RIF1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description replication timing regulatory factor 1|This gene encodes a protein that shares homology with the yeast teleomere binding protein, Rap1 interacting factor 1. This protein localizes to aberrant telomeres may be involved in DNA repair. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010] (NCBI Entrez Gene Database, 55183)
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Genes

373 genes differentially expressed following the RIF1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 3.08539
ZFP92 ZFP92 zinc finger protein 3.08539
PCDHA2 protocadherin alpha 2 3.08539
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 3.08539
DLK1 delta-like 1 homolog (Drosophila) 3.08539
NTN5 netrin 5 3.08539
VWF von Willebrand factor 3.08539
LDHC lactate dehydrogenase C 3.08539
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 3.08539
GJB1 gap junction protein, beta 1, 32kDa 3.08539
ACTA1 actin, alpha 1, skeletal muscle 3.08539
YY2 YY2 transcription factor 3.08539
ELL3 elongation factor RNA polymerase II-like 3 3.08539
AKNAD1 AKNA domain containing 1 3.08539
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 3.08539
UPK1A uroplakin 1A 3.08539
RASL10A RAS-like, family 10, member A 3.08539
TTLL13 tubulin tyrosine ligase like 13 3.08539
NECTIN4 nectin cell adhesion molecule 4 3.08539
EXOC3L4 exocyst complex component 3-like 4 3.08539
CXCL14 chemokine (C-X-C motif) ligand 14 3.08539
ISLR2 immunoglobulin superfamily containing leucine-rich repeat 2 3.08539
SIX1 SIX homeobox 1 3.08539
C2ORF72 chromosome 2 open reading frame 72 3.08539
TP63 tumor protein p63 3.08539
C19ORF38 chromosome 19 open reading frame 38 3.06445
GDNF glial cell derived neurotrophic factor 3.06445
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 3.06445
ENTHD1 ENTH domain containing 1 3.06445
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 3.06445
CD209 CD209 molecule 3.06445
DPEP2 dipeptidase 2 3.06445
BLZF1 basic leucine zipper nuclear factor 1 3.06445
UNC13C unc-13 homolog C (C. elegans) 3.06445
TM4SF20 transmembrane 4 L six family member 20 3.06445
AMTN amelotin 3.06445
SLC46A3 solute carrier family 46, member 3 3.06445
PTAFR platelet-activating factor receptor 3.06445
UNC45B unc-45 homolog B (C. elegans) 3.06445
RFPL3 ret finger protein-like 3 3.06445
FAM221B family with sequence similarity 221, member B 3.06445
LEP leptin 3.06445
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 3.06445
TWIST1 twist family bHLH transcription factor 1 3.06445
ABRA actin binding Rho activating protein 3.06445
AMPD1 adenosine monophosphate deaminase 1 3.06445
VPREB3 pre-B lymphocyte 3 3.06445
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) 3.06445
LPO lactoperoxidase 3.06445
IL17B interleukin 17B 3.06445
IL17F interleukin 17F 3.06445
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 3.06445
CFAP53 cilia and flagella associated protein 53 3.06445
INS insulin 3.06445
CACNB3 calcium channel, voltage-dependent, beta 3 subunit 3.06445
SPP2 secreted phosphoprotein 2, 24kDa 3.06445
RGPD4 RANBP2-like and GRIP domain containing 4 3.06445
MROH1 maestro heat-like repeat family member 1 3.06445
SHE Src homology 2 domain containing E 3.06445
PRDM12 PR domain containing 12 3.06445
MRC1 mannose receptor, C type 1 3.06445
PRR22 proline rich 22 3.06445
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 3.06445
RP1 retinitis pigmentosa 1 (autosomal dominant) 3.06445
PI16 peptidase inhibitor 16 3.06445
SCPPPQ1 secretory calcium-binding phosphoprotein proline-glutamine rich 1 3.06445
C20ORF202 chromosome 20 open reading frame 202 3.06445
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 3.06445
