RHOH Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description ras homolog family member H|The protein encoded by this gene is a member of the Ras superfamily of guanosine triphosphate (GTP)-metabolizing enzymes. The encoded protein is expressed in hematopoietic cells, where it functions as a negative regulator of cell growth and survival. This gene may be hypermutated or misexpressed in leukemias and lymphomas. Chromosomal translocations in non-Hodgkin's lymphoma occur between this locus and B-cell CLL/lymphoma 6 (BCL6) on chromosome 3, leading to the production of fusion transcripts. Alternative splicing in the 5' untranslated region results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2013] (NCBI Entrez Gene Database, 399)
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Genes

333 genes differentially expressed following the RHOH gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SLC46A2 solute carrier family 46, member 2 3.19432
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 3.19432
FETUB fetuin B 3.19432
BATF basic leucine zipper transcription factor, ATF-like 3.19432
ASB14 ankyrin repeat and SOCS box containing 14 3.19432
MT1HL1 metallothionein 1H-like 1 3.19432
NEU4 sialidase 4 3.19432
RPE65 retinal pigment epithelium-specific protein 65kDa 3.19432
SSTR5 somatostatin receptor 5 3.19432
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 3.19432
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 3.19432
CSTL1 cystatin-like 1 3.19432
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 3.19432
CABP4 calcium binding protein 4 3.19432
MAGEA6 melanoma antigen family A6 3.19432
ZEB2 zinc finger E-box binding homeobox 2 3.19432
TMEM151A transmembrane protein 151A 3.19432
CNTNAP4 contactin associated protein-like 4 3.19432
TCHH trichohyalin 3.19432
DDN dendrin 3.19432
EPB42 erythrocyte membrane protein band 4.2 3.19432
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 3.19432
PBOV1 prostate and breast cancer overexpressed 1 3.19432
ARSA arylsulfatase A 3.19432
TRIM73 tripartite motif containing 73 3.19432
MRC1 mannose receptor, C type 1 3.19432
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 3.19432
ITIH6 inter-alpha-trypsin inhibitor heavy chain family, member 6 3.19432
HIC1 hypermethylated in cancer 1 3.19432
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 3.19432
FGF9 fibroblast growth factor 9 3.19432
RNASE9 ribonuclease, RNase A family, 9 (non-active) 3.19432
ELL3 elongation factor RNA polymerase II-like 3 3.19432
OR6B1 olfactory receptor, family 6, subfamily B, member 1 3.19432
TAS2R19 taste receptor, type 2, member 19 3.19432
CRYGN crystallin, gamma N 3.19432
SHD Src homology 2 domain containing transforming protein D 3.19432
STRA8 stimulated by retinoic acid 8 3.19432
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 3.19432
ADAMTSL5 ADAMTS-like 5 3.19432
BAAT bile acid CoA:amino acid N-acyltransferase 3.19432
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 3.19432
GUCY2D guanylate cyclase 2D, membrane (retina-specific) 3.19432
RGPD3 RANBP2-like and GRIP domain containing 3 3.19432
ANKK1 ankyrin repeat and kinase domain containing 1 3.19432
KYNU kynureninase 3.19432
IRX3 iroquois homeobox 3 3.19432
FAM167B family with sequence similarity 167, member B 3.19432
LOC124909439 uncharacterized LOC124909439 3.19432
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 3.19432
LOC122539214 Zinc finger protein LOC122539214 3.19432
