RHOQ Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description ras homolog family member Q|This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein is an important signalling protein for sarcomere assembly and has been shown to play a significant role in the exocytosis of the solute carrier family 2, facilitated glucose transporter member 4 and other proteins, possibly acting as the signal that turns on the membrane fusion machinery. Three related pseudogene have been identified on chromosomes 2 and 14. [provided by RefSeq, Aug 2011] (NCBI Entrez Gene Database, 23433)
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Genes

310 genes differentially expressed following the RHOQ gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
NPIPB9 nuclear pore complex interacting protein family, member B9 2.71324
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4 2.71324
CAMK2B calcium/calmodulin-dependent protein kinase II beta 2.71324
OR56A4 olfactory receptor, family 56, subfamily A, member 4 2.71324
CIMIP4 ciliary microtubule inner protein 4 2.71324
RHOJ ras homolog family member J 2.71324
ADTRP androgen-dependent TFPI-regulating protein 2.71324
CNTNAP2 contactin associated protein-like 2 2.70372
RASSF10 Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 2.70372
MMP10 matrix metallopeptidase 10 2.70372
GJA10 gap junction protein, alpha 10, 62kDa 2.70372
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 2.70372
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 2.70372
PAX7 paired box 7 2.70372
XCL1 chemokine (C motif) ligand 1 2.70372
SERPINA11 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 2.70372
GLYAT glycine-N-acyltransferase 2.70372
PCDHB8 protocadherin beta 8 2.70372
ZNF662 zinc finger protein 662 2.70372
TEX13A testis expressed 13A 2.70372
FABP1 fatty acid binding protein 1, liver 2.70372
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 2.70372
SCGB3A1 secretoglobin, family 3A, member 1 2.70372
CX3CL1 chemokine (C-X3-C motif) ligand 1 2.70372
OR52A5 olfactory receptor, family 52, subfamily A, member 5 2.70372
FABP4 fatty acid binding protein 4, adipocyte 2.70372
SHCBP1L SHC SH2-domain binding protein 1-like 2.70372
ACOT12 acyl-CoA thioesterase 12 2.70372
LGALS4 lectin, galactoside-binding, soluble, 4 2.70372
CPLX3 complexin 3 2.70372
HMX3 H6 family homeobox 3 2.70372
SPACA5 sperm acrosome associated 5 2.70372
KCNU1 potassium channel, subfamily U, member 1 2.70372
TPH1 tryptophan hydroxylase 1 2.70372
HOXB2 homeobox B2 2.70372
LMBRD1 LMBR1 domain containing 1 2.70372
BHMT2 betaine--homocysteine S-methyltransferase 2 2.70372
MISP mitotic spindle positioning 2.70372
MYOM3 myomesin 3 2.70372
TCAF2 TRPM8 channel-associated factor 2 2.70372
BSX brain-specific homeobox 2.70372
ZNF556 zinc finger protein 556 2.70372
OR1L6 olfactory receptor, family 1, subfamily L, member 6 2.70372
OR7A17 olfactory receptor, family 7, subfamily A, member 17 2.70372
MROH6 maestro heat-like repeat family member 6 2.70372
GNG13 guanine nucleotide binding protein (G protein), gamma 13 2.70372
ANXA2R annexin A2 receptor 2.70372
SPMIP1 sperm microtubule inner protein 1 2.70372
PTH1R parathyroid hormone 1 receptor 2.70372
MCHR1 melanin-concentrating hormone receptor 1 2.70372
LTB4R2 leukotriene B4 receptor 2 2.70372
SOHLH1 spermatogenesis and oogenesis specific basic helix-loop-helix 1 2.70372
SCEL sciellin 2.70372
SPRR2F small proline-rich protein 2F 2.70372
APOBEC3H apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H 2.70372
ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12 2.70372
ASB4 ankyrin repeat and SOCS box containing 4 2.70372
CFAP97D1 CFAP97 domain containing 1 2.70372
CBY2 chibby family member 2 2.70372
DRC5 dynein regulatory complex subunit 5 2.70372
PNMA6F PNMA family member 6F 2.70372
THSD8 thrombospondin type 1 domain containing 8 2.70372
LINC02268 long intergenic non-protein coding RNA 2268 2.70372
SMIM43 small integral membrane protein 43 2.70372
CIBAR2 CBY1 interacting BAR domain containing 2 2.70372
CLEC20A C-type lectin domain containing 20A 2.70372
