| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | RMC-6236 perturbation in COLO 205 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the RMC-6236_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LCN2 | lipocalin 2 | 0.16851 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.143885 |
| B2M | beta-2-microglobulin | 0.132544 |
| LMO7 | LIM domain 7 | 0.113496 |
| RNF213 | ring finger protein 213 | 0.113063 |
| EXT1 | exostosin glycosyltransferase 1 | 0.107926 |
| MACC1 | metastasis associated in colon cancer 1 | 0.103266 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | 0.0893995 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0845187 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0798641 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0773168 |
| MUC13 | mucin 13, cell surface associated | 0.0648111 |
| DST | dystonin | 0.0642313 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0602226 |
| ETV6 | ets variant 6 | 0.0587118 |
| DUSP16 | dual specificity phosphatase 16 | 0.0581542 |
| ATP10B | ATPase, class V, type 10B | 0.0563234 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0539327 |
| PDZD8 | PDZ domain containing 8 | 0.0504622 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | 0.0500822 |
| TMC5 | transmembrane channel-like 5 | 0.0493972 |
| MX2 | MX dynamin-like GTPase 2 | 0.0489525 |
| MX1 | MX dynamin-like GTPase 1 | 0.0484765 |
| LURAP1L | leucine rich adaptor protein 1-like | 0.0477976 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.046205 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0458754 |
| FNIP2 | folliculin interacting protein 2 | 0.0434193 |
| SFTPA2 | surfactant protein A2 | 0.0431193 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0416891 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0407217 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0403624 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.039705 |
| TRIM2 | tripartite motif containing 2 | 0.0395512 |
| LIMA1 | LIM domain and actin binding 1 | 0.0384842 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0379204 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0378491 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.037502 |
| FTL | ferritin, light polypeptide | 0.0364571 |
| ADAR | adenosine deaminase, RNA-specific | 0.0355244 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0347921 |
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | 0.0345204 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0342473 |
| SERINC5 | serine incorporator 5 | 0.0342157 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0336838 |
| KYNU | kynureninase | 0.0331466 |
| CTSB | cathepsin B | 0.0324913 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0308948 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.030697 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0303494 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.0300301 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0291955 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.0284638 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0284179 |
| RBM47 | RNA binding motif protein 47 | 0.0278821 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0278633 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0275994 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0269147 |
| OAS1 | 2'-5'-oligoadenylate synthetase 1, 40/46kDa | 0.0268734 |
| MYO5B | myosin VB | 0.0268717 |
| TSC22D1 | TSC22 domain family, member 1 | 0.026818 |
| SIK3 | SIK family kinase 3 | 0.0263091 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0260002 |
| SYT1 | synaptotagmin I | 0.0252057 |
| SP100 | SP100 nuclear antigen | 0.0247649 |
| AOPEP | aminopeptidase O (putative) | 0.0246273 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0245139 |
| DPP4 | dipeptidyl-peptidase 4 | 0.0243369 |
| FAT1 | FAT atypical cadherin 1 | 0.0241087 |
| ZNF292 | zinc finger protein 292 | 0.0239932 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0239685 |
| RND3 | Rho family GTPase 3 | 0.0236058 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0232671 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0227873 |
| SET | SET nuclear proto-oncogene | 0.0227165 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.022467 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0223412 |
| IFNGR1 | interferon gamma receptor 1 | 0.0222194 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | 0.0220702 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.02205 |
| PTGR1 | prostaglandin reductase 1 | 0.0219091 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0216899 |
| SLC40A1 | solute carrier family 40 (iron-regulated transporter), member 1 | 0.0216182 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0213267 |
| TXNRD1 | thioredoxin reductase 1 | 0.0211265 |
| DSTN | destrin (actin depolymerizing factor) | 0.0210711 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0208515 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0207964 |
| RPL7L1 | ribosomal protein L7-like 1 | 0.0207907 |
| HKDC1 | hexokinase domain containing 1 | 0.0206972 |
| MAP3K1 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase | 0.0206955 |
| CLOCK | clock circadian regulator | 0.0205995 |
| DSPP | dentin sialophosphoprotein | 0.0205397 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0204662 |
| YAP1 | Yes-associated protein 1 | 0.0202995 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | 0.0202642 |
| ATP9A | ATPase, class II, type 9A | 0.0201746 |
| ANXA4 | annexin A4 | 0.0201387 |