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) 3.06445
ADRB1 adrenoceptor beta 1 3.06445
TMEM40 transmembrane protein 40 3.06445
DOK7 docking protein 7 3.06445
DOK2 docking protein 2, 56kDa 3.06445
GCSAM germinal center-associated, signaling and motility 3.06445
TAF11 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa 3.06445
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 3.06445
SPRR2A small proline-rich protein 2A 3.06445
H2BK1 H2B.K variant histone 1 3.06445
PLPP4 phospholipid phosphatase 4 3.06445
PNMA8B PNMA family member 8B 3.06445
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 3.06445
KY kyphoscoliosis peptidase 3.06445
ROPN1B rhophilin associated tail protein 1B 3.06445
AVPR1A arginine vasopressin receptor 1A 3.06445
AANAT aralkylamine N-acetyltransferase 3.06445
ALX4 ALX homeobox 4 3.06445
CCDC42 coiled-coil domain containing 42 3.06445
DLK2 delta-like 2 homolog (Drosophila) 3.06445
FOXD4L1 forkhead box D4-like 1 3.06445
NXPE4 neurexophilin and PC-esterase domain family, member 4 3.06445
CLDN5 claudin 5 3.06445
TUBA3D tubulin, alpha 3d 3.06445
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 3.06445
P2RY8 purinergic receptor P2Y, G-protein coupled, 8 3.06445
TMEM225 transmembrane protein 225 3.06445
MYBPHL myosin binding protein H-like 3.06445
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 3.06445
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 3.06445
HPR haptoglobin-related protein 3.06445
GOLGA6L4 golgin A6 family-like 4 3.06445
LRRC73 leucine rich repeat containing 73 3.06445
TIMD4 T-cell immunoglobulin and mucin domain containing 4 3.06445
ABHD15 abhydrolase domain containing 15 3.06445
KLRF1 killer cell lectin-like receptor subfamily F, member 1 3.06445
TLR7 toll-like receptor 7 3.06445
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 3.06445
SCRT2 scratch family zinc finger 2 3.06445
CXCL16 chemokine (C-X-C motif) ligand 16 3.06445
ANXA10 annexin A10 3.06445
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 3.06445
ARHGAP20 Rho GTPase activating protein 20 3.06445
KLHL41 kelch-like family member 41 3.06445
TBC1D10C TBC1 domain family, member 10C 3.06445
PRM1 protamine 1 3.06445
GOLGA6B golgin A6 family, member B 3.06445
CALHM3 calcium homeostasis modulator 3 3.06445
F2RL2 coagulation factor II (thrombin) receptor-like 2 3.06445
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 3.06445
FIBIN fin bud initiation factor homolog (zebrafish) 3.06445
PCDHGA5 protocadherin gamma subfamily A, 5 3.06445
MUC19 mucin 19, oligomeric 3.06445
SDE2 SDE2 telomere maintenance homolog (S. pombe) 3.06445
HHLA2 HERV-H LTR-associating 2 3.06445
AQP6 aquaporin 6, kidney specific 3.06445
IGFBP7 insulin-like growth factor binding protein 7 3.06445
ERICH6 glutamate-rich 6 3.06445
IL13 interleukin 13 3.06445
RNF112 ring finger protein 112 3.06445
SUPT20HL1 suppressor of Ty 20 homolog (S. cerevisiae)-like 1 3.06445
EFCAB3 EF-hand calcium binding domain 3 3.06445
DQX1 DEAQ box RNA-dependent ATPase 1 3.06445
KLHL6 kelch-like family member 6 3.06445
S100A14 S100 calcium binding protein A14 3.06445
C11ORF91 chromosome 11 open reading frame 91 3.06445
DHH desert hedgehog 3.06445
KLK5 kallikrein-related peptidase 5 3.06445
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 3.06445
GPR150 G protein-coupled receptor 150 3.06445
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 3.06445
IL25 interleukin 25 3.06445
GAS2L2 growth arrest-specific 2 like 2 3.06445
ETV3L ets variant 3-like 3.06445
CXORF58 chromosome X open reading frame 58 3.06445
ZNF835 zinc finger protein 835 3.06445
STRC stereocilin 3.06445
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 3.06445
