RMC-6236_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description RMC-6236 perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the RMC-6236_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.16672
FTH1 ferritin, heavy polypeptide 1 0.165233
EEF2 eukaryotic translation elongation factor 2 0.147585
ALCAM activated leukocyte cell adhesion molecule 0.114944
MYH9 myosin, heavy chain 9, non-muscle 0.11012
ZBTB20 zinc finger and BTB domain containing 20 0.109079
IGFBP3 insulin-like growth factor binding protein 3 0.108092
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.103218
FLNA filamin A, alpha 0.085676
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0853554
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0779748
B2M beta-2-microglobulin 0.0765285
RPS2 ribosomal protein S2 0.0716688
RPL12 ribosomal protein L12 0.0712366
RACK1 receptor for activated C kinase 1 0.0694412
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0691827
MACROD2 MACRO domain containing 2 0.0683873
MYOF myoferlin 0.0664541
RHEX regulator of hemoglobinization and erythroid cell expansion 0.0660794
RPS8 ribosomal protein S8 0.0660738
GOLGB1 golgin B1 0.0660033
SET SET nuclear proto-oncogene 0.0656746
MACC1 metastasis associated in colon cancer 1 0.0633858
SRRM2 serine/arginine repetitive matrix 2 0.062868
RPS12 ribosomal protein S12 0.0611932
OXR1 oxidation resistance 1 0.0592017
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0579139
NCEH1 neutral cholesterol ester hydrolase 1 0.0558085
ATXN1 ataxin 1 0.0557894
BBS9 Bardet-Biedl syndrome 9 0.0557697
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0555604
ANXA1 annexin A1 0.0555512
LOC102724023 ES1 protein homolog, mitochondrial 0.0541318
PCBP2 poly(rC) binding protein 2 0.0540365
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0534823
RPL23 ribosomal protein L23 0.053155
RPS6 ribosomal protein S6 0.0529818
EIF1 eukaryotic translation initiation factor 1 0.0515464
ENO1 enolase 1, (alpha) 0.0501999
RPS3 ribosomal protein S3 0.0500382
TJP1 tight junction protein 1 0.0497655
PRELID2 PRELI domain containing 2 0.0484141
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0483955
LAMB3 laminin, beta 3 0.047531
KRT7 keratin 7, type II 0.0466411
ZSWIM6 zinc finger, SWIM-type containing 6 0.0457943
RPL9 ribosomal protein L9 0.044974
DSPP dentin sialophosphoprotein 0.0446269
RPL35A ribosomal protein L35a 0.044086
RPS17 ribosomal protein S17 0.0435647
SVIL supervillin 0.0432475
ZFP36L1 ZFP36 ring finger protein-like 1 0.043188
PTPRK protein tyrosine phosphatase, receptor type, K 0.043011
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0426003
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0424363
ZNF608 zinc finger protein 608 0.0405508
TPI1 triosephosphate isomerase 1 0.0400878
RPL26 ribosomal protein L26 0.0399572
AHNAK2 AHNAK nucleoprotein 2 0.0393779
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0389219
RPL11 ribosomal protein L11 0.0387457
BICC1 BicC family RNA binding protein 1 0.038662
THSD7A thrombospondin, type I, domain containing 7A 0.0383728
RNF213 ring finger protein 213 0.0376732
LDHA lactate dehydrogenase A 0.0372502
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.037178
SKAP2 src kinase associated phosphoprotein 2 0.0370251
HSPA8 heat shock 70kDa protein 8 0.0366462
SFTPA2 surfactant protein A2 0.0366423
PCLO piccolo presynaptic cytomatrix protein 0.0365431
RPS4X ribosomal protein S4, X-linked 0.0363749
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0363122
APLP2 amyloid beta (A4) precursor-like protein 2 0.0361956
FTL ferritin, light polypeptide 0.035883
AEBP2 AE binding protein 2 0.035498
RUNX1 runt-related transcription factor 1 0.0353645
RPL31 ribosomal protein L31 0.03515
RPL37A ribosomal protein L37a 0.0349665
CLDN4 claudin 4 0.0344811
SQSTM1 sequestosome 1 0.0343044
RPL3 ribosomal protein L3 0.0340828
EZR ezrin 0.033463
YBX1 Y box binding protein 1 0.0333761
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0330578
RPS27A ribosomal protein S27a 0.0329476
APOL1 apolipoprotein L, 1 0.0328959
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0328097
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0323754
MBNL1 muscleblind-like splicing regulator 1 0.0322443
RPL5 ribosomal protein L5 0.0321913
ZNF638 zinc finger protein 638 0.0320465
ACTG1 actin gamma 1 0.0319982
TRIM2 tripartite motif containing 2 0.0316285
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0316228
BRD2 bromodomain containing 2 0.0316072
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0314975
ITGB6 integrin, beta 6 0.0312271
ITGAV integrin, alpha V 0.0311775
RAD51B RAD51 paralog B 0.0311623
DSG2 desmoglein 2 0.0309999

decreased expression

Symbol Name Standardized Value
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.143847
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.141043
