| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | RMC-6236 perturbation in C32 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the RMC-6236_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.216187 |
| VIM | vimentin | 0.202764 |
| FN1 | fibronectin 1 | 0.201769 |
| SFTPA2 | surfactant protein A2 | 0.107762 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.098862 |
| MT2A | metallothionein 2A | 0.0786694 |
| ENO1 | enolase 1, (alpha) | 0.0784419 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.07152 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0673328 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0668147 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.0588931 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0550445 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0544467 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0540689 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0476869 |
| B2M | beta-2-microglobulin | 0.0476335 |
| LDHA | lactate dehydrogenase A | 0.0433937 |
| CD44 | CD44 molecule (Indian blood group) | 0.0418455 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0409511 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0404886 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0394548 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.037536 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0355564 |
| CENPF | centromere protein F, 350/400kDa | 0.0341277 |
| ACTN1 | actinin, alpha 1 | 0.0339243 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0337773 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0336849 |
| PLIN2 | perilipin 2 | 0.0329612 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0328435 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0319811 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0315118 |
| TPR | translocated promoter region, nuclear basket protein | 0.0314596 |
| MKI67 | marker of proliferation Ki-67 | 0.0307207 |
| TXNIP | thioredoxin interacting protein | 0.0299596 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0294341 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0294163 |
| SOX10 | SRY (sex determining region Y)-box 10 | 0.0293595 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.028531 |
| NRP2 | neuropilin 2 | 0.0264544 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0261278 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0248048 |
| CAMSAP2 | calmodulin regulated spectrin-associated protein family, member 2 | 0.02479 |
| PCBP2 | poly(rC) binding protein 2 | 0.0244645 |
| SCARB2 | scavenger receptor class B, member 2 | 0.0242997 |
| ADM | adrenomedullin | 0.0239634 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0239325 |
| STRIP2 | striatin interacting protein 2 | 0.0236379 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0236255 |
| LAMB1 | laminin, beta 1 | 0.0235842 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0233511 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0233407 |
| RNASE12 | ribonuclease, RNase A family, 12 (non-active) | 0.02243 |
| DSTN | destrin (actin depolymerizing factor) | 0.0224211 |
| LEF1 | lymphoid enhancer-binding factor 1 | 0.0222668 |
| RPS2 | ribosomal protein S2 | 0.0222501 |
| FRMD4A | FERM domain containing 4A | 0.022149 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.021711 |
| CD74 | CD74 molecule, major histocompatibility complex, class II invariant chain | 0.0214958 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0211403 |
| VEGFA | vascular endothelial growth factor A | 0.021122 |
| CDH19 | cadherin 19, type 2 | 0.021114 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.0210089 |
| IFITM1 | interferon induced transmembrane protein 1 | 0.0209917 |
| SVIL | supervillin | 0.0209676 |
| ZFP36 | ZFP36 ring finger protein | 0.0209525 |
| MSN | moesin | 0.0201532 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0200621 |
| UTRN | utrophin | 0.0195059 |
| ARRDC3 | arrestin domain containing 3 | 0.0194883 |
| RPS12 | ribosomal protein S12 | 0.0194784 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0192701 |
| ADAR | adenosine deaminase, RNA-specific | 0.019081 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0189913 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0189157 |
| RPL37A | ribosomal protein L37a | 0.0188897 |
| SON | SON DNA binding protein | 0.0188461 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0187267 |
| RCAN1 | regulator of calcineurin 1 | 0.018612 |
| YBX1 | Y box binding protein 1 | 0.0185725 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0185087 |
| HMGA2 | high mobility group AT-hook 2 | 0.0184695 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0183484 |
| DST | dystonin | 0.0183388 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | 0.0181503 |
| PLEC | plectin | 0.0177454 |
| RHBDF2 | rhomboid 5 homolog 2 (Drosophila) | 0.0175543 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0174569 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0173724 |
| BAZ1B | bromodomain adjacent to zinc finger domain, 1B | 0.0171374 |
| SET | SET nuclear proto-oncogene | 0.0170679 |
| WWOX | WW domain containing oxidoreductase | 0.0169771 |
| SETBP1 | SET binding protein 1 | 0.0168242 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0168052 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0167648 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0166464 |
| BOD1L1 | biorientation of chromosomes in cell division 1-like 1 | 0.0164776 |
| GAS7 | growth arrest-specific 7 | 0.0164371 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0164357 |
