| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | RMC-6236 perturbation in HCT15 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the RMC-6236_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EEF2 | eukaryotic translation elongation factor 2 | 0.157696 |
| PCBP2 | poly(rC) binding protein 2 | 0.068877 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0585635 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0566102 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.054998 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0510672 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0419018 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0417392 |
| BRD2 | bromodomain containing 2 | 0.041298 |
| TXNIP | thioredoxin interacting protein | 0.0412117 |
| INTS6 | integrator complex subunit 6 | 0.0409485 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0408655 |
| RACK1 | receptor for activated C kinase 1 | 0.0392566 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0372206 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0367855 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0364168 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0361392 |
| RPL3 | ribosomal protein L3 | 0.0358256 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0356514 |
| GOLGA4 | golgin A4 | 0.0355965 |
| LRRC23 | leucine rich repeat containing 23 | 0.0354055 |
| ZNF638 | zinc finger protein 638 | 0.0347479 |
| SFTPA2 | surfactant protein A2 | 0.0339699 |
| CANX | calnexin | 0.0332045 |
| RPS2 | ribosomal protein S2 | 0.032454 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0320376 |
| ATF4 | activating transcription factor 4 | 0.0310544 |
| RPS3 | ribosomal protein S3 | 0.0309357 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0296434 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.0288992 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0280117 |
| CTSB | cathepsin B | 0.0271094 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0264402 |
| RUNX1 | runt-related transcription factor 1 | 0.0241162 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0230273 |
| RPL26 | ribosomal protein L26 | 0.0228204 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0227246 |
| FLNA | filamin A, alpha | 0.0224347 |
| TMF1 | TATA element modulatory factor 1 | 0.0216892 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0212099 |
| RPL12 | ribosomal protein L12 | 0.0209519 |
| RPS18 | ribosomal protein S18 | 0.0208079 |
| HOMER1 | homer scaffolding protein 1 | 0.0206305 |
| SON | SON DNA binding protein | 0.0204159 |
| RPS8 | ribosomal protein S8 | 0.0201253 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.020097 |
| MACROD2 | MACRO domain containing 2 | 0.0194953 |
| RPS4X | ribosomal protein S4, X-linked | 0.0192512 |
| DSPP | dentin sialophosphoprotein | 0.0190267 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | 0.0187257 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0186392 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0185175 |
| TPI1 | triosephosphate isomerase 1 | 0.0183162 |
| B2M | beta-2-microglobulin | 0.0182228 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0181986 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0181326 |
| TBC1D15 | TBC1 domain family, member 15 | 0.0181145 |
| JUN | jun proto-oncogene | 0.0180201 |
| RIPK1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.0177566 |
| RPS3A | ribosomal protein S3A | 0.0176203 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.017502 |
| RPS12 | ribosomal protein S12 | 0.0173763 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0172212 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0171157 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.017031 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0170169 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0169625 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0168746 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0168486 |
| RPS7 | ribosomal protein S7 | 0.0164835 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.01632 |
| DMXL2 | Dmx-like 2 | 0.0161677 |
| SMARCA2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 | 0.0161404 |
| CLU | clusterin | 0.0160594 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0158165 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.0158149 |
| XPOT | exportin, tRNA | 0.0158077 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0157363 |
| PGM3 | phosphoglucomutase 3 | 0.0153827 |
| ZRANB1 | zinc finger, RAN-binding domain containing 1 | 0.0152963 |
| RPL18 | ribosomal protein L18 | 0.0152533 |
| CDC14A | cell division cycle 14A | 0.0151028 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0150234 |
| RPS26 | ribosomal protein S26 | 0.0149079 |
| ITSN2 | intersectin 2 | 0.014897 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0147776 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0146931 |
| BMS1 | BMS1 ribosome biogenesis factor | 0.0146803 |
| SERINC1 | serine incorporator 1 | 0.0146798 |
| ERO1B | endoplasmic reticulum oxidoreductase 1 beta | 0.0145762 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0145742 |
| MATR3 | matrin 3 | 0.0145126 |
| RPL7 | ribosomal protein L7 | 0.0141929 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0141118 |
| SARS1 | seryl-tRNA synthetase 1 | 0.0139687 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0139263 |
| SF3A1 | splicing factor 3a, subunit 1, 120kDa | 0.0138906 |
| CALCOCO2 | calcium binding and coiled-coil domain 2 | 0.0137536 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | 0.0136998 |