SEPTIN12 septin 12 2.70372
GARIN4 golgi associated RAB2 interactor family member 4 2.70372
RDH8 retinol dehydrogenase 8 (all-trans) 2.70372
KL klotho 2.70372
DNASE2B deoxyribonuclease II beta 2.70372
TMEM235 transmembrane protein 235 2.70372
TMEM276-ZFTRAF1 TMEM276-ZFTRAF1 readthrough 2.70372
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 2.70372
PCDHA2 protocadherin alpha 2 2.70372
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 2.70372
BPIFA2 BPI fold containing family A, member 2 2.70372
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 2.70372
NRN1 neuritin 1 2.70372
IL4 interleukin 4 2.70372
MYH13 myosin, heavy chain 13, skeletal muscle 2.70372
ACE2 angiotensin I converting enzyme 2 2.70372
GDF9 growth differentiation factor 9 2.70372
C7 complement component 7 2.70372
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 2.70372
CREB3L3 cAMP responsive element binding protein 3-like 3 2.70372
C1QTNF9 C1q and tumor necrosis factor related protein 9 2.70372
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 2.70372
C1QL2 complement component 1, q subcomponent-like 2 2.70372
HSPB6 heat shock protein, alpha-crystallin-related, B6 2.70372
FBXL8 F-box and leucine-rich repeat protein 8 2.70372
RBP4 retinol binding protein 4, plasma 2.70372
NCR3 natural cytotoxicity triggering receptor 3 2.70372
PCDHGB5 protocadherin gamma subfamily B, 5 2.70372
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 2.70372
CLRN2 clarin 2 2.70372
FAIM2 Fas apoptotic inhibitory molecule 2 2.70372
SOSTDC1 sclerostin domain containing 1 2.70372
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 2.70372
REG1A regenerating islet-derived 1 alpha 2.70372
LMX1A LIM homeobox transcription factor 1, alpha 2.70372
TOPAZ1 testis and ovary specific PAZ domain containing 1 2.70372
SFTA2 surfactant associated 2 2.70372
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 2.70372
NPY2R neuropeptide Y receptor Y2 2.70372
DRC7 dynein regulatory complex subunit 7 2.70372
OR11G2 olfactory receptor, family 11, subfamily G, member 2 2.70372
RPA4 replication protein A4, 30kDa 2.70372
KCNK5 potassium channel, two pore domain subfamily K, member 5 2.70372
MAP3K19 mitogen-activated protein kinase kinase kinase 19 2.70372
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 2.70372
BPIFB1 BPI fold containing family B, member 1 2.70372
GOLGA6D golgin A6 family, member D 2.70372
LHX5 LIM homeobox 5 2.70372
LRRC25 leucine rich repeat containing 25 2.70372
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C 2.70372
DEFB107B defensin, beta 107B 2.70372
KNCN kinocilin 2.70372
RGS11 regulator of G-protein signaling 11 2.70372
F2RL3 coagulation factor II (thrombin) receptor-like 3 2.70372
TCEA3 transcription elongation factor A (SII), 3 2.70372
ZSCAN4 zinc finger and SCAN domain containing 4 2.70372
SPATA4 spermatogenesis associated 4 2.70372
TRPM8 transient receptor potential cation channel, subfamily M, member 8 2.70372
GRAP2 GRB2-related adaptor protein 2 2.70372
PLA2G1B phospholipase A2, group IB (pancreas) 2.70372
RP1 retinitis pigmentosa 1 (autosomal dominant) 2.70372
MSMB microseminoprotein, beta- 2.70372
GPR179 G protein-coupled receptor 179 2.70372
PDZRN4 PDZ domain containing ring finger 4 2.70372
MROH2A maestro heat-like repeat family member 2A 2.70372
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 2.70372
ZNF598 zinc finger protein 598 2.70372
CRHBP corticotropin releasing hormone binding protein 2.70372
SAMD7 sterile alpha motif domain containing 7 2.70372
PRR35 proline rich 35 2.70372
SPINT4 serine peptidase inhibitor, Kunitz type 4 2.70372
CD226 CD226 molecule 2.70372
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 2.70372
MMP13 matrix metallopeptidase 13 2.70372
VPS37C vacuolar protein sorting 37 homolog C (S. cerevisiae) 2.70372
TGM4 transglutaminase 4 2.70372
CGB7 chorionic gonadotropin, beta polypeptide 7 2.70372
SYTL4 synaptotagmin-like 4 2.70372
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 2.70372
MAGEA12 melanoma antigen family A12 2.70372
FCAR Fc fragment of IgA receptor 2.70372
