| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | RMC-6236 perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the RMC-6236_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NLGN1 | neuroligin 1 | 0.259092 |
| VIM | vimentin | 0.235987 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.225588 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.217485 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.148818 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.102951 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0955576 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0790061 |
| PCBP2 | poly(rC) binding protein 2 | 0.0777169 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0695126 |
| ANXA1 | annexin A1 | 0.0691525 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0644583 |
| TENM3 | teneurin transmembrane protein 3 | 0.0613645 |
| CALR | calreticulin | 0.0567031 |
| TPI1 | triosephosphate isomerase 1 | 0.0553078 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0537141 |
| RPS3 | ribosomal protein S3 | 0.0529838 |
| PCDH7 | protocadherin 7 | 0.0524834 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0514798 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.0513726 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | 0.0500405 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0494339 |
| TMSB10 | thymosin beta 10 | 0.0476505 |
| PDGFC | platelet derived growth factor C | 0.0474246 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0455835 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0450898 |
| OLR1 | oxidized low density lipoprotein (lectin-like) receptor 1 | 0.0450625 |
| RPS12 | ribosomal protein S12 | 0.0448755 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0446301 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0413398 |
| CDK6 | cyclin-dependent kinase 6 | 0.0400212 |
| PCDH9 | protocadherin 9 | 0.0389684 |
| HMGA2 | high mobility group AT-hook 2 | 0.038308 |
| RPS2 | ribosomal protein S2 | 0.0381125 |
| TPM3 | tropomyosin 3 | 0.0378823 |
| WWOX | WW domain containing oxidoreductase | 0.0366983 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0363775 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0363387 |
| HDAC9 | histone deacetylase 9 | 0.036096 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0357428 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0356813 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0352443 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0350927 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0350351 |
| FTL | ferritin, light polypeptide | 0.034634 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0343501 |
| AREG | amphiregulin | 0.0337599 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0332036 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0330382 |
| YAP1 | Yes-associated protein 1 | 0.0324651 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | 0.0318966 |
| RRM2 | ribonucleotide reductase M2 | 0.0303033 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0297541 |
| RPL26 | ribosomal protein L26 | 0.0294852 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.029364 |
| RACK1 | receptor for activated C kinase 1 | 0.0288551 |
| MED13L | mediator complex subunit 13-like | 0.0284085 |
| NEGR1 | neuronal growth regulator 1 | 0.0281824 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0278162 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0278158 |
| MPG | N-methylpurine-DNA glycosylase | 0.0277397 |
| RPL3 | ribosomal protein L3 | 0.0274543 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0272114 |
| PRDX1 | peroxiredoxin 1 | 0.0272101 |
| CCND1 | cyclin D1 | 0.0272046 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0270885 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0266399 |
| DST | dystonin | 0.0265905 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0261893 |
| CELF2 | CUGBP, Elav-like family member 2 | 0.0260552 |
| EPHA6 | EPH receptor A6 | 0.0259498 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0258853 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.025353 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0252857 |
| IPO7 | importin 7 | 0.0250399 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0248137 |
| ENO1 | enolase 1, (alpha) | 0.0246802 |
| YBX3 | Y box binding protein 3 | 0.0246518 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0246139 |
| RPS8 | ribosomal protein S8 | 0.024284 |
| CEP112 | centrosomal protein 112kDa | 0.0242609 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0241949 |
| RPS7 | ribosomal protein S7 | 0.0240581 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0240425 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | 0.0237834 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0227852 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.0225041 |
| SFTPA2 | surfactant protein A2 | 0.022442 |
| EPHA5 | EPH receptor A5 | 0.0221186 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0217116 |
| EXOC4 | exocyst complex component 4 | 0.0215863 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0215402 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0214808 |
| FLNA | filamin A, alpha | 0.0213297 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0210416 |
| CLPTM1L | CLPTM1-like | 0.0210309 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.020903 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0208912 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.0207477 |
| EDN1 | endothelin 1 | 0.0205396 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.27562 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0824675 |