| GNL2 | guanine nucleotide binding protein-like 2 (nucleolar) | 0.0136018 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.290162 |
| PTMA | prothymosin, alpha | -0.221704 |
| FAT1 | FAT atypical cadherin 1 | -0.158185 |
| NDRG1 | N-myc downstream regulated 1 | -0.116573 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.102393 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0890171 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0876735 |
| TMSB10 | thymosin beta 10 | -0.0741147 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0701022 |
| PKM | pyruvate kinase, muscle | -0.0688479 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0672412 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.063828 |
| SERINC5 | serine incorporator 5 | -0.0629259 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0623978 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0597796 |
| ACTG1 | actin gamma 1 | -0.0584568 |
| TENM3 | teneurin transmembrane protein 3 | -0.0578674 |
| TUBA1B | tubulin, alpha 1b | -0.0575032 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0564587 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0515331 |
| POTEF | POTE ankyrin domain family, member F | -0.0503476 |
| TPM4 | tropomyosin 4 | -0.0492161 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0491263 |
| MED13L | mediator complex subunit 13-like | -0.0487456 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0477912 |
| KRT19 | keratin 19, type I | -0.0470435 |
| ACTN4 | actinin, alpha 4 | -0.0468351 |
| MKI67 | marker of proliferation Ki-67 | -0.0466423 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0465799 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0438316 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0417914 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.0411914 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0404501 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0383603 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0370736 |
| LOC112694756 | uncharaterized LOC112694756 | -0.036458 |
| TUBB | tubulin, beta class I | -0.036048 |
| XPO1 | exportin 1 | -0.0360271 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0360252 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0357415 |
| CACNB4 | calcium channel, voltage-dependent, beta 4 subunit | -0.0356125 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0353997 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.03523 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0350591 |
| ASPH | aspartate beta-hydroxylase | -0.033964 |
| TMEM123 | transmembrane protein 123 | -0.0339528 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0334121 |
| PTK2 | protein tyrosine kinase 2 | -0.0330939 |
| SETD5 | SET domain containing 5 | -0.0328168 |
| MEF2A | myocyte enhancer factor 2A | -0.0326819 |
| TXNRD1 | thioredoxin reductase 1 | -0.0326733 |
| SHROOM3 | shroom family member 3 | -0.0324718 |
| HMGA1 | high mobility group AT-hook 1 | -0.0322687 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0321316 |
| ITGB4 | integrin, beta 4 | -0.0320672 |
| CDCP1 | CUB domain containing protein 1 | -0.0319334 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0318249 |
| KRT8 | keratin 8, type II | -0.0315466 |
| DIAPH3 | diaphanous-related formin 3 | -0.0315058 |
| NF1 | neurofibromin 1 | -0.0312769 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0311633 |
| HMGA2 | high mobility group AT-hook 2 | -0.030921 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0308166 |
| WASF2 | WAS protein family, member 2 | -0.0307542 |
| PGK1 | phosphoglycerate kinase 1 | -0.0305926 |
| ACACA | acetyl-CoA carboxylase alpha | -0.030562 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0304588 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.030455 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0304273 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0303709 |
| GNAS | GNAS complex locus | -0.0298133 |
| TUBA1C | tubulin, alpha 1c | -0.0296836 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0296554 |
| HMGB1 | high mobility group box 1 | -0.0296511 |
| S100A6 | S100 calcium binding protein A6 | -0.0296389 |
| RAD51B | RAD51 paralog B | -0.029531 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0294489 |
| CYB5B | cytochrome b5 type B (outer mitochondrial membrane) | -0.0293876 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0292796 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0291872 |
| RHOA | ras homolog family member A | -0.0291687 |
| EREG | epiregulin | -0.0291151 |
| MSI2 | musashi RNA-binding protein 2 | -0.0290494 |
| TAOK1 | TAO kinase 1 | -0.0290051 |
| MYOF | myoferlin | -0.0289464 |
| INSIG1 | insulin induced gene 1 | -0.0288226 |
| CENPF | centromere protein F, 350/400kDa | -0.0287464 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.028684 |
| S100A10 | S100 calcium binding protein A10 | -0.0286653 |
| TCF12 | transcription factor 12 | -0.0286192 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0283257 |
| DNM2 | dynamin 2 | -0.0281855 |
| RIC1 | RAB6A GEF complex partner 1 | -0.0275584 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0274205 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0270891 |
| PFN1 | profilin 1 | -0.0270435 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0270356 |
| ZNF207 | zinc finger protein 207 | -0.027013 |
| DENND4C | DENN/MADD domain containing 4C | -0.0269884 |
| RTN4 | reticulon 4 | -0.0269165 |
