| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | RMC-6236 perturbation in A498 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the RMC-6236_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.181388 |
| KYNU | kynureninase | 0.0661096 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0599189 |
| FTL | ferritin, light polypeptide | 0.0571506 |
| TXNRD1 | thioredoxin reductase 1 | 0.0443808 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0400443 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0399165 |
| PBX1 | pre-B-cell leukemia homeobox 1 | 0.0385047 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0368235 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.035444 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0338357 |
| PALLD | palladin, cytoskeletal associated protein | 0.031696 |
| SFTPA2 | surfactant protein A2 | 0.0301545 |
| CSF1 | colony stimulating factor 1 (macrophage) | 0.0290807 |
| PLIN2 | perilipin 2 | 0.0288797 |
| ENAH | enabled homolog (Drosophila) | 0.0284548 |
| B2M | beta-2-microglobulin | 0.0278995 |
| TLE4 | transducin-like enhancer of split 4 | 0.0259179 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0248355 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0247511 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.023938 |
| RNF213 | ring finger protein 213 | 0.023469 |
| CP | ceruloplasmin (ferroxidase) | 0.0233253 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0231545 |
| RPS2 | ribosomal protein S2 | 0.0231025 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.022972 |
| IFI44L | interferon-induced protein 44-like | 0.0204104 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0193697 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0184222 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0183999 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.017978 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0178491 |
| GPC5 | glypican 5 | 0.0174229 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0167598 |
| RPL12 | ribosomal protein L12 | 0.0166438 |
| INTS6 | integrator complex subunit 6 | 0.0163628 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | 0.016215 |
| SLC4A4 | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 | 0.0160183 |
| SP100 | SP100 nuclear antigen | 0.0159844 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0159299 |
| MYOF | myoferlin | 0.0158343 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0152723 |
| SLFN5 | schlafen family member 5 | 0.0151701 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | 0.0150309 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0149389 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.0147763 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0142098 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0135384 |
| ZBTB41 | zinc finger and BTB domain containing 41 | 0.0133669 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.013309 |
| PCBP3 | poly(rC) binding protein 3 | 0.0131291 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0129875 |
| RBPMS | RNA binding protein with multiple splicing | 0.0129307 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0129257 |
| RPS4X | ribosomal protein S4, X-linked | 0.0129189 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0127586 |
| MGST1 | microsomal glutathione S-transferase 1 | 0.0127585 |
| TUT7 | terminal uridylyl transferase 7 | 0.012723 |
| MX1 | MX dynamin-like GTPase 1 | 0.0127065 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0123826 |
| SAA2 | serum amyloid A2 | 0.0122338 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | 0.0121892 |
| ATF3 | activating transcription factor 3 | 0.012151 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0118458 |
| AHNAK | AHNAK nucleoprotein | 0.0117929 |
| GBP2 | guanylate binding protein 2, interferon-inducible | 0.0117555 |
| PCMTD1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 | 0.0117513 |
| PLK2 | polo-like kinase 2 | 0.0117412 |
| TGFB2 | transforming growth factor, beta 2 | 0.0117011 |
| ABLIM1 | actin binding LIM protein 1 | 0.0114249 |
| ADAR | adenosine deaminase, RNA-specific | 0.011325 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0113099 |
| KLF6 | Kruppel-like factor 6 | 0.0112751 |
| FNIP2 | folliculin interacting protein 2 | 0.0110427 |
| NNMT | nicotinamide N-methyltransferase | 0.0109669 |
| FHL2 | four and a half LIM domains 2 | 0.0109607 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0108098 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | 0.0107444 |
| PLSCR2 | phospholipid scramblase 2 | 0.0107261 |
| GLIS3 | GLIS family zinc finger 3 | 0.0107103 |
| CHMP5 | charged multivesicular body protein 5 | 0.0104907 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0104277 |
| SIK2 | salt-inducible kinase 2 | 0.0104245 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0103809 |
| RPS7 | ribosomal protein S7 | 0.0101284 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | 0.00999877 |
| ARRDC3 | arrestin domain containing 3 | 0.00997716 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | 0.00993395 |
| IDH1 | isocitrate dehydrogenase 1 (NADP+), soluble | 0.00993109 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.00988038 |
| EEA1 | early endosome antigen 1 | 0.00978369 |
| RACK1 | receptor for activated C kinase 1 | 0.00973879 |
| CANX | calnexin | 0.00970851 |
| EPAS1 | endothelial PAS domain protein 1 | 0.00968484 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.00967527 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.00960099 |
| ATF4 | activating transcription factor 4 | 0.00958544 |
| RPL26 | ribosomal protein L26 | 0.00956413 |