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0920147
DLC1 DLC1 Rho GTPase activating protein -0.0738497
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0680253
ANKRD10 ankyrin repeat domain 10 -0.056473
LIMCH1 LIM and calponin homology domains 1 -0.055816
NF1 neurofibromin 1 -0.0542849
BICD1 bicaudal D homolog 1 (Drosophila) -0.0482669
SBF2 SET binding factor 2 -0.0460711
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.045443
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0440099
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0422827
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0422793
WDR45B WD repeat domain 45B -0.0417454
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0413997
PTK2 protein tyrosine kinase 2 -0.0413447
DLG1 discs, large homolog 1 (Drosophila) -0.0410796
NPEPPS aminopeptidase puromycin sensitive -0.0396529
RNF145 ring finger protein 145 -0.0391333
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0389891
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0389763
BIRC6 baculoviral IAP repeat containing 6 -0.0385842
ASPH aspartate beta-hydroxylase -0.0381378
HMGA2 high mobility group AT-hook 2 -0.0377882
CLINT1 clathrin interactor 1 -0.0370798
NDRG1 N-myc downstream regulated 1 -0.0369625
CCND1 cyclin D1 -0.0357851
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0342862
TXNRD1 thioredoxin reductase 1 -0.0340314
TM9SF3 transmembrane 9 superfamily member 3 -0.033959
UPP1 uridine phosphorylase 1 -0.0338553
TUBB tubulin, beta class I -0.0332863
MAP4 microtubule-associated protein 4 -0.0322466
GARS1 glycyl-tRNA synthetase 1 -0.0317846
MARCHF6 membrane associated ring-CH-type finger 6 -0.0315116
TPD52 tumor protein D52 -0.0313414
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0312258
ZNF292 zinc finger protein 292 -0.0308884
CDCP1 CUB domain containing protein 1 -0.0305662
ZFAND3 zinc finger, AN1-type domain 3 -0.0303609
SFXN1 sideroflexin 1 -0.0303409
RASA3 RAS p21 protein activator 3 -0.0299649
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.029713
SETD5 SET domain containing 5 -0.0295554
TCERG1 transcription elongation regulator 1 -0.0293682
U2SURP U2 snRNP-associated SURP domain containing -0.0293395
FLNB filamin B, beta -0.0293132
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0289868
DOCK4 dedicator of cytokinesis 4 -0.028698
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0286118
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0283538
TJP2 tight junction protein 2 -0.0281269
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0279579
IARS1 isoleucyl-tRNA synthetase 1 -0.0279423
PTBP2 polypyrimidine tract binding protein 2 -0.0276342
FNBP1L formin binding protein 1-like -0.0275703
USP3 ubiquitin specific peptidase 3 -0.0272036
ZMYM2 zinc finger, MYM-type 2 -0.0271697
PGK1 phosphoglycerate kinase 1 -0.0271391
ARHGAP26 Rho GTPase activating protein 26 -0.0270585
WAC WW domain containing adaptor with coiled-coil -0.026777
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0267029
NCOR1 nuclear receptor corepressor 1 -0.0266703
ATP13A3 ATPase type 13A3 -0.0263677
HMGA1 high mobility group AT-hook 1 -0.0263547
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.0262609
RLF rearranged L-myc fusion -0.026055
KMT2E lysine (K)-specific methyltransferase 2E -0.0260481
KPNB1 karyopherin (importin) beta 1 -0.0260052
RAB7A RAB7A, member RAS oncogene family -0.0258821
RAB1A RAB1A, member RAS oncogene family -0.0258773
VEZT vezatin, adherens junctions transmembrane protein -0.0255567
NOP58 NOP58 ribonucleoprotein -0.025446
RTN4 reticulon 4 -0.0254202
PDS5B PDS5 cohesin associated factor B -0.0253157
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0250183
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0249998
ACACA acetyl-CoA carboxylase alpha -0.0246913
ANLN anillin, actin binding protein -0.0245573
UBE2K ubiquitin-conjugating enzyme E2K -0.024542
FRAS1 Fraser extracellular matrix complex subunit 1 -0.0245381
BTBD7 BTB (POZ) domain containing 7 -0.024505
ADAM10 ADAM metallopeptidase domain 10 -0.0244729
MIS18BP1 MIS18 binding protein 1 -0.0244549
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.024002
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0239341
ATG7 autophagy related 7 -0.0238528
TEX10 testis expressed 10 -0.0238359
TUBA1B tubulin, alpha 1b -0.0234127
FOXJ3 forkhead box J3 -0.0234124
FBXL2 F-box and leucine-rich repeat protein 2 -0.0233919
ANKRD11 ankyrin repeat domain 11 -0.0233289
EGR1 early growth response 1 -0.023288
KDM3A lysine (K)-specific demethylase 3A -0.0232417
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0232356
BRWD1 bromodomain and WD repeat domain containing 1 -0.0231564
USP24 ubiquitin specific peptidase 24 -0.0231214
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0230398
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) -0.0228619