THEM5 thioesterase superfamily member 5 2.70372
ENTPD8 ectonucleoside triphosphate diphosphohydrolase 8 2.70372
OR52N4 olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene) 2.70372
OR52K1 olfactory receptor, family 52, subfamily K, member 1 2.70372
TMEM156 transmembrane protein 156 2.70372
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 2.70372
TEX38 testis expressed 38 2.70372
ADRA1D adrenoceptor alpha 1D 2.70372
CD33 CD33 molecule 2.70372
LDHAL6A lactate dehydrogenase A-like 6A 2.69551
IP6K2 inositol hexakisphosphate kinase 2 2.69551
LBHD1 LBH domain containing 1 2.69551
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 2.69551
PKP3 plakophilin 3 2.69551
NR4A3 nuclear receptor subfamily 4, group A, member 3 2.69551
MYO7A myosin VIIA 2.69551
RAMP3 receptor (G protein-coupled) activity modifying protein 3 2.69551
TUBB4B tubulin, beta 4B class IVb 2.66809
GLIPR1 GLI pathogenesis-related 1 2.63272
HLA-DMA major histocompatibility complex, class II, DM alpha 2.62968
AGBL4 ATP/GTP binding protein-like 4 2.62609
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 2.62566
CYB5D2 cytochrome b5 domain containing 2 2.59504
KMT5A lysine methyltransferase 5A 2.54347
TUG1 taurine up-regulated 1 (non-protein coding) 2.532
HPX hemopexin 2.51186
TMEM50B transmembrane protein 50B 2.47545
HES2 hes family bHLH transcription factor 2 2.45829
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 2.45829
TF transferrin 2.45829
PPP4R3A protein phosphatase 4 regulatory subunit 3A 2.45018
FAM229B family with sequence similarity 229, member B 2.44298
SLC67A2 solute carrier family 67 member 2 2.41031
DNAJC30 DnaJ (Hsp40) homolog, subfamily C, member 30 2.379
DCLRE1B DNA cross-link repair 1B 2.36036
OTOF otoferlin 2.35359
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 2.35217
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 2.34782
BACE1 beta-site APP-cleaving enzyme 1 2.33632
MOCS2 molybdenum cofactor synthesis 2 2.32662
LTB lymphotoxin beta (TNF superfamily, member 3) 2.3182
LPAR2 lysophosphatidic acid receptor 2 2.30878
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 2.30633
TSPAN32 tetraspanin 32 2.30577
FAM229A family with sequence similarity 229, member A 2.29298
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 2.27963
FAM194C family with sequence similarity 149 member C 2.27963
DMWD dystrophia myotonica, WD repeat containing 2.2701
PHACTR2 phosphatase and actin regulator 2 2.25711
ASXL2 additional sex combs like transcriptional regulator 2 2.18233
SELENOT selenoprotein T 2.17951
GUCY1A2 guanylate cyclase 1, soluble, alpha 2 2.1738
CHPT1 choline phosphotransferase 1 2.16941
TMEM9B TMEM9 domain family, member B 2.09043
ZBTB1 zinc finger and BTB domain containing 1 2.08388
GGCX gamma-glutamyl carboxylase 2.07307
CTNND2 catenin (cadherin-associated protein), delta 2 2.0615
EFCAB13 EF-hand calcium binding domain 13 2.03018
ZNF219 zinc finger protein 219 2.02818
H2AC20 H2A clustered histone 20 2.02707
ATAD2B ATPase family, AAA domain containing 2B 2.02562
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 2.02539
ZBTB44 zinc finger and BTB domain containing 44 2.0163
COL6A2 collagen, type VI, alpha 2 2.01426
MYT1L myelin transcription factor 1-like 2.01426
TRIP6 thyroid hormone receptor interactor 6 2.00861

decreased expression

Symbol Name Standardized Value
RAMACL RNA guanine-7 methyltransferase activating subunit like -2.70372
SLC25A45 solute carrier family 25, member 45 -2.70372
EGFL6 EGF-like-domain, multiple 6 -2.70372
RHOQ ras homolog family member Q -2.70372
ARHGEF25 Rho guanine nucleotide exchange factor (GEF) 25 -2.70372
LOC124904542 uncharacterized LOC124904542 -2.70372
SHISA3 shisa family member 3 -2.70372
POT1 protection of telomeres 1 -2.70372
CEL carboxyl ester lipase -2.70372
GLRA1 glycine receptor, alpha 1 -2.70372
TBX6 T-box 6 -2.70372
H3C6 H3 clustered histone 6 -2.70372
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 -2.70372
BRICD5 BRICHOS domain containing 5 -2.69551
MYO1A myosin IA -2.69551
TAS2R46 taste receptor, type 2, member 46 -2.69551