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 3.06445
MYADML2 myeloid-associated differentiation marker-like 2 3.06445
CSF1R colony stimulating factor 1 receptor 3.06445
DCT dopachrome tautomerase 3.06445
TBX1 T-box 1 3.06445
FGB fibrinogen beta chain 3.06445
CRYBA1 crystallin, beta A1 3.06445
SCNN1D sodium channel, non voltage gated 1 delta subunit 3.06445
MORN5 MORN repeat containing 5 3.06445
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 3.06445
NR5A1 nuclear receptor subfamily 5, group A, member 1 3.06445
SLC38A3 solute carrier family 38, member 3 3.06445
BCL2L15 BCL2-like 15 3.06445
QRFP pyroglutamylated RFamide peptide 3.06445
UPK1B uroplakin 1B 3.06445
AKR1B15 aldo-keto reductase family 1, member B15 3.06445
SLC36A3 solute carrier family 36, member 3 3.06445
CHAD chondroadherin 3.06445
APOB apolipoprotein B 3.06445
GH1 growth hormone 1 3.06445
ZNF534 zinc finger protein 534 3.06445
C5AR2 complement component 5a receptor 2 3.06445
CLCNKB chloride channel, voltage-sensitive Kb 3.06445
FZD1 frizzled class receptor 1 3.06445
IL10RA interleukin 10 receptor, alpha 3.06445
CD80 CD80 molecule 3.06445
RHAG Rh-associated glycoprotein 3.06445
TRPM5 transient receptor potential cation channel, subfamily M, member 5 3.06445
PXT1 peroxisomal, testis specific 1 3.06445
VAX2 ventral anterior homeobox 2 3.06445
PALMD palmdelphin 3.06445
PF4V1 platelet factor 4 variant 1 3.06445
IL17REL interleukin 17 receptor E-like 3.06445
AHSG alpha-2-HS-glycoprotein 3.06445
PCDHGB4 protocadherin gamma subfamily B, 4 3.06445
IL33 interleukin 33 3.06445
BSX brain-specific homeobox 2.98059
LOXHD1 lipoxygenase homology domains 1 2.96329
C1QTNF7 C1q and tumor necrosis factor related protein 7 2.96329
GP1BA glycoprotein Ib (platelet), alpha polypeptide 2.96329
C22ORF23 chromosome 22 open reading frame 23 2.96329
CDK5RAP3 CDK5 regulatory subunit associated protein 3 2.92636
TRAPPC1 trafficking protein particle complex 1 2.79204
EFNB2 ephrin-B2 2.78641
TMEM120A transmembrane protein 120A 2.78641
MUL1 mitochondrial E3 ubiquitin protein ligase 1 2.76711
SF3A1 splicing factor 3a, subunit 1, 120kDa 2.68421
RASA2 RAS p21 protein activator 2 2.67083
EIF4H eukaryotic translation initiation factor 4H 2.65265
RPP21 ribonuclease P/MRP 21kDa subunit 2.65188
LDHA lactate dehydrogenase A 2.64973
FAM168B family with sequence similarity 168, member B 2.63134
TRIM59 tripartite motif containing 59 2.63134
ATP13A5 ATPase type 13A5 2.6085
SLF1 SMC5-SMC6 complex localization factor 1 2.55566
ZNF550 zinc finger protein 550 2.52053
TYMS thymidylate synthetase 2.46915
RCE1 Ras converting CAAX endopeptidase 1 2.46004
RUVBL1 RuvB-like AAA ATPase 1 2.44044
MAP2K2 mitogen-activated protein kinase kinase 2 2.43226
TRAIP TRAF interacting protein 2.41387
PLN phospholamban 2.41387
PCDHB12 protocadherin beta 12 2.41387
MCM9 minichromosome maintenance complex component 9 2.40465
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha 2.3976
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast) 2.36419
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 2.36055
MFSD2A major facilitator superfamily domain containing 2A 2.36055
C6ORF89 chromosome 6 open reading frame 89 2.33977
DIS3L2 DIS3 like 3'-5' exoribonuclease 2 2.33977
MCRIP1 MAPK regulated corepressor interacting protein 1 2.33181
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 2.30648
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 2.30648
TARBP1 TAR (HIV-1) RNA binding protein 1 2.30648
TUNAR TCL1 upstream neural differentiation-associated RNA 2.30648
ZBED8L ZBED8 like 2.30037
CAPN15 calpain 15 2.26111
QSOX1 quiescin Q6 sulfhydryl oxidase 1 2.25735
ING1 inhibitor of growth family, member 1 2.25717