| FLNA | filamin A, alpha | 0.0163376 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0162139 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.297766 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.229681 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0977276 |
| NDRG1 | N-myc downstream regulated 1 | -0.0938969 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0906927 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0886303 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0868294 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0865785 |
| VGF | VGF nerve growth factor inducible | -0.0843476 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0793804 |
| NLGN1 | neuroligin 1 | -0.0787705 |
| PTK2 | protein tyrosine kinase 2 | -0.0779245 |
| PHF21A | PHD finger protein 21A | -0.0773821 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0772776 |
| CDC73 | cell division cycle 73 | -0.0759612 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | -0.0736581 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0692657 |
| NBAS | neuroblastoma amplified sequence | -0.0679013 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0664957 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0661869 |
| TRIM2 | tripartite motif containing 2 | -0.0617865 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0600037 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0599058 |
| GDF15 | growth differentiation factor 15 | -0.058097 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0577192 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0575134 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0566078 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | -0.0555416 |
| RHEB | Ras homolog enriched in brain | -0.0553808 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0552174 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0549904 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0530292 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0524271 |
| SRPK2 | SRSF protein kinase 2 | -0.0514421 |
| TMEM123 | transmembrane protein 123 | -0.0510362 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0491736 |
| FMNL2 | formin-like 2 | -0.0489254 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.048559 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.047764 |
| SCFD2 | sec1 family domain containing 2 | -0.0471341 |
| HELZ | helicase with zinc finger | -0.0471171 |
| CUX1 | cut-like homeobox 1 | -0.0466132 |
| COPA | coatomer protein complex, subunit alpha | -0.046568 |
| GPC6 | glypican 6 | -0.0456857 |
| CHSY1 | chondroitin sulfate synthase 1 | -0.0448509 |
| RNF24 | ring finger protein 24 | -0.0445959 |
| RFX7 | regulatory factor X, 7 | -0.0436486 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0429486 |
| INSIG1 | insulin induced gene 1 | -0.0425385 |
| MEF2A | myocyte enhancer factor 2A | -0.042538 |
| COG5 | component of oligomeric golgi complex 5 | -0.0422288 |
| NPR2 | natriuretic peptide receptor 2 | -0.042177 |
| CDK14 | cyclin-dependent kinase 14 | -0.0416521 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0411603 |
| TPD52 | tumor protein D52 | -0.0404903 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0402269 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0399469 |
| RYBP | RING1 and YY1 binding protein | -0.039561 |
| ZNF292 | zinc finger protein 292 | -0.0395388 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0395217 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | -0.0394554 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0394472 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0394368 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0387207 |
| CD109 | CD109 molecule | -0.0386334 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0382714 |
| GNAS | GNAS complex locus | -0.0382622 |
| TAC4 | tachykinin 4 (hemokinin) | -0.0375629 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.037519 |
| FUS | FUS RNA binding protein | -0.0372852 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0365653 |
| OXR1 | oxidation resistance 1 | -0.036519 |
| DENND1A | DENN/MADD domain containing 1A | -0.0364987 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0360229 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0354325 |
| TNFRSF19 | tumor necrosis factor receptor superfamily, member 19 | -0.0350394 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0349962 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.034896 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0344713 |
| WDR45B | WD repeat domain 45B | -0.0340722 |
| EGR1 | early growth response 1 | -0.0339965 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0336037 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.033276 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0331942 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.0329885 |
| RLF | rearranged L-myc fusion | -0.0329619 |
| NUP58 | nucleoporin 58 | -0.032958 |
| FOXJ3 | forkhead box J3 | -0.0325457 |
| CALU | calumenin | -0.0318461 |
| PRELID2 | PRELI domain containing 2 | -0.0315323 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.031122 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.031114 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | -0.0306678 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0306511 |
| NAV2 | neuron navigator 2 | -0.03041 |
| TMEM263 | transmembrane protein 263 | -0.0298088 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.0296557 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0293328 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0290448 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0288555 |
