RIPK2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description receptor-interacting serine-threonine kinase 2|This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 8767)
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Genes

350 genes differentially expressed following the RIPK2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 2.54575
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) 2.54575
TNC tenascin C 2.54575
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 2.54575
PRTN3 proteinase 3 2.54575
S100A11 S100 calcium binding protein A11 2.54575
MAGED4 melanoma antigen family D4 2.54575
ADGRE3 adhesion G protein-coupled receptor E3 2.54575
RUFY4 RUN and FYVE domain containing 4 2.54575
CALHM2 calcium homeostasis modulator 2 2.54575
PIWIL3 piwi-like RNA-mediated gene silencing 3 2.54575
CERKL ceramide kinase-like 2.54575
PNPLA1 patatin-like phospholipase domain containing 1 2.54575
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2 2.54575
AKAP3 A kinase (PRKA) anchor protein 3 2.54575
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.54575
LMOD2 leiomodin 2 (cardiac) 2.54575
ADRA1B adrenoceptor alpha 1B 2.54575
THEM6 thioesterase superfamily member 6 2.54575
PDE1B phosphodiesterase 1B, calmodulin-dependent 2.54575
ABLIM3 actin binding LIM protein family, member 3 2.54575
PTPRU protein tyrosine phosphatase, receptor type, U 2.50729
TNNI1 troponin I type 1 (skeletal, slow) 2.48191
TRIM77 tripartite motif containing 77 2.48191
PDYN prodynorphin 2.48191
CAMP cathelicidin antimicrobial peptide 2.48191
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 2.48191
SRSF2 serine/arginine-rich splicing factor 2 2.48191
TPBGL trophoblast glycoprotein-like 2.48191
SIX2 SIX homeobox 2 2.48191
HRH1 histamine receptor H1 2.48191
HRH4 histamine receptor H4 2.48191
ZACN zinc activated ligand-gated ion channel 2.48191
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 2.48191
KNG1 kininogen 1 2.48191
SYCP2 synaptonemal complex protein 2 2.48191
NOD2 nucleotide-binding oligomerization domain containing 2 2.48191
RFX6 regulatory factor X, 6 2.48191
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 2.48191
NANOS3 nanos homolog 3 (Drosophila) 2.48191
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 2.48191
ETV2 ets variant 2 2.48191
DNAAF2 dynein, axonemal, assembly factor 2 2.48191
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow 2.48191
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial 2.48191
FAM9B family with sequence similarity 9, member B 2.48191
KIAA1755 KIAA1755 2.48191
C1GALT1C1L C1GALT1-specific chaperone 1 like 2.48191
S100A5 S100 calcium binding protein A5 2.48191
DDR1 discoidin domain receptor tyrosine kinase 1 2.48191
APOA2 apolipoprotein A-II 2.48191
SIGLEC7 sialic acid binding Ig-like lectin 7 2.48191
SSTR5 somatostatin receptor 5 2.48191
ASPA aspartoacylase 2.48191
GYPB glycophorin B (MNS blood group) 2.48191
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 2.48191
NOTUM notum pectinacetylesterase homolog (Drosophila) 2.48191
PSCA prostate stem cell antigen 2.48191
C8ORF74 chromosome 8 open reading frame 74 2.48191
LHX6 LIM homeobox 6 2.48191
C1ORF232 chromosome 1 open reading frame 230 2.48191
H1-6 H1.6 linker histone, cluster member 2.48191
STING1 stimulator of interferon response cGAMP interactor 1 2.48191
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1 2.48191
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 2.48191
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 2.48191