UQCRB ubiquinol-cytochrome c reductase binding protein 2.23799
NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha 2.23664
RPN2 ribophorin II 2.23567
RPUSD4 RNA pseudouridylate synthase domain containing 4 2.22278
HCFC2 host cell factor C2 2.21033
TMEM87B transmembrane protein 87B 2.2038
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 2.2023
LRP5 low density lipoprotein receptor-related protein 5 2.18862
DNAJC21 DnaJ (Hsp40) homolog, subfamily C, member 21 2.18314
ZNF419 zinc finger protein 419 2.15807
LDAH lipid droplet associated hydrolase 2.15398
MRPS14 mitochondrial ribosomal protein S14 2.15377
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 2.15377
PEX14 peroxisomal biogenesis factor 14 2.145
RFC4 replication factor C (activator 1) 4, 37kDa 2.145
SESN3 sestrin 3 2.145
ENOPH1 enolase-phosphatase 1 2.14496
HAUS6 HAUS augmin-like complex, subunit 6 2.14304
PPDPF pancreatic progenitor cell differentiation and proliferation factor 2.14016
RSKR ribosomal protein S6 kinase related 2.14016
NRBP2 nuclear receptor binding protein 2 2.13755
RAD23B RAD23 homolog B (S. cerevisiae) 2.12144
UBE2H ubiquitin-conjugating enzyme E2H 2.11909
CENPL centromere protein L 2.11447
RNASEH2C ribonuclease H2, subunit C 2.10458
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 2.08663
CLK3 CDC-like kinase 3 2.05919
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1 2.03338
CCNL1 cyclin L1 2.03338
PYCARD PYD and CARD domain containing 2.02668
SFT2D3 SFT2 domain containing 3 2.0251
KCNK13 potassium channel, two pore domain subfamily K, member 13 2.01126
ACVR1C activin A receptor, type IC 2.01126
CBY3 chibby homolog 3 (Drosophila) 2.01126
FAM194C family with sequence similarity 149 member C 2.01126

decreased expression

Symbol Name Standardized Value
SCD5 stearoyl-CoA desaturase 5 -3.08539
HIST1H2BI histone cluster 1, H2bi -3.08539
SMTNL2 smoothelin-like 2 -3.08539
GSG1L GSG1-like -3.08539
C9ORF153 chromosome 9 open reading frame 153 -3.08539
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 -3.08539
CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7 -3.08539
MBD6 methyl-CpG binding domain protein 6 -3.06445
PTPRE protein tyrosine phosphatase, receptor type, E -3.06445
SLC30A10 solute carrier family 30, member 10 -3.06445
ZNF517 zinc finger protein 517 -3.06445
JPH2 junctophilin 2 -3.06445
AGA-DT AGA divergent transcript -3.06445
PTPRB protein tyrosine phosphatase, receptor type, B -3.06445
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -3.06445
LOXL4 lysyl oxidase-like 4 -3.06445
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 -3.06445
FCGBP Fc fragment of IgG binding protein -3.06445
SBNO2 strawberry notch homolog 2 (Drosophila) -3.06445
TOMM20L translocase of outer mitochondrial membrane 20 homolog (yeast)-like -3.06445
NPY neuropeptide Y -3.06445
DEGS2 delta(4)-desaturase, sphingolipid 2 -3.06445
EQTN equatorin, sperm acrosome associated -3.06445
TSHR thyroid stimulating hormone receptor -3.06445
TGFBR3 transforming growth factor, beta receptor III -3.06445
HIGD1B HIG1 hypoxia inducible domain family, member 1B -3.06445
PGLYRP1 peptidoglycan recognition protein 1 -3.06445
CD177 CD177 molecule -3.06445
VCX3B variable charge, X-linked 3B -3.06445
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G -3.06445
RASGRP4 RAS guanyl releasing protein 4 -3.06445
ZCCHC14 zinc finger, CCHC domain containing 14 -3.06445
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 -3.06445
EMILIN1 elastin microfibril interfacer 1 -3.06445
STMND1 stathmin domain containing 1 -3.06445
HTRA3 HtrA serine peptidase 3 -3.06445
PNLIPRP2 pancreatic lipase-related protein 2 -3.06445
