EVL Enah/Vasp-like
FLNA filamin A, alpha
FMNL1 formin-like 1
FMNL2 formin-like 2
FMNL3 formin-like 3
GOPC golgi-associated PDZ and coiled-coil motif containing
GRB2 growth factor receptor-bound protein 2
H2AB1 H2A.B variant histone 1
H2AC14 H2A clustered histone 14
H2AC18 H2A clustered histone 18
H2AC20 H2A clustered histone 20
H2AC4 H2A clustered histone 4
H2AC6 H2A clustered histone 6
H2AC7 H2A clustered histone 7
H2AJ H2A.J histone
H2AX H2A.X variant histone
H2AZ2 H2A.Z variant histone 2
H2BC1 H2B clustered histone 1
H2BC11 H2B clustered histone 11
H2BC12 H2B clustered histone 12
H2BC12L H2B clustered histone 12 like
H2BC13 H2B clustered histone 13
H2BC14 H2B clustered histone 14
H2BC15 H2B clustered histone 15
H2BC17 H2B clustered histone 17
H2BC21 H2B clustered histone 21
H2BC26 H2B clustered histone 26
H2BC3 H2B clustered histone 3
H2BC4 H2B clustered histone 4
H2BC5 H2B clustered histone 5
H2BC9 H2B clustered histone 9
H3-3A H3.3 histone A
H3C15 H3 clustered histone 15
H3C8 H3 clustered histone 8
H4C1 H4 clustered histone 1
INCENP inner centromere protein antigens 135/155kDa
IQGAP1 IQ motif containing GTPase activating protein 1
IQGAP2 IQ motif containing GTPase activating protein 2
IQGAP3 IQ motif containing GTPase activating protein 3
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB3BP integrin beta 3 binding protein (beta3-endonexin)
KDM1A lysine (K)-specific demethylase 1A
KDM4C lysine (K)-specific demethylase 4C
KIF14 kinesin family member 14
KIF18A kinesin family member 18A
KIF2A kinesin heavy chain member 2A
KIF2B kinesin family member 2B
KIF2C kinesin family member 2C
KIF5A kinesin family member 5A
KIF5B kinesin family member 5B
KLC1 kinesin light chain 1
KLC2 kinesin light chain 2
KLC3 kinesin light chain 3
KLC4 kinesin light chain 4
KLK2 kallikrein-related peptidase 2
KLK3 kallikrein-related peptidase 3
KNL1 kinetochore scaffold 1
KNTC1 kinetochore associated 1
KTN1 kinectin 1 (kinesin receptor)
LIMK1 LIM domain kinase 1
LIMK2 LIM domain kinase 2
LIN7B lin-7 homolog B (C. elegans)
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAPK1 mitogen-activated protein kinase 1
MAPK11 mitogen-activated protein kinase 11
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPRE1 microtubule-associated protein, RP/EB family, member 1
MEN1 multiple endocrine neoplasia I
MIS12 MIS12 kinetochore complex component
MRTFA myocardin related transcription factor A
MYH10 myosin, heavy chain 10, non-muscle
MYH11 myosin, heavy chain 11, smooth muscle
MYH14 myosin, heavy chain 14, non-muscle
MYH9 myosin, heavy chain 9, non-muscle
MYL12B myosin, light chain 12B, regulatory
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle
MYL9 myosin, light chain 9, regulatory
MYLK myosin light chain kinase
NCF1 neutrophil cytosolic factor 1
NCF2 neutrophil cytosolic factor 2
NCF4 neutrophil cytosolic factor 4, 40kDa
NCK1 NCK adaptor protein 1
NCKAP1 NCK-associated protein 1
NCKAP1L NCK-associated protein 1-like
NCKIPSD NCK interacting protein with SH3 domain
NCOA2 nuclear receptor coactivator 2
NDC80 NDC80 kinetochore complex component
NDE1 nudE neurodevelopment protein 1
NDEL1 nudE neurodevelopment protein 1-like 1
NF2 neurofibromin 2 (merlin)
NOX1 NADPH oxidase 1
NOX3 NADPH oxidase 3
NOXA1 NADPH oxidase activator 1
NOXO1 NADPH oxidase organizer 1
NSL1 NSL1, MIS12 kinetochore complex component
NUDC nudC nuclear distribution protein