| TXNIP | thioredoxin interacting protein | 0.00952881 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.00947483 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.135482 |
| CD44 | CD44 molecule (Indian blood group) | -0.100761 |
| VIM | vimentin | -0.0961358 |
| NDRG1 | N-myc downstream regulated 1 | -0.0938281 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0838478 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0762227 |
| FRMD4A | FERM domain containing 4A | -0.0711102 |
| RAI14 | retinoic acid induced 14 | -0.0705281 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0653054 |
| RTN4 | reticulon 4 | -0.0649567 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0568105 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0533526 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.052044 |
| NAV2 | neuron navigator 2 | -0.0503808 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0499306 |
| TMSB10 | thymosin beta 10 | -0.0483661 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0483221 |
| DIAPH3 | diaphanous-related formin 3 | -0.0478244 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.044103 |
| CALU | calumenin | -0.0435973 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0425981 |
| ATP13A3 | ATPase type 13A3 | -0.0421451 |
| ASPH | aspartate beta-hydroxylase | -0.039941 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0399129 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0382725 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0375963 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | -0.0374597 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0364817 |
| CDCP1 | CUB domain containing protein 1 | -0.0362281 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0361675 |
| HLA-B | major histocompatibility complex, class I, B | -0.0358379 |
| CTSD | cathepsin D | -0.0356179 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0352737 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0351392 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0349525 |
| FMNL2 | formin-like 2 | -0.0348407 |
| RUNX1 | runt-related transcription factor 1 | -0.0334513 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0334242 |
| PKM | pyruvate kinase, muscle | -0.0332066 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0331655 |
| CADM1 | cell adhesion molecule 1 | -0.0331468 |
| CD82 | CD82 molecule | -0.0331196 |
| RPS6 | ribosomal protein S6 | -0.0331191 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0330348 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0326557 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.032469 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0324136 |
| FAM107B | family with sequence similarity 107, member B | -0.0322798 |
| PTK2 | protein tyrosine kinase 2 | -0.0315168 |
| NOP58 | NOP58 ribonucleoprotein | -0.031285 |
| SPAG9 | sperm associated antigen 9 | -0.0311655 |
| PTMA | prothymosin, alpha | -0.0311616 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0311509 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.030552 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0302178 |
| OSBPL3 | oxysterol binding protein-like 3 | -0.0301643 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0301453 |
| GNAS | GNAS complex locus | -0.0301249 |
| RBM39 | RNA binding motif protein 39 | -0.0300503 |
| POTEF | POTE ankyrin domain family, member F | -0.0290768 |
| SRPK2 | SRSF protein kinase 2 | -0.0286647 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0284349 |
| RRM2 | ribonucleotide reductase M2 | -0.0283696 |
| PALS2 | protein associated with LIN7 2, MAGUK p55 family member | -0.0281244 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0281156 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.0277767 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0275988 |
| PFN1 | profilin 1 | -0.0273032 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0272815 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.0269961 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.026984 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0267724 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0262783 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0261506 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0261494 |
| CDK6 | cyclin-dependent kinase 6 | -0.025801 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | -0.025757 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0255629 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0253837 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0253504 |
| HIPK2 | homeodomain interacting protein kinase 2 | -0.0252469 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0251996 |
| COG5 | component of oligomeric golgi complex 5 | -0.025101 |
| CKAP4 | cytoskeleton-associated protein 4 | -0.0248547 |
| JMJD1C | jumonji domain containing 1C | -0.0248026 |
| GOLGA4 | golgin A4 | -0.0245593 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0243979 |
| MTDH | metadherin | -0.0243613 |
| PRKCA | protein kinase C, alpha | -0.0242876 |
| PDE8A | phosphodiesterase 8A | -0.0241862 |
| RHEB | Ras homolog enriched in brain | -0.0241526 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0240598 |
| CBX3 | chromobox homolog 3 | -0.0236368 |
| CLTC | clathrin, heavy chain (Hc) | -0.0236302 |
| HMGA1 | high mobility group AT-hook 1 | -0.0233508 |
| TUBA1B | tubulin, alpha 1b | -0.0233269 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0231483 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0231016 |
| COPA | coatomer protein complex, subunit alpha | -0.0229894 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.022857 |