ANGPTL8 angiopoietin like 8 3.19432
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 3.19432
GIPC3 GIPC PDZ domain containing family, member 3 3.19432
GPR35 G protein-coupled receptor 35 3.19432
BNC1 basonuclin 1 3.19432
ADRB3 adrenoceptor beta 3 3.19432
DOK7 docking protein 7 3.19432
DEPP1 DEPP autophagy regulator 1 3.19432
RTL5 retrotransposon Gag like 5 3.19432
CCDC190 coiled-coil domain containing 190 3.19432
OR56B2 olfactory receptor family 56 subfamily B member 2 3.19432
FAM240A family with sequence similarity 240 member A 3.19432
C17ORF114 chromosome 17 open reading frame 114 3.19432
GREP1 glycine rich extracellular protein 1 3.19432
GLYATL1B glycine-N-acyltransferase like 1B 3.19432
CLEC20A C-type lectin domain containing 20A 3.19432
PPDPFL pancreatic progenitor cell differentiation and proliferation factor like 3.19432
PPP1R2C PPP1R2C family member C 3.19432
SPACDR sperm acrosome developmental regulator 3.19432
ZNF441 zinc finger protein 441 3.19432
LY6H lymphocyte antigen 6 complex, locus H 3.19432
F5 coagulation factor V (proaccelerin, labile factor) 3.19432
CPNE4 copine IV 3.19432
FPR2 formyl peptide receptor 2 3.19432
FAM153A family with sequence similarity 153, member A 3.19432
RAET1E retinoic acid early transcript 1E 3.19432
SLC22A14 solute carrier family 22, member 14 3.19432
WEE2 WEE1 homolog 2 (S. pombe) 3.19432
CFHR5 complement factor H-related 5 3.19432
BCAR3 breast cancer anti-estrogen resistance 3 3.19432
NKAPL NFKB activating protein-like 3.19432
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 3.19432
KLHL33 kelch-like family member 33 3.19432
CHRD chordin 3.19432
GATA6 GATA binding protein 6 3.19432
ASIC4 acid sensing (proton gated) ion channel family member 4 3.19432
PNPLA1 patatin-like phospholipase domain containing 1 3.19432
PTH parathyroid hormone 3.19432
MYOT myotilin 3.19432
FAM186A family with sequence similarity 186, member A 3.19432
SCN7A sodium channel, voltage gated, type VII alpha subunit 3.19432
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 3.19432
SCRT2 scratch family zinc finger 2 3.19432
EQTN equatorin, sperm acrosome associated 3.19432
PLA2G4E phospholipase A2, group IVE 3.19432
AQP6 aquaporin 6, kidney specific 3.19432
S100Z S100 calcium binding protein Z 3.19432
CYSLTR1 cysteinyl leukotriene receptor 1 3.19432
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 3.19432
POLR3B polymerase (RNA) III (DNA directed) polypeptide B 3.19432
SERINC4 serine incorporator 4 3.19432
SPATA4 spermatogenesis associated 4 3.19432
CLEC4G C-type lectin domain family 4, member G 3.19432
BAHCC1 BAH domain and coiled-coil containing 1 3.19432
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase) 3.19432
GPR12 G protein-coupled receptor 12 3.19432
CASS4 Cas scaffolding protein family member 4 3.19432
TNR tenascin R 3.19432
C17ORF107 chromosome 17 open reading frame 107 3.19432
PCDHGB4 protocadherin gamma subfamily B, 4 3.19432
LRCOL1 leucine rich colipase-like 1 3.19432
CCDC158 coiled-coil domain containing 158 3.19432
CNTF ciliary neurotrophic factor 3.19432
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 3.19432
LCNL1 lipocalin-like 1 3.19432
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 3.19432
IL1B interleukin 1, beta 3.19432
PCDHAC2 protocadherin alpha subfamily C, 2 3.19432
LAMB3 laminin, beta 3 3.19432
DENND2D DENN/MADD domain containing 2D 3.19432
EVI2A ecotropic viral integration site 2A 3.19432