IQCF5 IQ motif containing F5 2.48191
PROZ protein Z, vitamin K-dependent plasma glycoprotein 2.48191
ASB5 ankyrin repeat and SOCS box containing 5 2.48191
ASB2 ankyrin repeat and SOCS box containing 2 2.48191
PLAAT4 phospholipase A and acyltransferase 4 2.48191
VEGFD vascular endothelial growth factor D 2.48191
CBLIF cobalamin binding intrinsic factor 2.48191
GNG5B G protein subunit gamma 5B 2.48191
MUCL3 mucin like 3 2.48191
CLEC20A C-type lectin domain containing 20A 2.48191
CPHXL cytoplasmic polyadenylated homeobox like 2.48191
DNAAF6 dynein axonemal assembly factor 6 2.48191
MEIOSIN meiosis initiator 2.48191
GARIN1A golgi associated RAB2 interactor 1A 2.48191
JAML junction adhesion molecule like 2.48191
KASH5 KASH domain containing 5 2.48191
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 2.48191
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 2.48191
SCRT1 scratch family zinc finger 1 2.48191
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 2.48191
CLIP4 CAP-GLY domain containing linker protein family, member 4 2.48191
OR56B2 olfactory receptor family 56 subfamily B member 2 2.48191
CFAP99 cilia and flagella associated protein 99 2.48191
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 2.48191
FRMD7 FERM domain containing 7 2.48191
RAET1E retinoic acid early transcript 1E 2.48191
FFAR2 free fatty acid receptor 2 2.48191
SCRT2 scratch family zinc finger 2 2.48191
PPIL4 peptidylprolyl isomerase (cyclophilin)-like 4 2.48191
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 2.48191
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 2.48191
OOSP1 oocyte secreted protein 1, pseudogene 2.48191
VCX3A variable charge, X-linked 3A 2.48191
TACR2 tachykinin receptor 2 2.48191
EXOC3L1 exocyst complex component 3-like 1 2.48191
PIWIL1 piwi-like RNA-mediated gene silencing 1 2.48191
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G 2.48191
TFEC transcription factor EC 2.48191
TLR4 toll-like receptor 4 2.48191
SLC22A14 solute carrier family 22, member 14 2.48191
TPRX1 tetra-peptide repeat homeobox 1 2.48191
ANKRD62 ankyrin repeat domain 62 2.48191
PIH1D2 PIH1 domain containing 2 2.48191
HHLA2 HERV-H LTR-associating 2 2.48191
GCOM1 GRINL1A complex locus 1 2.48191
DVL2 dishevelled segment polarity protein 2 2.48191
CLEC4C C-type lectin domain family 4, member C 2.48191
MAB21L2 mab-21-like 2 (C. elegans) 2.48191
CCDC27 coiled-coil domain containing 27 2.48191
ODF4 outer dense fiber of sperm tails 4 2.48191
IFITM5 interferon induced transmembrane protein 5 2.48191
POF1B premature ovarian failure, 1B 2.48191
DNAH12 dynein, axonemal, heavy chain 12 2.48191
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 2.48191
KRT14 keratin 14, type I 2.48191
KRT15 keratin 15, type I 2.48191
TBPL2 TATA box binding protein like 2 2.48191
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 2.48191
DUSP26 dual specificity phosphatase 26 (putative) 2.48191
SPTBN4 spectrin, beta, non-erythrocytic 4 2.48191
LRRC43 leucine rich repeat containing 43 2.48191
CYS1 cystin 1 2.48191
CT55 cancer/testis antigen 55 2.48191
CCL15 chemokine (C-C motif) ligand 15 2.48191
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A 2.48191
SIAH3 siah E3 ubiquitin protein ligase family member 3 2.48191
CSF1R colony stimulating factor 1 receptor 2.48191
GPC5 glypican 5 2.48191
TSPAN13 tetraspanin 13 2.48191
POU4F3 POU class 4 homeobox 3 2.48191
OTP orthopedia homeobox 2.48191
CASQ2 calsequestrin 2 (cardiac muscle) 2.48191
