| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | RMC-6236 perturbation in BT-474 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the RMC-6236_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.301675 |
| RPL19 | ribosomal protein L19 | 0.215213 |
| RPL23 | ribosomal protein L23 | 0.196727 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.145558 |
| PTMA | prothymosin, alpha | 0.112347 |
| DSPP | dentin sialophosphoprotein | 0.108472 |
| TENM2 | teneurin transmembrane protein 2 | 0.101519 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0999952 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0976527 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0970128 |
| DUSP16 | dual specificity phosphatase 16 | 0.0826401 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | 0.0753016 |
| TRPS1 | trichorhinophalangeal syndrome I | 0.0726161 |
| ENAH | enabled homolog (Drosophila) | 0.0716814 |
| RPS3 | ribosomal protein S3 | 0.071078 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | 0.070807 |
| SLFN5 | schlafen family member 5 | 0.0691739 |
| SET | SET nuclear proto-oncogene | 0.0685549 |
| TMSB4X | thymosin beta 4, X-linked | 0.0669451 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | 0.0659135 |
| PRRC2C | proline-rich coiled-coil 2C | 0.065376 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0650434 |
| B2M | beta-2-microglobulin | 0.0632193 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | 0.0623853 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0611275 |
| SAMD12 | sterile alpha motif domain containing 12 | 0.057968 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0573156 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0552998 |
| RPL12 | ribosomal protein L12 | 0.053838 |
| UNC13B | unc-13 homolog B (C. elegans) | 0.0537287 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0527053 |
| CLTC | clathrin, heavy chain (Hc) | 0.0525763 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0519928 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0519427 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0501763 |
| AHNAK | AHNAK nucleoprotein | 0.049983 |
| ENO1 | enolase 1, (alpha) | 0.0490303 |
| INSR | insulin receptor | 0.0489845 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0484851 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0484078 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0471504 |
| SP100 | SP100 nuclear antigen | 0.0453366 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0449565 |
| CANX | calnexin | 0.0442758 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0436366 |
| VAV3 | vav 3 guanine nucleotide exchange factor | 0.0429865 |
| LDHA | lactate dehydrogenase A | 0.0429116 |
| NEBL | nebulette | 0.0428248 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0426925 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0423224 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0416061 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0412115 |
| PRLR | prolactin receptor | 0.0409329 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0408067 |
| TC2N | tandem C2 domains, nuclear | 0.04018 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0392779 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0389999 |
| PBX1 | pre-B-cell leukemia homeobox 1 | 0.0386289 |
| SERINC3 | serine incorporator 3 | 0.0381394 |
| PSMD3 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 | 0.0380516 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.0378416 |
| KIF5B | kinesin family member 5B | 0.0376485 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0373813 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0373386 |
| BCAS1 | breast carcinoma amplified sequence 1 | 0.0370847 |
| CALR | calreticulin | 0.0366852 |
| DSTN | destrin (actin depolymerizing factor) | 0.0364712 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.036261 |
| TPM3 | tropomyosin 3 | 0.035783 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0357797 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | 0.0352132 |
| CD164 | CD164 molecule, sialomucin | 0.0351448 |
| GOLGB1 | golgin B1 | 0.0349465 |
| ADAR | adenosine deaminase, RNA-specific | 0.0349435 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | 0.0338695 |
| PGM2L1 | phosphoglucomutase 2-like 1 | 0.0336278 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0333229 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0329269 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0327778 |
| MLLT6 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 | 0.0324329 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0323584 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0323509 |
| PFDN4 | prefoldin subunit 4 | 0.0321305 |
| CENPF | centromere protein F, 350/400kDa | 0.0320871 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0318275 |
| RABGAP1 | RAB GTPase activating protein 1 | 0.0315159 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0313477 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.0313418 |
| YPEL2 | yippee-like 2 (Drosophila) | 0.0312874 |
| PGK1 | phosphoglycerate kinase 1 | 0.0308993 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0308091 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0307442 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0306877 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.030645 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0305284 |
| RPS6KA5 | ribosomal protein S6 kinase, 90kDa, polypeptide 5 | 0.0304185 |
| RPS8 | ribosomal protein S8 | 0.0303886 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0301752 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0299415 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0299404 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GRB10 | growth factor receptor-bound protein 10 | -0.0666932 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.059524 |
