RMC-6236_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description RMC-6236 perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the RMC-6236_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.202537
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.190274
TIMP3 TIMP metallopeptidase inhibitor 3 0.156278
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.145866
KYNU kynureninase 0.124634
AKAP12 A kinase (PRKA) anchor protein 12 0.115995
B2M beta-2-microglobulin 0.106779
MT2A metallothionein 2A 0.0938041
FTH1 ferritin, heavy polypeptide 1 0.0869929
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0857498
VIM vimentin 0.0840096
HDAC9 histone deacetylase 9 0.0812574
SFTPA2 surfactant protein A2 0.0791773
MYLK myosin light chain kinase 0.0732123
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.072888
EEF2 eukaryotic translation elongation factor 2 0.0652745
AHR aryl hydrocarbon receptor 0.0600785
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0593938
STC1 stanniocalcin 1 0.0546448
EIF1 eukaryotic translation initiation factor 1 0.0540406
PTMA prothymosin, alpha 0.0537146
CANX calnexin 0.0535458
CD44 CD44 molecule (Indian blood group) 0.053117
CTSB cathepsin B 0.0529692
FTL ferritin, light polypeptide 0.052921
CREB5 cAMP responsive element binding protein 5 0.0467078
ERRFI1 ERBB receptor feedback inhibitor 1 0.0464349
RPS8 ribosomal protein S8 0.043432
ENO1 enolase 1, (alpha) 0.0428938
HLA-A major histocompatibility complex, class I, A 0.0423206
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0414813
SAMD4A sterile alpha motif domain containing 4A 0.0406052
CALR calreticulin 0.0388962
RACK1 receptor for activated C kinase 1 0.0386148
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0382352
ATF4 activating transcription factor 4 0.0372586
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0366399
RPL12 ribosomal protein L12 0.0353231
RPS6 ribosomal protein S6 0.0352382
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0344207
PDE5A phosphodiesterase 5A, cGMP-specific 0.0335464
RPS3 ribosomal protein S3 0.032987
TXNIP thioredoxin interacting protein 0.0325793
RPS2 ribosomal protein S2 0.032167
LDHA lactate dehydrogenase A 0.0317173
ATXN1 ataxin 1 0.0315338
C1S complement component 1, s subcomponent 0.0313615
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0310157
NFE2L1 nuclear factor, erythroid 2-like 1 0.0307799
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0302914
LGALS1 lectin, galactoside-binding, soluble, 1 0.0296857
AHNAK AHNAK nucleoprotein 0.0294235
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0293148
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0288371
TPT1 tumor protein, translationally-controlled 1 0.0287796
VEGFA vascular endothelial growth factor A 0.0284532
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 0.0283333
TMSB4X thymosin beta 4, X-linked 0.0277312
APP amyloid beta (A4) precursor protein 0.0276786
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0276631
TLN1 talin 1 0.0275
ENO2 enolase 2 (gamma, neuronal) 0.0262086
JUN jun proto-oncogene 0.0256459
MYH9 myosin, heavy chain 9, non-muscle 0.025248
RPL23 ribosomal protein L23 0.0249884
RPS13 ribosomal protein S13 0.024853
TPI1 triosephosphate isomerase 1 0.0248074
CLU clusterin 0.0247528
CALU calumenin 0.0247339
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0240142
RPL37A ribosomal protein L37a 0.0239223
TPM4 tropomyosin 4 0.0238254
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0235902
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0234671
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0233451
S100A6 S100 calcium binding protein A6 0.0230799
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0229412
IGFBP5 insulin-like growth factor binding protein 5 0.0223522
TPM3 tropomyosin 3 0.0222428
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.022155
RPS4X ribosomal protein S4, X-linked 0.0221047
INHBA inhibin, beta A 0.0216257
PCBP2 poly(rC) binding protein 2 0.0213149
RPL7A ribosomal protein L7a 0.0212957
RPLP1 ribosomal protein, large, P1 0.0211202
RHOA ras homolog family member A 0.0209902
KTN1 kinectin 1 (kinesin receptor) 0.0208896
SCARB2 scavenger receptor class B, member 2 0.0201882
RPL7 ribosomal protein L7 0.0201325
TXNRD1 thioredoxin reductase 1 0.019961
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.019915
MKI67 marker of proliferation Ki-67 0.0197013
PLIN2 perilipin 2 0.0196936
FLNA filamin A, alpha 0.01969
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K 0.019509
RPL35A ribosomal protein L35a 0.0194546
ANXA1 annexin A1 0.0193768
KALRN kalirin, RhoGEF kinase 0.0190738
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0190719
SRRM2 serine/arginine repetitive matrix 2 0.0190236

decreased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 -0.221876
NALF1 NALCN channel auxiliary factor 1 -0.146338
GRB10 growth factor receptor-bound protein 10 -0.144742