LDLRAD2 low density lipoprotein receptor class A domain containing 2 -3.06445
VEGFD vascular endothelial growth factor D -3.06445
UBE2QL1 ubiquitin-conjugating enzyme E2Q family-like 1 -3.06445
CDH15 cadherin 15, type 1, M-cadherin (myotubule) -3.06445
ERMN ermin, ERM-like protein -3.06445
ZNF541 zinc finger protein 541 -3.06445
PATL2 protein associated with topoisomerase II homolog 2 (yeast) -3.06445
CBR3 carbonyl reductase 3 -3.06445
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1 -3.06445
CNGA4 cyclic nucleotide gated channel alpha 4 -3.06445
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2 -3.06107
TBC1D16 TBC1 domain family, member 16 -3.00119
RNF207 ring finger protein 207 -2.95008
KAT2B K(lysine) acetyltransferase 2B -2.93641
DPEP3 dipeptidase 3 -2.93188
ZNF841 zinc finger protein 841 -2.91495
FAM133A family with sequence similarity 133, member A -2.91495
MSANTD3 Myb/SANT-like DNA-binding domain containing 3 -2.91218
LIN9 lin-9 DREAM MuvB core complex component -2.79782
SNX15 sorting nexin 15 -2.79736
MEX3B mex-3 RNA binding family member B -2.74255
TMPRSS11E transmembrane protease, serine 11E -2.73432
MOG myelin oligodendrocyte glycoprotein -2.68566
PDLIM3 PDZ and LIM domain 3 -2.68554
WDR27 WD repeat domain 27 -2.67064
YIPF4 Yip1 domain family, member 4 -2.64973
TARS3 threonyl-tRNA synthetase 3 -2.6331
ADCK2 aarF domain containing kinase 2 -2.59032
DET1 de-etiolated homolog 1 (Arabidopsis) -2.583
NAAA N-acylethanolamine acid amidase -2.57196
SUN2 Sad1 and UNC84 domain containing 2 -2.52053
ZNF160 zinc finger protein 160 -2.48843
STYX serine/threonine/tyrosine interacting protein -2.48028
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma -2.48028
DBF4 DBF4 zinc finger -2.46439
SIRT4 sirtuin 4 -2.40764
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like -2.3893
CMIP c-Maf inducing protein -2.35959
ZNF396 zinc finger protein 396 -2.34765
ZC3H11A zinc finger CCCH-type containing 11A -2.34765
ALOX5 arachidonate 5-lipoxygenase -2.30648
SHISA4 shisa family member 4 -2.30648
E2F4 E2F transcription factor 4, p107/p130-binding -2.30333
SNX8 sorting nexin 8 -2.25717
RBM11 RNA binding motif protein 11 -2.2356
H4C11 H4 clustered histone 11 -2.2356
VPS26C VPS26 endosomal protein sorting factor C -2.23145
BRAF B-Raf proto-oncogene, serine/threonine kinase -2.22278
CASR calcium-sensing receptor -2.21362
TAFA1 TAFA chemokine like family member 1 -2.21033
STUM stum, mechanosensory transduction mediator homolog -2.21033
TRIM9 tripartite motif containing 9 -2.207
GLG1 golgi glycoprotein 1 -2.18314
PAXBP1 PAX3 and PAX7 binding protein 1 -2.16528
HGH1 HGH1 homolog (S. cerevisiae) -2.16284
SCN8A sodium channel, voltage gated, type VIII alpha subunit -2.14949
PPP1R16B protein phosphatase 1, regulatory subunit 16B -2.145
CDC45 cell division cycle 45 -2.14426
IFT46 intraflagellar transport 46 -2.14016
GOLIM4 golgi integral membrane protein 4 -2.13698
ADRA2C adrenoceptor alpha 2C -2.13524
TSR2 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) -2.1352
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -2.13285
ZNF491 zinc finger protein 491 -2.12639
CHMP1A charged multivesicular body protein 1A -2.11917
STK26 serine/threonine protein kinase 26 -2.07567
RNF144B ring finger protein 144B -2.03792
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -2.03338
GTF2H2C GTF2H2 family member C -2.03338
KCTD14 potassium channel tetramerization domain containing 14 -2.03338
TRMT10C tRNA methyltransferase 10 homolog C (S. cerevisiae) -2.03306
SPATA33 spermatogenesis associated 33 -2.01691
DHDH dihydrodiol dehydrogenase (dimeric) -2.01126
TRIQK triple QxxK/R motif containing -2.0103
SYK spleen tyrosine kinase -2.00775
RAI14 retinoic acid induced 14 -2.00041