| EGR1 | early growth response 1 | -0.0551939 |
| FBXO11 | F-box protein 11 | -0.0422603 |
| ZNF804A | zinc finger protein 804A | -0.0412321 |
| NHSL1 | NHS-like 1 | -0.0410664 |
| TMEM123 | transmembrane protein 123 | -0.0408868 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0391645 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0390682 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0383798 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0379111 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0346353 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0302216 |
| EHBP1 | EH domain binding protein 1 | -0.028923 |
| HMGA1 | high mobility group AT-hook 1 | -0.0269101 |
| WDR45B | WD repeat domain 45B | -0.0258255 |
| WASF2 | WAS protein family, member 2 | -0.0255507 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0253357 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0247096 |
| USP34 | ubiquitin specific peptidase 34 | -0.024585 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0242996 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0236141 |
| ASPH | aspartate beta-hydroxylase | -0.0232952 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0232091 |
| CDK17 | cyclin-dependent kinase 17 | -0.0226481 |
| NABP1 | nucleic acid binding protein 1 | -0.0223586 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0220758 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.021962 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0219571 |
| RPL6 | ribosomal protein L6 | -0.0216463 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0212355 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0202288 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0200231 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0196737 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.019515 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0193912 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0193217 |
| RAB10 | RAB10, member RAS oncogene family | -0.0191819 |
| TMEM41B | transmembrane protein 41B | -0.0191578 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0191335 |
| H1-0 | H1.0 linker histone | -0.0191024 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0190382 |
| TMEM131 | transmembrane protein 131 | -0.0189256 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0188311 |
| TUBB | tubulin, beta class I | -0.0187643 |
| MEMO1 | mediator of cell motility 1 | -0.0184644 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0183851 |
| KCMF1 | potassium channel modulatory factor 1 | -0.0183636 |
| RPL38 | ribosomal protein L38 | -0.0183177 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0182401 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0182137 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0181709 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0180853 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0180729 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0178504 |
| PCNP | PEST proteolytic signal containing nuclear protein | -0.01772 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0175504 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0173962 |
| GLG1 | golgi glycoprotein 1 | -0.0171688 |
| RPS6 | ribosomal protein S6 | -0.0170231 |
| TUBA1B | tubulin, alpha 1b | -0.016948 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0169 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0167806 |
| RPS29 | ribosomal protein S29 | -0.0167134 |
| TENT4A | terminal nucleotidyltransferase 4A | -0.0166421 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0165032 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.016489 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0162847 |
| SNX14 | sorting nexin 14 | -0.0162183 |
| MYL12B | myosin, light chain 12B, regulatory | -0.016179 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | -0.0157728 |
| ARL5B | ADP-ribosylation factor-like 5B | -0.0157317 |
| TASOR2 | transcription activation suppressor family member 2 | -0.0156279 |
| GNAS | GNAS complex locus | -0.0155679 |
| NUP58 | nucleoporin 58 | -0.0153714 |
| ABI2 | abl-interactor 2 | -0.0153084 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0152595 |
| UBE2K | ubiquitin-conjugating enzyme E2K | -0.0152477 |
| MTAP | methylthioadenosine phosphorylase | -0.0152064 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0151532 |
| CDK12 | cyclin-dependent kinase 12 | -0.0149722 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.0149301 |
| RPLP0 | ribosomal protein, large, P0 | -0.0147943 |
| RPS15 | ribosomal protein S15 | -0.0146896 |
| GNB4 | guanine nucleotide binding protein (G protein), beta polypeptide 4 | -0.0145635 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0145195 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.014456 |
| PPP1CC | protein phosphatase 1, catalytic subunit, gamma isozyme | -0.0141982 |
| SBNO1 | strawberry notch homolog 1 (Drosophila) | -0.0140885 |
| NBAS | neuroblastoma amplified sequence | -0.0139893 |
| GRB2 | growth factor receptor-bound protein 2 | -0.0139872 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0138475 |
| ACTG1 | actin gamma 1 | -0.0138029 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0137906 |
| GORASP2 | golgi reassembly stacking protein 2, 55kDa | -0.0137532 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0137456 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0136995 |
| AP3S1 | adaptor-related protein complex 3, sigma 1 subunit | -0.0136191 |
| LARP1 | La ribonucleoprotein domain family, member 1 | -0.0135876 |
| COG5 | component of oligomeric golgi complex 5 | -0.0134387 |
