| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | RMC-6236 perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the RMC-6236_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.240501 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0994471 |
| MAP1B | microtubule-associated protein 1B | 0.0966353 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.089745 |
| DST | dystonin | 0.088527 |
| HDAC9 | histone deacetylase 9 | 0.0863408 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0854679 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0814113 |
| AHNAK | AHNAK nucleoprotein | 0.0719053 |
| COL5A1 | collagen, type V, alpha 1 | 0.0682343 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | 0.0680069 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.062873 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0614028 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0599215 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0598031 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0579544 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0514488 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0497601 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0496076 |
| CALR | calreticulin | 0.0470643 |
| HSPB1 | heat shock 27kDa protein 1 | 0.0452739 |
| DSPP | dentin sialophosphoprotein | 0.0435254 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.042099 |
| L1CAM | L1 cell adhesion molecule | 0.0418692 |
| ENO1 | enolase 1, (alpha) | 0.0413628 |
| TPM4 | tropomyosin 4 | 0.0412421 |
| EZR | ezrin | 0.0410512 |
| CANX | calnexin | 0.0404861 |
| TPM3 | tropomyosin 3 | 0.0401084 |
| CSTB | cystatin B (stefin B) | 0.039565 |
| TMSB4X | thymosin beta 4, X-linked | 0.0386022 |
| FLNA | filamin A, alpha | 0.037735 |
| RHOA | ras homolog family member A | 0.0371518 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0366905 |
| FN1 | fibronectin 1 | 0.0349242 |
| LDHA | lactate dehydrogenase A | 0.0345171 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0339669 |
| SFTPA2 | surfactant protein A2 | 0.0337038 |
| EGFR | epidermal growth factor receptor | 0.0334489 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0333034 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0321037 |
| POTEF | POTE ankyrin domain family, member F | 0.031923 |
| MSN | moesin | 0.0317684 |
| SORBS2 | sorbin and SH3 domain containing 2 | 0.0316793 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0310738 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0309468 |
| DCLK2 | doublecortin-like kinase 2 | 0.0306354 |
| LMNA | lamin A/C | 0.03002 |
| PEA15 | phosphoprotein enriched in astrocytes 15 | 0.0299539 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0298641 |
| FSTL1 | follistatin-like 1 | 0.0293745 |
| ANXA1 | annexin A1 | 0.0289369 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0284919 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0273689 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | 0.0273422 |
| S100A11 | S100 calcium binding protein A11 | 0.0267944 |
| ANKRD30B | ankyrin repeat domain 30B | 0.0266048 |
| RNF213 | ring finger protein 213 | 0.0263588 |
| SP100 | SP100 nuclear antigen | 0.0262448 |
| PLXNA2 | plexin A2 | 0.0258922 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0257142 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.025547 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.0254178 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0247703 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | 0.0243354 |
| PCDH7 | protocadherin 7 | 0.0242096 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0235739 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | 0.023383 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0232538 |
| CDH13 | cadherin 13 | 0.0229922 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0228779 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0226059 |
| SET | SET nuclear proto-oncogene | 0.0224331 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0219805 |
| CLIC3 | chloride intracellular channel 3 | 0.0215158 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0212076 |
| RND3 | Rho family GTPase 3 | 0.0208374 |
| TPI1 | triosephosphate isomerase 1 | 0.0208128 |
| B2M | beta-2-microglobulin | 0.020682 |
| RHOB | ras homolog family member B | 0.0205527 |
| TENM3 | teneurin transmembrane protein 3 | 0.0205091 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0199738 |
| CENPF | centromere protein F, 350/400kDa | 0.019927 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0197988 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0196546 |
| SPDL1 | spindle apparatus coiled-coil protein 1 | 0.0193985 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0191832 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.0187835 |
| SLFN5 | schlafen family member 5 | 0.0187585 |
| TRABD2B | TraB domain containing 2B | 0.0185524 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0184507 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | 0.0182707 |
| NUCB2 | nucleobindin 2 | 0.0180418 |
| RPS2 | ribosomal protein S2 | 0.0179069 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0175902 |
| FMN2 | formin 2 | 0.0173394 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0171534 |
| KLF6 | Kruppel-like factor 6 | 0.0170182 |
