| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | RMC-6236 perturbation in A549 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the RMC-6236_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.27423 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.192293 |
| VIM | vimentin | 0.133654 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.101492 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0892367 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0635925 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0604305 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0561907 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0529942 |
| RPS2 | ribosomal protein S2 | 0.05084 |
| TXNRD1 | thioredoxin reductase 1 | 0.0498717 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0496448 |
| DSTN | destrin (actin depolymerizing factor) | 0.0483161 |
| B2M | beta-2-microglobulin | 0.0480541 |
| KYNU | kynureninase | 0.047673 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0449094 |
| RNF213 | ring finger protein 213 | 0.044849 |
| PALLD | palladin, cytoskeletal associated protein | 0.0431953 |
| LDHA | lactate dehydrogenase A | 0.0411065 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0394476 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0383702 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0378417 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0376298 |
| RACK1 | receptor for activated C kinase 1 | 0.0358636 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0358606 |
| TCIM | transcriptional and immune response regulator | 0.0355811 |
| PCBP2 | poly(rC) binding protein 2 | 0.0355502 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0355415 |
| CA12 | carbonic anhydrase XII | 0.0352165 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0351737 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0344963 |
| BICC1 | BicC family RNA binding protein 1 | 0.0342355 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0341414 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0331453 |
| RPS17 | ribosomal protein S17 | 0.0322351 |
| RPS3 | ribosomal protein S3 | 0.0317956 |
| RPL26 | ribosomal protein L26 | 0.0316659 |
| RPS12 | ribosomal protein S12 | 0.0311288 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0307733 |
| MYADM | myeloid-associated differentiation marker | 0.0282089 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0276658 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0276068 |
| RPL12 | ribosomal protein L12 | 0.0273827 |
| DST | dystonin | 0.0269023 |
| MYOF | myoferlin | 0.0268321 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0267528 |
| CP | ceruloplasmin (ferroxidase) | 0.0266288 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0264557 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0251736 |
| SFTPA2 | surfactant protein A2 | 0.0247259 |
| SP100 | SP100 nuclear antigen | 0.0244507 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0241805 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0238621 |
| TNS3 | tensin 3 | 0.0230231 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | 0.0229545 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0227924 |
| RBPMS | RNA binding protein with multiple splicing | 0.0227017 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | 0.0226392 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0221938 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | 0.022014 |
| LMO7 | LIM domain 7 | 0.0220111 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0220051 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0218396 |
| ATF3 | activating transcription factor 3 | 0.0214023 |
| POTEF | POTE ankyrin domain family, member F | 0.0208462 |
| RHCG | Rh family, C glycoprotein | 0.020771 |
| RPL37A | ribosomal protein L37a | 0.0203864 |
| RPS8 | ribosomal protein S8 | 0.020349 |
| DSPP | dentin sialophosphoprotein | 0.0203409 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0199592 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.019596 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0194779 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0191853 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | 0.0191513 |
| MAP7 | microtubule-associated protein 7 | 0.0190799 |
| RPS19 | ribosomal protein S19 | 0.018947 |
| DUSP16 | dual specificity phosphatase 16 | 0.0188029 |
| RPS7 | ribosomal protein S7 | 0.0187204 |
| ATF4 | activating transcription factor 4 | 0.0180926 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0179945 |
| SET | SET nuclear proto-oncogene | 0.0179113 |
| KRT7 | keratin 7, type II | 0.0178174 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0178129 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0178077 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0177022 |
| CA8 | carbonic anhydrase VIII | 0.0175932 |
| ETNK1 | ethanolamine kinase 1 | 0.0174663 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | 0.0173927 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0173043 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0171604 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0170882 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0170872 |
| FAT1 | FAT atypical cadherin 1 | 0.017074 |
| MYO10 | myosin X | 0.0168384 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0168304 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0168177 |
| ARHGAP42 | Rho GTPase activating protein 42 | 0.0167814 |
| TPI1 | triosephosphate isomerase 1 | 0.0166224 |
| HDGF | hepatoma-derived growth factor | 0.016581 |