| MCL1 | myeloid cell leukemia 1 | -0.0588769 |
| NDRG1 | N-myc downstream regulated 1 | -0.0542833 |
| SRCIN1 | SRC kinase signaling inhibitor 1 | -0.0471571 |
| ASPH | aspartate beta-hydroxylase | -0.0452374 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | -0.0438217 |
| VMP1 | vacuole membrane protein 1 | -0.0427081 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0412558 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0385448 |
| MT2A | metallothionein 2A | -0.0366489 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0364592 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0348075 |
| FASN | fatty acid synthase | -0.0342326 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0340353 |
| EGR1 | early growth response 1 | -0.033368 |
| AHCTF1 | AT hook containing transcription factor 1 | -0.0332827 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0330483 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0326373 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0323741 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.0320597 |
| NABP1 | nucleic acid binding protein 1 | -0.0304093 |
| VIPR2 | vasoactive intestinal peptide receptor 2 | -0.0298923 |
| PTK2 | protein tyrosine kinase 2 | -0.0292362 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.029205 |
| ACTN4 | actinin, alpha 4 | -0.0285314 |
| SMYD3 | SET and MYND domain containing 3 | -0.0279226 |
| DENND1A | DENN/MADD domain containing 1A | -0.0277045 |
| NIBAN2 | niban apoptosis regulator 2 | -0.02674 |
| TMEM165 | transmembrane protein 165 | -0.025666 |
| AZIN1 | antizyme inhibitor 1 | -0.0249857 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0249414 |
| DST | dystonin | -0.0247884 |
| VCL | vinculin | -0.0238941 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0237902 |
| PARD3 | par-3 family cell polarity regulator | -0.0235619 |
| TRA2B | transformer 2 beta homolog (Drosophila) | -0.0233965 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0231569 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0227245 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0226955 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0226399 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0223576 |
| DTNA | dystrobrevin, alpha | -0.0223218 |
| RTN4 | reticulon 4 | -0.0220071 |
| USP53 | ubiquitin specific peptidase 53 | -0.0219208 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0215155 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0214766 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0210178 |
| CCNL1 | cyclin L1 | -0.0209784 |
| S100A9 | S100 calcium binding protein A9 | -0.0207827 |
| S100A14 | S100 calcium binding protein A14 | -0.0207478 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0205462 |
| LDLR | low density lipoprotein receptor | -0.0204563 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | -0.0201178 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0200499 |
| POLD3 | polymerase (DNA-directed), delta 3, accessory subunit | -0.0199439 |
| NCOA3 | nuclear receptor coactivator 3 | -0.0198046 |
| ITGB6 | integrin, beta 6 | -0.0187984 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0186638 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0186154 |
| PRELID2 | PRELI domain containing 2 | -0.0185723 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0183537 |
| TNS3 | tensin 3 | -0.0181571 |
| FLNB | filamin B, beta | -0.0177751 |
| STK17A | serine/threonine kinase 17a | -0.0177155 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0176001 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0175307 |
| S100A8 | S100 calcium binding protein A8 | -0.0174518 |
| SRPK2 | SRSF protein kinase 2 | -0.017431 |
| TENM4 | teneurin transmembrane protein 4 | -0.0173125 |
| CD44 | CD44 molecule (Indian blood group) | -0.0172666 |
| SHB | Src homology 2 domain containing adaptor protein B | -0.0171995 |
| GRB7 | growth factor receptor-bound protein 7 | -0.0171714 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0169392 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0169325 |
| POLA1 | polymerase (DNA directed), alpha 1, catalytic subunit | -0.0168952 |
| TMEM41B | transmembrane protein 41B | -0.0168907 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0167794 |
| SMAD3 | SMAD family member 3 | -0.0167577 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0164715 |
| SLC22A23 | solute carrier family 22, member 23 | -0.0162411 |
| MMP24OS | MMP24 opposite strand | -0.0162295 |
| ATAD2 | ATPase family, AAA domain containing 2 | -0.0161647 |
| RGS6 | regulator of G-protein signaling 6 | -0.0161317 |
| NBAS | neuroblastoma amplified sequence | -0.0161129 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0158834 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.015762 |
| UQCC1 | ubiquinol-cytochrome c reductase complex assembly factor 1 | -0.0156072 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0155025 |
| TPD52 | tumor protein D52 | -0.0153094 |
| MXD1 | MAX dimerization protein 1 | -0.0152701 |
| U2SURP | U2 snRNP-associated SURP domain containing | -0.0152203 |
| RYK | receptor-like tyrosine kinase | -0.015157 |
| E2F3 | E2F transcription factor 3 | -0.0150282 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0150278 |
| ANXA5 | annexin A5 | -0.0146249 |
| RYBP | RING1 and YY1 binding protein | -0.0146091 |
| TRIM25 | tripartite motif containing 25 | -0.014571 |
| FAM3C | family with sequence similarity 3, member C | -0.0145274 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0145098 |