| RASAL2 | RAS protein activator like 2 | 0.0169994 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0168796 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.234012 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.175564 |
| LOX | lysyl oxidase | -0.168494 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.107693 |
| MT2A | metallothionein 2A | -0.105568 |
| TMSB10 | thymosin beta 10 | -0.0860054 |
| PLAT | plasminogen activator, tissue | -0.085831 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0858308 |
| FBN1 | fibrillin 1 | -0.0840911 |
| UBC | ubiquitin C | -0.0801194 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0725755 |
| CD99 | CD99 molecule | -0.0689026 |
| LOXL2 | lysyl oxidase-like 2 | -0.067329 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0646002 |
| STC1 | stanniocalcin 1 | -0.0627491 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0613205 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0612444 |
| COL1A2 | collagen, type I, alpha 2 | -0.0574136 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0572564 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0555659 |
| OGA | O-GlcNAcase | -0.0521267 |
| SBF2 | SET binding factor 2 | -0.0518082 |
| HIP1 | huntingtin interacting protein 1 | -0.0496655 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0495802 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0485951 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0471601 |
| THBS2 | thrombospondin 2 | -0.0467084 |
| COL5A2 | collagen, type V, alpha 2 | -0.0459326 |
| VIM | vimentin | -0.0458794 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0458034 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.045659 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0453339 |
| HLA-B | major histocompatibility complex, class I, B | -0.0438816 |
| GPC6 | glypican 6 | -0.043725 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0423381 |
| GLIS3 | GLIS family zinc finger 3 | -0.0413375 |
| ATP13A3 | ATPase type 13A3 | -0.0411371 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0402909 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0397396 |
| RTN4 | reticulon 4 | -0.0392836 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0383494 |
| COL3A1 | collagen, type III, alpha 1 | -0.0368015 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0367991 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0365885 |
| NF1 | neurofibromin 1 | -0.0356979 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0355489 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0353672 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0347084 |
| NDRG1 | N-myc downstream regulated 1 | -0.0346454 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0345434 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0344915 |
| PXDN | peroxidasin | -0.0344804 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0341399 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.033862 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0337635 |
| ZNF207 | zinc finger protein 207 | -0.0326717 |
| CCND1 | cyclin D1 | -0.0323163 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0322634 |
| AUTS2 | autism susceptibility candidate 2 | -0.0320721 |
| MT1X | metallothionein 1X | -0.0318135 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0318085 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0316907 |
| FRMD5 | FERM domain containing 5 | -0.0313464 |
| TNIP1 | TNFAIP3 interacting protein 1 | -0.0312041 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0311649 |
| FRMD4A | FERM domain containing 4A | -0.0310558 |
| JAZF1 | JAZF zinc finger 1 | -0.0304555 |
| TMOD1 | tropomodulin 1 | -0.0303992 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0302286 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0299323 |
| GNAS | GNAS complex locus | -0.0297551 |
| COG5 | component of oligomeric golgi complex 5 | -0.0297486 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0296041 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0293386 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.029052 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0288344 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0288328 |
| RUNX1 | runt-related transcription factor 1 | -0.0288104 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.028677 |
| HLA-E | major histocompatibility complex, class I, E | -0.0285191 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0282306 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0282256 |
| HDLBP | high density lipoprotein binding protein | -0.028111 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0279533 |
| NAV2 | neuron navigator 2 | -0.0279252 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.0274924 |
| ANXA2 | annexin A2 | -0.0270564 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0263964 |
| GOLGA4 | golgin A4 | -0.0263658 |
| GLG1 | golgi glycoprotein 1 | -0.0263423 |
| DENND5A | DENN/MADD domain containing 5A | -0.0263116 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0262252 |
| LRRC49 | leucine rich repeat containing 49 | -0.0258114 |
| WTAP | Wilms tumor 1 associated protein | -0.0257421 |
| AVL9 | AVL9 homolog (S. cerevisiase) | -0.0255174 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0253752 |
| NGLY1 | N-glycanase 1 | -0.0253641 |
| FNIP1 | folliculin interacting protein 1 | -0.0250801 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0247435 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0247182 |