NUF2 NUF2, NDC80 kinetochore complex component
NUP107 nucleoporin 107kDa
NUP133 nucleoporin 133kDa
NUP160 nucleoporin 160kDa
NUP37 nucleoporin 37kDa
NUP43 nucleoporin 43kDa
NUP85 nucleoporin 85kDa
NUP98 nucleoporin 98kDa
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PDPK1 3-phosphoinositide dependent protein kinase 1
PFN1 profilin 1
PFN2 profilin 2
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PKN1 protein kinase N1
PKN2 protein kinase N2
PKN3 protein kinase N3
PLK1 polo-like kinase 1
PMF1 polyamine-modulated factor 1
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PPP1R12B protein phosphatase 1, regulatory subunit 12B
PPP1R14A protein phosphatase 1, regulatory (inhibitor) subunit 14A
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PPP2R5D protein phosphatase 2, regulatory subunit B', delta
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PRC1 protein regulator of cytokinesis 1
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRKCZ protein kinase C, zeta
PTK2 protein tyrosine kinase 2
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RANBP2 RAN binding protein 2
RANGAP1 Ran GTPase activating protein 1
RCC2 regulator of chromosome condensation 2
RHOA ras homolog family member A
RHOB ras homolog family member B
RHOC ras homolog family member C
RHOD ras homolog family member D
RHOG ras homolog family member G
RHOQ ras homolog family member Q
RHPN1 rhophilin, Rho GTPase binding protein 1
RHPN2 rhophilin, Rho GTPase binding protein 2
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
ROPN1 rhophilin associated tail protein 1
RPS27 ribosomal protein S27
RTKN rhotekin
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCAI suppressor of cancer cell invasion
SEC13 SEC13 homolog (S. cerevisiae)
SEH1L SEH1-like (S. cerevisiae)
SFN stratifin
SGO1 shugoshin 1
SGO2 shugoshin 2
SKA1 spindle and kinetochore associated complex subunit 1
SKA2 spindle and kinetochore associated complex subunit 2
SPC24 SPC24, NDC80 kinetochore complex component
SPC25 SPC25, NDC80 kinetochore complex component
SPDL1 spindle apparatus coiled-coil protein 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRF serum response factor (c-fos serum response element-binding transcription factor)
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2
TAOK1 TAO kinase 1
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TUBA1A tubulin, alpha 1a
TUBA1B tubulin, alpha 1b
TUBA1C tubulin, alpha 1c
TUBA3C tubulin, alpha 3c
TUBA3E tubulin, alpha 3e
TUBA4A tubulin, alpha 4a
TUBA4B tubulin, alpha 4b
TUBA8 tubulin, alpha 8
TUBAL3 tubulin, alpha-like 3
TUBB1 tubulin, beta 1 class VI
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TUBB3 tubulin, beta 3 class III
TUBB4A tubulin, beta 4A class IVa
TUBB4B tubulin, beta 4B class IVb
TUBB6 tubulin, beta 6 class V
TUBB8 tubulin, beta 8 class VIII
TUBB8B tubulin beta 8B
WAS Wiskott-Aldrich syndrome
WASF1 WAS protein family, member 1
WASF2 WAS protein family, member 2
WASF3 WAS protein family, member 3
WASL Wiskott-Aldrich syndrome-like
WIPF1 WAS/WASL interacting protein family, member 1
WIPF2 WAS/WASL interacting protein family, member 2
WIPF3 WAS/WASL interacting protein family, member 3
XPO1 exportin 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZW10 zw10 kinetochore protein
ZWILCH zwilch kinetochore protein
ZWINT ZW10 interacting kinetochore protein