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 3.19432
CCDC170 coiled-coil domain containing 170 3.19432
UPK1B uroplakin 1B 3.19432
RAD9B RAD9 homolog B (S. pombe) 3.19432
NR1D1 nuclear receptor subfamily 1, group D, member 1 3.19432
CTRB1 chymotrypsinogen B1 3.19432
DND1 DND microRNA-mediated repression inhibitor 1 3.19432
THBD thrombomodulin 3.19432
SAMD5 sterile alpha motif domain containing 5 3.19432
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 3.19432
AMH anti-Mullerian hormone 3.19432
TPPP2 tubulin polymerization-promoting protein family member 2 3.19432
CDH17 cadherin 17, LI cadherin (liver-intestine) 3.19432
NR5A1 nuclear receptor subfamily 5, group A, member 1 3.19432
LYZ lysozyme 3.19432
NOBOX NOBOX oogenesis homeobox 3.19432
TRHR thyrotropin-releasing hormone receptor 3.19432
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 3.19432
NEUROD1 neuronal differentiation 1 3.19432
LST1 leukocyte specific transcript 1 3.19432
GPBAR1 G protein-coupled bile acid receptor 1 3.19432
TMEM86A transmembrane protein 86A 3.19432
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 3.19432
BPIFC BPI fold containing family C 3.19432
TRPM2 transient receptor potential cation channel, subfamily M, member 2 3.19432
CD80 CD80 molecule 3.19432
MSLN mesothelin 3.19432
PTPN1 protein tyrosine phosphatase, non-receptor type 1 3.19432
PTPN7 protein tyrosine phosphatase, non-receptor type 7 3.19432
ADRA1D adrenoceptor alpha 1D 3.19432
PADI1 peptidyl arginine deiminase, type I 3.19432
ANGPTL6 angiopoietin-like 6 3.19432
IRX5 iroquois homeobox 5 3.19432
MMP10 matrix metallopeptidase 10 3.19432
CHRDL2 chordin-like 2 3.19432
POPDC2 popeye domain containing 2 3.19432
PRRX1 paired related homeobox 1 3.19432
FAM25A family with sequence similarity 25, member A 3.19432
FOSB FBJ murine osteosarcoma viral oncogene homolog B 3.19432
TMIGD2 transmembrane and immunoglobulin domain containing 2 3.19432
TBC1D28 TBC1 domain family, member 28 3.19432
ALOX15B arachidonate 15-lipoxygenase, type B 3.19432
MC5R melanocortin 5 receptor 3.19432
CALML6 calmodulin-like 6 3.19432
ZNF285 zinc finger protein 285 3.11903
ARG1 arginase 1 3.05305
BHMT betaine--homocysteine S-methyltransferase 3.05305
FCRL5 Fc receptor-like 5 3.05305
RBBP4 retinoblastoma binding protein 4 2.98108
RAB11FIP5 RAB11 family interacting protein 5 (class I) 2.96187
HECTD2 HECT domain containing E3 ubiquitin protein ligase 2 2.94134
RPRML reprimo-like 2.89456
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.85642
TRAPPC2L trafficking protein particle complex 2-like 2.74589
ITCH itchy E3 ubiquitin protein ligase 2.67034
TPRG1L tumor protein p63 regulated 1-like 2.59905
ASF1B anti-silencing function 1B histone chaperone 2.59905
EXPH5 exophilin 5 2.53682
DPEP1 dipeptidase 1 (renal) 2.4641
VCP valosin containing protein 2.4515
PEBP1 phosphatidylethanolamine binding protein 1 2.38458
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 2.37423
PLCD1 phospholipase C, delta 1 2.36506
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived) 2.35453
DALRD3 DALR anticodon binding domain containing 3 2.35
WBP2NL WBP2 N-terminal like 2.34971
UBAC2 UBA domain containing 2 2.34097
CAPN11 calpain 11 2.33185
PTGR1 prostaglandin reductase 1 2.33088
FBH1 F-box DNA helicase 1 2.32753
CCR10 chemokine (C-C motif) receptor 10 2.31902
HAPLN4 hyaluronan and proteoglycan link protein 4 2.28418
LRRTM4 leucine rich repeat transmembrane neuronal 4 2.26524
ZNF823 zinc finger protein 823 2.24328