CLEC18B C-type lectin domain family 18, member B 2.48191
RPL18A ribosomal protein L18a 2.48191
C22ORF31 chromosome 22 open reading frame 31 2.48191
LHX9 LIM homeobox 9 2.48191
NTN3 netrin 3 2.48191
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 2.48191
FSHR follicle stimulating hormone receptor 2.48191
PTPN20 protein tyrosine phosphatase, non-receptor type 20 2.48191
CEL carboxyl ester lipase 2.48191
ITGB7 integrin, beta 7 2.48191
CRYBA1 crystallin, beta A1 2.48191
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 2.48191
TF transferrin 2.48191
CD200R1 CD200 receptor 1 2.48191
TPPP2 tubulin polymerization-promoting protein family member 2 2.48191
CCDC154 coiled-coil domain containing 154 2.48191
LRRC74B leucine rich repeat containing 74B 2.48191
FGF16 fibroblast growth factor 16 2.48191
ICAM2 intercellular adhesion molecule 2 2.48191
GCM2 glial cells missing homolog 2 (Drosophila) 2.48191
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) 2.48191
C5ORF46 chromosome 5 open reading frame 46 2.48191
ALLC allantoicase 2.48191
PRCP prolylcarboxypeptidase (angiotensinase C) 2.48191
IFNE interferon, epsilon 2.48191
ASCL1 achaete-scute family bHLH transcription factor 1 2.48191
CDCP2 CUB domain containing protein 2 2.48191
HEPACAM hepatic and glial cell adhesion molecule 2.48191
C17ORF78 chromosome 17 open reading frame 78 2.48191
PGM5 phosphoglucomutase 5 2.48191
UBD ubiquitin D 2.48191
OR6B3 olfactory receptor, family 6, subfamily B, member 3 2.48191
AMPD1 adenosine monophosphate deaminase 1 2.48191
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 2.48191
PRSS21 protease, serine, 21 (testisin) 2.48191
HRG histidine-rich glycoprotein 2.48191
DMTN dematin actin binding protein 2.48191
WFDC11 WAP four-disulfide core domain 11 2.48191
NFE2 nuclear factor, erythroid 2 2.48191
IER5L immediate early response 5-like 2.48191
TMEM52B transmembrane protein 52B 2.48191
R3HDML R3H domain containing-like 2.48191
LIN9 lin-9 DREAM MuvB core complex component 2.43422
SFT2D1 SFT2 domain containing 1 2.41879
PROC protein C (inactivator of coagulation factors Va and VIIIa) 2.3799
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 2.3799
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 2.3799
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 2.36789
RAB9A RAB9A, member RAS oncogene family 2.36339
SPAAR small regulatory polypeptide of amino acid response 2.33805
GABRD gamma-aminobutyric acid (GABA) A receptor, delta 2.33805
IAH1 isoamyl acetate-hydrolyzing esterase 1 homolog (S. cerevisiae) 2.32066
GPR149 G protein-coupled receptor 149 2.32066
TIA1 TIA1 cytotoxic granule-associated RNA binding protein 2.30821
LTBP2 latent transforming growth factor beta binding protein 2 2.30696
TRMO tRNA methyltransferase O 2.30696
VAT1L vesicle amine transport 1-like 2.30221
ACBD4 acyl-CoA binding domain containing 4 2.29049
LDHA lactate dehydrogenase A 2.24713
SOX9 SRY (sex determining region Y)-box 9 2.24518
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 2.24132
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 2.21489
PSENEN presenilin enhancer gamma secretase subunit 2.20582
GCFC2 GC-rich sequence DNA-binding factor 2 2.19926
TERF2IP telomeric repeat binding factor 2, interacting protein 2.19479
NCBP2 nuclear cap binding protein subunit 2, 20kDa 2.19315
REEP6 receptor accessory protein 6 2.19315
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) 2.19235
S100A6 S100 calcium binding protein A6 2.19235
CAPN12 calpain 12 2.18347