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.142558
FN1 fibronectin 1 -0.140135
PDE4D phosphodiesterase 4D, cAMP-specific -0.129196
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.101871
EGFR epidermal growth factor receptor -0.0706738
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0676003
ASPH aspartate beta-hydroxylase -0.0658616
RTN4 reticulon 4 -0.0649498
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0583655
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0550924
GARS1 glycyl-tRNA synthetase 1 -0.0543343
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0523771
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0512321
TAS2R14 taste receptor, type 2, member 14 -0.0512069
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0503589
STK17A serine/threonine kinase 17a -0.0483464
GNAS GNAS complex locus -0.0458383
TNNC1 troponin C type 1 (slow) -0.0434055
SBF2 SET binding factor 2 -0.0425014
ZNF804A zinc finger protein 804A -0.0422021
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0421099
ACTN4 actinin, alpha 4 -0.0414375
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0405268
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.040338
BIRC6 baculoviral IAP repeat containing 6 -0.0397299
FAM20C family with sequence similarity 20, member C -0.0394328
NAMPT nicotinamide phosphoribosyltransferase -0.0385801
NAV3 neuron navigator 3 -0.0384427
SMC4 structural maintenance of chromosomes 4 -0.0375284
PTK2 protein tyrosine kinase 2 -0.0373163
GLS2 glutaminase 2 (liver, mitochondrial) -0.037267
VCL vinculin -0.0366356
KCTD16 potassium channel tetramerization domain containing 16 -0.0365893
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.036348
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0354649
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.034532
PSD3 pleckstrin and Sec7 domain containing 3 -0.0343712
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0341937
TENT5A terminal nucleotidyltransferase 5A -0.0339384
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0336658
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0331498
MBD5 methyl-CpG binding domain protein 5 -0.0330985
SEC24D SEC24 family member D -0.0322122
ACTN1 actinin, alpha 1 -0.0314603
GPC6 glypican 6 -0.0307758
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0306443
DIAPH3 diaphanous-related formin 3 -0.0303248
RPTOR regulatory associated protein of MTOR, complex 1 -0.0302904
SDK1 sidekick cell adhesion molecule 1 -0.0301838
ANTXR2 anthrax toxin receptor 2 -0.0301448
LYPD6B LY6/PLAUR domain containing 6B -0.030133
SYT1 synaptotagmin I -0.029539
CDK14 cyclin-dependent kinase 14 -0.0293374
ZMYND8 zinc finger, MYND-type containing 8 -0.0293354
RIGI RNA sensor RIG-I -0.0291862
GLIS3 GLIS family zinc finger 3 -0.0288769
SMC5 structural maintenance of chromosomes 5 -0.0282597
KDM4B lysine (K)-specific demethylase 4B -0.0279063
HDAC4 histone deacetylase 4 -0.0277101
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0275814
ANLN anillin, actin binding protein -0.0273301
IGF2 insulin-like growth factor 2 -0.0271582
AFAP1 actin filament associated protein 1 -0.027136
CDH12 cadherin 12, type 2 (N-cadherin 2) -0.026564
PKM pyruvate kinase, muscle -0.0264691
LPP LIM domain containing preferred translocation partner in lipoma -0.0262973
ATM ATM serine/threonine kinase -0.0260823
MMP12 matrix metallopeptidase 12 -0.0260788
SOX5 SRY (sex determining region Y)-box 5 -0.025809
FMNL2 formin-like 2 -0.0257513
RAB7A RAB7A, member RAS oncogene family -0.0256771
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0252323
PAPPA2 pappalysin 2 -0.0251755
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0251343
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0249114
PRELID2 PRELI domain containing 2 -0.0248225
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0245854
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0245127
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0244268
TENM3 teneurin transmembrane protein 3 -0.024207
MAML3 mastermind-like 3 (Drosophila) -0.023672
RUNX1 runt-related transcription factor 1 -0.0234574
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0232209
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0231842
SHB Src homology 2 domain containing adaptor protein B -0.0231751
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0231002
CADM1 cell adhesion molecule 1 -0.0230497
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0229909
FUS FUS RNA binding protein -0.0229865
OR51B5 olfactory receptor, family 51, subfamily B, member 5 -0.0229769
NF1 neurofibromin 1 -0.022915
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.022863
THOC2 THO complex 2 -0.022769
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0227457
AUTS2 autism susceptibility candidate 2 -0.0227054
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0225725
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0224145