| OPTN | optineurin | 0.0162293 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.122027 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.120385 |
| GRB10 | growth factor receptor-bound protein 10 | -0.081975 |
| USP3 | ubiquitin specific peptidase 3 | -0.0774841 |
| SPAG9 | sperm associated antigen 9 | -0.0740051 |
| HELZ | helicase with zinc finger | -0.0634147 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0614825 |
| EFNA5 | ephrin-A5 | -0.0610231 |
| ASPH | aspartate beta-hydroxylase | -0.0560535 |
| FLNB | filamin B, beta | -0.0548498 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.054699 |
| PDE10A | phosphodiesterase 10A | -0.0546498 |
| FMNL2 | formin-like 2 | -0.0541471 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.053166 |
| NDRG1 | N-myc downstream regulated 1 | -0.0530181 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0523318 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0519007 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0514881 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0479821 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0469091 |
| KCTD9 | potassium channel tetramerization domain containing 9 | -0.0457186 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0437237 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0437125 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0419182 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0417319 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0402153 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0402029 |
| RTN4 | reticulon 4 | -0.0393632 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0393455 |
| MCL1 | myeloid cell leukemia 1 | -0.0392331 |
| GOLGA4 | golgin A4 | -0.038101 |
| PTK2 | protein tyrosine kinase 2 | -0.037717 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0374919 |
| USP34 | ubiquitin specific peptidase 34 | -0.0374455 |
| MT1X | metallothionein 1X | -0.0373756 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0372327 |
| ECT2 | epithelial cell transforming 2 | -0.0371751 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0368223 |
| VEZT | vezatin, adherens junctions transmembrane protein | -0.0363716 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0361066 |
| RIN2 | Ras and Rab interactor 2 | -0.0360886 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0357652 |
| ANXA2 | annexin A2 | -0.0353551 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0352903 |
| STC1 | stanniocalcin 1 | -0.0352292 |
| PTMA | prothymosin, alpha | -0.0348333 |
| MT2A | metallothionein 2A | -0.0343789 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0340562 |
| PARD3 | par-3 family cell polarity regulator | -0.0335809 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0331137 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0324157 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0322669 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0320261 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0319308 |
| OGA | O-GlcNAcase | -0.031615 |
| NBAS | neuroblastoma amplified sequence | -0.0315381 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0310666 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0308711 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0305079 |
| SETD5 | SET domain containing 5 | -0.0303789 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | -0.0301147 |
| WDR45B | WD repeat domain 45B | -0.0300409 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0294669 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0294126 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0292427 |
| FBXO11 | F-box protein 11 | -0.0291559 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0290843 |
| AUTS2 | autism susceptibility candidate 2 | -0.02901 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0289936 |
| PDE8A | phosphodiesterase 8A | -0.0289736 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0288708 |
| DENND4C | DENN/MADD domain containing 4C | -0.0286598 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0284706 |
| NUP58 | nucleoporin 58 | -0.0280255 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | -0.0276589 |
| KCMF1 | potassium channel modulatory factor 1 | -0.027625 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0276027 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | -0.027471 |
| PRKCA | protein kinase C, alpha | -0.0274363 |
| NAV2 | neuron navigator 2 | -0.0274168 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0272348 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0266981 |
| NF1 | neurofibromin 1 | -0.0266799 |
| SBF2 | SET binding factor 2 | -0.0264827 |
| SRP54 | signal recognition particle 54kDa | -0.0263762 |
| CEP95 | centrosomal protein 95kDa | -0.0263262 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0261616 |
| EGR1 | early growth response 1 | -0.0259669 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0258107 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0257078 |
| ARL5B | ADP-ribosylation factor-like 5B | -0.0256261 |
| ATP13A3 | ATPase type 13A3 | -0.0253359 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.024962 |
| RBM39 | RNA binding motif protein 39 | -0.024935 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0249025 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0248764 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0248485 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0248474 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.0247254 |
| SUCO | SUN domain containing ossification factor | -0.0245815 |