LRRC28 leucine rich repeat containing 28 2.18186
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial 2.18054
ANXA5 annexin A5 2.17014
GARNL3 GTPase activating Rap/RanGAP domain-like 3 2.17
KCP kielin/chordin-like protein 2.14664
SLC49A4 solute carrier family 49 member 4 2.14119
PM20D1 peptidase M20 domain containing 1 2.12796
ANKLE2 ankyrin repeat and LEM domain containing 2 2.12796
AMT aminomethyltransferase 2.10695
COMMD10 COMM domain containing 10 2.10212
ITGB1BP1 integrin beta 1 binding protein 1 2.09627
UQCRH ubiquinol-cytochrome c reductase hinge protein 2.07657
KMT5C lysine methyltransferase 5C 2.06452
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1 2.05352
EXTL3 exostosin-like glycosyltransferase 3 2.04543
TM9SF1 transmembrane 9 superfamily member 1 2.0261
ZFYVE16 zinc finger, FYVE domain containing 16 2.02586
ETNK1 ethanolamine kinase 1 2.02491
GABPB2 GA binding protein transcription factor, beta subunit 2 2.02149
SF3B6 splicing factor 3b, subunit 6, 14kDa 2.01758
FIBP fibroblast growth factor (acidic) intracellular binding protein 2.01278
NECTIN1 nectin cell adhesion molecule 1 2.0091
ELOF1 elongation factor 1 homolog (S. cerevisiae) 2.00658
RIPOR3 RIPOR family member 3 2.00658

decreased expression

Symbol Name Standardized Value
KCNK13 potassium channel, two pore domain subfamily K, member 13 -2.54575
TTC16 tetratricopeptide repeat domain 16 -2.54575
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 -2.54575
VPREB3 pre-B lymphocyte 3 -2.54575
TUFT1 tuftelin 1 -2.54575
CTF1 cardiotrophin 1 -2.54575
TMEM191C transmembrane protein 191C -2.54575
CCL2 chemokine (C-C motif) ligand 2 -2.54575
MST1R macrophage stimulating 1 receptor -2.48191
CHD9 chromodomain helicase DNA binding protein 9 -2.48191
RASAL1 RAS protein activator like 1 (GAP1 like) -2.48191
GRHPR glyoxylate reductase/hydroxypyruvate reductase -2.48191
BMP2 bone morphogenetic protein 2 -2.48191
ZNF664-RFLNA ZNF664-RFLNA readthrough -2.48191
DCLRE1C DNA cross-link repair 1C -2.48191
RBM44 RNA binding motif protein 44 -2.48191
ACRBP acrosin binding protein -2.48191
GRM2 glutamate receptor, metabotropic 2 -2.48191
PSD2 pleckstrin and Sec7 domain containing 2 -2.48191
RAB7A RAB7A, member RAS oncogene family -2.48191
ARL16 ADP-ribosylation factor-like 16 -2.48191
KIAA2012 KIAA2012 -2.48191
GPR183 G protein-coupled receptor 183 -2.48191
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4 -2.48191
CAPN11 calpain 11 -2.48191
SCRG1 stimulator of chondrogenesis 1 -2.48191
ACOT1 acyl-CoA thioesterase 1 -2.48191
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 -2.48191
SIX3 SIX homeobox 3 -2.48191
ATP6V0E2 ATPase, H+ transporting V0 subunit e2 -2.48191
STKLD1 serine/threonine kinase-like domain containing 1 -2.48191
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -2.48191
HCRTR1 hypocretin (orexin) receptor 1 -2.48191
PON1 paraoxonase 1 -2.48191
PCDHB4 protocadherin beta 4 -2.48191
SCN4A sodium channel, voltage gated, type IV alpha subunit -2.48191
PROB1 proline-rich basic protein 1 -2.48191
MYH15 myosin, heavy chain 15 -2.48191
ASB12 ankyrin repeat and SOCS box containing 12 -2.48191
SRL sarcalumenin -2.48191
IFT27 intraflagellar transport 27 -2.48191
RPL23 ribosomal protein L23 -2.48191
ANKRD53 ankyrin repeat domain 53 -2.48191
CRYBA4 crystallin, beta A4 -2.48191
COX8C cytochrome c oxidase subunit VIIIC -2.48191
SHISA8 shisa family member 8 -2.48191
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa -2.48191
ZNF723 zinc finger protein 723 -2.48191