OR52E4 olfactory receptor, family 52, subfamily E, member 4 -2.69551
PODNL1 podocan-like 1 -2.69551
COPZ2 coatomer protein complex, subunit zeta 2 -2.69551
C2ORF80 chromosome 2 open reading frame 80 -2.69551
F7 coagulation factor VII (serum prothrombin conversion accelerator) -2.69551
ALPG alkaline phosphatase, germ cell -2.69551
PLEK2 pleckstrin 2 -2.69551
GZMM granzyme M (lymphocyte met-ase 1) -2.69551
TLE6 transducin-like enhancer of split 6 -2.69551
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -2.69551
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1 -2.69551
PARP3 poly (ADP-ribose) polymerase family, member 3 -2.69551
USP26 ubiquitin specific peptidase 26 -2.69551
ASPG asparaginase -2.69551
TAL2 T-cell acute lymphocytic leukemia 2 -2.69551
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 -2.69551
EDN1 endothelin 1 -2.69551
GABRD gamma-aminobutyric acid (GABA) A receptor, delta -2.69551
POF1B premature ovarian failure, 1B -2.69551
ITM2A integral membrane protein 2A -2.69551
NPFFR1 neuropeptide FF receptor 1 -2.69551
ZNF541 zinc finger protein 541 -2.69551
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 -2.69551
TBXA2R thromboxane A2 receptor -2.69551
RUFY4 RUN and FYVE domain containing 4 -2.69551
ALOXE3 arachidonate lipoxygenase 3 -2.69551
STRC stereocilin -2.69551
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial -2.69551
PXT1 peroxisomal, testis specific 1 -2.69551
INTS5 integrator complex subunit 5 -2.65223
FUZ fuzzy planar cell polarity protein -2.60603
CDC6 cell division cycle 6 -2.54347
KIRREL2 kin of IRRE like 2 (Drosophila) -2.5213
BRD3 bromodomain containing 3 -2.5019
TINF2 TERF1 (TRF1)-interacting nuclear factor 2 -2.50066
C18ORF32 chromosome 18 open reading frame 32 -2.49111
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 -2.46874
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.46248
IRF8 interferon regulatory factor 8 -2.45797
EGFR epidermal growth factor receptor -2.42485
TSPAN33 tetraspanin 33 -2.42485
FMC1 formation of mitochondrial complex V assembly factor 1 homolog -2.40396
CNTLN centlein, centrosomal protein -2.37752
FTH1 ferritin, heavy polypeptide 1 -2.33397
EYA3 EYA transcriptional coactivator and phosphatase 3 -2.33397
TOMM5 translocase of outer mitochondrial membrane 5 homolog (yeast) -2.32662
DPEP3 dipeptidase 3 -2.32614
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.30878
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -2.28914
SHROOM2 shroom family member 2 -2.28914
SLC4A11 solute carrier family 4, sodium borate transporter, member 11 -2.27757
FGF13 fibroblast growth factor 13 -2.27567
AKT3 v-akt murine thymoma viral oncogene homolog 3 -2.23872
ZCCHC18 zinc finger, CCHC domain containing 18 -2.21779
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 -2.20559
ATP2A3 ATPase, Ca++ transporting, ubiquitous -2.20179
CCDC68 coiled-coil domain containing 68 -2.20179
TEAD4 TEA domain family member 4 -2.18218
GPAM glycerol-3-phosphate acyltransferase, mitochondrial -2.17455
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -2.13957
FLOT2 flotillin 2 -2.13658
DMRT1 doublesex and mab-3 related transcription factor 1 -2.13042
PXDC1 PX domain containing 1 -2.13042
GSN gelsolin -2.12623
ANO9 anoctamin 9 -2.10775
PRIMPOL primase and polymerase (DNA-directed) -2.10018
BAHCC1 BAH domain and coiled-coil containing 1 -2.10018
STK40 serine/threonine kinase 40 -2.09623
CRYZ crystallin, zeta (quinone reductase) -2.09623
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -2.07894
GET3 guided entry of tail-anchored proteins factor 3, ATPase -2.07894
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.07765
HACD2 3-hydroxyacyl-CoA dehydratase 2 -2.07307
PUS10 pseudouridylate synthase 10 -2.06625
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 -2.03956
MPC2 mitochondrial pyruvate carrier 2 -2.02818
D2HGDH D-2-hydroxyglutarate dehydrogenase -2.02562
AAMP angio-associated, migratory cell protein -2.02562
SPRY3 sprouty homolog 3 (Drosophila) -2.02539
RBM7 RNA binding motif protein 7 -2.01133
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -2.00861