ADNP activity-dependent neuroprotector homeobox 2.24151
HEXD hexosaminidase D 2.23525
FLNA filamin A, alpha 2.2352
NPTN neuroplastin 2.22118
PPP4R4 protein phosphatase 4, regulatory subunit 4 2.22118
CFAP68 cilia and flagella associated protein 68 2.21433
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 2.20194
GCK glucokinase (hexokinase 4) 2.19779
SDC2 syndecan 2 2.14079
DOK5 docking protein 5 2.12801
CMTR1 cap methyltransferase 1 2.1135
WHR1 winged helix repair factor 1 2.11117
RYR2 ryanodine receptor 2 (cardiac) 2.10778
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 2.10734
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 2.10132
MBOAT7 membrane bound O-acyltransferase domain containing 7 2.07675
PDPR pyruvate dehydrogenase phosphatase regulatory subunit 2.06856
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae) 2.06723
WDR72 WD repeat domain 72 2.05408
MYL9 myosin, light chain 9, regulatory 2.05339
VCX variable charge, X-linked 2.04955
NT5E 5'-nucleotidase, ecto (CD73) 2.04955
TMEM198 transmembrane protein 198 2.04535
SH3KBP1 SH3-domain kinase binding protein 1 2.04182
GLI1 GLI family zinc finger 1 2.02738
F2RL1 coagulation factor II (thrombin) receptor-like 1 2.01543
FN3K fructosamine 3 kinase 2.01069
MED22 mediator complex subunit 22 2.00509
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 2.00318

decreased expression

Symbol Name Standardized Value
RAG1 recombination activating gene 1 -3.19432
EFHB EF-hand domain family, member B -3.19432
WFDC8 WAP four-disulfide core domain 8 -3.19432
ENPEP glutamyl aminopeptidase (aminopeptidase A) -3.19432
GET4 golgi to ER traffic protein 4 homolog (S. cerevisiae) -3.19432
AQP4 aquaporin 4 -3.19432
HGF hepatocyte growth factor (hepapoietin A; scatter factor) -3.19432
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 -3.19432
MFAP4 microfibrillar-associated protein 4 -3.19432
SPTBN5 spectrin, beta, non-erythrocytic 5 -3.19432
PCDHGB1 protocadherin gamma subfamily B, 1 -3.19432
BMP2 bone morphogenetic protein 2 -3.19432
EPHB3 EPH receptor B3 -3.19432
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) -3.19432
ARMCX6 armadillo repeat containing, X-linked 6 -3.19432
DHRS2 dehydrogenase/reductase (SDR family) member 2 -3.19432
CLEC4C C-type lectin domain family 4, member C -3.19432
E2F2 E2F transcription factor 2 -3.19432
PCDH20 protocadherin 20 -3.19432
LDLRAD2 low density lipoprotein receptor class A domain containing 2 -3.19432
CD247 CD247 molecule -3.19432
LYPD1 LY6/PLAUR domain containing 1 -3.19432
PRDM7 PR domain containing 7 -3.19432
PGA5 pepsinogen 5, group I (pepsinogen A) -3.19432
FLT3LG fms-related tyrosine kinase 3 ligand -3.19432
CXCL16 chemokine (C-X-C motif) ligand 16 -3.19432
FOSL2 FOS-like antigen 2 -3.19432
BCO1 beta-carotene oxygenase 1 -3.19432
IL1A interleukin 1, alpha -3.19432
CSMD3 CUB and Sushi multiple domains 3 -3.19432
SPEG SPEG complex locus -3.19432
ZCCHC18 zinc finger, CCHC domain containing 18 -3.19432
PGLYRP1 peptidoglycan recognition protein 1 -3.19432
PTPRQ protein tyrosine phosphatase, receptor type, Q -3.19432
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast) -2.92757
N4BP3 NEDD4 binding protein 3 -2.82212
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B -2.73819
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 -2.71828
SMIM24 small integral membrane protein 24 -2.66517
KCNV2 potassium channel, voltage gated modifier subfamily V, member 2 -2.63368