| PCBP2 | poly(rC) binding protein 2 | 0.0199318 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0198698 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0196145 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ANXA2 | annexin A2 | -0.158784 |
| EGR1 | early growth response 1 | -0.151742 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.142123 |
| INTS6 | integrator complex subunit 6 | -0.140792 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.115136 |
| EZR | ezrin | -0.105758 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | -0.0958982 |
| SQSTM1 | sequestosome 1 | -0.0876661 |
| ANKRD10 | ankyrin repeat domain 10 | -0.08614 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0859711 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0858853 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0827057 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0824389 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0756554 |
| TM4SF19 | transmembrane 4 L six family member 19 | -0.0710647 |
| NDRG1 | N-myc downstream regulated 1 | -0.0709482 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0676662 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0674649 |
| SDC4 | syndecan 4 | -0.0669553 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0643177 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0640143 |
| EFNB2 | ephrin-B2 | -0.0615277 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.0568864 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0566582 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0553611 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.05511 |
| TNS4 | tensin 4 | -0.0546491 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0538858 |
| VCL | vinculin | -0.0537596 |
| PRKCA | protein kinase C, alpha | -0.0532336 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0522155 |
| LAMA4 | laminin, alpha 4 | -0.0515811 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0514617 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0509608 |
| AREG | amphiregulin | -0.0504704 |
| MCL1 | myeloid cell leukemia 1 | -0.0501751 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0492276 |
| NPSR1 | neuropeptide S receptor 1 | -0.049041 |
| MORF4L2 | mortality factor 4 like 2 | -0.0488895 |
| HM13 | histocompatibility (minor) 13 | -0.0480625 |
| SHB | Src homology 2 domain containing adaptor protein B | -0.0471027 |
| GOLGB1 | golgin B1 | -0.0469001 |
| ITGA6 | integrin, alpha 6 | -0.0463808 |
| ASPH | aspartate beta-hydroxylase | -0.0463222 |
| AHI1 | Abelson helper integration site 1 | -0.0458362 |
| IRF1 | interferon regulatory factor 1 | -0.0454604 |
| HDLBP | high density lipoprotein binding protein | -0.0443895 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0442758 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0439923 |
| UFM1 | ubiquitin-fold modifier 1 | -0.0437994 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0437773 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0432066 |
| PKM | pyruvate kinase, muscle | -0.0422751 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0421841 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0413027 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0411599 |
| PLSCR2 | phospholipid scramblase 2 | -0.0392605 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0391198 |
| VPS37B | vacuolar protein sorting 37 homolog B (S. cerevisiae) | -0.0390905 |
| COG6 | component of oligomeric golgi complex 6 | -0.038617 |
| HLA-B | major histocompatibility complex, class I, B | -0.0375542 |
| S100A10 | S100 calcium binding protein A10 | -0.0370904 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0367323 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0366654 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0363555 |
| RBM39 | RNA binding motif protein 39 | -0.0358254 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0357294 |
| FOSL1 | FOS-like antigen 1 | -0.035696 |
| TUFT1 | tuftelin 1 | -0.0355434 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0349273 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | -0.0346572 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0343279 |
| CALU | calumenin | -0.0342049 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0340307 |
| LRRC8A | leucine rich repeat containing 8 family, member A | -0.0335543 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | -0.0335311 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0334013 |
| SPAG9 | sperm associated antigen 9 | -0.033311 |
| DIS3 | DIS3 exosome endoribonuclease and 3'-5' exoribonuclease | -0.0330769 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | -0.0327352 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | -0.0327056 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0326754 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.0325955 |
| SEC24D | SEC24 family member D | -0.0321453 |
| LDLR | low density lipoprotein receptor | -0.0321026 |
| POU2F2 | POU class 2 homeobox 2 | -0.0320434 |
| ANKRD17 | ankyrin repeat domain 17 | -0.031927 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0318245 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.03178 |
| IRS2 | insulin receptor substrate 2 | -0.0317367 |
| ACTN4 | actinin, alpha 4 | -0.0315911 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0315171 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0311851 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0311688 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0311559 |
| SDCBP2 | syndecan binding protein (syntenin) 2 | -0.0310336 |
| GNAS | GNAS complex locus | -0.0310054 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -0.0305272 |
| TM9SF2 | transmembrane 9 superfamily member 2 | -0.0304948 |
| ARF4 | ADP-ribosylation factor 4 | -0.0302428 |