SWSAP1 SWIM-type zinc finger 7 associated protein 1 -2.48191
MAP3K12 mitogen-activated protein kinase kinase kinase 12 -2.48191
TSBP1 testis expressed basic protein 1 -2.48191
KLHL1 kelch-like family member 1 -2.48191
INSM1 insulinoma-associated 1 -2.48191
GNG3 guanine nucleotide binding protein (G protein), gamma 3 -2.48191
DRC8 dynein regulatory complex subunit 8 -2.48191
PPP1R37 protein phosphatase 1, regulatory subunit 37 -2.48191
WDR17 WD repeat domain 17 -2.48191
MMP3 matrix metallopeptidase 3 -2.48191
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 -2.48191
PFN4 profilin family, member 4 -2.48191
PRAM1 PML-RARA regulated adaptor molecule 1 -2.48191
SHOX short stature homeobox -2.48191
ACP7 acid phosphatase 7, tartrate resistant (putative) -2.48191
U2AF1L4 U2 small nuclear RNA auxiliary factor 1-like 4 -2.45738
GJD3 gap junction protein, delta 3, 31.9kDa -2.45738
CASD1 CAS1 domain containing 1 -2.4123
RHOBTB2 Rho-related BTB domain containing 2 -2.3987
BBS9 Bardet-Biedl syndrome 9 -2.39793
CCDC13 coiled-coil domain containing 13 -2.3815
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like -2.35427
BAMBI BMP and activin membrane-bound inhibitor -2.33863
THOC5 THO complex 5 -2.31087
TBC1D13 TBC1 domain family, member 13 -2.30821
H2BC12 H2B clustered histone 12 -2.30821
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 -2.30821
TCF12 transcription factor 12 -2.29808
TRABD2A TraB domain containing 2A -2.29803
ZNF641 zinc finger protein 641 -2.29803
KIF5C kinesin family member 5C -2.29318
CGN cingulin -2.26766
SMG8 SMG8 nonsense mediated mRNA decay factor -2.22576
GNA14 guanine nucleotide binding protein (G protein), alpha 14 -2.22199
MAPK4 mitogen-activated protein kinase 4 -2.21344
TC2N tandem C2 domains, nuclear -2.19404
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -2.19235
WDR47 WD repeat domain 47 -2.19235
PHACTR4 phosphatase and actin regulator 4 -2.19235
RPL10A ribosomal protein L10a -2.19235
PYGB phosphorylase, glycogen; brain -2.19235
TCEA1 transcription elongation factor A (SII), 1 -2.18054
TCEA2 transcription elongation factor A (SII), 2 -2.17967
DDX49 DEAD (Asp-Glu-Ala-Asp) box polypeptide 49 -2.17587
ALKBH6 alkB, alkylation repair homolog 6 (E. coli) -2.15903
LATS2 large tumor suppressor kinase 2 -2.15644
BATF3 basic leucine zipper transcription factor, ATF-like 3 -2.14119
DNAH10 dynein, axonemal, heavy chain 10 -2.14119
H4C2 H4 clustered histone 2 -2.14119
HDAC4 histone deacetylase 4 -2.14119
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -2.13909
H1-3 H1.3 linker histone, cluster member -2.13878
TRIM38 tripartite motif containing 38 -2.13749
COPRS coordinator of PRMT5, differentiation stimulator -2.13433
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -2.12796
FOCAD focadhesin -2.11994
MBD6 methyl-CpG binding domain protein 6 -2.11941
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8 -2.10212
ECE1 endothelin converting enzyme 1 -2.09494
INTS4 integrator complex subunit 4 -2.08179
MRTFB myocardin related transcription factor B -2.07827
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) -2.06313
CENPI centromere protein I -2.06153
CYTH1 cytohesin 1 -2.03673
ZNF148 zinc finger protein 148 -2.03201
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2 -2.03201
FTCDNL1 formiminotransferase cyclodeaminase N-terminal like -2.03201
MAK male germ cell-associated kinase -2.02491
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha -2.02149
H2AC13 H2A clustered histone 13 -2.02149