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 -2.58346
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 -2.55409
C1ORF167 chromosome 1 open reading frame 167 -2.55409
SNX24 sorting nexin 24 -2.54059
NRXN3 neurexin 3 -2.51847
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -2.51847
FAM120B family with sequence similarity 120B -2.51272
MRPL11 mitochondrial ribosomal protein L11 -2.4859
DIPK2A divergent protein kinase domain 2A -2.46961
MSRB1 methionine sulfoxide reductase B1 -2.46961
SH3BP4 SH3-domain binding protein 4 -2.45771
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled -2.40593
OGG1 8-oxoguanine DNA glycosylase -2.38221
AP4M1 adaptor-related protein complex 4, mu 1 subunit -2.37519
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1 -2.36961
FBXO34 F-box protein 34 -2.35453
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -2.35453
NKD2 naked cuticle homolog 2 (Drosophila) -2.35453
ZFP36L1 ZFP36 ring finger protein-like 1 -2.35453
SCYL2 SCY1-like 2 (S. cerevisiae) -2.30191
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha -2.30118
CLSTN1 calsyntenin 1 -2.30118
SCUBE1 signal peptide, CUB domain, EGF-like 1 -2.30118
EHD2 EH-domain containing 2 -2.28583
TTLL3 tubulin tyrosine ligase-like family member 3 -2.27565
ZNF536 zinc finger protein 536 -2.2444
NTF4 neurotrophin 4 -2.2444
NPIPB6 nuclear pore complex interacting protein family, member B6 -2.24151
PEX12 peroxisomal biogenesis factor 12 -2.24151
COL28A1 collagen, type XXVIII, alpha 1 -2.24151
PCDH9 protocadherin 9 -2.24151
TNC tenascin C -2.24151
DLD dihydrolipoamide dehydrogenase -2.24151
LGR6 leucine-rich repeat containing G protein-coupled receptor 6 -2.24151
ADGRD2 adhesion G protein-coupled receptor D2 -2.24151
PROK2 prokineticin 2 -2.24151
SKAP2 src kinase associated phosphoprotein 2 -2.23789
UBE2E1 ubiquitin-conjugating enzyme E2E 1 -2.21841
CCNC cyclin C -2.21391
C6ORF163 chromosome 6 open reading frame 163 -2.20071
SAT1 spermidine/spermine N1-acetyltransferase 1 -2.19779
MAN2A2 mannosidase, alpha, class 2A, member 2 -2.18637
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) -2.17247
CUL7 cullin 7 -2.17247
GPSM2 G-protein signaling modulator 2 -2.17247
KCNMB4 potassium channel subfamily M regulatory beta subunit 4 -2.16842
OPA1 optic atrophy 1 (autosomal dominant) -2.16058
PARP14 poly (ADP-ribose) polymerase family, member 14 -2.16058
RGMB repulsive guidance molecule family member b -2.15629
MAGEE1 melanoma antigen family E1 -2.15524
API5 apoptosis inhibitor 5 -2.14079
POLI polymerase (DNA directed) iota -2.12801
C1ORF54 chromosome 1 open reading frame 54 -2.10132
TBC1D8B TBC1 domain family, member 8B (with GRAM domain) -2.07753
COMMD6 COMM domain containing 6 -2.07675
SRSF10 serine/arginine-rich splicing factor 10 -2.06856
ARHGAP45 Rho GTPase activating protein 45 -2.06856
SLCO3A1 solute carrier organic anion transporter family, member 3A1 -2.0646
WRAP53 WD repeat containing, antisense to TP53 -2.06282
CARD10 caspase recruitment domain family, member 10 -2.05907
KPTN kaptin (actin binding protein) -2.05627
POR P450 (cytochrome) oxidoreductase -2.04258
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28 -2.0418
KCNK10 potassium channel, two pore domain subfamily K, member 10 -2.0418
MYEF2 myelin expression factor 2 -2.0297
SETD1A SET domain containing 1A -2.01784
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase -2.01549
ZNF623 zinc finger protein 623 -2.00068